Newdoxime

Newdoxime Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Newdoxime is a brand name. Its generic name is Cefpodoxime.

Introduction

Newdoxime (also referred to as cefpodoxime proxetil) is an antibiotic used to treat sinus infections, bronchitis, pneumonia, ENT infections, skin infections, and certain urinary tract infections. The drug belongs to a class of antibiotics called cephalosporins and is produced in oral, and intravenous formats.

Uses

Newdoxime is used to treat a variety of bacterial infections such as sinusitis, bronchitis, pneumonia, otitis media, cellulitis, urinary tract infections, skin and skin structure infections, and pharyngitis/tonsillitis.

Mechanism of Action

Newdoxime works by inhibiting bacterial cell wall synthesis. This leads to an influx of water and causes the cell wall to rupture, thus killing the bacteria. In addition, the drug has some activity against certain types of fungi, viruses and protozoa.

How Long Does It Take to Work

Newdoxime usually begins to take effect within 1-2 days of administration. However, it may take up to 5-7 days to experience full relief of symptoms.

Absorption, Route of Elimination, Dosage and Administration

Newdoxime is rapidly and almost completely absorbed from the gastrointestinal tract. The drug is eliminated primarily through the kidneys and the excretion rate is slow. The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours. Oral suspension formulations are available in 50 and 100 mg/5 mL strengths.

Side Effects

Common side effects of cefpodoxime include diarrhea, nausea, vomiting, abdominal pain, dizziness, headache, fatigue, rash, and skin sensitivity. Severe side effects include anaphylaxis, kidney damage, and fainting. Newdoxime can also cause abnormal liver function test results and thrombocytopenia.

Toxicity

Newdoxime is generally well-tolerated. Overdose symptoms include nausea, vomiting, diarrhea, dizziness, rapid heart rate, and rare seizures.

Precautions

Newdoxime should be avoided in patients with history of allergy to cephalosporins. The drug should not be used in patients with impaired kidney or liver function. It should also be used with caution in pregnant and breastfeeding women.

Interaction

Newdoxime may interact with other medications such as antacids, warfarin, digoxin, probenecid, and certain drugs for HIV/AIDS, etc. Drugs that interact with cefpodoxime include: paroxetine; phenytoin; ritonavir; certain fluoroquinolone antibiotics such as ciprofloxacin, norfloxacin, and ofloxacin; and certain anti-seizure drugs such as phenytoin, valproic acid, and carbamazepine.

Disease Interaction

Newdoxime may interact with certain medical conditions such as kidney disease, history of allergic reactions to other cephalosporin antibiotics, and intestinal inflammation due to infection or the use of antibiotics. Newdoxime should be used with caution in patients with kidney disease. It should not be used in patients if there is an existing intestine infection or if the patient has recently been taking antibiotics.

Drug Interaction

Drug interactions may occur when cefpodoxime is taken with other medications such as antacids, warfarin, probenecid, and certain HIV drugs. Newdoxime should not be used together with drugs like paroxetine, phenytoin, ritonavir, certain fluoroquinolone antibiotics (ciprofloxacin, norfloxacin, ofloxacin), certain anti-seizure drugs (phenytoin, valproic acid, carbamazepine), etc. Patients should inform their physicians of any medications they are currently taking before taking cefpodoxime.

Food Interactions

Newdoxime should be taken with a full glass of water. Food can decrease the absorption of cefpodoxime, so the drug should be taken at least 2 hours before or after a meal. Avoid consumption of dairy products, antacids, iron supplements, and vitamins within 2 hours of taking cefpodoxime.

Pregnancy Use

Newdoxime is likely safe to use during pregnancy. However, it is best to consult a doctor before taking cefpodoxime during pregnancy.

Lactation Use

Newdoxime is not known to be harmful when breastfeeding. However, it is best to consult a doctor before taking cefpodoxime while breastfeeding.

Acute Overdose

Acute overdose of cefpodoxime can result in nausea, dizziness, rapid heart rate, and seizures. Seek medical help if overdose is suspected.

Contraindication

Newdoxime is contraindicated in patients with known allergy to cephalosporins.

Dosage Information

The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours.

Direction of Use

Newdoxime should be taken orally with a full glass of water. It should be taken with or without food. It should not be taken with dairy products, antacids, iron supplements, or vitamins.

Storage Condition

Newdoxime should be stored in a tight container, away from light and moisture, at room temperature (15-30°C).

Volume of Distribution

Newdoxime has a volume of distribution of 0.3 - 0.5 L/kg.

Half-Life

The average half-life of cefpodoxime is about 2 - 4 hours.

Clearance

The average clearance of cefpodoxime is 50 - 70 mL/min.

Here you find in details version of Newdoxime

Some Frequently Asked Questions About Newdoxime

What is Newdoxime?

Newdoxime is an antibiotic used to treat certain types of bacterial infections. It belongs to a class of antibiotics called cephalosporins that work by stopping the growth of bacteria.

What infections does Newdoxime treat?

Newdoxime is used to treat infections caused by certain bacteria, such as lower respiratory tract infections, otitis media (middle ear infections), skin infections, and urinary tract infections.

How does Newdoxime work?

Newdoxime works by attacking the bacteria that cause the infection. It works by interfering with the bacteria’s ability to make cell walls, which results in the death of the bacteria.

Who should take Newdoxime?

Newdoxime should be taken by those who have been prescribed it by a doctor to treat a bacterial infection. It should not be taken by anyone who has an allergy to cephalosporin antibiotics.

How do I take Newdoxime?

Newdoxime should be taken as directed by your doctor. The dosage and length of treatment will depend on the infection being treated. The tablets should be taken with a full glass of water. If you forget to take a dose, take it as soon as you remember.

What are the possible side effects of taking Newdoxime?

Some common side effects of taking Newdoxime may include nausea, vomiting, diarrhea, or skin rash. Serious side effects include easy bleeding or bruising, yellowing skin or eyes, chest pain, or difficulty breathing. Tell your doctor if you experience any of these side effects.

What if I am allergic to Newdoxime?

If you are allergic to Newdoxime or other cephalosporin antibiotics, do not take this drug. Tell your doctor about any allergies that you have before beginning treatment.

Can I take Newdoxime with other medications?

Before taking Newdoxime, tell your doctor if you are taking any other medications, especially probenecid, sulfamethoxazole, or valproic acid. Some medications may interact with Newdoxime, so it is important to discuss them with your doctor before beginning treatment.

Can Newdoxime be used to treat a viral infection?

No, Newdoxime is not effective for treating viral infections since it only attacks bacterial infections.

What is the recommended dosage for Newdoxime?

The recommended dosage of Newdoxime depends on the infection being treated and on the patient's age and weight. It is important to follow your doctor's instructions when taking Newdoxime.

Can Newdoxime be used during pregnancy?

Newdoxime is generally considered safe to use during pregnancy, but it is always best to consult your doctor before taking any medication during pregnancy.

Can I miss a dose of Newdoxime?

If you miss a dose of Newdoxime, take it as soon as possible. However, if it is close to the time for your next dose, skip the missed dose and continue with your normal schedule.

Is Newdoxime safe for children?

Yes, Newdoxime is safe to use in children. However, it is important to follow your doctor's instructions for dosage and duration of treatment.

Does Newdoxime have any interactions with food?

No, Newdoxime does not have any known food interactions.

Can I drink alcohol while taking Newdoxime?

It is not recommended to drink alcohol while taking Newdoxime, as it may increase the chance of side effects.

Does Newdoxime cause headaches?

Newdoxime can cause headaches as a side effect in some people. If you experience headaches while taking Newdoxime, contact your doctor.

How long should I take Newdoxime?

Your doctor will determine how long you should take Newdoxime. It is important to follow your doctor’s instructions for the duration of treatment.

Can Newdoxime affect the liver?

Newdoxime can potentially cause liver damage in rare cases. If you notice any symptoms of liver damage, such as yellowing of the skin or eyes, contact your doctor.

What should I do if I develop an allergic reaction to Newdoxime?

If you develop an allergic reaction while taking Newdoxime, stop taking the medication and contact your doctor immediately.

Is Newdoxime available as a generic drug?

Yes, Newdoxime is available as a generic drug.

Does Newdoxime cause drowsiness?

Newdoxime can cause drowsiness as a side effect in some people. If you experience drowsiness while taking Newdoxime, contact your doctor.

Can I take Newdoxime with other antibiotics?

No, Newdoxime should not be taken with other antibiotics since it can lead to increased side effects and altered effectiveness.

Can Newdoxime treat sore throats?

No, Newdoxime is not effective for treating sore throat caused by viral infections.

Can Newdoxime be used to treat bacterial meningitis?

Yes, Newdoxime can be used to treat bacterial meningitis.

Can Newdoxime be used to treat strep throat?

Yes, Newdoxime can be used to treat strep throat.

Is Newdoxime available in other forms such as an oral suspension?

Yes, Newdoxime is also available as an oral suspension.

Can I take Newdoxime for a long period of time?

It is not recommended to take Newdoxime for a long period of time, as it can lead to overgrowth of certain bacteria and lead to antibiotic resistance.

Can I take Newdoxime with ibuprofen?

Yes, Newdoxime can be taken with ibuprofen.

Is it safe to take Newdoxime while breastfeeding?

It is not recommended to take Newdoxime while breastfeeding because it can pass into breast milk and affect the infant. Contact your doctor before taking Newdoxime while breastfeeding.

Can Newdoxime be used to treat ear infections?

Yes, Newdoxime can be used to treat ear infections.

Can Newdoxime treat urinary tract infections?

Yes, Newdoxime can be used to treat urinary tract infections.

Is Newdoxime safe for people with kidney or liver disease?

People with kidney or liver disease should use Newdoxime with caution, as it is broken down by the kidneys and liver. Talk to your doctor before taking Newdoxime if you have kidney or liver disease.

Can Newdoxime make you tired?

Yes, Newdoxime can cause fatigue as a side effect in some people. Talk to your doctor if you experience fatigue while taking Newdoxime.

How often do I need to take Newdoxime?

You should take Newdoxime as directed by your doctor. The frequency of doses will depend on the infection as well as the patient’s age and weight.

What laboratory tests should be done while taking Newdoxime?

Your doctor may recommend certain laboratory tests such as a complete blood count, liver function tests, or kidney function tests while taking Newdoxime.

Can Newdoxime be used in animals such as cats or dogs?

Yes, Newdoxime can be used in cats and dogs, but only under the direction of a veterinarian.

What should I do if I miss a dose of Newdoxime?

If you miss a dose of Newdoxime, take it as soon as possible. If it is close to the time for your next dose, skip the missed dose and continue on your regular schedule.

What can happen if I take an overdose of Newdoxime?

If you take an overdose of Newdoxime, contact your doctor or local poison control center immediately. Symptoms of an overdose may include nausea, dizziness, or difficulty breathing.

Should I avoid activities that require mental alertness while taking Newdoxime?

Yes, it is best to avoid activities that require mental alertness while taking Newdoxime because it can cause drowsiness and dizziness as side effects.

Can Newdoxime cause nausea and vomiting?

Yes, Newdoxime can cause nausea and vomiting as side effects. Talk to your doctor if you experience nausea and vomiting while taking Newdoxime.