Nelate
Nelate Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nelate is a brand name. Its generic name is Strontium Ranelate.
Nelate Introduction
Strontium ranelate is a medication used to treat osteoporosis. It is a member of the family of drugs known as bone-forming drugs and works by increasing both bone formation and bone mineralization, thereby decreasing bone resorption. Strontium ranelate is considered a slow-release medication and can take up to six months before its full effect is expected.
Uses for Nelate
Strontium ranelate is approved for the treatment of postmenopausal osteoporosis in women and men with existing vertebral fractures. It is also used for secondary prevention of spine and non-vertebral fractures and for the treatment of glucocorticoid-induced osteoporosis. Strontium ranelate may also be used as an adjunct to calcium and vitamin D and pharmaceutical interventions for primary prevention of osteoporosis.
Mechanism of Action
Strontium ranelate works by increasing both bone formation and bone mineralization. This makes it different from other bone-forming medications, which usually focus on blocking bone resorption. Strontium ranelate also binds to collagen, the protein backbone of bones. This binding is believed to stabilize the bone matrix and increase the synthesis of new bone.
How Long Does it Take to Work?
Typically, the effects of strontium ranelate can be seen after six months of use. The full treatment course is usually 12 months, depending on the individual patient. During this time, osteoporosis progression may be slowed down significantly and bone mineral density can be increased.
Absorption
Strontium ranelate is rapidly absorbed after oral administration. Peak plasma concentrations are achieved approximately two hours after administration. The bioavailability of strontium ranelate is approximately 40%.
Route of Elimination
Strontium ranelate is eliminated by the kidneys. The majority of the drug is excreted as unchanged strontium ranelate in the urine. The metabolic end products of strontium ranelate show no quantifiable levels in the bloodstream.
Dosage & Administration
The recommended dose of strontium ranelate is two grams taken once daily in the morning on an empty stomach. It is important to take strontium ranelate with a full glass of water. The dose should not be exceeded and should be adjusted for patients with kidney or liver disease.
Side Effects
Strontium ranelate can cause nausea, vomiting, constipation, headache, skin rash, itching, dizziness, increased frequency of urination, and joint pain. Severe allergic reactions, including anaphylaxis, may occur in rare cases. Patients should contact their healthcare provider if any of these symptoms become severe or persist.
Toxicity
Strontium ranelate is considered to be relatively safe with few adverse reactions reported in clinical trials. In general, the risk of toxicity is low. High doses of strontium ranelate have been found to be toxic in animal studies, so large doses should be avoided.
Precaution
There are no known drug interactions with strontium ranelate. However, patients should always inform their healthcare provider of any medications, supplements, or herbal remedies they are taking before starting strontium ranelate.
Interactions
There are no known interactions between strontium ranelate and other drugs. However, patients should always inform their healthcare provider of any medications, supplements, or herbal remedies they are taking before starting strontium ranelate.
Disease Interactions
Strontium ranelate should be used with caution in patients with kidney or liver disease. It is also not recommended for use in patients with active gastrointestinal problems, as these may interfere with the absorption of strontium ranelate.
Drug Interactions
There are no known drug interactions with strontium ranelate. However, patients should always inform their healthcare provider of any medications, supplements, or herbal remedies they are taking before starting strontium ranelate.
Food Interactions
Strontium ranelate should be taken with a full glass of water on an empty stomach. It should not be taken with or immediately after a meal. Foods high in calcium, such as dairy products, may impede the absorption of strontium ranelate and should therefore be avoided.
Pregnancy Use
Strontium ranelate is not recommended for use in pregnant women, as the safety of the drug has not been established. There are currently no well-controlled studies on the use of strontium ranelate during pregnancy.
Lactation Use
Strontium ranelate is not recommended for use in lactating women, as the safety of the drug has not been established. There are currently no well-controlled studies on the use of strontium ranelate while breastfeeding.
Acute Overdose
The symptoms of an acute overdose of strontium ranelate are unknown. In case of overdose, contact a poison control center right away and seek medical attention.
Contraindication
Strontium ranelate should not be used in patients with an allergy to strontium, or in patients with severely impaired renal function.
Use Direction
The recommended dose of strontium ranelate is two grams taken once daily in the morning on an empty stomach. It is important to take strontium ranelate with a full glass of water. The dose should not be exceeded and should be adjusted for patients with kidney or liver disease.
Storage Condition
Strontium ranelate should be stored at room temperature in a tightly closed container. It should be protected from light and moisture. Keep this and all medication out of the reach of children.
Volume of Distribution
The volume of distribution of strontium ranelate is approximately 16 liters.
Half Life
The elimination half-life of strontium ranelate is approximately 1.5 hours.
Clearance
Strontium ranelate is eliminated by the kidneys. The clearance of the drug is approximately 6.7 ml/min.
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