Mikayel

Mikayel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Mikayel is a brand name. Its generic name is Amikacin.

Mikayel

Mikayel is a bactericidal aminoglycoside antibiotic that is famous for its broad-spectrum coverage against gram-positive and gram-negative bacteria. It is used in the treatment of life-threatening infections caused by multidrug-resistant bacteria, such as Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus species, and Acinetobacter species.

Uses

Mikayel is used to treat severe infections including septicemia, endocarditis, pneumonia, meningitis, gonorrhea, and urinary tract infections caused by susceptible organisms. It may also be used to treat other bacterial infections as determined by your doctor.

Mechanism of Action

Mikayel works by binding to bacterial ribosomes and inhibiting bacterial protein synthesis, ultimately leading to cell death. Its broad spectrum of activity is attributed to its ability to affect several targets in the bacterial cell, including ribosomes, DNA-dependent RNA Polymerase, and RNA Polymerase.

How Long Does it Take to Work?

The effects of amikacin typically begin within an hour after administration and peak two to four hours later. It is typically administered as an intravenous or intramuscular injection, and its effects last for 24-48 hours.

Absorption

Mikayel is rapidly and completely absorbed after parenteral administration. It is not highly lipophilic and thus does not readily cross the blood-brain barrier.

Route of Elimination

Mikayel is eliminated primarily by glomerular filtration and by active transport of drug into renal tubules. An insignificant amount is also eliminated in the feces.

Dosage

The dosage of amikacin depends on the patient’s age, weight, renal function, and severity of the infection. Usual doses are 15–30 mg/kg/day every 12-24 hours, administered intravenously or intramuscularly, with some clinicians recommending once-daily dosing. Dosages generally should not exceed 2 g/day.

Administration

Mikayel should be administered as an intravenous infusion or intramuscular injection. When administered intravenously, amikacin should not be administered at a rate exceeding 2 mg/kg per minute to avoid the risk of nephrotoxicity.

Side Effects

Side effects of amikacin include nausea, vomiting, diarrhea, rash, fever, dizziness, headache, tinnitus, reversible hearing loss, and renal toxicity. In the event of an overdose, amikacin may also cause ototoxicity and reversible neuromuscular blockade.

Toxicity

Mikayel is mainly eliminated through the kidneys; therefore, care should be taken to monitor renal function in patients with impaired renal function. Mikayel should not be administered in patients with severe renal impairment or in patients with blood levels of amikacin greater than 20 mcg/mL, as it may lead to severe toxicity.

Precautions

Prior to receiving amikacin, patients should be carefully assessed for allergies, potential drug interactions, and renal function. It is important to periodically monitor amikacin levels in serum as well as urine to monitor for potential toxicity and ensure the drug is being adequately eliminated.

Interactions

Mikayel may interact with other medications such as certain antibiotics, certain antacids, and loop diuretics. It is important to tell your doctor about all medications you are taking in order to avoid any adverse interactions.

Disease Interaction

Mikayel may increase the effects of neuromuscular blocking drugs or reduce the effectiveness of oral contraceptives. It may also interact with certain antibiotics, such as neomycin, tobramycin, and kanamycin.

Drug Interactions

Mikayel is known to interact with antibiotics, antacids, loop diuretics, and other medications. It is important to tell your doctor about all the medications you are taking, including prescription drugs, non-prescription drugs, and herbs, in order to avoid potential drug interactions.

Food Interactions

Mikayel is not known to interact with food, however it is important to take amikacin at least one hour before or two hours after meals to ensure optimal absorption of the medication.

Pregnancy Use

Mikayel should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. Mikayel may pass into breast milk and could potentially harm a nursing baby. Consult your doctor before using amikacin if you are pregnant or breast-feeding.

Lactation

Mikayel should not be used during breastfeeding due to potential risk of harm to the nursed infant. Consult your doctor before using amikacin if you are breastfeeding.

Acute Overdose

In the event of an overdose, amikacin may cause ototoxicity, reversible neuromuscular blockade, and renal toxicity. Treatment of an overdose consists of supportive care and forced diuresis.

Contraindication

Mikayel should not be used in patients with hypersensitivity to aminoglycoside antibiotics. It should also not be used in patients with severe renal impairment or in patients with a history of convulsions.

Use Direction

Mikayel should be used as directed by your doctor. It should be taken exactly as prescribed and at the advised dosage recommended by your doctor to ensure that the desired therapeutic effects are achieved.

Storage Conditions

Mikayel should be stored at room temperature, away from heat, moisture, and light. It should also be kept out of reach of children and pets.

Volume Of Distribution

The volume of distribution of amikacin is approximated to be 0.2–0.4 L/kg in adults and 0.3–0.5 L/kg in children.

Half Life

The half-life of amikacin is approximately 1.5-2 hours in adults and 1.5-3 hours in children.

Clearance

The clearance of amikacin is approximately 10–14 mL/min/1.73m2 in adults and 22–40 ml/min/1.73 m2 in children.

Here you find in details version of Mikayel

Some Frequently Asked Questions About Mikayel

What is Mikayel?

Mikayel is an antibiotic used to treat a wide range of bacterial infections, including some respiratory tract infections, urinary tract infections, and certain skin and skin structure infections.

How long does it take for Mikayel to work?

The length of time it takes for Mikayel to work varies depending on the type and severity of the infection being treated, as well as the individual patient. Generally speaking, most people begin to feel some relief from their symptoms within 48-72 hours.

What are the side effects of Mikayel?

Common side effects of amikacin include nausea, vomiting, diarrhea, rash, and dizziness. These side effects usually resolve after treatment finishes. More serious side effects may occur in rare cases, such as renal and auditory toxicity.

Does Mikayel cause hearing loss?

High doses of amikacin can cause hearing loss, although this is rare. If you experience any sudden changes in hearing, contact your doctor immediately.

What happens if I miss a dose of Mikayel?

If you miss a dose of Mikayel, take it as soon as you remember. If it is close to your next dose, skip the missed dose and take your regular dose as scheduled.

Can I drink alcohol while taking Mikayel?

It is not recommended to drink alcohol while taking Mikayel, as it may increase the risk of side effects. It is best to avoid alcohol while taking any medications.

Can I take other medications while taking Mikayel?

It is important to tell your doctor if you are taking any other medications, including supplements and herbal remedies. Certain medicines may interact with Mikayel, and this could increase the risk of side effects.

Can Mikayel be used for bacterial infections that do not respond to other antibiotics?

Yes, Mikayel may be used to treat certain bacterial infections that are resistant to other antibiotics. It is important to follow your doctor’s instructions when taking any medication.

Is it safe to use Mikayel during pregnancy?

Mikayel is not recommended for use during pregnancy, as it has the potential to cause harm to the unborn baby. If you are pregnant or planning to become pregnant, tell your doctor before taking any medications.

Can Mikayel be used to treat a kidney infection?

Yes, Mikayel can be used to treat certain types of kidney infections. If you suspect you have a kidney infection, it is important to see your doctor so they can prescribe the correct antibiotic.

How long does Mikayel stay in the body?

The elimination half-life of Mikayel is approximately 3-4 hours. This means that half of the drug is eliminated from the body within 3-4 hours after taking it. The total time it takes for the drug to be completely eliminated from the body is about 11-15 hours.

Can Mikayel be taken with food?

Yes, Mikayel can be taken with food. Eating a light meal before taking the medication may help to reduce any stomach upset. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat gonorrhea?

Yes, Mikayel can be used to treat certain types of gonorrhea. It is important to take the medication exactly as prescribed by your doctor. It is also important to follow-up with another dose of antibiotics to ensure that all the bacteria are eliminated.

Does Mikayel need to be refrigerated?

No, Mikayel does not need to be refrigerated. It is recommended to store the medication at room temperature, away from light and moisture.

Can Mikayel be used to treat a sinus infection?

Yes, Mikayel can be used to treat certain types of sinus infections. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel cause a rash?

Yes, Mikayel can cause a rash in some people. If you experience any skin rash or other reactions while taking Mikayel, contact your doctor immediately.

Does Mikayel affect birth control?

Yes, Mikayel can interfere with the effectiveness of certain types of birth control. If you are using hormonal birth control be sure to use a backup method while taking Mikayel.

Is Mikayel safe for long-term use?

Yes, Mikayel is generally considered safe for long-term use when taken as prescribed by your doctor. However, it is important to follow your doctor's instructions and to monitor for any side effects.

Is Mikayel an over the counter medication?

No, Mikayel is not an over the counter medication. It is a prescription medication and must be prescribed by a doctor.

Does Mikayel cause photosensitivity?

Yes, Mikayel can cause photosensitivity. If you are taking this medication, you should try to avoid prolonged direct exposure to sunlight and wear sunscreen when going outside.

Can Mikayel be used to treat urinary tract infections?

Yes, Mikayel can be used to treat certain types of urinary tract infections. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat a bladder infection?

Yes, Mikayel can be used to treat certain types of bladder infections. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat an ear infection?

Yes, Mikayel can be used to treat certain types of ear infections. It is important to take the medication exactly as prescribed by your doctor.

What is the difference between Mikayel and other antibiotics?

Mikayel is a type of aminoglycoside antibiotic, which is different from other types of antibiotics. It is generally used to treat infections caused by gram-negative bacteria, while other antibiotics are more commonly used for infections caused by gram-positive bacteria.

Can Mikayel be used for a strep throat?

Yes, Mikayel can be used to treat certain types of strep throat infections. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used for a pneumonia?

Yes, Mikayel can be used to treat certain types of pneumonia. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat a bronchitis?

Yes, Mikayel can be used to treat certain types of bronchitis. It is important to take the medication exactly as prescribed by your doctor.

Are there any foods or beverages to avoid while taking Mikayel?

It is not recommended to drink alcohol while taking Mikayel, as it may increase the risk of side effects. It is also recommended to avoid caffeinated beverages, since they may increase the risk of side effects. It is also best to avoid taking any other medications while taking Mikayel, unless approved by your doctor.

Does Mikayel cause drowsiness?

Yes, Mikayel can cause drowsiness in some people. If you experience drowsiness while taking Mikayel, it is best to avoid activities that require concentration, such as driving or operating heavy machinery.

Can Mikayel be used for a bloodstream infection?

Yes, Mikayel can be used to treat certain types of bloodstream infections. It is important to take the medication exactly as prescribed by your doctor.

What should I do if I experience an allergic reaction to Mikayel?

If you experience any signs of an allergic reaction to Mikayel, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, you should stop taking the medication and seek immediate medical attention.

Can Mikayel be used to treat meningitis?

Yes, Mikayel can be used to treat certain types of meningitis. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat a shigella infection?

Yes, Mikayel can be used to treat certain types of shigella infections. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat a staph infection?

Yes, Mikayel can be used to treat certain types of staph infections. It is important to take the medication exactly as prescribed by your doctor.

What is the recommended dosage of Mikayel?

The recommended dosage of Mikayel varies depending on the type and severity of the infection being treated, as well as the individual patient. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be crushed?

No, Mikayel tablets should not be crushed or broken. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat a yeast infection?

No, Mikayel is not effective against yeast infections. It is important to see your doctor if you suspect you are suffering from a yeast infection, as other types of treatments are available.

Can Mikayel be used to treat a UTI?

Yes, Mikayel can be used to treat certain types of urinary tract infections (UTI). It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat an abscess?

Yes, Mikayel can be used to treat certain types of abscesses. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat an anthrax infection?

Yes, Mikayel can be used to treat certain types of anthrax infections. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat an MRSA infection?

Yes, Mikayel can be used to treat certain types of methicillin-resistant staphylococcus aureus (MRSA) infections. It is important to take the medication exactly as prescribed by your doctor.

Can Mikayel be used to treat an HIV infection?

No, Mikayel is not effective against HIV infections. HIV is a virus and must be treated with antiretroviral medication.