Migergot Suppository
Migergot Suppository Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Migergot Suppository is a brand name. Its generic name is Ergotamine + Caffeine.
Introduction
Migergot Suppository is a combination of ergot alkaloids and caffeine used to treat acute migraine headaches and tension headaches. It is used for the acute relief of headaches, including severe migraines. This combination has been used for many years to treat migraine and tension headache symptoms, including nausea, photophobia (sensitivity to light) and phonophobia (sensitivity to sound).Uses for
Migergot Suppository is indicated for the acute relief of migraine and tension-type headaches. It is not a preventive therapy and should not be used for headache prevention.Mechanism of action
Ergotamine and caffeine both act as vasoconstrictors, reducing the size of the dilated blood vessels in the head, thus reducing the pain of a migraine attack. Caffeine enhances the ability of ergotamine to constrict the blood vessels in the head, increasing its effectiveness.How long does it take to work?
Migergot Suppository generally takes effect within 30 minutes of ingestion and can last up to several hours.Absorption
Migergot Suppository is rapidly absorbed from the gastrointestinal tract. The peak plasma concentration of the combination is reached within 1 hour.Route of Elimination
Migergot Suppository is metabolized in the liver and the metabolites are excreted in the urine.Dosage
Migergot Suppository is available in tablet form, with the usual dosage being 2 tablets containing 1mg ergotamine and 100mg caffeine. The dosage of the tablets may be increased if no relief from symptoms is achieved.Administration
Migergot Suppository should be taken orally with water. It is preferably taken on an empty stomach and can be taken up to four times a day, but no more often than every 4 hours.Side Effect
Common side effects of Migergot Suppository include nausea, vomiting, abdominal pain, dizziness, drowsiness, weakness, and effervescence. Other side effects include chest pain, diarrhea, headache, joint pain, seizures, itching, swelling, and rashes.Toxicity
Migergot Suppository is not toxic if taken as prescribed. However, if too much is taken or taken too frequently, it can lead to ergotism, a serious medical condition of prolonged vasoconstriction in the extremities that can lead to tissue damage.Precautions
Migergot Suppository should not be taken by individuals who have coronary artery disease, uncontrolled hypertension, peripheral vascular disease, hepatic or renal impairment, or severe headaches that are unresponsive to other treatment. It should also not be taken by pregnant women or nursing mothers.Interaction
Migergot Suppository can potentially interact with other drugs, such as macrolide antibiotics, antifungal medications (fluconazole, itraconazole), rifampicin, tricyclic antidepressants, anti-seizure medications, calcium channel blockers, and isoniazid.Disease Interactions
Migergot Suppository should not be taken by individuals with uncontrolled hypertension, coronary artery disease, peripheral vascular disease, hepatic impairment, renal impairment or severe headaches unresponsive to other treatments. It should also not be taken by pregnant women or nursing mothers.Drug Interactions
Migergot Suppository can interact with other drugs, therefore, it is best to consult a doctor before taking any other drugs in combination with Migergot Suppository.Food Interactions
Migergot Suppository should not be taken with large amounts of food or large meals since they can reduce the absorption of the medication. It is also important to avoid alcohol or caffeine when taking Migergot Suppository, as this can increase the risk of side effects.Pregnancy Use
Migergot Suppository should not be used during pregnancy, especially during the first trimester. If taken during the second or third trimester, close monitoring by a physician is recommended.Lactation Use
Migergot Suppository should not be taken by nursing mothers as it can enter the breast milk and harm the infant.Acute Overdose
If an overdose of Migergot Suppository is suspected, seek immediate medical attention. Symptoms of overdose include headache, dizziness, tachycardia, extreme anxiety, restlessness, confusion, hallucinations, seizures, bradycardia, and even coma.Contraindications
Migergot Suppository is contraindicated in individuals with coronary artery disease, uncontrolled hypertension, peripheral vascular disease, hepatic or renal impairment, and patients with severe headaches unresponsive to other treatments. It should also be avoided in pregnant and nursing women.Use Direction
Migergot Suppository should be taken orally with water. It is best to take it on an empty stomach and no more often than every four hours. The usual dose is 2 tablets containing 1mg ergotamine and 100 mg caffeine. The dosage may be increased if no relief from symptoms is achieved.Storage Condition
Migergot Suppository should be stored at room temperature, between 15 and 30°C (59 and 86°F). It should be kept in a tightly closed container, and out of reach of children.Volume of Distribution
The volume of distribution of ergotamine + caffeine is not well known but is likely to be low as it is a highly lipid soluble drug.Half Life
The half life of ergotamine + caffeine is approximately 1.2 hours.Clearance
The clearance of ergotamine + caffeine has not been well studied, however, it is expected to be both hepatic and renal.Here you find in details version of Migergot Suppository