Midromax

Midromax Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Midromax is a brand name. Its generic name is Meldonium.

Midromax Introduction

Midromax is a drug prescribed for the treatment of ischemic heart disease and cerebral stroke. It is also used to treat chronic fatigue syndrome, diabetes, and as an adjunct to cancer treatment. It is a synthetic benzamide derivative and is sold under the brand name Mildronate.

Uses for

Midromax is primarily used to treat ischemic heart disease and to reduce the symptoms of cerebral ischemia in order to improve long-term outcomes. It is also used to prevent myocardial damage caused by certain drugs and medications, improve tolerance to physical exercises, and manage acute ischemic stroke.

Mechanism of Action

Midromax works by increasing cellular energy production while decreasing its consumption. It increases ATP synthesis in the mitochondria by upregulating various enzymes in the citric acid cycle, thus leading to an increased rate of fat breakdown, increased oxygen uptake, and enhanced energy production. It also increases glycolysis and reduces long-term ischemic damage to the myocardium.

How Long Does it Take to Work?

Midromax works rapidly, with significant clinical effects seen within two to three hours of administration. The duration of its effects may last up to six hours.

Absorption

Midromax is rapidly and completely absorbed after oral administration. It is thought that its short half-life is due to rapid absorption and metabolism.

Route of Elimination

Midromax is metabolized in the liver with most of the drug being eliminated through the kidneys in the form of metabolites.

Dosage

Midromax is available as a tablet in a dosages of 0.5, 0.75, 1, and 2 grams. It should be taken orally with a glass of water once a day. For long-term ischemic heart disease, a daily dose of three grams is recommended.

Administration

Midromax should be taken orally with a glass of water once a day. For long-term ischemic heart disease therapy, a daily dose of three grams is recommended. The dose should be reduced in patients with renal impairment or in the elderly.

Side Effect

The most common side effects of Midromax include headache, nausea, vomiting, and dizziness. Other possible side effects include heart palpitations, abdominal pain, and constipation. In rare cases, serious cardiac events such as myocardial infarction have been reported.

Toxicity

Midromax is generally well-tolerated with few cases of acute intoxications reported in the literature. The most common side effects include headache, nausea, vomiting, and dizziness. Correctly dosed Midromax is considered to be safe and has a low potential for toxicity.

Precaution

Midromax should not be taken with alcohol, certain medications, or in combination with certain medical conditions. Patients should inform their doctor of any medications or supplements they are taking before starting treatment with Midromax. Furthermore, Midromax should be used with caution in patients with renal impairment or the elderly.

Interactions

Midromax is known to interact with certain medications, including alcohol, anticoagulants, and antiplatelet medications. It is also known to interact with certain medical conditions, such as hypertension, myocardial infarction, and diabetes. Patients should inform their doctor of any medications or supplements they are taking before using Midromax.

Disease Interaction

Midromax is not known to interact with any diseases, however it is not recommended for use in patients with certain medical conditions. These conditions include hypertension, myocardial infarction, and diabetes. Patients with these conditions should be monitored closely when taking Midromax.

Drug Interaction

Midromax is known to interact with certain medications, including alcohol, anticoagulants, and antiplatelet medications. Patients should inform their doctor of any medications or supplements they are taking before starting treatment with Midromax.

Food Interactions

Midromax does not seem to interact with food, however it is best to take it with a meal or snack to reduce the potential of stomach upset.

Pregnancy Use

Midromax is not recommended for use in pregnant women due to lack of safety and efficacy data.

Lactation Use

Midromax is not recommended for use in breastfeeding women due to lack of safety and efficacy data.

Acute Overdose

If an overdose is suspected, seek immediate medical attention. Symptoms of overdose include nausea, vomiting and dizziness.

Contraindication

Midromax is contraindicated in patients with hypersensitivity to benzamides or any of its components, as well as in patients with severe hepatic impairment or with severe renal impairment.

Use Directions

Patients should take Midromax exactly as prescribed by their doctor. The tablets should be taken orally with a glass of water once a day, with or without food. The dosage should be adjusted according to each patient's response.

Storage Condition

Midromax tablets should be stored at room temperature, in a dry and dark place, and out of reach of children.

Volume of Distribution

Midromax's volume of distribution is approximately 0.44-1.50 L/kg, indicating that it is moderately distributed throughout the body.

Half Life

The half-life of Midromax is approximately three to six hours.

Clearance

Midromax is eliminated from the body by the kidneys, with approximately 60-80% of the drug being excreted unchanged in the urine.

Here you find in details version of Midromax

Some Frequently Asked Questions About Midromax

What is Midromax?

Midromax, also known as mildronate, is an anti-ischemic medication that is used to help prevent some complications of diabetes and heart disease. It is usually given to people after a heart attack or stroke.

What is Midromax used for?

Midromax is primarily used to help prevent an ischemic stroke by improving the patient's circulation. It also may help treat angina (chest pain), abdominal pain, and other heart-related conditions.

How does Midromax work?

Midromax works by increasing the oxygen supply to the heart muscle, which increases the production of ATP (adenosine triphosphate), the molecule that stores and transports energy in cells. This increases the energy available to the heart muscle which helps prevent an ischemic stroke.

When should I take Midromax?

It is recommended that Midromax be taken 30 minutes prior to exposure to extreme physical or mental stress. It is also recommended that the medication be taken at least three times a day with plenty of fluids.

What are the side effects of Midromax?

The most common side effects of Midromax include headache, fatigue, nausea, and vomiting. Other side effects include dizziness, lightheadedness, chest pain, and irregular heartbeat. If you experience any of these side effects, contact your doctor immediately.

Can I take Midromax with other medications?

It is important to talk to your doctor before taking any other medications with Midromax. Taking other medications may cause interactions or interfere with Midromax’s effectiveness.

Can I drink alcohol while taking Midromax?

It is not recommended to drink alcohol while taking Midromax. Alcohol may decrease the effectiveness of the medication and increase the risk of side effects.

What should I avoid while taking Midromax?

You should avoid activities that increase your heart rate or breathing, such as heavy exercise or sport. You should also avoid swimming, saunas, and long baths, as well as activities that require you to be in a warm or hot environment.

What if I forget to take a dose of Midromax?

If you forget to take a dose of Midromax, take it as soon as you remember, unless it is almost time for the next dose. In this case, skip the missed dose and take your next dose at the regular time.

What happens if I overdose on Midromax?

If you or someone else has overdosed on Midromax, contact your local poison control center or emergency room immediately. Symptoms of an overdose may include irregular heartbeat, paleness, fainting, chest pain, and seizures.

Is there a generic version of Midromax?

Yes, there is a generic version of Midromax. The generic version is called mildronate and is made by various manufacturers.

Is meldonium an FDA approved drug?

Yes, Midromax has been approved by the U.S. Food and Drug Administration (FDA) for use in treating ischemic stroke.

Can I buy meldonium without a prescription?

No, you cannot buy meldonium without a prescription as it is a prescription-only medication.

Does Midromax cause withdrawal symptoms?

No, Midromax does not cause withdrawal symptoms when stopped. However, symptoms of a heart condition can return if the medication is stopped.

What is the recommended dosage for Midromax?

The recommended dose for Midromax is 500-1000mg taken three times daily. Your doctor may adjust your dosage based on your medical condition and how you respond to treatment.

Can women take Midromax?

Yes, women can take Midromax for the treatment of an ischemic stroke. However, it is important to consult with your doctor before starting Midromax as it may not be suitable for other conditions or if you are pregnant.

Can I take Midromax with high blood pressure medication?

Yes, you can take Midromax with certain high blood pressure medications. However, it is important to talk to your doctor first before taking any medications, as some may interact with each other.

Can I take Midromax with warfarin?

Yes, you can take Midromax with warfarin, as long as your doctor has approved it. It is important to talk to your doctor if you are currently taking warfarin, as Midromax can interact with it.

Will Midromax cause weight gain?

Weight gain is not a common side effect of Midromax. However, if you experience any weight gain while taking Midromax, notify your doctor as soon as possible.

Does Midromax cause drowsiness?

Drowsiness is not a common side effect of Midromax. However, if you experience any drowsiness while taking Midromax, inform your doctor as soon as possible.

Does Midromax affect fertility?

Midromax has not been proven to affect fertility in males or females. However, medication should not be used during pregnancy unless the benefits clearly outweigh the risks.

Is Midromax available in an injectable form?

No, Midromax is available only in a tablet form.

Does Midromax contain sulfa?

No, Midromax does not contain sulfa.

Are there any dietary restrictions when taking Midromax?

No, there are no specific dietary restrictions when taking Midromax.

Can I take Midromax if I am diabetic?

Yes, Midromax can be used to help prevent certain complications of diabetes. It is important to talk to your doctor about any medication you are taking before starting Midromax.

Can Midromax cause a rash?

Rarely, Midromax can cause a rash. If this occurs, contact your doctor as soon as possible.

Does Midromax cause headaches?

Headaches are a common side effect of Midromax. If headaches become severe or are accompanied by blurred vision, contact your doctor.

Can someone who is pregnant take Midromax?

No, Midromax should not be taken during pregnancy unless the benefits clearly outweigh the risks.

Can Midromax be taken with other heart medications?

Yes, Midromax may be taken with other heart medications. However, it is important to talk to your doctor before taking any medications, as some may interact with each other.

Does Midromax interact with any other medications?

Yes, Midromax may interact with certain medications. It is important to tell your doctor about any other medications you are taking before starting Midromax.

What are the long-term side effects of Midromax?

The long-term side effects of Midromax are generally mild and may include headache, fatigue, nausea, vomiting, and dizziness. If you experience any serious side effects, contact your doctor immediately.

Can I take Midromax for high cholesterol?

No, Midromax is not approved for the treatment of high cholesterol. Talk to your doctor for other medications that can help lower cholesterol.

Does Midromax affect blood pressure?

Yes, Midromax may affect blood pressure. The medication should only be taken if your doctor has approved it.

Can I take Midromax with an ACE inhibitor?

Yes, you can take Midromax with an ACE inhibitor as long as your doctor has approved it. It is important to talk to your doctor first before taking any medications, as some may interact with each other.

Can Midromax cause liver damage?

No, Midromax does not cause liver damage. However, if you experience any of the following symptoms, call your doctor immediately; yellowing of skin or eyes, abdominal pain, dark urine, fatigue, nausea, or vomiting.

Can I take Midromax with an anticoagulant?

Yes, you can take Midromax with an anticoagulant as long as your doctor has approved it. It is important to talk to your doctor first before taking any medications, as some may interact with each other.

Does Midromax interact with warfarin?

Yes, Midromax can interact with warfarin. It is important to tell your doctor about any other medications you are taking before starting Midromax.

Does Midromax cause hair loss?

No, Midromax does not cause hair loss. However, if you experience any hair loss while taking Midromax, notify your doctor as soon as possible.

Is Midromax safe for long term use?

Yes, Midromax is generally safe for long term use. However, it is important to talk to your doctor before starting Midromax or any other medication as some may interact with each other.

Does Midromax have any interactions with grapefruit juice?

Yes, Midromax may interact with grapefruit juice. It is important to talk to your doctor before taking any medication with grapefruit juice as some may interact with each other.

Is Midromax a controlled substance?

No, Midromax is not a controlled substance.

Does Midromax interact with herbal supplements?

Yes, Midromax may interact with some herbal supplements. It is important to talk to your doctor before taking any medication with herbal supplements as some may interact with each other.

Can Midromax cause constipation?

Yes, Midromax may cause constipation. Drinking plenty of fluids and eating a healthy diet may help to prevent or treat constipation.

What is the recommended duration of Midromax use?

The duration of Midromax use may vary depending on the condition being treated, the patient's response to treatment, and other factors. Your doctor will inform you on the recommended duration of use.