Migranol (Sumatriptan Succinate)

Migranol (Sumatriptan Succinate) Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Migranol (Sumatriptan Succinate) is a brand name. Its generic name is Sumatriptan Succinate.

Migranol (Sumatriptan Succinate)

Migranol (Sumatriptan Succinate) is a prescription medication used for the purpose of treating migraine headaches and cluster headaches. It works to reduce inflammation and constrict the blood vessels in the head. This reduces certain chemicals released by the nerves, which can lead to the pain associated with headaches.

Uses

Migranol (Sumatriptan Succinate) is indicated for the treatment of migraine headaches and cluster headaches. It is available as an oral tablet, a nasal spray, and an injection.

Mechanism of Action

Migranol (Sumatriptan Succinate) binds to a receptor called the serotonin 5-HT1 receptor, which results in a decrease in neuron excitability. This reduces the pain signals that travel from these neurons to the brain, and so relieves the pain associated with migraine and cluster headaches.

How Long Does it Take to Work?

Migranol (Sumatriptan Succinate) works quickly, with pain relief typically occurring within 30 minutes or less. However this can vary depending on the individual.

Absorption

Migranol (Sumatriptan Succinate) is fairly rapidly absorbed when taken orally, with peak concentrations in the blood occurring within 1-2 hours. When taken via a nasal spray, peak concentrations occur much more quickly, within just 15-30 minutes.

Route of Elimination

Migranol (Sumatriptan Succinate) is eliminated from the body through both renal and hepatic pathways, mainly as metabolites. It is eliminated through the urine and the faeces.

Dosage

For the treatment of migraine headaches, the recommended adult dose of Migranol (Sumatriptan Succinate) is 25mg (or one tablet), taken at the onset of headache symptoms. If the initial dose is effective, no further doses are recommended. If unrelieved, a second dose may be taken two hours after the initial dose. The maximum daily dose is 100mg (or 4 tablets). For the treatment of cluster headaches, the recommended adult dose of Migranol (Sumatriptan Succinate) is 6-12mg injected subcutaneously, taken at the onset of headache symptoms. If the initial dose is effective, no further doses are recommended. If the headache is unrelieved, a second dose may be taken one hour after the initial dose, however the maximum daily dose should not exceed 12mg per 24 hours.

Administration

Migranol (Sumatriptan Succinate) can be taken orally with food or without, however its effectiveness is typically decreased when it is taken with food. If taken via a nasal spray, two sprays should be used (as two sprays are more effective than just one) and it should be sprayed into one nostril, while breathing in deeply. If taken via an injection, it should be injected into the skin of the thigh, abdomen, or upper arm.

Side Effects

Commonly reported side effects of Migranol (Sumatriptan Succinate) include dizziness, fatigue, drowsiness, hot flashes, nausea, vomiting, and tingling or numbness in the hands or feet. Rarely, serious side effects such as chest pain, difficulty breathing, uncontrolled bleeding, and allergic reactions may occur.

Toxicity

The lethal dose of Migranol (Sumatriptan Succinate) has not been studied in humans, however in animal studies the lethal dose has been reported to be in excess of 30 times the recommended therapeutic dose. Overdose can lead to cardiac arrhythmia, hypertension, seizures, and death. Treatment is focused on supportive care.

Precautions

Migranol (Sumatriptan Succinate) should be used with caution in patients with a history of cardiovascular disease, stroke, Transient Ischemic Attacks (TIAs), peripheral vascular disease, liver impairment, renal impairment, hypertension, and serotonin syndrome. It should be used with extreme caution in pregnant and lactating women.

Interactions

Migranol (Sumatriptan Succinate) may interact with other medications, which can cause serious side effects. It should not be taken with MAO inhibitors, medications for depression or anxiety, or propranolol. It should also not be taken with any medications containing ergot, as this can lead to serious side effects.

Disease Interactions

Migranol (Sumatriptan Succinate) should not be used if the patient has ischemic bowel disease, heart disease, uncontrolled hypertension, peripheral vascular disease, or basilar or hemiplegic migraines.

Drug Interactions

Migranol (Sumatriptan Succinate) may interact with a wide variety of drugs, including antidepressants, fluoxetine, tamoxifen, warfarin, clonidine, and atazanavir. It is recommended to speak to your doctor or pharmacist before taking any medications while taking Migranol (Sumatriptan Succinate).

Food Interactions

Migranol (Sumatriptan Succinate) should not be taken with alcohol, as this can increase the risk of side effects. It should also not be taken with food, as this can decrease its effectiveness.

Pregnancy Use

Migranol (Sumatriptan Succinate) should be used in pregnancy only if the potential benefit outweighs the potential risk, and only if the patient is at risk for severe and/or life-threatening disease. It is not known if it is excreted in breast milk, so it should be avoided during breastfeeding.

Lactation Use

Migranol (Sumatriptan Succinate) has not been studied in breastfeeding women, therefore it is not recommended for use in this population. If breastfeeding, it is best to avoid taking this medication.

Acute Overdose

Symptoms of acute overdose with Migranol (Sumatriptan Succinate) can include nausea, vomiting, dizziness, loss of consciousness, seizures, and arrhythmia. Treatment should consist of supportive care and monitoring of vital signs. Gastric lavage may be indicated in severe cases.

Contraindications

Migranol (Sumatriptan Succinate) is contraindicated in patients with ischemic bowel disease, stroke or transient ischemic attack (TIA) within the past 6 months, uncontrolled hypertension, basilar or hemiplegic migraines, and hypersensitivity to this drug. It should also not be taken in conjunction with MAO inhibitors or medication for depression or anxiety.

Use Directions

Migranol (Sumatriptan Succinate) should be taken exactly as prescribed by your doctor. It should not be taken more often than prescribed, and should be taken with caution in individuals with a history of cardiovascular problems, liver or kidney impairment, or hypertension. If you miss a dose, take it as soon as you remember, unless it is close to the time of your next dose.

Storage Conditions

Migranol (Sumatriptan Succinate) should be stored at room temperature away from direct sunlight and heat. It should be kept away from children and pets.

Volume of Distribution

The volume of distribution of Migranol (Sumatriptan Succinate) has not been established.

Half Life

The half life of Migranol (Sumatriptan Succinate) is approximately two hours.

Clearance

Clearance of Migranol (Sumatriptan Succinate) has not been established.

Here you find in details version of Migranol (Sumatriptan Succinate)

Some Frequently Asked Questions About Migranol (Sumatriptan Succinate)

1. What is Migranol (Sumatriptan Succinate)?

Migranol (Sumatriptan Succinate) is a prescription medication used to treat migraines and cluster headaches in adults.

2. How does Migranol (Sumatriptan Succinate) work?

Migranol (Sumatriptan Succinate) works by targeting the serotonin receptors in the brain, narrowing or constricting the blood vessels, and decreasing the release of certain substances in the brain that can cause migraine pain and other symptoms.

3. Can Migranol (Sumatriptan Succinate) be used to prevent migraines?

No, Migranol (Sumatriptan Succinate) is not intended to be used for the prevention of migraines. It is only used to treat migraines after they have occurred.

4. How should Migranol (Sumatriptan Succinate) be taken?

Migranol (Sumatriptan Succinate) should be taken at the first sign of a migraine. The recommended dose is one25 mg tablet. It may be taken with or without food.

5. How long does Migranol (Sumatriptan Succinate) take to start working?

Migranol (Sumatriptan Succinate) typically starts working within 30 minutes. It is important to take it as soon as possible after symptoms start.

6. How long does Migranol (Sumatriptan Succinate) last?

Migranol (Sumatriptan Succinate) may last for up to 8 hours. It is important to talk to a doctor if the symptoms are not improved after taking Migranol (Sumatriptan Succinate).

7. What are the possible side effects of Migranol (Sumatriptan Succinate)?

The most common side effects of Migranol (Sumatriptan Succinate) include nausea, dizziness, feeling tired, and flushing. Other possible side effects may include chest pain, heartburn, anxiety, and confusion. Talk to a doctor if any side effects occur.

8. Can Migranol (Sumatriptan Succinate) be used to treat other conditions?

No, Migranol (Sumatriptan Succinate) should only be used to treat migraines and cluster headaches as directed by a doctor. It should not be used to treat any other conditions.

9. Is Migranol (Sumatriptan Succinate) safe for pregnant women?

Migranol (Sumatriptan Succinate) is not recommended for pregnant women, as its safety in this population is not established. Women who are pregnant or planning to become pregnant should discuss the risks and benefits of this medication with their doctor.

10. What is the difference between Migranol (Sumatriptan Succinate) and Imitrex?

Migranol (Sumatriptan Succinate) and Imitrex are both brand names for the same medication, sumatriptan. Sumatriptan is used to treat migraines and cluster headaches in adults.

11. Is Migranol (Sumatriptan Succinate) available as a generic?

Yes, Migranol (Sumatriptan Succinate) is available as a generic alternative to the brand name medication, Imitrex.

12. Is Migranol (Sumatriptan Succinate) covered by insurance?

It depends on the specific insurance plan. Migranol (Sumatriptan Succinate) may be covered under certain prescription drug plans. It is best to contact an insurance provider for details.

13. Should Migranol (Sumatriptan Succinate) be taken with food?

Migranol (Sumatriptan Succinate) may be taken with or without food. It is recommended to take Migranol (Sumatriptan Succinate) as soon as possible after the onset of symptoms.

14. What is the recommended dose of Migranol (Sumatriptan Succinate)?

The recommended dose for adults is one 25 mg tablet. Talk to a doctor if the migraine symptoms do not improve after taking Migranol (Sumatriptan Succinate).

15. What should be done if a dose of Migranol (Sumatriptan Succinate) is missed?

If a dose of Migranol (Sumatriptan Succinate) is missed, it should be taken as soon as possible. Do not take a double dose to make up for a missed dose.

16. Is Migranol (Sumatriptan Succinate) safe for children?

Migranol (Sumatriptan Succinate) is not recommended for children under the age of 18. Talk to a doctor to determine the best treatment for a child.

17. What other medications should not be taken with Migranol (Sumatriptan Succinate)?

Migranol (Sumatriptan Succinate) should not be taken with other medications used to treat headaches and migraines, such as ergotamine, treximet, and frova. Talk to a doctor before taking Migranol (Sumatriptan Succinate) with any other medications.

18. Is Migranol (Sumatriptan Succinate) a controlled substance?

No, Migranol (Sumatriptan Succinate) is not a controlled substance.

19. What are the storage instructions for Migranol (Sumatriptan Succinate)?

Migranol (Sumatriptan Succinate) tablets should be stored at room temperature, away from direct sunlight and moisture. Keep Migranol (Sumatriptan Succinate) out of the reach of children.

20. What forms does Migranol (Sumatriptan Succinate) come in?

Migranol (Sumatriptan Succinate) is available as 25 mg tablets. It is also available as a nasal spray, oral soluble film, and injection.

21. Does Migranol (Sumatriptan Succinate) interact with other drugs or foods?

Yes, Migranol (Sumatriptan Succinate) may interact with other drugs or foods. It is important to discuss all medications and supplements with a doctor before taking Migranol (Sumatriptan Succinate).

22. Should Migranol (Sumatriptan Succinate) be taken while breastfeeding?

Migranol (Sumatriptan Succinate) is not recommended for women who are breastfeeding. Talk to a doctor for alternative treatment options.

23. What precautions should be taken when taking Migranol (Sumatriptan Succinate)?

It is important to follow the directions of a doctor when taking Migranol (Sumatriptan Succinate). Do not take more than the recommended dose or take it more often than prescribed. Also, do not take Migranol (Sumatriptan Succinate) if you have a history of heart problems or stroke.

24. Is Migranol (Sumatriptan Succinate) habit forming?

No, Migranol (Sumatriptan Succinate) is not habit forming and does not cause addiction.

25. What should be done if an overdose of Migranol (Sumatriptan Succinate) is taken?

If an overdose of Migranol (Sumatriptan Succinate) is taken, seek emergency medical attention right away. Some of the symptoms of an overdose include fainting, chest pain, shortness of breath, and a fast heartbeat.

26. Is Migranol (Sumatriptan Succinate) available over-the-counter?

No, Migranol (Sumatriptan Succinate) is a prescription medication and is only available with a doctor's prescription.

27. Should Migranol (Sumatriptan Succinate) be taken with alcohol?

No, it is not recommended to take Migranol (Sumatriptan Succinate) with alcohol. Alcohol may increase the risk of side effects.

28. Does Migranol (Sumatriptan Succinate) cause drowsiness?

Yes, drowsiness is a common side effect of Migranol (Sumatriptan Succinate). It is important to monitor for drowsiness and do not drive or operate any machinery if feeling drowsy.

29. Is Migranol (Sumatriptan Succinate) safe for elderly patients?

Yes, Migranol (Sumatriptan Succinate) is generally safe for elderly patients. However, it is best to talk to a doctor about any other medical conditions before taking Migranol (Sumatriptan Succinate).

30. When should Migranol (Sumatriptan Succinate) not be taken?

Migranol (Sumatriptan Succinate) should not be taken if you are allergic to it or any other ingredients in the medication. It should also not be taken if you have a history of heart problems or stroke, or if you are taking any other medications for treatment of headaches or migraines.