Metrozeb
Metrozeb Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Metrozeb is a brand name. Its generic name is Di-Iodohydroxyquinoline + Metronidazole.
Introduction
Di-iodohydroxyquinoline and Metronidazole (commonly known as Flagyl) are two medications used to treat a variety of bacterial infections. These medications are considered to be powerful antibiotics and are usually prescribed together to maximize the effectiveness of treatment.Uses for
Di-iodohydroxyquinoline and Metronidazole are often used to treat a variety of bacterial infections, including:- Urinary tract infections
- Gastrointestinal infections
- Skin infections
- Respiratory infections
- Amebic dysentery
- Some sexually transmitted diseases
Mechanism of Action
Di-iodohydroxyquinoline and Metronidazole work together to inhibit bacterial growth by interfering with DNA synthesis. Specifically, these medications inhibit the synthesis of 3 essential enzymes in bacteria (DNA gyrase, topoisomerase IV, and β-subunit of DNA-dependent RNA polymerase) which are necessary for bacterial cell division. This interference causes mutations to occur in the bacterial genetic material, leading to an eventual cell death and destruction of the bacteria.How Long Does It Take to Work
The time it takes for Di-Iodohydroxyquinoline and Metronidazole to take effect varies greatly depending on the severity of the bacterial infection, as well as the individual’s response to the medication. Generally, however, these medications should begin to work within a few days of starting treatment.Absorption
Di-iodohydroxyquinoline is very well absorbed in the stomach and intestines, while its absorption is slightly decreased by food. Metronidazole is even better absorbed, and reaches maximum plasma concentrations in about one hour after oral administration.Route of Elimination
Di-iodohydroxyquinoline is eliminated primarily through the kidney in unchanged form. Metronidazole is also excreted unchanged primarily through the kidneys, but a small fraction is metabolized in the liver and eliminated as metabolites.Dosage
The usual adult dose of di-iodohydroxyquinoline/metronidazole is one oral tablet containing 500mg of di-iodohydroxyquinoline and 200mg of metronidazole taken two or three times a day. The dose may be adjusted for elderly patients, as well as patients who have impaired kidney function. Patients should also be aware that they may need to take the drug for longer than seven days in order to eliminate bacterial infection.Administration
The recommended route of administration for Di-iodohydroxyquinoline and Metronidazole is oral, with the patient taking one tablet containing 500mg of di-iodohydroxyquinoline and 200mg of metronidazole two or three times a day. The tablets should be swallowed whole with plenty of water, and should not be chewed or crushed.Side Effect
Di-iodohydroxyquinoline and Metronidazole have been known to cause a variety of side effects in some individuals. These can include:- Nausea and vomiting
- Diarrhea
- Headache
- Dizziness
- Rash or itching
- Constipation
- Mood swings
- Metallic taste in the mouth
Toxicity
High doses of Di-iodohydroxyquinoline and Metronidazole have been known to cause acute toxicity. Symptoms of an overdose may include headache, dizziness, vomiting, stomach pain, diarrhea, and difficulty breathing. In cases of severe toxicity, hospitalization and support may be necessary.Precautions
Patients taking Di-iodohydroxyquinoline and Metronidazole should be cautioned to avoid alcoholic beverages, as combining these medications with alcohol can cause extreme nausea, vomiting, flushing, and lightheadedness. Patients should also avoid exposure to direct sunlight, and use a sunscreen if they will be outdoors.Interactions
Di-iodohydroxyquinoline and Metronidazole may interact with other medications, including anticoagulants, lithium, certain antiepileptic drugs, and antacids. Therefore, patients should be sure to inform their doctor of any other medications they are currently taking before they begin treatment with this combination drug.Disease Interactions
Patients with certain medical conditions may not be able to take Di-iodohydroxyquinoline and Metronidazole. In particular, patients with a history of liver or kidney disease should use caution when taking this combination drug.Drug Interactions
Di-iodohydroxyquinoline and Metronidazole may interact with certain drugs, including anticoagulants, lithium, certain antiepileptic drugs, and antacids. Therefore, patients should be sure to inform their doctor of any other medications they are currently taking before they begin treatment with this combination drug.Food Interactions
Di-iodohydroxyquinoline and Metronidazole may interact with certain foods, including dairy products and mineral supplements. In particular, dairy products may reduce the effectiveness of this combination drug, so patients taking this medication should use caution when consuming dairy.Pregnancy Use
Di-iodohydroxyquinoline and Metronidazole are generally not recommended during pregnancy. Patients should discuss with their doctor the potential risks associated with taking this medicine while pregnant.Lactation Use
It is not known if Di-iodohydroxyquinoline and Metronidazole are passed through breast milk. Therefore, this medication should not be used by women who are breastfeeding.Acute Overdose
Acute overdoses of Di-iodohydroxyquinoline and Metronidazole can have serious side effects, including headache, dizziness, vomiting, stomach pain, diarrhea, and difficulty breathing. In cases of severe toxicity, hospitalization and supportive care may be necessary.Contraindications
Di-iodohydroxyquinoline and Metronidazole should not be used in patients with a known hypersensitivity to this medication, and should also be avoided in patients with a history of liver or kidney disease.Use Direction
Di-iodohydroxyquinoline and Metronidazole should be taken orally two or three times a day, with one tablet containing 500mg of di-iodohydroxyquinoline and 200mg of metronidazole. The tablets should be swallowed whole with plenty of water, and should not be chewed or crushed.Storage Conditions
Di-iodohydroxyquinoline and Metronidazole should be stored in a cool, dry place at room temperature, away from light and moisture.Volume of Distribution
The apparent volume of distribution of di-iodohydroxyquinoline and metronidazole is approximately 0.8 to 1.2 L/kg.Half Life
The terminal half-life of di-iodohydroxyquinoline and metronidazole is approximately 16 to 24 hours.Clearance
The apparent clearance of di-iodohydroxyquinoline and metronidazole is approximately 0.2 to 0.4 L/hr/kg.Here you find in details version of Metrozeb