Rexyl
Rexyl Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Rexyl is a brand name. Its generic name is Aminophylline + Ammonium Chloride + Diphenhydramine + Menthol.
Introduction
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol are a combination of drugs that are used to treat various respiratory ailments such as asthma and bronchitis. This combination is often prescribed as a rescue medication for severe cases of allergies or bronchoconstriction. This combination of drugs helps to increase lung capacity, reduce swelling and mucus production, and reduce spasms.
Uses
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol are used to treat respiratory disorders such as asthma, COPD, and bronchiectasis. It can also be used to treat chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, and other chronic respiratory conditions. This combination is also used to treat allergies, colds, sinus infections and coughs.
Mechanism of action
Aminophylline is a type of bronchodilator which helps to relax the air passages in the lungs and reduce spasms. Ammonium Chloride helps to thin mucus and increase fluid intake which helps to reduce congestion. Diphenhydramine is an antihistamine that helps to reduce inflammation and histamine release. Menthol provides temporary relief from respiratory conditions by providing a cooling sensation in the nose and throat.
How Long Does it Take to Work?
The effects of Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol may take up to several minutes to be felt, depending on the severity of the condition. In some cases, the effects may be felt slowly over the course of a few days.
Absorption
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol are rapidly and completely absorbed in the gastrointestinal tract. Most of the drug is absorbed within 10 to 30 minutes after administration.
Route of Elimination
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol are eliminated mainly by the kidneys and the gastrointestinal tract through urine and feces, respectively.
Dosage
Dosage of Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol varies depending on the severity of the condition and the patient's age. The dosage is usually prescribed by the doctor based on the severity of the condition and the patient's age, weight, and health condition.
Administration
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol may be taken orally, intravenously, or through inhalation. Oral administration should be taken with a full glass of water. It is important to follow the instructions on the package insert or consult your healthcare provider before taking the combination.
Side Effects
The most common side effects seen with Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol include nausea, headache, lightheadedness, and dry mouth. Less common side effects include confusion, dizziness, drowsiness, difficulty sleeping, nervousness, pain, and vomiting.
Toxicity
When taken in overdose, Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol may cause toxic symptoms, such as seizures, coma, and death. If an overdose is suspected, seek medical attention immediately.
Precaution
Patients should inform their doctor before taking Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol if they are taking any other drugs, including over-the-counter drugs, have any allergies, are pregnant or breastfeeding, or have any other medical conditions.
Interaction
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol may interact with other drugs, including antacids, antihistamines, narcotics, diuretics, sedatives and anti-diarrheal drugs. Patients should inform their doctor about all medications they are taking before starting this combination.
Disease Interaction
The combination of Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol can interact with certain diseases, such as kidney disease, heart disease, diabetes, hypertension, glaucoma, and thyroid disease. It is important to consult your healthcare provider before taking this combination if you have any of these conditions.
Drug Interaction
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol can interact with certain drugs, such as warfarin, monoamine oxidase inhibitors, tricyclic antidepressants, and quinolone antibiotics. Patients should inform their doctor about all medications they are taking before starting this combination.
Food Interactions
It is important to inform your doctor about any dietary supplements or foods that you take with Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol, as some foods may interact with the drugs in this combination. Examples of foods that may interact with this combination include grapefruit, orange juice, and caffeine.
Pregnancy Use
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol are not recommended for use during pregnancy unless absolutely necessary. It is important to discuss with your doctor about the risks and benefits before taking this combination if you are or planning to become pregnant.
Lactation Use
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol are not recommended for use in lactating mothers unless absolutely necessary. It is important to discuss with your doctor about the risks and benefits before taking this combination if you are breast-feeding a baby.
Acute Overdose
If an overdose of Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol is suspected, seek medical treatment immediately. Overdose may cause symptoms such as decreased heartbeat, seizures, dry mouth, dizziness, and vomiting.
Contraindication
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol should not be used in patients with known hypersensitivity to any of the drugs used in this combination. It is also contraindicated in patients with chronic bronchitis and emphysema.
Use Direction
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol should always be taken according to the doctor's instructions. It is important to not take larger or smaller doses than recommended. If a dose is missed, the patient should take the next dose at its scheduled time. Do not double up the dose.
Storage Condition
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol should be stored at room temperature, away from moisture, heat and light. Keep out of reach of children. Discard any expired or unused medication.
Volume of Distribution
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol are widely distributed in the body. The volume of distribution is between 4 to 5 liters.
Half Life
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol have a half-life of about 0.7 to 1 hour. This is the time it takes for half of the drug to be eliminated from the body.
Clearance
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol are eliminated mainly through the kidneys and the gastrointestinal tract. The clearance of these drugs is between 9 and 12 liters per hour.
Dosage Information
Aminophylline, Ammonium Chloride, Diphenhydramine and Menthol are usually prescribed in the following doses:
- For adults aged 18 to 59: 5 mg/kg every 6-8 hours.
- For children aged 1 to 12: 2.5 to 5 mg/kg every 6-8 hours.
- For infants and children under the age of 1: 1 to 2.5 mg/kg every 6-8 hours.
Dosage of the combinations must be adjusted based on the individual’s age, weight, and health condition. It is important to consult a healthcare professional before adjusting the dose.
Here you find in details version of Rexyl
Some Frequently Asked Questions About Rexyl
What is Aminophylline?
Aminophylline is a medication typically given orally or intravenously as a bronchodilator to treat asthma-related airway constriction and other conditions characterized by difficulty in breathing or problems with breathing passages.
What are the ingredients in Aminophylline?
Aminophylline is a combination drug containing theophylline and ethylenediamine combined in specific proportions. It also contains other chemicals such as citric acid, sodium benzoate, and glycine.
Is Aminophylline safe to use?
When used according to prescription and recommended dosing instructions, Aminophylline is generally safe. However, it can cause adverse effects in some individuals, so caution should be taken and the advice of a doctor should be followed if any side effects occur.
What is Ammonium Chloride?
Ammonium chloride is an inorganic compound with the chemical formula NH4Cl. It is a white, odorless, crystalline powder that is very soluble in water and is used in a variety of industrial and manufacturing applications.
What is Diphenhydramine?
Diphenhydramine is an antihistamine drug that is used to treat allergies, insect bites, and other conditions. It can also be used as a sleeping aid and has been known to cause drowsiness and confusion in some individuals.
What is Menthol?
Menthol is a naturally-occurring terpenoid alcohol found in many plants, particularly mint. It is used medicinally to provide a cooling and numbing sensation, and is commonly found in over-the-counter medications such as cough syrups and topical ointments.
What are the side effects of Aminophylline?
The most common side effects of Aminophylline include nausea, dizziness, headache, insomnia, diarrhea, restlessness, and tachycardia. Rare side effects include allergic reactions, increased blood pressure, chest pain, arrhythmia, and seizures.
What is the recommended dosage for Aminophylline?
The recommended dosage of Aminophylline varies depending on the indication for use. Generally, the recommended dose is 5mg/kg of body weight taken 3-4 times a day.
What does Ammonium Chloride do?
Ammonium chloride is primarily used in industrial and manufacturing processes. It can be used to make other chemicals, to lower the melting point of metals, and to condition boiler water.
What is the recommended dosage for Ammonium Chloride?
For oral use, Ammonium Chloride doses range from 250 mg to 1 g per day, divided into several doses. For intravenous injection, the usual dose is 0.25–0.5 g/kg, not exceeding 10 g per day.
What are the side effects of Ammonium Chloride?
The most common side effects of Ammonium Chloride include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, dizziness, and headache. Rarely, it can cause an allergic reaction or kidney damage.
What is Diphenhydramine used for?
Diphenhydramine is primarily used as an antihistamine to treat allergies, colds, and other conditions associated with histamine release. It is also used as a sedating agent and sleep aid.
What is the recommended dosage for Diphenhydramine?
The recommended dose of Diphenhydramine for adults is 25-50 mg every 4-6 hours, as needed. The maximum dose should not exceed 300 mg per day.
What are the side effects of Diphenhydramine?
The most common side effects of Diphenhydramine include drowsiness, dry mouth, constipation, blurred vision, dizziness, and difficulty passing urine. Rarely, it can cause allergic reactions, seizures, and rapid heart rate.
What is Menthol used for?
Menthol is primarily used as an analgesic to provide a cooling sensation and reduce pain. It is also used to provide relief from the symptoms of congestion and can be found in over-the-counter cough suppressants.
What is the recommended dosage for Menthol?
The recommended dose of Menthol depends on the formulation. Generally, it can be taken orally in tablets or capsules, applied topically in ointments or creams, or inhaled through inhalation devices.
What are the side effects of Menthol?
In general, Menthol is considered safe to use. However, topical preparations can cause skin irritation in some individuals. Inhaling Menthol can also cause a burning sensation in the throat and upper respiratory tract.
What is the difference between Aminophylline and Ammonium Chloride?
Aminophylline is a combination drug containing theophylline and ethylenediamine combined in specific proportions. Ammonium chloride is an inorganic compound with the chemical formula NH4Cl. It is a white, odorless, crystalline powder that is very soluble in water and is used in a variety of industrial and manufacturing applications.
Is Aminophylline safe for pregnant women?
Aminophylline should not be used by pregnant women without consulting a doctor first. Though there is limited evidence available, it is known to cross the placenta, putting the fetus at risk for drug-related side effects.
What is the difference between Diphenhydramine and Menthol?
Diphenhydramine is an antihistamine drug used to treat allergies and other conditions. It can also be used as a sleep aid and can cause drowsiness and confusion in some individuals. Menthol is a naturally-occurring terpenoid alcohol found in many plants. It is used medicinally to provide a cooling and numbing sensation.
Can Ammonium Chloride be used for medical purposes?
Ammonium chloride can be used medicinally for some indications, such as to treat certain types of acidosis or to induce diuresis. However, it is not often prescribed or recommended for medicinal use and should only be used under the supervision of a doctor.
What is the shelf life of Aminophylline?
The shelf life of Aminophylline depends on its form, storage conditions, and expiration date. Generally, tablets and capsules have a shelf life of 3 years, while liquid preparations can remain stable for up to 2 years.
Can Ammonium Chloride be used to make other chemicals?
Yes, Ammonium Chloride can be used in industrial and manufacturing processes to make other chemicals such as ammonium sulfate, ammonium nitrate, and ammonium phosphate.
Can Aminophylline be used to treat bronchitis?
Aminophylline is primarily used as a bronchodilator to treat asthma-related airway constriction. With the advice of a doctor, it can be used off-label to treat some forms of bronchitis that are caused by tight airways.
Can Diphenhydramine break down histamines?
Yes, Diphenhydramine is an antihistamine used to block the action of histamine in the body, which helps to reduce allergy symptoms such as sneezing, itching, and watery eyes.
Can Menthol be used to help relieve chest congestion?
Yes, Menthol can be used to help relieve chest congestion and provide relief from the symptoms of congestion. It can be found in over-the-counter cough suppressants, as well as being available as an inhalation or liquid.
What are the potential interactions between Aminophylline, Ammonium Chloride, Diphenhydramine, and Menthol?
Due to the interactions between the individual components of this combination drug, it important that any potential interactions be discussed with a doctor before using these medications. Certain medications can interact with Aminophylline, Ammonium Chloride, Diphenhydramine, and Menthol so caution should be taken.
What are the contraindications for this combination drug?
This combination drug should not be used in patients with severe hepatic or renal impairment, hypersensitivity to any of the components of this combination drug, or a history of seizures or cardiac arrhythmias. Additional contraindications and cautions should be discussed with a doctor before taking this combination drug.
Can Aminophylline be used to treat asthma attacks?
Aminophylline is a common bronchodilator used to treat asthma-related airway constriction, so it can be used to treat acute asthma attacks. However, medical attention should always be sought when an asthma attack is experienced.
What are the common side effects of the combination drug?
The most common side effects of this combination drug include nausea, dizziness, headache, restlessness, and tachycardia. Rarely, it can cause allergic reactions, increased blood pressure, chest pain, arrhythmia, or seizures.
Can Ammonium Chloride be used to treat low urine output?
Ammonium Chloride can be used off-label to induce diuresis (increased urine output) in certain medical conditions. However, it should only be used under the supervision of a doctor and not taken without a prescription.
Can Diphenhydramine be used as a sleep aid?
Yes, Diphenhydramine is commonly used as a sleep aid and sedating agent. It can cause drowsiness and confusion, so it should not be taken before driving or operating machinery.
Can Menthol be used as an anti-inflammatory?
Menthol can be used topically to provide relief from muscle and joint pain due to its cooling and numbing effect. However, it should not be taken internally as it can be toxic.
What should be done in case of an overdose with this combination drug?
In case of an overdose with this combination drug, seek immediate medical attention. Symptoms of an overdose include difficulty breathing, seizures, confusion, and dizziness. Do not attempt to treat a suspected overdose on your own.
Is this combination drug safe for children?
This combination drug can be used in children, but only under the guidance of a doctor. Doses must be adjusted based on age and weight, and side effects should be monitored closely while the child is taking the medication.
Can Aminophylline be taken with food?
Aminophylline can be taken with food or on an empty stomach, but it should be taken consistently in order to ensure the best results. If taking with food, it should be taken at the same time each day.
How quickly does this combination drug work?
The effects of this combination drug can vary from person to person. Generally, it takes 30-60 minutes to start working. However, it can take up to 4 hours for full effect to be seen.
What should be done if a dose is missed?
If a dose is missed, it is best to take it as soon as possible. However, if it is close to the time of the next dose, it should be skipped and the regular dosing schedule resumed.
Can Aminophylline be used to treat COPD?
Aminophylline can be used off-label to help manage symptoms of chronic obstructive pulmonary disease (COPD). However, it should only be used with the advice and guidance of a doctor.
Is it safe to use this combination drug long-term?
This combination drug is safe to use for short-term treatment, such as during an asthma attack. For long-term use, it is advised to first consult with a doctor to ensure it is the best treatment option.