Mesilon
Mesilon Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Mesilon is a brand name. Its generic name is Pyridostigmine.
Introduction
Mesilon is a prescription medication that is used to treat a limited range of disorders related to nerve and muscle function. It is used to treat myasthenia gravis, an autoimmune disorder characterized by weakness and fatigue; certain types of nausea and vomiting; and post-operative weakness. It is also sometimes used before surgery as a preoperative medication to improve muscle strength.Uses
Mesilon is used to treat a number of conditions related to nerve and muscle function, including:- Myasthenia gravis, an autoimmune disorder characterized by weakness and fatigue
- Certain types of nausea and vomiting, particularly that caused by chemotherapy or radiation therapy
- Post-operative weakness
- Preoperative medication to improve muscle strength
Mechanism of Action
Mesilon works by increasing the amount of acetylcholine in the body. Acetylcholine is a neurotransmitter, a chemical that sends signals between nerve cells. By increasing the amount of acetylcholine available, Mesilon enhances nerve transmission, leading to an increase in muscle strength and improved nerve and muscle function in people with myasthenia gravis.How Long Does it Take to Work?
Mesilon typically starts to improve muscle strength and functioning within an hour after it is taken, and its effects can last 4 to 8 hours. It may take several weeks to observe the full effect, and the dose may need to be increased to achieve the desired result.Absorption
Mesilon is rapidly and completely absorbed when taken orally.Route of Elimination
Mesilon is primarily metabolized in the liver and eliminated through the kidneys in the form of inactive metabolites.Dosage
Mesilon is available as an oral extended-release tablet (Mestinon) and oral syrup and tablets (Regonol). The usual recommended dose is 1 to 3 tablets or 10 mL of the oral syrup every 4 to 6 hours. For the treatment of myasthenia gravis, the dose may be increased up to 8 tablets or 40 mL of the oral syrup per day.Administration
Mesilon should be taken orally with or without food. For the syrup preparation, shake well before use. Provide an adequate water supply while taking Mesilon.Side Effects
Common side effects of Mesilon include headache, nausea, diarrhea, constipation, abdominal pain, and dizziness. Other side effects may include increased sweating, flushing, feeling of warmth, difficulty sleeping, and increased urination.Toxicity
Mesilon is generally well tolerated at recommended doses; however, an overdose can cause symptoms such as nausea, vomiting, abdominal pain, blurred vision, fast or irregular heartbeat, increased sweating, and confusion.Precautions
Mesilon should be used with caution in people with decreased kidney or liver function, ulcerative colitis, uncontrolled asthma, adrenal gland problems, and an underactive thyroid. It should not be taken by people with a known hypersensitivity to Mesilon or other choline esters.Interactions
Mesilon may interact with medications used to treat asthma and chronic obstructive pulmonary disease (COPD); quinidine, a heart medication; medications used to treat depression; neostigmine, a similar medication; as well as some antibiotics and antifungal medications.Disease Interactions
Mesilon may cause an increase in blood sugar levels in people with diabetes and may increase the risk of seizures in people with a history of seizure disorders. It can increase the effects of medications used to treat depression. It may worsen symptoms in people with ulcerative colitis.Drug Interactions
Mesilon may increase the side effects of medications used to treat asthma and COPD, as well as quinidine, a heart medication. It may increase the risk of seizures in people taking certain medications used to treat depression. In addition, Mesilon may interact with certain antibiotics and antifungal medications.Food Interactions
Mesilon should be taken with a full glass of water or other liquids. Taking it with too little liquid can increase the risk of side effects.Pregnancy Use
Mesilon is safe to use during pregnancy in the short term. Its safety during long-term use has not been established.Lactation Use
It is not known if Mesilon passes into breast milk. Breastfeeding mothers should discuss the risks and benefits of taking Mesilon with their healthcare provider.Acute Overdose
An overdose of Mesilon can be dangerous. Symptoms of an overdose may include nausea, vomiting, abdominal pain, blurred vision, fast or irregular heartbeat, increased sweating, and confusion. Seek medical attention immediately if an overdose is suspected.Contraindication
Mesilon should not be used in people with a known hypersensitivity to Mesilon or other choline esters.Use Direction
Mesilon should be taken orally with or without food, at intervals of 4 to 6 hours. The usual recommended dose is 1 to 3 tablets or 10 mL of the syrup every 4 to 6 hours. The dose may be increased up to 8 tablets or 40 mL of the syrup per day. Provide an adequate water supply while taking Mesilon.Storage Conditions
Mesilon should be stored at room temperature, away from direct light, heat, and moisture.Volume of Distribution
The volume of distribution of Mesilon is not known.Half Life
The half-life of Mesilon is between 1.5 to 4 hours.Clearance
Mesilon is cleared from the body via the kidneys.Here you find in details version of Mesilon
Some Frequently Asked Questions About Mesilon
.What is Mesilon?
Mesilon is an anticholinesterase medication used to treat the symptoms of myasthenia gravis, a chronic neuromuscular disorder.
What does Mesilon treat?
Mesilon is used to treat the symptoms of myasthenia gravis, a chronic neuromuscular disorder.
How does Mesilon work?
It works by blocking the breakdown of a certain natural substance (acetylcholine) in your body. This action increases the amount of acetylcholine, which helps to improve muscle strength.
What is the dosage of Mesilon?
The usual dose for adults is 60 to 120 milligrams (mg) three times daily. Your doctor may adjust your dose depending on your symptoms. Children should take lower doses.
Are there any side effects associated with Mesilon?
The most common side effects of Mesilon are nausea, vomiting, abdominal cramps, and diarrhea. Other side effects include dizziness, headache, blurred vision, and difficulty sleeping.
Is it safe to take Mesilon while pregnant or breastfeeding?
No, it is not recommended to take Mesilon while pregnant or breastfeeding. Talk to your doctor before taking this medication if you are pregnant or breastfeeding.
Can I take other medications with Mesilon?
Tell your doctor about all the medications you are taking, including over-the-counter drugs and supplements. Do not start taking a new medication without talking to your doctor first.
What should I do if I miss a dose of Mesilon?
If you miss a dose of Mesilon, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule.
What should I do if I overdose on Mesilon?
If you think you have taken too much of this medication, call your doctor or local poison control center right away. If you experience facial muscle spasms, sweating, or increased urination, seek medical help immediately.
Is there an alternative medication to Mesilon?
Yes, there are alternatives to Mesilon. These include medications such as prednisone, azathioprine, mycophenolate mofetil, and intravenous immunoglobin.
What should I avoid when taking Mesilon?
Avoid drinking alcohol while taking Mesilon. Alcohol can increase the side effects of this medication.
Is there anything I should watch for while taking Mesilon?
Yes. Monitor your blood pressure closely while taking this medication. Also watch out for signs of muscle weakness, such as difficulty speaking, swallowing, or walking, and report any issues to your doctor right away.
What other drugs can interact with Mesilon?
Mesilon can interact with other medications, such as antibiotics, antifungals, antidepressants, and heart medications. Tell your doctor about all the medications you are taking before starting Mesilon.
Are there any common side effects associated with Mesilon?
The most common side effects of Mesilon are nausea, vomiting, abdominal cramps, and diarrhea. Other side effects include dizziness, headache, blurred vision, and difficulty sleeping.
Is Mesilon a narcotic?
No, Mesilon is not a narcotic. It is an anticholinesterase medication.
Can Mesilon be used to treat other conditions?
No, Mesilon is only approved for the treatment of myasthenia gravis. It is not approved for other conditions.
Is it safe to take Mesilon long-term?
Yes, it is generally safe to take Mesilon long-term for the treatment of myasthenia gravis. Talk to your doctor about any potential risks before taking this medication long-term.
Can Mesilon cause allergic reactions?
Yes, Mesilon can cause allergic reactions. Symptoms of an allergic reaction can include rash, itching, swelling, and difficulty breathing.
Can I stop taking Mesilon without consulting my doctor?
No, you should not stop taking Mesilon without consulting your doctor first. The symptoms of myasthenia gravis can be managed with medications, and stopping medications without consulting your doctor can make them worse.
Can I buy Mesilon over the counter?
No, Mesilon is only available by prescription.
What should I do if I experience side effects from Mesilon?
If you experience side effects from Mesilon, contact your doctor right away. Your doctor may need to adjust your dose or switch you to a different medication.
Is there any monitoring I should do while taking Mesilon?
Yes. Your doctor may need to monitor your heart rate and blood pressure while you are taking Mesilon.
Can I take Mesilon for more than 6 months?
Yes, it is generally safe to take Mesilon long-term for the treatment of myasthenia gravis. Talk to your doctor about any potential risks before taking this medication long-term.
Does Mesilon interact with any foods?
No, Mesilon does not interact with any foods.
Can I take Mesilon with other medications?
Yes, but you should always tell your doctor about all the medications you are taking, including over-the-counter drugs and supplements. Do not start taking a new medication without talking to your doctor first.
Are there any precautions I should take when taking Mesilon?
Yes. You should avoid drinking alcohol while taking Mesilon. Also, be sure to monitor your blood pressure closely while taking this medication.
Is it safe to take Mesilon with other medications for myasthenia gravis?
Yes, it is safe to take Mesilon with other medications for myasthenia gravis. However, you should always talk to your doctor about any potential interactions between medications.
Can Mesilon be used to treat other medical conditions?
No, Mesilon is only approved for the treatment of myasthenia gravis. It is not approved for other conditions.
Can Mesilon cause an increase in heart rate?
Yes, Mesilon can cause an increase in heart rate. Monitor your heart rate closely while taking this medication, and contact your doctor right away if you experience any rapid or irregular heart beats.
Can Mesilon cause headaches?
Yes, Mesilon can cause headaches. If you experience a headache while taking this medication, contact your doctor right away.
Can Mesilon be taken at night?
Yes, Mesilon can be taken at night. Follow your doctor's instructions on when and how to take your medication.
Can I stop taking Mesilon after a few days?
No, you should not stop taking Mesilon without consulting your doctor first. The symptoms of myasthenia gravis can be managed with medications, and stopping medications without consulting your doctor can make them worse.
What should I do if I have trouble swallowing Mesilon tablets?
If you have difficulty swallowing tablets, you can ask your doctor about other forms of Mesilon, such as capsules or liquid. You may also be able to crush the tablets and mix them with food or fluids for easier swallowing.
Is it safe to take Mesilon while breastfeeding?
No, it is not recommended to take Mesilon while breastfeeding. Talk to your doctor before taking this medication if you are breastfeeding.
Does Mesilon interact with any other medications?
Yes, Mesilon can interact with other medications, such as antibiotics, antifungals, antidepressants, and heart medications. Tell your doctor about all the medications you are taking before starting Mesilon.
What should I do if I experience blurred vision while taking Mesilon?
If you experience blurred vision while taking Mesilon, contact your doctor right away. Blurred vision can be a sign of an underlying medical condition.
Can Mesilon cause liver damage?
No, Mesilon does not cause liver damage. However, it can cause other side effects, such as nausea, vomiting, abdominal cramps, and diarrhea.
Can I take Mesilon while pregnant?
No, it is not recommended to take Mesilon while pregnant. Talk to your doctor before taking this medication if you are pregnant.
Can Mesilon cause weight gain?
No, Mesilon does not cause weight gain. However, it can cause other side effects, such as nausea, vomiting, abdominal cramps, and diarrhea.
Can I take Mesilon with food?
Yes, you can take Mesilon with food. It is usually taken three times a day, with meals or snacks.
Can I take over-the-counter medications while taking Mesilon?
Yes, but you should always tell your doctor about all the medications you are taking, including over-the-counter drugs and supplements. Do not start taking a new medication without talking to your doctor first.