Mepivacaine

Mepivacaine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Mepivacaine is a brand name. Its generic name is Mepivacaine.

Mepivacaine

Mepivacaine is a local anesthetic pain reliever that has been in use since the mid-1960s. It is a type of amino amide of the ester class, that is most commonly used as a nerve block or for dental procedures. The drug stops the flow of certain signals along the nerves towards the brain and creates a numb sensation and reduces the feeling of pain in the affected area.

Uses for Mepivacaine

Mepivacaine is commonly used for nerve blocks, spinal anesthesia, and dental procedures. It can be used to reduce pain during minor medical procedures. Additionally, it is used epidurally or infiltration as a local anesthetic for percutaneous nerve block or regional anesthetic. Mepivacaine may also be used for other conditions as determined by your doctor.

Mechanism of Action

Mepivacaine blocks nerve conduction by stopping the flow of certain signals along the nerves towards the brain. The specific drugs inhibit neuronal conduction by blocking the influx of sodium into the neuron during the action potential, reducing both its threshold for stimulation and its absolute refractory period. This effect can last for several hours after the medication has been administered.

How Long Does It Take to Work?

Mepivacaine usually begins to take effect within 2-5 minutes after the injection. However, the effects may last for several hours after the medication has been administered.

Absorption

Mepivacaine is rapidly and extensively absorbed after its injection either intramuscularly or epidurally. Its continuous infusion is reported to be more effective than local anesthetic bolus injection.

Route of Elimination

Mepivacaine is metabolized in the liver and its metabolites are excreted in the urine.

Dosage

The dosage of mepivacaine varies according to the procedure being performed. It is usually administered via intramuscular or epidural injection. The accepted dosing of mepivacaine for various procedures are as follows:

• Nerve Block: 0.5% to 1% concentration: 2 mg/kg
• Epidural Anesthesia: 0.5% to 1% concentration: 3 mg/kg
• Percutaneous Nerve Block: 1% to 2% concentration: 2 to 5 mL
• Spinal Anesthesia: 0.5 to 1% concentration: 5 mg/kg

Administration

Mepivacaine should only be administered by a qualified healthcare professional. It is typically injected into the muscle or into the epidural space. For nerve blocks, the concentration and dosage should be determined by a healthcare provider depending on the procedure being performed.

Side Effect

The most common side effects associated with the use of mepivacaine include headache, lightheadedness, numbness, and nausea. Other side effects may include rash, itching, seizures, and irregular heartbeat. If swelling, burning, or persistent pain occur, seek medical attention immediately.

Toxicity

Mepivacaine has a low oral LD50 compared to other local anesthetics, indicating a high risk of toxicity in the event of an overdose. Symptoms associated with toxicity can include twitching, severe headaches, seizures, and a slowed heartbeat. If an overdose occurs, seek medical attention immediately.

Precaution

Mepivacaine should not be used in patients who are pregnant or breastfeeding, as it can cause harm to the fetus or newborn infant. Additionally, it should be used with caution in patients with kidney or liver diseases, as they may experience increased levels of toxicity. Patients with cardiac disease should be monitored closely as mepivacaine can cause a decrease in blood pressure, an irregular heartbeat, and in some cases, cardiac arrest.

Interaction

Mepivacaine may interact with other medications, such as muscle relaxants, anticoagulants, antihypertensives, and other local anesthetics. Additionally, it may interact with substances such as alcohol, nicotine, and illicit drugs. Patients should inform their healthcare provider of any medications they are taking, prior to receiving mepivacaine.

Disease Interaction

Mepivacaine may interact with medical conditions such as liver disease, heart disease, respiratory depression, seizure disorder, and pregnancy. It is important for patients to inform their healthcare provider of any pre-existing medical condition before receiving the medication.

Drug Interaction

Mepivacaine may interact with other medications, which can lead to increased side effects, decreased effectiveness, or even a toxic reaction. When taking mepivacaine, patients should inform their healthcare provider of all other medications they are taking, including over the counter medications, vitamins, and herbal supplements.

Food Interactions

Mepivacaine may interact with certain foods and beverages, including alcohol. It is important to inform your doctor of any known food allergies or dietary restrictions, prior to taking the medication.

Pregnancy Use

Mepivacaine should not be used during pregnancy. It has been associated with an increased risk of adverse side effects and fetal abnormalities. Talk to your doctor about the risks and benefits before using the medicine during pregnancy.

Lactation Use

Mepivacaine should not be used while breastfeeding. It can pass into the breast milk and cause side effects in the nursing infant. Therefore, it is important to discuss the risks and benefits with your doctor before using the medication while breastfeeding.

Acute Overdose

In the event of an acute overdose, symptoms may include twitching, severe headaches, confusion, seizures, slowed heartbeat, and loss of consciousness. Seek medical attention immediately if an overdose is suspected.

Contraindication

Mepivacaine should not be used in patients who have a history of hypersensitivity to the drug, or to any of its components. It should also be used with caution in patients with certain medical conditions, such as liver or kidney disease, or cardiac disorders.

Use Direction

Mepivacaine should be administered under the supervision of a qualified healthcare professional in a hospital or clinical setting. The dose and concentration of the medication should be determined by a healthcare provider depending on the procedure being performed. Patients should follow their healthcare provider's instructions carefully.

Storage Condition

Mepivacaine should be stored at a controlled room temperature, between 59°F and 86°F (15°C and 30°C). Do not freeze and protect from light. Do not use the product if the expiration date has passed.

Volume of Distribution

The volume of distribution of mepivacaine is 0.2 - 0.4 L/kg.

Half Life

Mepivacaine has a half-life of 1-2 hours.

Clearance

Mepivacaine is mainly cleared through the kidneys. The renal clearance of mepivacaine is 0.04 mL/min/kg.

Here you find in details version of Mepivacaine

Some Frequently Asked Questions About Mepivacaine

What is Mepivacaine?

Mepivacaine is a local anesthetic commonly used for numbing up small areas of skin and mucous membranes. It is most commonly used in dental procedures, but it also can be used for a variety of other minor surgeries such as cosmetic procedures, or as a local anesthetic for pain relief.

How does Mepivacaine work?

Mepivacaine works by blocking the nerve impulses that would normally send pain signals to the brain. It does this by preventing the passage of sodium ions into the nerve cells, which is necessary for the cells to transmit pain signals. This numbs the area, preventing the patient from feeling any pain.

What are the side effects of Mepivacaine?

The most common side effect of Mepivacaine is a mild burning sensation at the injection site. Other side effects may include nausea, itching, and swelling. Most of these side effects are mild and do not last long. Rarely, more serious side effects such as allergic reactions or seizures can occur.

How long does Mepivacaine last?

The duration of Mepivacaine's effect depends on how much of the drug was used and the location in which it was injected. Generally, the effects of a single Mepivacaine injection will last between two and four hours.

Is Mepivacaine safe?

Yes, Mepivacaine is safe when it is administered properly. It is a medication that is used to block the sensations of pain by numbing an area, making it useful for a variety of surgeries and procedures. Your health care provider should be consulted for more information.

Can Mepivacaine be used during pregnancy?

Yes, Mepivacaine can be used during pregnancy. However, it is important that you inform your doctor if you are pregnant before the procedure is done, as there may be certain risks or precautions that need to be taken.

Is Mepivacaine habit forming?

No, Mepivacaine is not habit forming. It is a local anesthetic that is only used to temporarily numb the area where it is injected, and it does not have any effects on the user's mental or emotional state.

Can Mepivacaine be used on children?

Yes, Mepivacaine can be used on children if it is necessary. However, it is important for parents to consult with their child's physician before the procedure to make sure it is safe for the child.

How should Mepivacaine be stored?

Mepivacaine should be stored in a dry place at room temperature. It should be kept away from direct sunlight or heat and not be placed in the refrigerator or freezer.

What if I miss a dose of Mepivacaine?

If you miss a dose of Mepivacaine, it is best to consult with your doctor for instructions. Mepivacaine is not a medication that is taken orally, so there is no need to make up for the missed dose.

Can I buy Mepivacaine over the counter?

No, Mepivacaine is not available over the counter. It is a prescription medication and should only be administered by a medical professional.

What is the cost of Mepivacaine?

The cost of Mepivacaine varies depending on the dosage and the quantity purchased. Generally Mepivacaine injection solutions cost between $10 and $25 per vial.

What should I avoid while taking Mepivacaine?

It is important to avoid driving or other activities that require alertness while taking Mepivacaine. You should also avoid drinking alcohol or taking any sedatives or sleeping pills while taking Mepivacaine.

Can Mepivacaine be used on cats and dogs?

Yes, Mepivacaine can be used on cats and dogs if it is necessary. However, it is important to only use Mepivacaine that is prescribed for use on animals, as using human-grade drugs may be dangerous for animals.

What should I tell my doctor before taking Mepivacaine?

Before taking Mepivacaine, you should tell your doctor about all medications and supplements you are currently taking, including any herbal or natural remedies. You should also tell your doctor if you have any pre-existing medical conditions or allergies.

What is the recommended dosage of Mepivacaine?

The recommended dosage of Mepivacaine varies depending on the procedure and the patient's age and weight. Your doctor or health care provider can provide more information about the correct dosage for your individual case.

Is Mepivacaine available in generic form?

Yes, Mepivacaine is available in generic form. Generic Mepivacaine has the same active ingredients as brand-name Mepivacaine and works the same way in the body.

Does Mepivacaine have any interaction with other drugs?

Yes, Mepivacaine may have interactions with some drugs and medications. Before taking Mepivacaine, you should always inform your doctor or health care provider of any other drugs or supplements that you are currently taking.

Does Mepivacaine have any side effects in the elderly?

Yes, elderly patients may be more likely to experience certain side effects of Mepivacaine than younger patients. These side effects may include dizziness, confusion, blurred vision, and drowsiness. You should always inform your doctor if you are elderly or have any pre-existing medical conditions before taking Mepivacaine.

Can I give a 2-year-old a dose of Mepivacaine?

No, Mepivacaine should not be administered to a 2-year-old. It should only be given to children under the age of 12 with the approval of a doctor or health care provider.

What is the maximum dosage of Mepivacaine?

The maximum dosage of Mepivacaine depends on the procedure and the individual patient. The exact dosage should always be determined by your doctor or health care provider.

Will Mepivacaine help reduce swelling?

No, Mepivacaine's primary purpose is to block nerve impulses which causes numbness. It will not help reduce swelling, but it may provide pain relief.

Can Mepivacaine be used in the eyes?

Yes, Mepivacaine can be used in the eyes for certain types of surgeries. However, it is important to talk to your doctor or health care provider before using Mepivacaine in the eyes.

How long does it take for Mepivacaine to take effect?

Mepivacaine typically takes effect within a few minutes of the injection. The effects of a single injection of Mepivacaine will typically last between two and four hours.

Can I take Mepivacaine while breastfeeding?

No, you should not take Mepivacaine while breastfeeding. Mepivacaine is not safe for use in lactating women and could be transferred to the infant through breast milk.

Can I use Mepivacaine on a large area?

No, Mepivacaine should not be used on large areas of the body because it can cause side effects such as nausea, trembling, and seizures. If you need to numb a large area, you should speak to your doctor for alternative options.

Can Mepivacaine be used on open wounds?

No, Mepivacaine should not be used on open wounds or areas of skin that have been damaged or irritated. Mepivacaine should only be used when the skin is intact.

Are there any alternatives to Mepivacaine?

Yes, there are other local anesthetics that can be used in place of Mepivacaine. Lidocaine and bupivacaine are two of the more commonly used local anesthetics.

What should I do if I experience a serious side effect from Mepivacaine?

If you experience a serious side effect or an allergic reaction from Mepivacaine, you should seek emergency medical attention immediately. Signs of an allergic reaction include difficulty breathing, hives, or swelling of the face, tongue, or throat.

Can Mepivacaine be used on broken skin?

No, Mepivacaine should not be used on broken or damaged skin. The drug can cause serious side effects when applied to open wounds, so you should speak to your doctor before using it on any broken skin.

Can I use Mepivacaine on my lip?

Yes, Mepivacaine can be used on the lips if it is necessary. However, it can cause a burning sensation when injected, so it should only be used as a last resort.

Is Mepivacaine safe for long-term use?

No, Mepivacaine is meant for short-term use only and should not be used for extended periods of time. Prolonged use of Mepivaciane can cause adverse effects on the patient's health.

Can I take Mepivacaine if I have diabetes?

Yes, you can take Mepivacaine if you have diabetes. However, it is important to inform your doctor if you have any pre-existing conditions before taking Mepivacaine.

How quickly does Mepivacaine take effect?

Mepivacaine usually takes effect within a few minutes of the injection. The effects of a single injection of Mepivacaine will typically last between two and four hours.