Medroxyprogesterone
Medroxyprogesterone Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Medroxyprogesterone is a brand name. Its generic name is Medroxyprogesterone (Acetate).
Introduction
Medroxyprogesterone is a progestin medication which is commonly used for contraception and in the treatment of menstrual disorders such as amenorrhea. It is also used for endometrial hyperplasia, dysfunctional uterine bleeding, endometriosis, and breast, endometrial, and renal cancer.Uses
Medroxyprogesterone is used to treat a variety of conditions, including contraception, menstrual disorders, endometrial hyperplasia, dysfunctional uterine bleeding, endometriosis, and breast, endometrial, and renal cancer.Mechanism of Action
Medroxyprogesterone works by inhibiting the action of natural progesterone, which is a hormone produced in the body. By blocking progesterone, medroxyprogesterone (acetate) alters the natural menstrual cycle and can be used to treat certain menstrual disorders. By altering the action of progesterone, it can also be used to treat endometrial hyperplasia, dysfunctional uterine bleeding, endometriosis, and certain types of cancer.How Long Does it Take to Work?
It generally takes several days before the effects of medroxyprogesterone (Acetate) can be seen. For contraception, it may take up to 7 days to become effective.Absorption
Medroxyprogesterone is rapidly and completely absorbed following oral administration. It is metabolized in the liver and excreted mainly through the feces.Route of Elimination
Medroxyprogesterone is metabolized in the liver and then eliminated mainly through the feces.Dosage
Medroxyprogesterone is available in various forms and strengths. The recommended dose for contraception is 5mg to 10mg once daily, on days 5-25 of the menstrual cycle. For endometrial hyperplasia, the recommended dose is 10mg taken daily for 2-4 weeks. For endometriosis and dysfunctional uterine bleeding, the recommended dose is 5mg taken twice daily for 5-10 days. The dose for treating endometrial cancer or breast cancer is 400-1000mg per day for 6-12 months.Administration
Medroxyprogesterone is typically administered orally, in the form of a tablet, capsule, or liquid solution.Side Effects
Medroxyprogesterone can cause a variety of side effects including headache, dizziness, fatigue, breast tenderness, nausea, vomiting, bloating, weight gain, fluid retention, mood swings, depression, and hair thinning.Toxicity
Medroxyprogesterone can be toxic if taken in high doses or in combination with certain medications.Precautions
Medroxyprogesterone should not be used in people who have liver or kidney disease, blood clotting disorders, or a history of stroke. It should also not be used in people who are pregnant or are breastfeeding.Interaction
Medroxyprogesterone can interact with other medications, including anticonvulsants, antidepressants, anabolic steroids, and antiretrovirals.Disease Interaction
Medroxyprogesterone can interact with certain diseases such as asthma, diabetes, epilepsy, hypertension, and heart failure.Drug Interaction
Medroxyprogesterone can interact with certain drugs such as salicylates, barbiturates, and antibiotics.Food Interactions
Medroxyprogesterone can interact with certain foods such as grapefruit, alcohol, and certain dairy products.Pregnancy Use
Medroxyprogesterone is not recommended for use during pregnancy, as it can cause birth defects.Lactation Use
Medroxyprogesterone is not recommended for use during lactation, as it can pass into breast milk.Acute Overdose
In case of an acute overdose of medroxyprogesterone (acetate), seek immediate medical attention. Symptoms of an overdose include nausea, vomiting, abdominal pain, dizziness, and rapid heart rate.Contraindication
Medroxyprogesterone is contraindicated in people who have liver or kidney disease, blood clotting disorders, a history of stroke, or who are pregnant or breastfeeding.Use Direction
Medroxyprogesterone must be taken exactly as prescribed by a doctor. The dosage and duration of use will vary depending on the condition being treated.Storage Condition
Medroxyprogesterone should be stored at room temperature in a dry and dark place.Volume of Distribution
The volume of distribution of medroxyprogesterone (acetate) is approximately 7.9 liters.Half Life
The half life of medroxyprogesterone (acetate) is approximately 11 to 14 hours.Clearance
The clearance of medroxyprogesterone (acetate) is approximately 15.5 liters/hr.Here you find in details version of Medroxyprogesterone