Maccef O

Maccef O Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Maccef O is a brand name. Its generic name is Cefpodoxime.

Introduction

Maccef O (also referred to as cefpodoxime proxetil) is an antibiotic used to treat sinus infections, bronchitis, pneumonia, ENT infections, skin infections, and certain urinary tract infections. The drug belongs to a class of antibiotics called cephalosporins and is produced in oral, and intravenous formats.

Uses

Maccef O is used to treat a variety of bacterial infections such as sinusitis, bronchitis, pneumonia, otitis media, cellulitis, urinary tract infections, skin and skin structure infections, and pharyngitis/tonsillitis.

Mechanism of Action

Maccef O works by inhibiting bacterial cell wall synthesis. This leads to an influx of water and causes the cell wall to rupture, thus killing the bacteria. In addition, the drug has some activity against certain types of fungi, viruses and protozoa.

How Long Does It Take to Work

Maccef O usually begins to take effect within 1-2 days of administration. However, it may take up to 5-7 days to experience full relief of symptoms.

Absorption, Route of Elimination, Dosage and Administration

Maccef O is rapidly and almost completely absorbed from the gastrointestinal tract. The drug is eliminated primarily through the kidneys and the excretion rate is slow. The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours. Oral suspension formulations are available in 50 and 100 mg/5 mL strengths.

Side Effects

Common side effects of cefpodoxime include diarrhea, nausea, vomiting, abdominal pain, dizziness, headache, fatigue, rash, and skin sensitivity. Severe side effects include anaphylaxis, kidney damage, and fainting. Maccef O can also cause abnormal liver function test results and thrombocytopenia.

Toxicity

Maccef O is generally well-tolerated. Overdose symptoms include nausea, vomiting, diarrhea, dizziness, rapid heart rate, and rare seizures.

Precautions

Maccef O should be avoided in patients with history of allergy to cephalosporins. The drug should not be used in patients with impaired kidney or liver function. It should also be used with caution in pregnant and breastfeeding women.

Interaction

Maccef O may interact with other medications such as antacids, warfarin, digoxin, probenecid, and certain drugs for HIV/AIDS, etc. Drugs that interact with cefpodoxime include: paroxetine; phenytoin; ritonavir; certain fluoroquinolone antibiotics such as ciprofloxacin, norfloxacin, and ofloxacin; and certain anti-seizure drugs such as phenytoin, valproic acid, and carbamazepine.

Disease Interaction

Maccef O may interact with certain medical conditions such as kidney disease, history of allergic reactions to other cephalosporin antibiotics, and intestinal inflammation due to infection or the use of antibiotics. Maccef O should be used with caution in patients with kidney disease. It should not be used in patients if there is an existing intestine infection or if the patient has recently been taking antibiotics.

Drug Interaction

Drug interactions may occur when cefpodoxime is taken with other medications such as antacids, warfarin, probenecid, and certain HIV drugs. Maccef O should not be used together with drugs like paroxetine, phenytoin, ritonavir, certain fluoroquinolone antibiotics (ciprofloxacin, norfloxacin, ofloxacin), certain anti-seizure drugs (phenytoin, valproic acid, carbamazepine), etc. Patients should inform their physicians of any medications they are currently taking before taking cefpodoxime.

Food Interactions

Maccef O should be taken with a full glass of water. Food can decrease the absorption of cefpodoxime, so the drug should be taken at least 2 hours before or after a meal. Avoid consumption of dairy products, antacids, iron supplements, and vitamins within 2 hours of taking cefpodoxime.

Pregnancy Use

Maccef O is likely safe to use during pregnancy. However, it is best to consult a doctor before taking cefpodoxime during pregnancy.

Lactation Use

Maccef O is not known to be harmful when breastfeeding. However, it is best to consult a doctor before taking cefpodoxime while breastfeeding.

Acute Overdose

Acute overdose of cefpodoxime can result in nausea, dizziness, rapid heart rate, and seizures. Seek medical help if overdose is suspected.

Contraindication

Maccef O is contraindicated in patients with known allergy to cephalosporins.

Dosage Information

The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours.

Direction of Use

Maccef O should be taken orally with a full glass of water. It should be taken with or without food. It should not be taken with dairy products, antacids, iron supplements, or vitamins.

Storage Condition

Maccef O should be stored in a tight container, away from light and moisture, at room temperature (15-30°C).

Volume of Distribution

Maccef O has a volume of distribution of 0.3 - 0.5 L/kg.

Half-Life

The average half-life of cefpodoxime is about 2 - 4 hours.

Clearance

The average clearance of cefpodoxime is 50 - 70 mL/min.

Here you find in details version of Maccef O

Some Frequently Asked Questions About Maccef O

What is Maccef O?

Maccef O is an antibiotic used to treat certain types of bacterial infections. It belongs to a class of antibiotics called cephalosporins that work by stopping the growth of bacteria.

What infections does Maccef O treat?

Maccef O is used to treat infections caused by certain bacteria, such as lower respiratory tract infections, otitis media (middle ear infections), skin infections, and urinary tract infections.

How does Maccef O work?

Maccef O works by attacking the bacteria that cause the infection. It works by interfering with the bacteria’s ability to make cell walls, which results in the death of the bacteria.

Who should take Maccef O?

Maccef O should be taken by those who have been prescribed it by a doctor to treat a bacterial infection. It should not be taken by anyone who has an allergy to cephalosporin antibiotics.

How do I take Maccef O?

Maccef O should be taken as directed by your doctor. The dosage and length of treatment will depend on the infection being treated. The tablets should be taken with a full glass of water. If you forget to take a dose, take it as soon as you remember.

What are the possible side effects of taking Maccef O?

Some common side effects of taking Maccef O may include nausea, vomiting, diarrhea, or skin rash. Serious side effects include easy bleeding or bruising, yellowing skin or eyes, chest pain, or difficulty breathing. Tell your doctor if you experience any of these side effects.

What if I am allergic to Maccef O?

If you are allergic to Maccef O or other cephalosporin antibiotics, do not take this drug. Tell your doctor about any allergies that you have before beginning treatment.

Can I take Maccef O with other medications?

Before taking Maccef O, tell your doctor if you are taking any other medications, especially probenecid, sulfamethoxazole, or valproic acid. Some medications may interact with Maccef O, so it is important to discuss them with your doctor before beginning treatment.

Can Maccef O be used to treat a viral infection?

No, Maccef O is not effective for treating viral infections since it only attacks bacterial infections.

What is the recommended dosage for Maccef O?

The recommended dosage of Maccef O depends on the infection being treated and on the patient's age and weight. It is important to follow your doctor's instructions when taking Maccef O.

Can Maccef O be used during pregnancy?

Maccef O is generally considered safe to use during pregnancy, but it is always best to consult your doctor before taking any medication during pregnancy.

Can I miss a dose of Maccef O?

If you miss a dose of Maccef O, take it as soon as possible. However, if it is close to the time for your next dose, skip the missed dose and continue with your normal schedule.

Is Maccef O safe for children?

Yes, Maccef O is safe to use in children. However, it is important to follow your doctor's instructions for dosage and duration of treatment.

Does Maccef O have any interactions with food?

No, Maccef O does not have any known food interactions.

Can I drink alcohol while taking Maccef O?

It is not recommended to drink alcohol while taking Maccef O, as it may increase the chance of side effects.

Does Maccef O cause headaches?

Maccef O can cause headaches as a side effect in some people. If you experience headaches while taking Maccef O, contact your doctor.

How long should I take Maccef O?

Your doctor will determine how long you should take Maccef O. It is important to follow your doctor’s instructions for the duration of treatment.

Can Maccef O affect the liver?

Maccef O can potentially cause liver damage in rare cases. If you notice any symptoms of liver damage, such as yellowing of the skin or eyes, contact your doctor.

What should I do if I develop an allergic reaction to Maccef O?

If you develop an allergic reaction while taking Maccef O, stop taking the medication and contact your doctor immediately.

Is Maccef O available as a generic drug?

Yes, Maccef O is available as a generic drug.

Does Maccef O cause drowsiness?

Maccef O can cause drowsiness as a side effect in some people. If you experience drowsiness while taking Maccef O, contact your doctor.

Can I take Maccef O with other antibiotics?

No, Maccef O should not be taken with other antibiotics since it can lead to increased side effects and altered effectiveness.

Can Maccef O treat sore throats?

No, Maccef O is not effective for treating sore throat caused by viral infections.

Can Maccef O be used to treat bacterial meningitis?

Yes, Maccef O can be used to treat bacterial meningitis.

Can Maccef O be used to treat strep throat?

Yes, Maccef O can be used to treat strep throat.

Is Maccef O available in other forms such as an oral suspension?

Yes, Maccef O is also available as an oral suspension.

Can I take Maccef O for a long period of time?

It is not recommended to take Maccef O for a long period of time, as it can lead to overgrowth of certain bacteria and lead to antibiotic resistance.

Can I take Maccef O with ibuprofen?

Yes, Maccef O can be taken with ibuprofen.

Is it safe to take Maccef O while breastfeeding?

It is not recommended to take Maccef O while breastfeeding because it can pass into breast milk and affect the infant. Contact your doctor before taking Maccef O while breastfeeding.

Can Maccef O be used to treat ear infections?

Yes, Maccef O can be used to treat ear infections.

Can Maccef O treat urinary tract infections?

Yes, Maccef O can be used to treat urinary tract infections.

Is Maccef O safe for people with kidney or liver disease?

People with kidney or liver disease should use Maccef O with caution, as it is broken down by the kidneys and liver. Talk to your doctor before taking Maccef O if you have kidney or liver disease.

Can Maccef O make you tired?

Yes, Maccef O can cause fatigue as a side effect in some people. Talk to your doctor if you experience fatigue while taking Maccef O.

How often do I need to take Maccef O?

You should take Maccef O as directed by your doctor. The frequency of doses will depend on the infection as well as the patient’s age and weight.

What laboratory tests should be done while taking Maccef O?

Your doctor may recommend certain laboratory tests such as a complete blood count, liver function tests, or kidney function tests while taking Maccef O.

Can Maccef O be used in animals such as cats or dogs?

Yes, Maccef O can be used in cats and dogs, but only under the direction of a veterinarian.

What should I do if I miss a dose of Maccef O?

If you miss a dose of Maccef O, take it as soon as possible. If it is close to the time for your next dose, skip the missed dose and continue on your regular schedule.

What can happen if I take an overdose of Maccef O?

If you take an overdose of Maccef O, contact your doctor or local poison control center immediately. Symptoms of an overdose may include nausea, dizziness, or difficulty breathing.

Should I avoid activities that require mental alertness while taking Maccef O?

Yes, it is best to avoid activities that require mental alertness while taking Maccef O because it can cause drowsiness and dizziness as side effects.

Can Maccef O cause nausea and vomiting?

Yes, Maccef O can cause nausea and vomiting as side effects. Talk to your doctor if you experience nausea and vomiting while taking Maccef O.