Lucicriz
Lucicriz Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Lucicriz is a brand name. Its generic name is Crizotinib.
Introduction
Lucicriz is a prescription drug that is used in the treatment of non-small cancer cell lung and anaplastic large cell lymphoma. This drug works by blocking part of a protein in the body called tyrosine kinase which helps cancer cells grow and spread.
Uses for
Lucicriz is used to treat non-small cell lung cancer in those who did not respond adequately to treatment with either chemotherapy or radiation therapy and in those with anaplastic large cell lymphoma (ALCL).
Mechanism of Action
Lucicriz works by inhibiting the action of the protein, tyrosine kinase, which helps cancer cells grow and spread. Tyrosine kinase has a key role in the signalling pathways in the cells that control cell proliferation, survival and progression.
How Long Does it Take to Work?
Lucicriz may begin to work as soon as two weeks after beginning treatment, although it may take longer for some people. Side effects can include fatigue, nausea, and vomiting.
Absorption
Lucicriz is well absorbed with an oral bioavailability of 77%-88%. It is eliminated predominantly unchanged in the urine via active tubular secretion.
Route of Elimination
Lucicriz is eliminated mainly unchanged in the urine via active tubular secretion.
Dosage
The recommended adult dose of crizotinib is 250 mg taken orally twice daily at least one hour before or two hours after meals, with or without water. It is important to take crizotinib consistently on the same days of each week, at the same time each day.
Administration
Lucicriz is taken orally, with or without water, once or twice a day at least one hour before or two hours after meals. It is important to take crizotinib consistently on the same days of each week, at the same time each day.
Side Effects
Common side effects of crizotinib can include:
- Fatigue
- Nausea
- Vomiting
- Loss of appetite
- Constipation
- Dry mouth
- Rash
- Muscle/joint aches
Toxicity
Lucicriz is well tolerated when administered at the recommended dosage. However, it can cause serious, toxic effects on some organs, including liver and kidney when taken with certain other drugs or when overdosed.
Precautions
Before starting treatment with crizotinib, tell your healthcare provider if you have diabetes, heart disease, liver or kidney problems or any other medical condition. Also tell your healthcare provider about all the medicines you take including prescription and non-prescription medications, vitamins and herbal supplements.
Interactions
Lucicriz may interact with other medications, such as certain antibiotics, antidepressants, seizure medications, and heart medications. It is important to tell your healthcare provider about all the medicines you take, including prescription and non-prescription medications, vitamins and herbal supplements.
Disease Interactions
Lucicriz may interact with certain diseases, such as diabetes, heart disease, and liver or kidney problems. It is important to tell your healthcare provider about any medical conditions before taking crizotinib.
Drug Interactions
Lucicriz may interact with certain drugs, such as antibiotics, antidepressants, seizure medications, and heart medications. It is important to tell your healthcare provider about all the medicines you take before taking crizotinib.
Food Interactions
Lucicriz may interact with certain foods, such as grapefruit juice. It is important to inform your healthcare provider before starting treatment with crizotinib.
Pregnancy Use
It is not known whether crizotinib is safe or effective in pregnant women. In general, pregnant women should not take crizotinib unless absolutely necessary.
Lactation Use
Lucicriz is not recommended for use in breastfeeding women. It is not known whether the drug passes into breast milk.
Acute Overdose
Symptoms of crizotinib overdose may include nausea, vomiting, diarrhea, abdominal pain, and decreased appetite.
Contraindication
Lucicriz is contraindicated in patients with known hypersensitivity to the drug or any of its inactive ingredients. It is also contraindicated in patients who have shown previous hypersensitivity reactions to the class of drugs known as crizotinib-related compounds.
Use Direction
The recommended adult dose of crizotinib is 250 mg taken orally twice daily at least one hour before or two hours after meals, with or without water. It is important to take crizotinib consistently on the same days of each week, at the same time each day.
Storage Condition
Lucicriz is stored at room temperature in a dry and dark place. Keep it away from children and pets. Dispose of any unused crizotinib tablets if the expiration date has passed.
Volume of Distribution
The volume of distribution of crizotinib is approximately 20.9 liters.
Half Life
The half-life of crizotinib is approximately 40 hours.
Clearance
The clearance of crizotinib is approximately 8.8 liters/minute.
Here you find in details version of Lucicriz