Lomir
Lomir Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Lomir is a brand name. Its generic name is Isradipine.
Introduction
Lomir belongs to a class of drugs known as calcium channel blockers. It is mainly used to treat hypertension by relaxing the muscles in and around blood vessels, allowing them to widen and reducing the pressure within the vessel.Uses
Lomir is primarily used to treat high blood pressure (hypertension). It is also used to manage other conditions related to high blood pressure, such as coronary artery disease and congestive heart failure.Mechanism of Action
Lomir works by blocking calcium from entering cells of the heart and blood vessels. By blocking calcium entry, the drug helps to reduce the amount of tension within the heart and blood vessels, which lowers blood pressure.How Long Does It Take to Work?
Lomir typically begins to take effect within one to two hours after taking it. Maximum blood pressure reduction occurs between four to six hours after dosing.Absorption
Lomir is absorbed rapidly in the stomach and intestine. Its peak plasma concentration is reached one hour after ingestion.Route of Elimination
Lomir is mainly eliminated through the kidneys. Approximately 73-86% of the drug is eliminated this way, with only 14-27% being eliminated through the feces.Dosage
The recommended starting dose of Lomir is 5 mg to 10 mg once a day at the same time each day. The maximum daily dose should not exceed 20 mg.Administration
Lomir should be taken with or without food, but it should not be taken with grapefruit juice as it can interfere with the effectiveness of the medication.Side Effects
Common side effects associated with Lomir are headache, dizziness, flushing, feeling tired or abdominal discomfort. Other more severe side effects can also occur, such as fever, chest pain or difficulty breathing. If any of these occur, contact a medical professional immediately.Toxicity
Lomir is generally well tolerated. In overdose, it may cause hypotension, bradycardia, and palpitations. It can also cause kidney impairment in more severe overdose cases.Precautions
Patients should inform their doctor or pharmacist if they are pregnant, breastfeeding, taking any other prescription or over-the-counter medication, or have had any allergic reactions to Lomir. Patients should also inform their doctor if they have any pre-existing medical conditions.Interactions
Lomir may interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics, antiarrhythmics, antihypertensives, and many other drugs. It is important to talk to your doctor or pharmacist to verify that Lomir is safe to take with other medications.Disease Interaction
Lomir should be used with caution in patients with pre-existing liver or renal disease. It may worsen the symptoms, and close monitoring is required.Drug Interaction
Lomir may interact with other medications such as diuretics, antiarrhythmics, antihypertensives, and many other drugs. It is important to talk to your doctor or pharmacist to verify that Lomir is safe to take with other medications.Food Interactions
High fat meals may decrease the absorption of Lomir, making it less effective. It is important to take Lomir with plain water and not to eat a large meal right before or after taking the medication.Pregnancy Use
Lomir should not be used in pregnant women unless the benefits outweigh the risks. It should not be taken during the first trimester of pregnancy.Lactation Use
Lomir should be used with caution in nursing mothers. Breastfeeding is not recommended while taking the drug.Acute Overdose
In case of acute overdose of Lomir, contact a doctor or poison control center immediately.Contraindication
Lomir should not be used in patients with known hypersensitivity to dihydropyride drugs. It should also be avoided in those with severe aortic outflow obstruction.Use Direction
The recommended starting dose of Lomir is 5 mg to 10 mg once a day at the same time each day. The maximum daily dose should not exceed 20 mg. The tablets should be taken orally with or without food.Storage Condition
Lomir should be stored in a cool, dry place, away from direct sunlight and moisture. It should not be kept in the bathroom or freezer.Volume of Distribution
The average volume of distribution of Lomir is 52L, indicating that it distributes well throughout the body.Half Life
The elimination half-life of Lomir is 8-10 hours.Clearance
The clearance of Lomir is 17-23mL/min/kg.Here you find in details version of Lomir
Some Frequently Asked Questions About Lomir
https://www.medicinesfaq.com/brand/lomir,
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http://www.hmdb.ca/metabolites/HMDB0014415,
http://www.genome.jp/dbget-bin/www_bget?drug:D00349,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3784,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505034,
https://www.chemspider.com/Chemical-Structure.3652.html,
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436176,
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=33910,
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6073,
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1648,
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000134,
http://www.pharmgkb.org/drug/PA450131,
http://www.rxlist.com/cgi/generic2/israd.htm,
https://www.drugs.com/cdi/isradipine.html,
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/dyn1152.shtml,
https://en.wikipedia.org/wiki/Isradipine,