Lialda
Lialda Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Lialda is a brand name. Its generic name is Mesalamine.
Lialda Introduction
Lialda, also known as 5-aminosalicylic acid, is a disease-modifying drug used to treat inflammatory bowel disease (IBD). It is also used to treat Crohn's disease, ulcerative colitis, and other intestinal disorders.
Uses for Lialda
Lialda is used to treat mild to moderate inflammation of the colon and rectum (ulcerative colitis) and inflammation of the small intestine (Crohn's disease). It is also used to maintain remission of mild to moderate ulcerative colitis.
Mechanism of Action
Lialda works by blocking the action of substances in the body that cause inflammation. It does this by inhibiting prostaglandin synthesis and reducing cell proliferation. It also blocks the production of cytokines, which are proteins released by certain cells in the body that cause inflammation.
How Long Does It Take to Work?
Lialda usually takes several weeks to start taking effect. It may take up to 12 weeks for patients with ulcerative colitis or Crohn's disease to experience symptom relief. Some patients may experience symptom relief in as little as four weeks.
Absorption
Lialda is rapidly and completely absorbed from the gastrointestinal tract. The peak plasma concentrations are usually reached within two hours after oral administration.
Route of Elimination
Lialda is eliminated rapidly as unchanged drug in the urine. The elimination half-life of mesalamine is approximately 1.5 to 4 hours.
Dosage
The typical recommended dosage of mesalamine for adults is 2.4 to 4.8 g/day in divided doses. For children, the dosage is 10 to 20 mg/kg/day in divided doses. Lialda should be taken with meals to maximize absorption.
Administration
Lialda can be taken orally, rectally, or intravenously. Oral administration is the most common form of use. Rectal forms of mesalamine are used for localized inflammation in the lower part of the GI tract and are usually given as an enema or suppository. Intravenous formulations of mesalamine are used to treat severe cases of ulcerative colitis or Crohn's disease.
Side Effects
Side effects of mesalamine can include headache, dizziness, nausea, vomiting, stomach pain, and rash. In rare cases, it may cause an allergic reaction that may cause swelling of the face, mouth, and tongue, difficulty breathing, and hives. Contact your doctor if you experience any of these symptoms.
Toxicity
Lialda has relatively low toxicity. It is generally well tolerated when taken at the recommended dosage. Overdose of mesalamine can cause nausea, vomiting, diarrhea, abdominal cramping, and headache.
Precautions
Lialda should be used with caution in people with kidney or liver disease. It may also interact with some medications, including aspirin, anticoagulants, and sulfa drugs, so it is important to tell your doctor about all medications you are taking. It is also important to inform your doctor of any allergies you have before taking mesalamine.
Interactions
Lialda may interact with other medications and supplements. These interactions can cause side effects or make the drugs less effective. It is important to tell your doctor about all medications and supplements you are taking. Your doctor will be able to advise you about potential interactions.
Diseases Interaction
Lialda may interact with certain diseases. It may worsen or cause symptoms of kidney failure, liver failure, or diabetes. It is important to tell your doctor about any other health conditions you have before taking mesalamine.
Drug Interactions
Lialda may interact with certain drugs, including aspirin, anticoagulants, and sulfa drugs. These interactions can decrease the effectiveness of the drugs or increase your risk for side effects. It is important to tell your doctor about all medications you are taking before taking mesalamine.
Food Interactions
Certain foods may interact with mesalamine. It is important to avoid alcohol and spicy/acidic foods while taking mesalamine. Also, it is important to drink plenty of fluids when taking mesalamine to prevent dehydration.
Pregnancy Use
Lialda should not be used during pregnancy unless it is absolutely necessary. It has not been adequately studied in pregnant women, so it is important to discuss the risks and benefits with your doctor.
Lactation Use
Lialda has been shown to be excreted in breast milk, so it should not be used by breastfeeding women unless it is absolutely necessary. It is important to discuss the risks and benefits with your doctor before taking mesalamine while breastfeeding.
Acute Overdose
An overdose of mesalamine can cause nausea, vomiting, diarrhea, abdominal cramping, and headache. If an acute overdose is suspected, seek medical attention immediately.
Contraindication
Lialda should not be used in people with a known hypersensitivity to 5-aminosalicylic acid or its excipients. It should also not be used in people with severe renal impairment or active peptic ulcer.
Use Direction
Lialda should be taken with food to maximize absorption. If you miss a dose, take it as soon as you remember, unless it is close to the time for the next dose, in which case skip the missed dose and take the next dose on time. Do not double up on doses.
Storage Condition
Lialda should be stored at room temperature, away from light and moisture. Keep out of reach of children.
Volume of Distribution
The volume of distribution of mesalamine is around 4 L/kg.
Half Life
The elimination half-life of mesalamine is approximately 1.5 to 4 hours.
Clearance
The clearance of mesalamine is approximately 10 mL/min/1.73 m2.
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