Depakote ER

Depakote ER Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Depakote ER is a brand name. Its generic name is Divalproex Sodium.

Introduction

Depakote ER is an anticonvulsant (anti-seizure) medication primarily used to treat epilepsy. It is also used to prevent migraine headaches and treat manic episodes associated with bipolar disorder. It belongs to a class of drugs called valproic acid derivatives.

Uses

Depakote ER is used primarily to treat epilepsy, myoclonic seizures, and generalized tonic-clonic seizures. It can also be used to prevent migraine headaches and treat manic episodes associated with bipolar disorder.

Mechanism of Action

Depakote ER works by blocking voltage-gated sodium channels and increasing the synthesis of the inhibitory neurotransmitter, GABA. It also suppresses the release of various inflammatory Cytokines, such as TNF-α, IL-1β, and IL-6, and thus helps to reduce inflammation.

How Long Does It Take to Work?

It usually takes about 1 to 4 weeks for the medication to become effective. During this time, the patient may experience an increase in seizure activity as the medication begins to work.

Absorption

Depakote ER is rapidly and completely absorbed from the gastrointestinal tract after oral administration.

Route of Elimination

Depakote ER is primarily eliminated via the kidneys. Approximately 90% of the medication is eliminated unchanged, with the remainder being converted to other metabolites.

Dosage

The dosage of Depakote ER varies depending on the condition being treated, age, and weight of the patient. It is typically taken one or two times per day, with or without food. The typical adult dosage is 250 mg to 1000 mg per day, divided into 2 to 3 doses.

Administration

Depakote ER is usually taken orally, with or without food. It can also be given intravenously.

Side Effects

Common side effects of Depakote ER include nausea, vomiting, drowsiness, dizziness, headache, and weight gain.

Toxicity

Depakote ER can be toxic in large doses. Symptoms of overdose include dizziness, drowsiness, confusion, seizures, and coma. In severe cases, it can cause liver and kidney damage.

Precautions

Depakote ER should not be used in people with liver disease, kidney disease, a known allergy to the medication, or a history of suicidal thoughts or behavior.

Interactions

Depakote ER can interact with other medications, including but not limited to hormonal contraceptives, corticosteroids, blood pressure medications, and antifungals. It can also interact with alcohol, opioids, and certain vitamins and supplements.

Disease Interactions

Depakote ER should not be used in people with liver or kidney disease, a history of drug or alcohol abuse, a known allergy to the medication, or a history of suicidal thoughts or behaviors.

Drug Interactions

Depakote ER may interact with other medications, such as warfarin, hormonal contraceptives, corticosteroids, blood pressure medications, and antifungals.

Food Interactions

Food can reduce the absorption of Depakote ER, and should therefore be taken with food if possible.

Pregnancy Use

Depakote ER is not recommended for use during pregnancy as it can cause birth defects in the fetus. Women who are pregnant or planning to become pregnant should talk to their doctor before taking this medication.

Lactation Use

Depakote ER passes into breast milk and may affect a nursing baby. Women who are breastfeeding should talk to their doctor before taking this medication.

Acute Overdose

Symptoms of an overdose include confusion, dizziness, drowsiness, seizures, and coma. In severe cases, it can cause liver and kidney damage.

Contraindication

Depakote ER should not be used in people with liver or kidney disease, a history of drug or alcohol abuse, a known allergy to the medication, or a history of suicidal thoughts or behaviors.

Use Directions

Depakote ER should be taken exactly as prescribed by your doctor. Do not take more, or less than the prescribed amount. Take it with or without food and swallow the tablet whole.

Storage Conditions

Depakote ER should be stored at room temperature, away from heat and direct light. Keep it out of reach of children and pets.

Volume of Distribution

The volume of distribution for Depakote ER is approximately 0.8 L/kg.

Half Life

The half-life of Depakote ER is approximately 15-18 hours.

Clearance

The elimination clearance of Depakote ER is 1.5 L/h/kg.

Here you find in details version of Depakote ER

Some Frequently Asked Questions About Depakote ER

What is the generic name for Depakote ER?

The generic name for Depakote ER is Valproic Acid.

What is Depakote ER used for?

Depakote ER is used to treat seizure disorders, as well as manic episodes associated with bipolar disorder.

How does Depakote ER work?

Depakote ER works by enhancing the action of neurotransmitters, such as GABA, that naturally regulate the activity of the central nervous system.

What are the side effects of Depakote ER?

Common side effects of Depakote ER may include drowsiness, nausea, weakness, dizziness, headache, menstrual changes, and changes in appetite, weight, or sleep.

What if I forget to take my dose of Depakote ER?

If you forget to take your dose of Depakote ER, take it as soon as you remember. But If it's almost time for the next dose, skip the missed dose and take the next one as scheduled.

Is Depakote ER safe for pregnant women?

Although Depakote ER is considered to be relatively safe for pregnant women, its use during pregnancy should only be considered when the potential benefits outweigh the possible risks.

Can I take Depakote ER if I have kidney problems?

Use of Depakote ER can be potentially dangerous for patients with kidney problems. Before taking this medication, talk to your doctor about your kidney function.

Can Depakote ER be used to treat depression?

No, Depakote ER is not typically used to treat depression as it can actually worsen some forms of depression.

How long does it take for Depakote ER to start working?

The effects of Depakote ER may start within a few days, but it may take up to 4 weeks for the full benefits of the medication to be noticed.

Can I drink alcohol while taking Depakote ER?

It is not recommended to consume alcohol while taking Depakote ER as this can increase the risk of side effects.

What other medications should I not take while on Depakote ER?

You should avoid taking aspirin, ibuprofen, naproxen, or other nonsteroidal anti-inflammatory drugs while taking Depakote ER as this can increase the risk of side effects.

Can I take Depakote ER with birth control pills?

Yes, you can take Depakote ER with birth control pills as long as your doctor approves.

How should I take Depakote ER?

Depakote ER should be taken exactly as prescribed by your doctor. Take it at the same time every day and do not increase your dose without talking to your doctor first.

Should I take Depakote ER with food?

Yes, you should take Depakote ER with a meal or snack to prevent stomach upset.

Will Depakote ER make me gain weight?

It is possible to gain weight while taking Depakote ER but this is not common. Talk to your doctor if you experience significant weight gain while taking this medication.

Does Depakote ER cause fatigue?

Drowsiness or fatigue can be a side effect of Depakote ER. Talk to your doctor if you experience unusual fatigue while taking this medication.

Can I take Depakote ER for migraines?

No, Depakote ER is not typically used to treat migraines, but your doctor can make other treatment recommendations.

Can I take Depakote ER with other medications?

Yes, you can take Depakote ER with other medications, but make sure to tell your doctor about all medications that you are taking as some interactions may occur.

What foods should I avoid while taking Depakote ER?

You should avoid grapefruit and grapefruit juice while taking Depakote ER as it can increase the levels of the medication in your body.

Should I be concerned about taking Depakote ER for a long period of time?

If you need to take Depakote ER for a long period of time, your doctor will likely monitor your liver function, cholesterol levels, and other indicators.

Can I take Depakote ER when I am breastfeeding?

It is not recommended to take Depakote ER while breastfeeding as it can pass into breast milk. Talk to your doctor about the best course of treatment for you.

Will Depakote ER cause hair loss?

Hair loss is a rare but potential side effect of Depakote ER. If you notice unexplained hair loss while taking this medication, contact your doctor right away.

Does Depakote ER interact with any vitamins?

Depakote ER may interact with certain vitamins, especially vitamins that contain iron. Talk to your doctor about taking vitamins while on this medication.

Can I take Depakote ER if I am taking blood thinners?

You should not take Depakote ER if you are taking a blood thinner as it can increase the risk of bleeding.

How often should I get blood tests while taking Depakote ER?

Your doctor may recommend getting routine lab tests to monitor your liver function while taking Depakote ER. Talk to your doctor about how often to get these tests.

What should I do if I experience liver problems while taking Depakote ER?

If you experience any signs of liver problems, such as yellowing of your skin or eyes, abdominal pain, dark urine, or fatigue, you should contact your doctor right away.

What if I experience an allergic reaction to Depakote ER?

If you experience any signs of an allergic reaction, such as hives, swelling, difficulty breathing, or rash, you should stop taking the medication and seek medical attention right away.

Can I take Depakote ER if I am taking antidepressants?

Yes, it is usually safe to take Depakote ER with antidepressants, but you should always talk to your doctor about any other medications you are taking.

Can I take Depakote ER if I have an anxiety disorder?

Yes, Depakote ER is sometimes prescribed to treat anxiety disorders, although it should only be taken under the supervision of your doctor.

Can Depakote ER be used to treat epilepsy?

Yes, Depakote ER is commonly used to treat seizure disorders, including some forms of epilepsy.

Can I take Depakote ER if I am elderly?

Yes, Depakote ER is sometimes prescribed to elderly patients, but the dose may need to be adjusted due to age related declines in kidney and liver functioning. Talk to your doctor about the best course of treatment for you.

Should I have regular eye exams while taking Depakote ER?

Yes, you should have regular eye exams while taking Depakote ER as this medication can cause vision changes.

Where can I get more information about Depakote ER?

You can get more information about Depakote ER from your doctor or pharmacist.

Can I stop taking Depakote ER without talking to my doctor?

No, you should not stop taking Depakote ER without talking to your doctor first as sudden discontinuation of the medication can cause serious withdrawal symptoms.

What is the typical dosage of Depakote ER?

The typical dosage of Depakote ER depends on the condition being treated and the age of the patient, and should be determined by a doctor.

Will Depakote ER affect my sex drive?

Decreased sex drive is a rare side effect of Depakote ER. Contact your doctor if you experience this side effect while taking this medication.

How common are stomach upset and nausea while taking Depakote ER?

Stomach upset and nausea are common side effects of Depakote ER. Taking the medication with food can help minimize these symptoms.

Can Depakote ER cause depression?

Although rare, depression can be a side effect of Depakote ER. Talk to your doctor if you experience any symptoms of depression while taking this medication.

Does Depakote ER interact with other drugs?

Yes, Depakote ER can interact with other drugs, including some over-the-counter medications. Always tell your doctor about any other medications you are taking.

Can Depakote ER cause headaches?

Yes, headaches are a common side effect of Depakote ER. If you experience headaches while taking this medication, contact your doctor.

What should I do if I forget to take my dose of Depakote ER?

If you forget to take your dose of Depakote ER, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and take the next one as scheduled.

Is Depakote ER associated with any risks for birth defects or pregnancy complications?

Although Depakote ER is generally considered safe for pregnant women, its use during pregnancy should only be considered when the potential benefits outweigh the possible risks.

Can I take Depakote ER if I have a history of liver problems?

You should not take Depakote ER if you have a history of liver problems or any other medical conditions. Talk to your doctor about your medical history before taking this medication.

Can I take Depakote ER if I have high cholesterol?

Yes, you can take Depakote ER if you have high cholesterol, but your doctor may monitor your cholesterol levels more closely while taking this medication.

Is Depakote ER effective for treating bipolar disorder?

Yes, Depakote ER is effective for treating manic episodes associated with bipolar disorder.

Is Depakote ER available over the counter?

No, Depakote ER is only available by prescription.