Ischevia
Ischevia Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ischevia is a brand name. Its generic name is Ivabradine.
Ischevia Introduction and Uses
Ischevia is an antiarrhythmic drug used in the treatment of symptomatic stable angina, specifically in those patients having hypertension and a resting heart rate of 75 beats per minute or greater. It is a selective if inhibitor – acting on the If current in the sinoatrial node of the heart. Its primary effect is to reduce heart rate, and in doing so, reduce the oxygen demand on the myocardium by up to 10–15%.
Mechanism of Action
Ischevia acts by selectively inhibiting the If current within the sinoatrial node, a specialized group of cells in the heart responsible for setting the pace of the heartbeat. The If current determines the slow-inward diastolic depolarization of the cells, meaning it determines how often the cells depolarize. By inhibiting the If current, the heart rate is decreased which reduces the oxygen demand of the myocardium.
How Long Does It Take to Work?
The effects of ivabradine can be seen within two hours of ingestion and its effect on heart rate is usually seen within two days. It is recommended to take the medication on an empty stomach to achieve the fullest effect.
Absorption
Ischevia is rapidly absorbed from the gut but its rate of absorption is not affected by food intake. After maximal absorption, the concentration of ivabradine in the circulation increases slowly and reaches its peak concentration after four to six hours.
Route of Elimination
Ischevia is primarily eliminated through biliary excretion. Following a single dose of ivabradine, approximately 68% of the dose was eliminated in the bile. The remainder of the dose is excreted in the urine and feces.
Dosage
Ischevia is available as oral tablets with doses ranging from 2.5 mg to 15 mg. The usual recommended dose for the treatment of stable angina is 7.5 mg once daily taken on an empty stomach. The dose can be titrated up to a maximum of 15 mg once daily if necessary.
Administration
Ischevia should be taken with a full glass of water and should be taken on an empty stomach, i.e. at least two hours after eating or two hours before eating, for maximum effect. To reduce the risk of dizziness, it is important to take this medication exactly as prescribed.
Side Effects
The most common side effects of ivabradine include dizziness, headache, nausea, bradycardia, fatigue, diarrhea, abdominal pain and dyspepsia. Patients should seek medical attention if these side effects persist or become worse. Rarely, serious side effects such as swelling, breathing difficulty and palpitations may occur.
Toxicity
The toxicity of ivabradine has not been established. There have been no reported cases of overdose with this drug. In the event of an overdose, symptomatic treatment is recommended.
Precautions
Patients with certain medical conditions should not take ivabradine, including those with severe bradycardia, severe hypotension, moderate to severe renal impairment, or heart failure of NYHA class III or IV. In addition, patients taking certain medications such as calcium channel blockers, vasodilators, beta-blockers, and certain antibiotics should not take ivabradine.
Interaction
Ischevia can interact with certain drugs, including calcium channel blockers, vasodilators such as nitroglycerin, certain antibiotics, beta-blockers, and digoxin. The combination of these drugs could cause an excessive bradycardia and hypotension. Close medical monitoring is recommended for patients taking these medications.
Disease Interaction
Patients with certain diseases should not take ivabradine, including those with severe bradycardia, severe hypotension, moderate to severe renal impairment, or heart failure of NYHA class III or IV. Certain medications, such as calcium channel blockers, vasodilators, beta-blockers, and certain antibiotics, can also interact with ivabradine and should be avoided in these patients.
Drug Interaction
Certain drugs, including calcium channel blockers, vasodilators, beta-blockers, and certain antibiotics, can interact with ivabradine and should be avoided. Ischevia should not be used concomitantly with other If current inhibitors due to the risk of additive bradycardic effect.
Food Interactions
The rate of absorption of ivabradine is not affected by food intake, but it is recommended to take on an empty stomach for maximum effect.
Pregnancy Use
Ischevia has not been studied in pregnant women and its use is not recommended. Animal studies have shown some evidence of fetotoxicity but a risk to humans has not been established.
Lactation Use
Ischevia has not been studied in women who are breastfeeding and its use is not recommended.
Acute Overdose
There are no known reports of an overdose of ivabradine and its toxicity has not been established. Symptomatic treatment should be initiated if an overdose is suspected.
Contraindication
Ischevia is contraindicated in patients with severe bradycardia, severe hypotension, moderate to severe renal impairment, or heart failure of NYHA class III or IV, as well as in patients taking certain medications such as calcium channel blockers, vasodilators, beta-blockers, and certain antibiotics.
Use Direction
Ischevia should be taken with a full glass of water and should be taken on an empty stomach, i.e. at least two hours after eating or two hours before eating, for maximum effect. The dose should be reduced in patients with renal impairment. The dose should be gradually reduced and/or discontinued in patients with a reduction in heart rate or increase in blood pressure.
Storage Condition
Ischevia should be stored between 4 C and 25 C. It should be kept away from direct moisture, humidity, and light.
Volume of Distribution
The volume of distribution of ivabradine is 11 liters.
Half Life
The elimination half-life of ivabradine is 6 hours.
Clearance
The clearance of ivabradine is 5.9 liters/hour.
Here you find in details version of Ischevia
Some Frequently Asked Questions About Ischevia
What is Ischevia?
Ischevia is a prescription medication used to treat chronic stable angina (chest pain) associated with chronic coronary artery disease. It works by reducing the heart rate to improve blood flow to the heart and reduce symptoms of angina.
What is Ischevia used for?
Ischevia is used to treat chronic stable angina (chest pain) associated with chronic coronary artery disease. It works by reducing the heart rate to improve blood flow to the heart and reduce symptoms of angina.
Who is Ischevia for?
Ischevia is for adults with chronic stable angina pectoris (chest pain) associated with chronic coronary artery disease. It may not be appropriate for those with certain medical conditions, so it’s important to talk to your doctor before taking it.
How does Ischevia work?
Ischevia works by reducing the heart rate. It blocks some of the nerve signals that tell your heart to beat faster and harder, reducing the amount of work your heart has to do. This helps to reduce symptoms of angina and improve blood flow to the heart.
What are the side effects of Ischevia?
The most common side effects of Ischevia include headache, nausea, dizziness, tiredness, and diarrhea. Other possible side effects include flushing, rash, and palpitations. If any of these side effects become persistent or bothersome, speak to your doctor.
Is Ischevia safe?
Yes, Ischevia is generally safe when taken as prescribed. However, like all medications, it may not be right for everyone. It’s important to talk to your doctor before taking Ischevia to make sure it is safe for you.
What is the dosage of Ischevia?
The recommended starting dose for Ischevia is 5 mg twice daily, taken with or without food. Your dose should be adjusted to a maximum of 7.5 mg twice daily depending on how you respond to the medication and any side effects you may experience.
Can I take other medications with Ischevia?
Yes, you can take other medications with Ischevia, but it’s important to talk to your doctor before combining it with any other medications. Certain medications may interfere with the way Ischevia works or increase your risk of side effects.
What should I do if I miss a dose of Ischevia?
If you miss a dose of Ischevia, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the regular time. Do not take a double dose of Ischevia to make up for a missed dose.
Is Ischevia available over the counter?
No, Ischevia is not available over the counter. It is a prescription medication that must be prescribed by a doctor.
Should I take Ischevia with food?
Ischevia can be taken with or without food. However, it may be best to take it with food to reduce the risk of nausea.
What are the warnings and precautions associated with Ischevia?
Ischevia should not be used if you are pregnant or breastfeeding. It is also important to tell your doctor if you have any other medical conditions or allergies, and if you are taking any other medications, supplements, or herbal remedies.
Can I drink alcohol with Ischevia?
It is not recommended to drink alcohol while taking Ischevia as it can increase the risk of certain side effects. If you choose to drink alcohol while taking Ischevia, it is important to do so in moderation.
Can I drive or operate machinery while taking Ischevia?
Ischevia can cause drowsiness and dizziness. It is best to avoid driving or operating machinery until you know how Ischevia affects you.
How long does Ischevia take to work?
It may take several weeks for Ischevia to have its full effect. Talk to your doctor if you do not notice any improvements in your symptoms after taking the medication for a few weeks.
What are the storage requirements for Ischevia
Ischevia should be stored at room temperature between 59 to 86 degrees Fahrenheit (15 to 30 degrees Celsius). Keep it in a closed, airtight container, away from heat, moisture, and direct sunlight.
Can Ischevia be crushed or split?
Do not crush or split the Ischevia tablets. Swallow them whole with a glass of water. Talk to your doctor or pharmacist if you have any difficulty swallowing the medication.
What is the cost of Ischevia?
The cost of Ischevia varies depending on where it is purchased. It may be covered by your insurance or may require a co-pay. Talk to your doctor or pharmacist about any questions you may have about the cost of Ischevia.
How should Ischevia be stored?
Ischevia should be stored at room temperature between 59 to 86 degrees Fahrenheit (15 to 30 degrees Celsius). Keep it in a closed, airtight container, away from heat, moisture, and direct sunlight.
Are there any interactions with Ischevia and other medications?
Yes. Ischevia may interact with certain medications, including beta-blockers, calcium channel blockers, and digoxin. It is important to talk to your doctor before taking any new medications while taking Ischevia.
What are the signs of an allergic reaction to Ischevia?
Signs of an allergic reaction to Ischevia may include hives, difficulty breathing, rash, itching, swelling of the face, throat, tongue, or lips, or wheezing. If you experience any of these symptoms, stop taking Ischevia and seek medical attention immediately.
Does Ischevia lower blood pressure?
No, Ischevia does not lower blood pressure. It is used to treat chronic stable angina (chest pain) associated with chronic coronary artery disease by reducing the heart rate.
Is Ischevia safe for long-term use?
Ischevia is generally safe for long-term use when taken as prescribed. However, it is important to talk to your doctor if you plan to take the medication for a long period of time.
Does Ischevia cause weight gain?
No, Ischevia does not cause weight gain. However, some people may gain weight while taking Ischevia due to other side effects, such as fatigue and dizziness, which can lead to overeating.
Does Ischevia cause erectile dysfunction?
No, there is no evidence that suggests Ischevia causes erectile dysfunction. However, some men may experience decreased sexual desire or difficulty getting an erection while taking Ischevia. If this occurs, talk to your doctor.
Does Ischevia affect blood sugar levels?
No, Ischevia does not affect blood sugar levels. However, some people with diabetes may experience changes in blood sugar levels while taking Ischevia. It’s important to monitor your blood sugar levels closely while taking Ischevia.
Can I take Ischevia while breastfeeding?
No, Ischevia should not be taken while breastfeeding. If you are breastfeeding, talk to your doctor before taking Ischevia to discuss whether it is safe for you.
Is Ischevia effective in treating angina?
Yes, Ischevia is effective in treating angina (chest pain) associated with chronic coronary artery disease. It works by reducing the heart rate to improve blood flow to the heart and reduce symptoms of angina.
Can I take a pain reliever while taking Ischevia?
Yes, it is generally safe to take a pain reliever such as ibuprofen or acetaminophen while taking Ischevia. However, it’s important to talk to your doctor before taking any new medications while taking Ischevia.
Does Ischevia cause insomnia?
No, there is no evidence that Ischevia causes insomnia. However, some people may experience insomnia or other sleep disturbances while taking Ischevia. If this occurs, talk to your doctor.
Does Ischevia cause constipation?
No, there is no evidence that Ischevia causes constipation. However, some people may experience constipation or other gastrointestinal side effects while taking Ischevia. If this occurs, talk to your doctor.
Does Ischevia interact with alcohol?
Yes, it is not recommended to drink alcohol while taking Ischevia as it can increase the risk of certain side effects. If you choose to drink alcohol while taking Ischevia, it is important to do so in moderation.
What should I do if I experience side effects from taking Ischevia?
If you experience any bothersome or persistent side effects while taking Ischevia, talk to your doctor. Your doctor may adjust your dose or offer other treatments to help reduce your symptoms.
Can I take Ischevia during pregnancy?
No, Ischevia should not be used during pregnancy as it may cause harm to the fetus. Talk to your doctor if you are pregnant or planning to become pregnant before taking Ischevia.
Does Ischevia have any long-term effects?
No serious long-term effects have been reported with the use of Ischevia. However, it is important to talk to your doctor before taking the medication for a long period of time.
How often should I take Ischevia?
Ischevia should be taken twice daily, with or without food. Your doctor will determine the right dosage for you based on your individual needs.
Is Ischevia a blood thinner?
No, Ischevia is not a blood thinner. It is used to treat chronic stable angina (chest pain) associated with chronic coronary artery disease by reducing the heart rate.
Does Ischevia cause fatigue?
Yes, fatigue is a common side effect of Ischevia. If you experience fatigue while taking Ischevia, talk to your doctor as your dose may need to be adjusted.
Does Ischevia cause hair loss?
No, there is no evidence that Ischevia causes hair loss. If you experience any unusual hair loss, talk to your doctor.
Does Ischevia cause dizziness?
Yes, dizziness is a common side effect of Ischevia. If you experience dizziness while taking Ischevia, talk to your doctor as your dose may need to be adjusted.
Can Ischevia be taken with other heart medications?
Yes, Ischevia can be taken with other heart medications, such as beta-blockers, calcium channel blockers, and digoxin. It is important to talk to your doctor before combining any medications.
Does Ischevia cause headaches?
Yes, headache is a common side effect of Ischevia. If you experience headaches while taking Ischevia, talk to your doctor as your dose may need to be adjusted.