Integrelin
Integrelin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Integrelin is a brand name. Its generic name is Eptifibatide.
Introduction
Integrelin is a cyclic heptapeptide used to prevent thrombosis (formation of blood clots) in patients with unstable angina or coronary artery disease. It is often referred to as a glycoprotein IIb/IIIa inhibitor.
Uses for
Integrelin is used to prevent thrombosis (blood clots) in patients with unstable angina or coronary artery disease. It is also used to treat additional cardiac disorders such as myocardial infarction (heart attack).
Mechanism of Action
Integrelin works by blocking the platelet glycoprotein IIb / IIIa receptor, preventing the binding of fibrinogen to platelets, and thus blocking the formation of a thrombus.
How Long Does it take to Work?
Integrelin usually starts to work within 20 minutes of administration. The full therapeutic effect of Integrelin can be accomplished in as little as an hour.
Absorption
Integrelin is rapidly absorbed after intravenous administration and its bioavailability is approximately 100%.
Route of Elimination
Integrelin is eliminated from the body primarily by the kidneys.
Dosage
The standard recommended dose of Integrelin is 180 µg/Kg (maximum of 18 mg) administered by intravenous infusion over 10 minutes. The infusion should be repeated with 90 µg/Kg (maximum of 9 mg) over one hour, followed by an additional infusion of 0.75 µg/Kg/minute (maximum of 7.5 mg per hour) as required.
Administration
Integrelin should only be administered under the supervision of a qualified medical practitioner. It should be given as an intravenous infusion.
Side Effects
Integrelin may cause side effects such as nausea, vomiting, headache, dizziness, back pain, chest pain, diarrhea, weakness, and rash. If any of these side effects are experienced, the patient should contact their physician immediately.
Toxicity
Integrelin is generally well tolerated. Overdose of Integrelin may cause serious hypotension, which may be treated with intravenous fluids and/or vasodilators.
Precaution
Integrelin should be used with caution in patients with a history of bleeding disorders or any other conditions in which bleeding is a risk.
Interaction
Integrelin is known to interact with certain other drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and heparin, which may increase the risk of bleeding.
Disease Interaction
Integrelin may be contraindicated in certain patients with a history of bleeding disorders or any other conditions in which bleeding is a risk.
Drug Interaction
Integrelin may interact with certain other drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and heparin, which may increase the risk of bleeding.
Food Interactions
Integrelin is known to interact with certain foods, such as grapefruit juice. Grapefruit juice should be avoided when taking Integrelin.
Pregnancy Use
Integrelin should not be used in pregnant women as safety in this population has not been established.
Lactation Use
Integrelin should be used with caution in breastfeeding women as it is not known if the drug passes into breast milk.
Acute Overdose
Overdose of Integrelin may cause serious hypotension, which may be treated with intravenous fluids and/or vasodilators. In cases of serious overdose, seek immediate medical attention.
Contraindication
Integrelin is contraindicated in patients with a history of bleeding disorders, recent surgery, or any other conditions in which bleeding is a risk.
Use Direction
Integrelin must only be administered by a qualified medical practitioner. It must be given as an intravenous infusion per the instruction of the prescribing physician.
Storage Condition
Integrelin should be stored at a temperature between 20-25°C.
Volume of Distribution
The volume of distribution of Integrelin is estimated as 118 liters.
Half Life
The elimination half-life of Integrelin is approximately 4.07 hours.
Clearance
The clearance of Integrelin is estimated as 11 liters/hour.
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