Intrifiban
Intrifiban Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Intrifiban is a brand name. Its generic name is Eptifibatide.
Introduction
Intrifiban is a cyclic heptapeptide used to prevent thrombosis (formation of blood clots) in patients with unstable angina or coronary artery disease. It is often referred to as a glycoprotein IIb/IIIa inhibitor.
Uses for
Intrifiban is used to prevent thrombosis (blood clots) in patients with unstable angina or coronary artery disease. It is also used to treat additional cardiac disorders such as myocardial infarction (heart attack).
Mechanism of Action
Intrifiban works by blocking the platelet glycoprotein IIb / IIIa receptor, preventing the binding of fibrinogen to platelets, and thus blocking the formation of a thrombus.
How Long Does it take to Work?
Intrifiban usually starts to work within 20 minutes of administration. The full therapeutic effect of Intrifiban can be accomplished in as little as an hour.
Absorption
Intrifiban is rapidly absorbed after intravenous administration and its bioavailability is approximately 100%.
Route of Elimination
Intrifiban is eliminated from the body primarily by the kidneys.
Dosage
The standard recommended dose of Intrifiban is 180 µg/Kg (maximum of 18 mg) administered by intravenous infusion over 10 minutes. The infusion should be repeated with 90 µg/Kg (maximum of 9 mg) over one hour, followed by an additional infusion of 0.75 µg/Kg/minute (maximum of 7.5 mg per hour) as required.
Administration
Intrifiban should only be administered under the supervision of a qualified medical practitioner. It should be given as an intravenous infusion.
Side Effects
Intrifiban may cause side effects such as nausea, vomiting, headache, dizziness, back pain, chest pain, diarrhea, weakness, and rash. If any of these side effects are experienced, the patient should contact their physician immediately.
Toxicity
Intrifiban is generally well tolerated. Overdose of Intrifiban may cause serious hypotension, which may be treated with intravenous fluids and/or vasodilators.
Precaution
Intrifiban should be used with caution in patients with a history of bleeding disorders or any other conditions in which bleeding is a risk.
Interaction
Intrifiban is known to interact with certain other drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and heparin, which may increase the risk of bleeding.
Disease Interaction
Intrifiban may be contraindicated in certain patients with a history of bleeding disorders or any other conditions in which bleeding is a risk.
Drug Interaction
Intrifiban may interact with certain other drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and heparin, which may increase the risk of bleeding.
Food Interactions
Intrifiban is known to interact with certain foods, such as grapefruit juice. Grapefruit juice should be avoided when taking Intrifiban.
Pregnancy Use
Intrifiban should not be used in pregnant women as safety in this population has not been established.
Lactation Use
Intrifiban should be used with caution in breastfeeding women as it is not known if the drug passes into breast milk.
Acute Overdose
Overdose of Intrifiban may cause serious hypotension, which may be treated with intravenous fluids and/or vasodilators. In cases of serious overdose, seek immediate medical attention.
Contraindication
Intrifiban is contraindicated in patients with a history of bleeding disorders, recent surgery, or any other conditions in which bleeding is a risk.
Use Direction
Intrifiban must only be administered by a qualified medical practitioner. It must be given as an intravenous infusion per the instruction of the prescribing physician.
Storage Condition
Intrifiban should be stored at a temperature between 20-25°C.
Volume of Distribution
The volume of distribution of Intrifiban is estimated as 118 liters.
Half Life
The elimination half-life of Intrifiban is approximately 4.07 hours.
Clearance
The clearance of Intrifiban is estimated as 11 liters/hour.
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