Indocin

Indocin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Indocin is a brand name. Its generic name is Ofloxacin.

Indocin

Indocin is an antibiotic medication used to treat certain types of infections. It can be used to treat various types of bacteria, such as respiratory tract infections, skin infections, urinary tract infections, and ear infections.

Uses for Indocin

Indocin is used to treat infections caused by a variety of bacteria, including: pneumonia, bronchitis, sinusitis, skin infections, urinary tract infections, and ear infections.

Mechanism of Action

Indocin works by inhibiting the growth of bacteria by interfering with its DNA replication process. It binds to the bacterial DNA gyrase and topoisomerase IV enzymes, which are required for the replication of bacterial DNA.

How Long Does it Take to Work?

Indocin typically begins to work within 48 hours of the start of treatment. The duration of treatment and the dosage may vary depending on the severity of the infection and the patient’s response to treatment.

Absorption

Indocin is rapidly and completely absorbed after oral administration. It can also be given intravenously or intramuscularly.

Route of Elimination

Indocin is mainly eliminated by the kidneys, with a small amount being metabolized by the liver. It is typically eliminated from the body within 24 hours.

Dosage

The dosage of ofloxacin depends on the type and severity of the infection being treated. Generally the recommended dosage is 200-400mg taken two to three times a day. Patients with impaired kidney function may need lower doses; in such cases the dose should be adjusted to the patient’s specific needs.

Administration

Indocin can be administered orally, intramuscularly, or intravenously. When taken orally, the drug is typically taken with food or a non-alcoholic beverage.

Side Effect

Common side effects of ofloxacin include nausea, vomiting, diarrhea, constipation, dizziness, headache, lightheadedness, itching, rash, and changes in taste. More serious side effects may include: confusion, hallucinations, abdominal pain, seizures, and fever.

Toxicity

Indocin is generally safe, however, it may be toxic if very high doses are taken. Symptoms of overdose include rapid heart rate, decreased breathing rate, confusion, and seizures.

Precautions

Before taking ofloxacin, it is important to tell your doctor if you are pregnant or breastfeeding, or if you have any liver or kidney problems, diabetes, or any allergies. It is also important to tell your doctor about any other medications, dietary supplements, or vitamins that you are taking, as these may interact with ofloxacin in a negative way.

Interaction

Indocin may interact with other medications, including antibiotics, antacids, and steroids. It may also interact with certain vitamins, foods, and alcohol. It is important to tell your doctor about all of these potential interactions before taking ofloxacin.

Disease Interaction

Indocin may interact with certain diseases, including diabetes, electrolyte imbalance, hypocalcemia, or renal or hepatic dysfunction. It is important to inform your doctor if you have any of these conditions before taking ofloxacin.

Drug Interaction

Indocin may interact with certain medications, including antibiotics, antacids, and steroids. It is important to tell your doctor if you are taking any of these or other medications before taking ofloxacin.

Food Interactions

Indocin may interact with certain foods, including milk products, dairy products, and fatty acids. It is important to tell your doctor if you are taking any of these or other foods before taking ofloxacin.

Pregnancy Use

Indocin should be used with caution in pregnant women, as it may cause harm to the unborn baby. If you are pregnant, you should talk to your doctor before taking this medication.

Lactation Use

Indocin has been known to pass into breast milk and may cause harm to a nursing baby. You should talk to your doctor before breastfeeding while taking this medication.

Acute Overdose

In cases of an overdose of ofloxacin, call your healthcare provider or poison control center right away. Symptoms of an overdose may include nausea, vomiting, dizziness, confusion, abdominal pain, seizures, and rapid heartbeat.

Contraindication

Indocin is contraindicated in patients who have known hypersensitivity to the drug, as well as those with known history of seizures or liver problems. It is also contraindicated in patients taking drugs that can interact with ofloxacin.

Use Direction

Indocin should be taken as prescribed by your healthcare provider. It can be taken with food, but should be taken with plenty of water. Do not skip doses and do not take more or less than prescribed. Do not stop taking the medication before finishing the full course, even if you feel better, as this may result in the infection coming back.

Storage Conditions

Indocin should be stored at room temperature away from light and moisture. Keep it away from pets and children.

Volume of Distribution

The volume of distribution of ofloxacin is approximately 1.2L/kg.

Half Life

The half-life of ofloxacin is about 6-8 hours.

Clearance

Indocin has a clearance of roughly 1.3 mL/min/kg.

Here you find in details version of Indocin

Some Frequently Asked Questions About Indocin

What is Indocin?

Indocin is a prescription antibiotic used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and infection of the prostate (prostatitis).

How does Indocin work?

Indocin works by preventing bacteria from producing the proteins needed for them to multiply and survive. This stops the infection from spreading and allows the body to fight off the infection.

What is the dosage of Indocin?

The dosage varies depending on the type and severity of the infection being treated. For adults, the usual dose is 200-400 mg every 12 hours for 10-14 days. The maximum dose is 800 mg.

What are the side effects of Indocin?

Common side effects of Indocin include nausea, vomiting, stomach pain, headache, dizziness, drowsiness, blurred vision, and ringing in the ears. If any of these side effects become severe or do not go away, talk to your doctor or pharmacist.

What should I avoid while taking Indocin?

Avoid drinking alcohol while taking Indocin, as this can increase the risk of certain side effects. It is also important to avoid direct exposure to sunlight or artificial sources of ultraviolet (UV) light, such as tanning beds, as Indocin may cause your skin to become more sensitive to UV light.

Should I take Indocin with food?

You may take Indocin either with or without food. Taking it with food may reduce stomach upset. However, it is important to drink a full glass of water with each dose.

Is Indocin safe to take during pregnancy?

It is not known if Indocin is safe to take during pregnancy. As with any medication, talk to your doctor before taking Indocin if you are pregnant or planning to become pregnant.

What if I forget to take a dose of Indocin?

If it is almost time for your next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at the same time. If you have any questions, talk to your doctor or pharmacist.

Can I take other medications with Indocin?

Do not take any other medications, including over-the-counter medications, vitamins, or supplements without first talking to your doctor. Some medications can interact with Indocin and should not be taken at the same time.

What should I do if I experience an allergic reaction to Indocin?

If you experience symptoms of an allergic reaction such as rash, hives, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat, stop taking Indocin and seek immediate medical attention.

Can Indocin be used to treat infections caused by viruses?

No, Indocin only works against bacteria. It is not effective for treating infections caused by viruses, such as colds or the flu.

Can I take Indocin with dairy products?

It is recommended that you take Indocin at least 2 hours before or after taking dairy products, as dairy products can reduce the effectiveness of the medication.

Can I drink alcohol while taking Indocin?

It is not recommended that you drink alcohol while taking Indocin, as this can increase the risk of certain side effects.

What should I do if I experience side effects from taking Indocin?

If any side effects become severe or do not go away, talk to your doctor or pharmacist. It is important to tell them about any side effects that you experience, even if they seem minor.

Can I still exercise while taking Indocin?

Yes, it is safe to exercise while taking Indocin. However, it is important to drink plenty of fluids to prevent dehydration, as this can increase the risk of certain side effects.

Does Indocin interact with other medications?

Yes, Indocin can interact with other medications. Do not take any other medications, including over-the-counter medications, vitamins, or supplements without first talking to your doctor.

Can I take acetaminophen while I am taking Indocin?

Yes, you can take acetaminophen while taking Indocin, as long as the dose is appropriate. However, it is important to avoid taking more than the recommended dose of acetaminophen.

Are there any foods or beverages I should avoid while taking Indocin?

It is recommended that you avoid taking Indocin at the same time as dairy products as they can reduce the effectiveness of the medication. You should also avoid drinking alcohol while taking Indocin as this can increase the risk of certain side effects.

Can I take other antibiotics at the same time as Indocin?

No, it is not recommended that you take other antibiotics at the same time as Indocin, as this could lead to the development of bacterial resistance. Talk to your doctor before taking any other antibiotics.

Can I take Indocin while breastfeeding?

Yes, Indocin can be taken while breastfeeding. However, it is important to talk to your doctor before taking any medications while breastfeeding, as some medications can pass into breast milk.

Can Indocin cause itching or skin rash?

Yes, Indocin can cause itching or skin rash. If you experience any of these symptoms, talk to your doctor or pharmacist. They may be able to change your medication to reduce the chance of these symptoms occurring.

Can Indocin cause drowsiness?

Yes, Indocin can cause drowsiness in some people. If you experience drowsiness after taking Indocin, it is important not to drive or operate heavy machinery until the effects have worn off.

Can I take Indocin for a long period of time?

Yes, you can take Indocin for a long period of time, but it is important to talk to your doctor first. Long-term use of Indocin may increase the risk of certain side effects.

What is the shelf life of Indocin?

The shelf life of Indocin tablets is 36 months after manufacture and 28 days after opening the package. It is important to take note of the expiration date printed on the package and never use expired medication.

Is Indocin an antibiotic and does it kill bacteria?

Yes, Indocin is an antibiotic. It works by preventing bacteria from producing the proteins they need to multiply and survive, thus killing the bacteria and treating the infection.

Is Indocin safe for children to take?

Indocin is approved for use in children and adolescents aged 1 year and older. However, talk to your doctor before giving Indocin to a child, as there may be some safety concerns.

Can children take the same dose of Indocin as adults?

No, the dose of Indocin for children is different from the dose for adults. Talk to your doctor or pharmacist for information about the correct dosage for your child.

Does Indocin treat gonorrhea?

Yes, Indocin is used to treat gonorrhea. However, it is important to take a full course of the medication to ensure that all of the bacteria causing the infection have been killed.

What is the mechanism of action of Indocin?

Indocin works by preventing bacteria from producing the proteins needed for them to multiply and survive. This stops the infection from spreading and allows the body to fight off the infection.

Do I need to finish the entire course of Indocin?

Yes, it is important to finish the entire course of Indocin. Stopping treatment too soon can lead to the infection coming back or becoming resistant to the medication.

Can Indocin be used to treat a sinus infection?

Yes, Indocin can be used to treat a sinus infection. Talk to your doctor for information about the correct dosage and duration of treatment.

Can I take Indocin if I have kidney disease?

Yes, Indocin can be taken if you have kidney disease. However, the dose may need to be adjusted, as Indocin is eliminated from the body by the kidneys. Talk to your doctor or pharmacist for more information.

Is Indocin available as a generic?

Yes, Indocin is available as a generic medication. It may be less expensive than the brand-name version of the drug, but it is equally effective.

Can I take Indocin if I am allergic to penicillin?

Yes, you can take Indocin if you are allergic to penicillin. Indocin is a different type of antibiotic and does not contain penicillin.

Is Indocin used to treat strep throat?

Yes, Indocin is sometimes used to treat strep throat. However, it is important to talk to your doctor first, as strep throat is caused by a type of bacteria that is not always sensitive to Indocin.

Do I need a prescription to buy Indocin?

Yes, Indocin is a prescription medication and you will need a prescription from your doctor to buy it. Do not take Indocin without first consulting your doctor.

Can Indocin be used to treat ear infections?

Yes, Indocin can be used to treat certain types of ear infections. Talk to your doctor or pharmacist to determine if Indocin is the appropriate treatment for your condition.