Indacin
Indacin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Indacin is a brand name. Its generic name is Indomethacin.
Indacin
Indacin is a non-steroidal anti-inflammatory drug (NSAID) belonging to the class of drugs called Indole Acetic Acid derivatives. It works by blocking the production of prostaglandins, the chemicals that cause inflammation, swelling, and pain which are responsible for symptoms caused by inflammatory diseases such as arthritis, tendinitis, bursitis, and gout. It is also used to alleviate migraine headaches and reduce fevers.
Uses for Indacin
Indacin is used to treat inflammatory diseases, reduce pain, swelling, and stiffness in joints and other structures. It is also used for pain relief in mild to moderate musculoskeletal and joint conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, tendinitis, and bursitis. It is also used for painful muscles and joints, such as caused by psoriatic arthritis, and to reduce fever caused by illnesses such as colds and flu.
Mechanism of Action
Indacin works by blocking the production of prostaglandins – the main chemical responsible for pain, swelling and inflammation. Blocking the production of prostaglandins can relieve inflammation, swelling and pain. By limiting the production of prostaglandins, indomethacin also reduces the inflammation and redness associated with certain conditions.
How Long Does It Take to Work?
The effects of indomethacin can be felt within 1-2 weeks, but it may take up to 6 weeks for the full effects to be seen. As with all medications, it's important to take indomethacin as directed and speak to a healthcare professional if any questions arise.
Absorption
Indacin is moderately absorbed from the gastrointestinal tract with peak concentrations reached 3 to 4 hours after oral administration.
Route of Elimination
Indacin is eliminated primarily by the kidneys via glomerular filtration and tubular secretion. Some is also metabolized in the liver by cytochrome P450 enzymes.
Dosage
The usual dose of indomethacin is 25-50 mg 3-4 times daily. The dose may be increased up to 100 mg 4 times daily, if necessary. It is important to take indomethacin exactly as prescribed by a doctor, and to not exceed the prescribed dose.
Administration
Indacin should be taken orally with food or a full glass of water to reduce side effects and to ensure that it is correctly absorbed. It should not be taken near meals or snacks as the food will reduce the absorption of the medication.
Side Effects
Common side effects include stomach upset, nausea, and vomiting, as well as headache, dizziness, and drowsiness. More serious side effects that require immediate medical attention include bloody stools or black, tarry stools, confusion, rapid heartbeat, or skin rash or itching.
Toxicity
Indacin is generally safe when taken at the recommended dosage. However, taking too much of this medication can cause serious side effects including kidney failure, abdominal pain, nausea, and vomiting. If any of these more serious side effects occur, contact a doctor immediately.
Precautions
Patients should inform their healthcare provider if they have any other medical conditions, are pregnant, breastfeeding, taking any medications or supplements, or have any allergies. Patients should also avoid activities that require alertness such as driving or operating machinery until the medication’s effects are known. Patients should not take indomethacin if bleeding or any other bleeding disorders are present.
Interactions
Indacin can interact with several other medications, including aspirin, NSAIDs, blood thinners, diuretics, lithium, and steroids. It is important to tell a healthcare provider about all medications being taken before starting indomethacin in order to avoid any drug interactions.
Disease Interactions
Patients with congestive heart failure or kidney or liver disease should not take indomethacin, as these conditions can increase the risk of certain side effects.
Drug Interactions
Indacin can interact negatively with certain drugs, including aspirin, NSAIDs, blood thinners, diuretics, lithium, and steroids. It is important to inform a healthcare provider about all medications being taken before starting indomethacin.
Food Interactions
Indacin should not be taken near meals or snacks as the food will reduce the absorption of the medication.
Pregnancy Use
Indacin should not be used by pregnant women, as it may cause harm to the unborn baby. Women who are breastfeeding should also not take indomethacin, as it can pass into breast milk.
Lactation Use
Indacin passes into breast milk and should not be taken by breastfeeding mothers.
Acute Overdose
Symptoms of acute indomethacin overdose may include nausea, vomiting, abdominal pain, dizziness, confusion, drowsiness, coma, and possibly seizures, coma, and death. If any of these side effects occur, seek medical attention immediately.
Contraindication
Indacin should not be taken by anyone with active gastrointestinal bleeding, history of bleeding disorders, or any other medical conditions that could be aggravated by taking indomethacin. It is also not recommended for use by people who are allergic to any of the ingredients in the medication.
Use Direction
It is important to take indomethacin exactly as prescribed. Do not use more or less than directed and never take it for a longer period of time than prescribed. The usual dose is 25-50 mg 3-4 times daily and may be increased up to 100 mg 4 times daily, if necessary.
Storage Condition
Store indomethacin at room temperature, away from direct sunlight, heat, and moisture. Do not store in the bathroom. Keep this medication away from children and pets.
Volume of Distribution
The volume of distribution of indomethacin is 0.17 L/kg.
Half-Life
The half-life of indomethacin is 2-4 hours.
Clearance
The clearance of indomethacin is 0.24 L/h/kg.
Here you find in details version of Indacin
Some Frequently Asked Questions About Indacin
What is Indacin?
Indacin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat various forms of arthritis, as well as gout and pain caused by inflammation. It is a generic medication and is available over-the-counter as capsules or tablets.
What is Indacin used for?
Indacin is used to reduce pain, inflammation, and stiffness in people with gout, osteoarthritis, and pain caused by rheumatic conditions such as bursitis, tendinitis, and ankylosing spondylitis.
How does Indacin work?
Indacin blocks the production of prostaglandins, which are substances in the body that can contribute to inflammation in certain conditions. By blocking the production of prostaglandins, Indacin can reduce inflammation and pain.
How should I take Indacin?
Follow your doctor’s instructions for taking Indacin. It is usually taken every 8 hours, with or without food. Swallow the capsules or tablets whole with a glass of water. Do not split, chew, or crush the capsules or tablets.
What are the side effects of Indacin?
Common side effects of Indacin include nausea, stomach pain, diarrhea, heartburn, headache, dizziness, drowsiness, and rash. Some people may experience more serious side effects including low blood pressure, kidney or liver damage, and bleeding. Tell your doctor if you experience any side effects.
What should I avoid while taking Indacin?
Avoid drinking alcohol while taking Indacin as it may increase the risk of liver or kidney damage. Avoid taking aspirin or other NSAIDs while taking Indacin, as it may increase the risk of stomach ulcers or bleeding. Tell your doctor if you have any questions about what to avoid while taking Indacin.
Is Indacin safe to take while pregnant?
It is not known if Indacin is safe for use during pregnancy. Talk to your doctor if you are pregnant or planning to become pregnant before taking Indacin. It is not recommended for use during the last 3 months of pregnancy.
Can I take Indacin if I'm breastfeeding?
It is not known if Indacin passes into breast milk. Talk to your doctor before taking Indacin if you are breastfeeding. Alternative forms of relief should be considered if you are nursing.
When should I not take Indacin?
Do not take Indacin if you have a history of stomach ulcers or bleeding; have had an allergic reaction to Indacin or other NSAIDs; or have asthma, severe kidney or liver function impairment, or heart failure. Talk to your doctor before taking Indacin.
Should I tell my doctor about any medications I'm taking when prescribed Indacin?
Yes. Tell your doctor about all of the medications you are taking, including any over-the-counter medications, vitamins, or herbal supplements, as these could affect the way Indacin works. Your doctor may suggest alternative forms of relief for you or adjust your dosage to accommodate your other medications.
What should I do if I miss a dose of Indacin?
If you miss a dose of Indacin, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses of Indacin at the same time. If you take more than the prescribed dose, contact your doctor or poison control center for advice.
How long does it take for the effects of Indacin to start working?
The effects of Indacin usually start working within 1 to 2 days after starting treatment. However, it can take several days or longer before the full effects can be felt. Talk to your doctor if you have any questions about the effects of Indacin or how long before it will start working.
Can I take other medications while taking Indacin?
Some medications can interact with Indacin. Tell your doctor about all of the medications you are taking, including any over-the-counter medications, vitamins, or herbal supplements, as these can affect how Indacin works. Your doctor may suggest alternative forms of relief for you or adjust your dosage to accommodate your other medications.
What other drugs interact with Indacin?
Some medications can interact with Indacin. These medications include aspirin and other NSAIDs, diuretics, lithium, methotrexate, probenecid, and warfarin. Talk to your doctor about all of the medications you are taking before taking Indacin.
What would happen if I overdose on Indacin?
If you think you may have overdosed on Indacin, contact an emergency room or poison control center immediately. Symptoms of an Indacin overdose can include nausea, vomiting, stomach pain, drowsiness, and dizziness.
Is it safe to take Indacin for a long period of time?
Indacin is generally well-tolerated, but it can cause stomach ulcers and bleeding after long-term use. Talk to your doctor if you are considering taking Indacin for a long period of time or if you experience any side effects while taking it.
Will I experience withdrawal symptoms if I stop taking Indacin?
It is not common for people to experience withdrawal symptoms when stopping Indacin. However, if you have been taking it for a long period of time, you should talk to your doctor before stopping as they can advise you on how to safely stop taking it.
What are some possible alternatives to Indacin?
There are many alternative medications to Indacin for treating pain, inflammation, and stiffness in people with gout, osteoarthritis, and rheumatic conditions. Examples of alternative medications include ibuprofen, naproxen, and celecoxib. Talk to your doctor about alternatives to Indacin.
Can I take Indacin for migraines or headaches?
No, Indacin is not recommended for use in treating migraines or headaches. Talk to your doctor about other medications that can be taken for migraines or headaches.
What is the difference between Indacin and other NSAIDs?
Indacin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat various forms of arthritis, as well as gout and pain caused by inflammation. Other NSAIDs work in a similar way but have different active ingredients. Talk to your doctor about which medication may be best for your symptoms.
Should I take Indacin on an empty stomach?
Indacin can be taken with or without food. It is important that you follow your doctor’s instructions for taking Indacin. Talk to your doctor if you have any questions about whether to take Indacin on an empty stomach.
What should I do if Indacin isn't working for my symptoms?
If Indacin isn't working for your symptoms, talk to your doctor. They may suggest alternative forms of relief for you or adjust your dosage. Do not increase your dosage of Indacin without talking to your doctor first.
Can I take Indacin if I'm allergic to aspirin or other NSAIDs?
No, Indacin should not be taken if you are allergic to aspirin or other NSAIDs. Talk to your doctor if you have any allergies that may affect your ability to take Indacin.
Does Indacin have any serious interactions with other medications or supplements?
Yes, some medications can interact with Indacin. These medications include aspirin and other NSAIDs, diuretics, lithium, methotrexate, probenecid, and warfarin. Talk to your doctor about all of the medications you are taking, including any supplements, before taking Indacin.
What should I do if I think I am experiencing side effects from Indacin?
If you are experiencing any side effects from Indacin, talk to your doctor right away. Do not stop taking the medication unless advised to do so by your doctor.
What is the maximum daily dose of Indacin I can take?
The maximum daily dose of Indacin depends on your individual medical history and the condition being treated. Talk to your doctor about the maximum daily dose of Indacin that is right for you.
Is Indacin available over-the-counter?
Indacin is available over-the-counter in the form of capsules or tablets. However, you should talk to your doctor before taking Indacin, as they can advise you on the correct dosage and any other medications or supplements you are taking.
How long does Indacin stay in my system?
Indacin has a half-life of approximately 4 to 7 hours, meaning that is the amount of time it takes for the drug to be reduced by half in the bloodstream. However, it can take several days or longer for the drug to be completely eliminated from your system.
Is Indacin safe for children to take?
No, Indacin is not recommended for use in children. Talk to your doctor about alternative forms of relief that may be safe for your child.
Should I take Indacin with food?
Indacin can be taken with or without food. It is important to follow your doctor's instructions for taking Indacin. Talk to your doctor about whether you should take Indacin with food.
Can I take Indacin if I have high blood pressure?
Yes, you can take Indacin if you have high blood pressure. However, it is important that you talk to your doctor about any conditions you have before taking it, as they can advise you on the correct dosage and any other medications or supplements you are taking.
Can I take Indacin if I have kidney or liver problems?
If you have kidney or liver problems, talk to your doctor before taking Indacin. Your doctor may suggest alternative forms of relief or adjust your dosage to accommodate your kidney or liver problems.
Does Indacin cause drowsiness?
Yes, drowsiness can be a side effect of taking Indacin. If you experience drowsiness while taking Indacin, do not drive or operate heavy machinery until these effects have worn off.
Could I become dependent on Indacin?
No, you cannot become physically dependent on Indacin. However, you should talk to your doctor before stopping use of Indacin, as they can advise you on how to safely stop taking it.
Is it safe to take Indacin with other pain relievers or anti-inflammatories?
No, it is not recommended to take Indacin with other pain relievers or anti-inflammatories. Talk to your doctor before taking any other medication or supplement while taking Indacin.
Can I drink alcohol while taking Indacin?
No, it is not recommended to drink alcohol while taking Indacin. Drinking alcohol while taking Indacin may increase the risk of kidney or liver damage.