Iminod
Iminod Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Iminod is a brand name. Its generic name is Imiquimod.
Iminod Introduction
Iminod is a topical immunomodulator indicated for the treatment of actinic keratoses (AKs), superficial basal cell carcinoma (sBCC) and genital warts in adults. Iminod is formulated as a cream in the 3.75%, 5% and 2.5% strengths.
Uses For
Iminod is an immunomodulator that stimulates the body's immune response, which can lead to the destruction of AKs, sBCC and genital warts. It can also be used as an adjunct in the treatment of cutaneous squamous cell carcinoma in situ (cSCCIS), molluscum contagiosum, and HPV types 6/11.
Mechanism of Action
Iminod works through a complex mechanism of action involving the potent activation of multiple innate and adaptive immune responses. On a cellular level, Iminod stimulates chemokine and cytokine production by antigen presenting cells (APCs) such as macrophages and dendritic cells which in turn leads to increased activity of CD4+ T-cells and cytotoxic CD8+ T-cytes in the tumor microenvironment.
How Long Does it Take to Work?
Although Iminod is an immunomodulator, and the immune response it stimulates can be long-term, individual responses to the therapy can vary greatly. Some patients report a response in as little as one month, while others may require 6 months or more of therapy. Consult with a healthcare professional to determine which treatment regimen is best for you.
Absorption
Iminod is highly lipophilic, allowing for quick absorption through the skin. In clinical studies, participants reported highest plasma concentrations of Iminod after four hours of application. Plasma concentrations continue to be observed up to 24 hours post-application.
Route of Elimination
The primary route of elimination of Iminod after topical application is through urinary excretion. In clinical studies 94.9% of the total dose was excreted in the urine within 12 hours of application. The remaining portion of the dose is believed to be eliminated through the feces.
Dosage
The dosage of Iminod is determined by the strength of the cream, the area of application and the patient’s condition and response to the therapy. The dose range of Iminod for the treatment of AKs is 2.5%, which is used in the 13-cm2 application area. The dose range for the treatment of sBCC and genital warts is 5%.
Administration
Iminod is applied topically to the affected area. Wash the hands before and after application and allow the cream to remain on the skin for the duration of the treatment. Do not cover with a bandage or other occlusive dressing unless instructed to do so by a healthcare professional.
Side Effects
Common side effects of Iminod include burning, soreness, redness, burning or stinging, crusting of the skin, flaking skin, inflammation, itching, swelling, tenderness, and ulceration. Rare side effects may include fever, headache, nausea, vomiting, and rash.
Toxicity
Iminod has low systemic toxicity due to the low systemic exposure and minimal bioavailability after topical application. However, in rare cases of accidental ingestion, Iminod can cause symptoms of nausea, vomiting and generalized itching. If Iminod is ingested, contact a healthcare provider or poison control center immediately.
Precautions
Before using Iminod, tell your healthcare provider if you are pregnant, breastfeeding, if you have any allergies, or if you take any drugs, supplements, or herbal remedies.
Interactions
Iminod has no known drug interactions. However, some medications may interact with Iminod including salicylates (such as aspirin and ibuprofen), other topical medications, and grapefruit juice.
Disease Interactions
Iminod should not be used in patients with known hypersensitivity to Iminod or any of its ingredients. In addition, patients with bleeding disorders, or immune system deficiencies should use caution when using Iminod. In patients with immunosuppression, the risk of hypersensitivity reactions may be increased.
Drug Interactions
No drug interactions have been clinically significant when Iminod is used as directed. However, patients should be aware that Iminod may increase the systemic absorption of certain medications when applied topically. These medications include salicylates (such as aspirin and ibuprofen) and other topical medications.
Food Interactions
No food interactions have been reported with the use of Iminod.
Pregnancy Use
Iminod should not be used during pregnancy unless the potential benefit to the mother outweighs the potential risk to the fetus. Women of childbearing age should use effective contraception during treatment with Iminod and for one month after treatment ends.
Lactation Use
It is unknown if Iminod is present in human milk. Women should not breastfeed while taking Iminod and for one month after treatment ends.
Acute Overdose
No information is available on overdoses with Iminod. If an overdose is suspected, contact your doctor or healthcare professional.
Contraindications
Iminod is contraindicated in patients who are hypersensitive to any of its components. As Iminod may increase the systemic absorption of certain medications when applied topically, patients should use caution when using Iminod with salicylates (such as aspirin and ibuprofen) and other topical medications.
Use Directions
Iminod is applied in a thin layer to the affected area, typically two to five times a week, depending on the strength and the type of condition being treated. Allow the medication to remain on the skin for the duration of the recommended time (typically 8-10 hours). Do not apply Iminod to areas with open wounds or burns. Wash your hands before and after applying Iminod.
Storage Condition
Iminod should be stored at room temperature between 15˚ and 25˚C (59˚ and 77˚F). Keep Iminod away from moisture, light and heat. Do not freeze.
Volume of Distribution
Iminod has a volume of distribution of approximately 7.4 L/kg, indicating that it is a lipophilic drug that is primarily distributed through tissue rather than plasma.
Half Life
The elimination half-life of Iminod is approximately 12 hours following topical application.
Clearance
Following systemic absorption, Iminod is cleared primarily through the kidneys. Approximately 93% of the total dose is excreted through the urine within the first 12 hours after application.
Here you find in details version of Iminod
Some Frequently Asked Questions About Iminod
.What is Iminod?
Iminod is a topical cream used to treat actinic keratosis (a pre-cancerous skin condition that's caused by too much sun exposure) and herpes simplex viruses. It can also be used to treat certain forms of skin cancer.
How does Iminod Work?
Iminod works by stimulating the body's immune system into fighting off the invader. Its active ingredients help to cause localized inflammation, which helps to cause the skin's immune system to recognize and then target the affected area. This helps to reduce the growth of abnormal skin cells, and can ultimately lead to the death of cancerous or pre-cancerous cells.
How is Iminod Applied?
Iminod is usually applied directly to the affected area, typically two or three times a week. Each application typically takes between several minutes to one hour. It's important to apply the cream as directed and to cleanse the area thoroughly afterward.
What are the Side Effects of Iminod?
Common side effects of Iminod include itching, burning, irritation, redness, swelling, crusting, scabbing, or pain at the application site. Less common side effects include headache, nausea, fever, chills, fatigue, muscle or joint pain, abdominal pain, and increased sensitivity to sunlight.
Who Should Not Use Iminod?
Iminod should not be used by pregnant women, breastfeeding women, or people who are allergic to any of its ingredients. Iminod also should not be used on any open wounds or other areas of skin damage.
Are There Any Warnings with Iminod?
Iminod should not be used near the eyes or genitals, and contact with these areas should be avoided. Other warnings include avoiding sun exposure, using sunscreen, and avoiding the use of other topical skin medications or cosmetics on the same area treated with this medication.
What is the Recommended Dosage of Iminod?
The recommended dosage of Iminod depends on the condition being treated, and the age and health of the patient. In general, adults should apply a thin layer twice a day, usually two or three days a week, for a period of three to four weeks. Children should use the cream less frequently and for a shorter time.
When Will I Notice Results With Iminod?
The effects of Iminod may become noticeable after one or two weeks of regular use. In some cases, it may take longer for the effects to be seen. Your doctor or dermatologist will be able to provide more specific instructions about when you should begin to notice results.
What can I Expect After Stopping Iminod Treatment?
After stopping treatment with Iminod, some patients may experience skin irritation, redness, or itching for a few days or longer. This is normal and should improve over time. If any symptoms persist or worsen, talk to your doctor for advice.
Will Iminod Make Me More Sensitive to Sunlight?
Yes, Iminod can make you more sensitive to sunlight. In order to avoid sunburn and other skin damage, be sure to wear sunscreen and protective clothing when spending time outdoors.
Should I Avoid Any Activities while Taking Iminod?
Yes, it's recommended that you avoid activities like swimming, hot tub use, and sunbathing while taking Iminod. These activities might make your skin more susceptible to irritation and sunburn.
Is Iminod Safe for Long-Term Use?
Iminod is generally safe for long-term use, but it's important to talk to your doctor if you're thinking of continuing the medication for an extended period. They will be able to give you more specific advice about whether long-term use is appropriate in your case.
Can Anyone Take Iminod?
No, Iminod is not suitable for everyone. In particular, pregnant or breastfeeding women should not use this medication. Additionally, people with certain skin conditions or skin reactions should not use Iminod. In these cases, alternative treatments should be considered.
What Happens If I Miss a Dose of Iminod?
If you miss a dose of Iminod, apply it as soon as you remember. If it is close to the time of the next dose, skip the missed dose and take the next dose as usual. Do not increase the amount of Iminod you apply in a single day.
How Long Does Iminod Take to Work?
The effects of Iminod may become noticeable after one or two weeks of regular use. It can take longer for the full effects of the medication to be seen. Talk to your doctor or dermatologist if you have any questions about when you should begin to notice results.
Can I Use Other Topical Medications or Cosmetics While Taking Iminod?
No, other topical medications or cosmetics should not be used on the same area that is treated with Iminod. Doing so can increase the risk of side effects, such as skin irritation or redness.
Is There Anything I Should Avoid Eating or Drinking While Taking Iminod?
No, there is no need to avoid certain foods or drinks while taking Iminod. However, it's important to follow a healthy diet and stay well-hydrated while taking this medication.
What Should I Tell My Doctor Before Taking Iminod?
Before starting treatment with Iminod, it’s important to tell your doctor if you have any allergies, any current medications or supplements you’re taking, and if you’re pregnant or breastfeeding. Your doctor will also need to know if you’ve had any previous skin reactions to topical creams or medications.
What Should I Do If I Have an Allergic Reaction to Iminod?
If you experience any signs of an allergic reaction to Iminod, such as skin rash, swelling, or difficulty breathing, contact your doctor right away. They may advise you to stop using the medication or recommend another treatment option.
Can Iminod be Used for Cold Sores?
Yes, Iminod can be used to treat cold sores, genital warts, and other herpes simplex virus infections. It should be applied as directed by your doctor.
Should Iminod Be Used for Skin Cancer?
Yes, Iminod can be used to treat certain types of skin cancer, such as basal cell carcinoma and cutaneous proliferation from Kaposi's sarcoma. However, it should be used in conjunction with other treatments, such as surgery or radiation.
Is Iminod Effective for Actinic Keratosis?
Yes, Iminod has been found to be effective for treating actinic keratosis, which is a pre-cancerous skin condition caused by excessive sun exposure. It should be applied as directed by your doctor.
Can Iminod be Used on Children?
Iminod can be used to treat children over the age of two. If Iminod is prescribed for a child, follow the instructions given by your doctor carefully, as children should use the medication less frequently and for a shorter time than adults.
Can I Put Makeup Over the Iminod Application Site?
No, makeup should not be applied to the Iminod application site. Doing so can lead to skin irritation or rash. It's important to cleanse the area thoroughly after applying Iminod. Makeup can be applied to the area once the cream has been fully absorbed.
What Should I Do if I Get Iminod on My Clothing?
Iminod can irreversibly stain clothing, so be sure to avoid contact with fabrics. If Iminod does get on clothing, it's important to remove the affected items and wash them in hot water as soon as possible. Cold water or dry cleaning is not recommended.
Is There Anything I Should Avoid Doing After Applying Iminod?
Yes, you should avoid swimming, hot tub use, and sunbathing for at least one hour after applying Iminod. These activities may make your skin more susceptible to irritation and sunburn.
Is It Normal for the Skin to Peel After Treatment with Iminod?
Yes, it is normal for the skin to peel or flake off after treatment with Iminod. If this happens, you can use a gentle moisturiser to help reduce the peeling and keep your skin feeling soft and comfortable.
Will Iminod Work for Everyone?
Unfortunately, Iminod is not always effective for everyone. Your doctor can offer advice and assistance in determining the best treatment for you.
How Long Should I Use Iminod for?
The length of treatment with Iminod varies and depends on the condition being treated and the age and health of the patient. In general, adults should apply the cream for a period of three to four weeks, while children should use the cream less frequently and for a shorter duration.
What Are the Precautions with Iminod?
Iminod should be used cautiously in people with kidney or liver disease, and may not be suitable for people with certain skin conditions. Additionally, Iminod can make the skin more sensitive to sunlight, so it's important to wear sunscreen and protective clothing when spending time outdoors.
Should I Tell My Doctor if I Experience Any Side Effects?
Yes, it's important to tell your doctor if you experience any side effects while using Iminod. They will be able to advise on whether any changes need to be made to your treatment plan.
Does Iminod Require a Prescription?
Yes, Iminod requires a prescription from a doctor. Talk to your doctor about whether Iminod is the right treatment for you.
Can I Buy Iminod Over the Counter?
No, Iminod is not available over the counter. In order to obtain this medication, you must get a prescription from a doctor.
Can I Use Iminod During Pregnancy?
No, Iminod should not be used during pregnancy. For those who are breastfeeding, it's important to stop breastfeeding for at least 24 hours after applying the cream.