IFN-gamma 1b
IFN-gamma 1b Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? IFN-gamma 1b is a brand name. Its generic name is Interferon gamma-1b.
Interferon-gamma 1b Introduction
IFN-gamma 1b (IFN-γ-1b) is a recombinant form of the naturally-occurring human interferon gamma (IFN-γ). It is used to treat certain infections, cancer, septic shock, and multiple sclerosis (MS).
Uses for Interferon Gamma-1b
IFN-gamma 1b is used to treat a number of conditions, including:
- Chronic Hepatitis B – an infectious liver disease
- Chronic Hepatitis C – an infectious blood-borne virus
- HIV infection
- Septic shock, a life-threatening complication of severe infection
- Certain types of cancer,such as chronic myelogenous leukemia
- Multiple sclerosis (MS), a chronic, progressive, and disabling neurological disease
Mechanism of Action
IFN-gamma 1b works by inhibiting certain cells from multiplying, which helps to reduce the amount of disease-causing organisms and toxins in the body. It also stimulates the body’s natural defense system to help fight against infection and disease.
How Long Does It Take to Work?
It usually takes 1-2 weeks for interferon gamma-1b to start working. However, this time period may vary from one person to another.
Absorption
IFN-gamma 1b is slowly and consistently absorbed from the injection site into the bloodstream. It takes several hours for the drug to reach full absorption.
Route of Elimination
IFN-gamma 1b is eliminated from the body through the kidneys and feces. Most of the drug is eliminated within 24 hours.
Dosage
IFN-gamma 1b is available in 4 mg/ml solution for intravenous (IV) infusion. The recommended dose of interferon gamma-1b is 1.6 million IU/m2 body surface area (BSA) administered once weekly for 16 weeks. The maximum recommended dose is 2.5 million IU/m2 BSA. The dose may be adjusted depending on the condition being treated and the patient’s response. If the patient is receiving a second dose, it should be administered 9 to 11 days after the first dose.
Administration
IFN-gamma 1b should be administered as an IV infusion over a period of 30 minutes. It should not be administered as an intramuscular injection or subcutaneous injection.
Side Effects
Common side effects of interferon gamma-1b include: nausea, fatigue, headache, fever, chills, chest pain, muscle pain, sore throat, and joint pain. These side effects usually resolve on their own and do not require medical attention.
Toxicity
IFN-gamma 1b has not been associated with serious toxicity in humans. However, it may cause serious side effects, including: bleeding, liver damage, decrease in white blood cells, severe allergic reactions, and severe skin reactions.
Precautions
Before using interferon gamma-1b, it is important to tell your doctor if you have had an allergic reaction to interferon gamma-1b, other interferons, or any other medications. Also, tell your doctor if you have had any other medical conditions, especially liver or kidney disease, diabetes, seizures, or a history of depression. As with any medication, pregnant and breastfeeding women should avoid using interferon gamma-1b, unless recommended by a doctor.
Interactions
IFN-gamma 1b may interact with certain drugs. It is important to tell your doctor if you are taking any other medications, including vitamins and supplements.
Disease Interactions
IFN-gamma 1b may interact with certain diseases. Tell your doctor if you have any other medical conditions, especially liver or kidney disease, diabetes, seizures, or a history of depression.
Drug Interactions
IFN-gamma 1b may interact with certain drugs. Tell your doctor if you are taking any other medications, including vitamins and supplements.
Food Interactions
There are no known food interactions with interferon gamma-1b.
Pregnancy Use
IFN-gamma 1b should not be used during pregnancy, unless recommended by a doctor.
Lactation Use
It is not recommended to use interferon gamma-1b while breastfeeding.
Acute Overdose
An acute overdose of interferon gamma-1b is unlikely to cause life-threatening side effects, but it can cause serious side effects. If an overdose is suspected, it is important to seek medical attention immediately.
Contraindications
IFN-gamma 1b should not be used in patients who have had a serious allergic reaction to interferon gamma-1b or any other medications. It should also not be used in patients with a history of depression or seizures.
Use Direction
IFN-gamma 1b should be used as directed by a doctor. It should be administered as an intravenous infusion over a period of 30 minutes. The recommended dose of interferon gamma-1b is 1.6 million IU/m2 body surface area (BSA) administered once weekly for 16 weeks. The maximum recommended dose is 2.5 million IU/m2 BSA.
Storage Condition
IFN-gamma 1b should be stored at room temperature, away from heat and light. It should also be kept out of reach of children.
Volume of Distribution
The volume of distribution of interferon gamma-1b is not known.
Half Life
The half-life of interferon gamma-1b is about 12 hours.
Clearance
The clearance rate of interferon gamma-1b is not known.
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