Icel

Icel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Icel is a brand name. Its generic name is Celecoxib.

Introduction

Icel, also known as Celebrex, is an NSAID medication used to treat various conditions of inflammation and pain. Commonly used to treat arthritis, Icel works by inhibiting the enzyme COX-2, reducing inflammation and decreasing pain.

Uses

Icel is commonly used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, menstrual pain, and pain caused by inflammation (such as that associated with injuries). It is also used to reduce the number of colorectal polyps in people with familial adenomatous polyposis.

Mechanism of Action

Icel works by inhibiting the COX-2 enzyme, which is responsible for the production of several pro-inflammatory mediators in the body. By blocking the action of this enzyme, the amount of these mediators is reduced, leading to decreased inflammation and pain.

How Long Does It Take to Work?

The effects of Icel usually begin within 3-4 days of taking the medication. It may take up to two weeks to feel the full effects of the medication.

Absorption

Icel is rapidly and extensively absorbed from the gastrointestinal tract after oral administration.

Route of Elimination

Icel is eliminated in the feces and urine. About 80% of an administered dose is recovered in feces as unchanged drug, metabolites, and biliary excretion products. About 30% of the drug is eliminated unchanged in the urine.

Dosage

The recommended adult dose for Icel is 200-400 mg taken twice daily. The maximum daily dose is 800 mg. Dosage should be adjusted in patients with impaired kidney function.

Administration

Icel should be taken with a full glass of water and should be taken on an empty stomach.

Side Effects

Common side effects of Icel include nausea, stomach pain, diarrhea, dizziness, constipation, gas, heartburn, drowsiness, headache, and rash. Some serious side effects may include swelling of the face, hands, feet, ankles, stomach pains, chest pain, and difficulty breathing.

Toxicity

Icel is generally well tolerated. However, Icel can cause serious side effects if taken in high doses and when used for long periods of time. The risk of serious side effects increases with the duration of treatment.

Precautions

Patients taking Icel should be aware of the potential risk for stomach ulcers and bleeding. Patients should also be aware of the risk of hypersensitivity reactions and kidney impairment associated with this medication.

Interaction

Icel can interact with other medications, including inhibitors of cytochrome P-450 isoenzymes, antibiotics, antifungals, antihypertensives, anticonvulsants, and some corticosteroids. Before using Icel, consult your doctor or pharmacist.

Disease Interaction

Patients with heart failure, high blood pressure, blood clotting disorders, or an allergy to NSAIDs should not take Icel. Patients with a pre-existing bleeding disorder, bleeding ulcer, or liver disease should use Icel with caution.

Drug Interactions

Icel may interact with a number of drugs, including warfarin, lithium, methotrexate, ACE inhibitors, and corticosteroids. Consult your doctor or pharmacist for a complete list of drug interactions.

Food Interactions

Alcohol should be avoided while taking Icel. Other foods high in fat may increase the rate of absorption of the medication.

Pregnancy Use

Icel is contraindicated in pregnant women. Other NSAIDs should be considered in pregnant women to avoid risk.

Lactation Use

Icel is contraindicated in breastfeeding women. Other NSAIDs should be considered in breastfeeding women to avoid risk.

Acute Overdose

In case of acute overdose, seek medical attention immediately. Symptoms may include confusion, vomiting, rash, stomach pain, and breathing difficulty.

Contraindication

Icel is contraindicated in pregnant women and breastfeeding women. Icel is also contraindicated in patients with a history of hypersensitivity reaction to Icel or any other NSAID.

Use Direction

Icel should be taken as directed by your health care provider. It should be taken with a full glass of water, and should be taken on an empty stomach. Do not exceed the recommended dosage.

Storage Condition

Icel should be stored at room temperature away from direct sunlight and heat. Keep out of reach of children.

Volume of Distribution

The average volume of distribution for Icel is approximately 17 L/kg.

Half Life

The average half-life of Icel is approximately 11 hours.

Clearance

The clearance for Icel is approximately 0.4 L/hr/kg.

Here you find in details version of Icel

Some Frequently Asked Questions About Icel

What is Icel?

Icel is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and stiffness caused by arthritis and some other conditions. It is sold under the brand names Celebrex and Celebra.

How does Icel work?

Icel is an anti-inflammatory drug that works by inhibiting the production of prostaglandins, substances that cause inflammation. This reduction in prostaglandins helps reduce pain and inflammation in patients with arthritis and other conditions.

What is the difference between Icel and other NSAIDs?

Icel is a newer generation of NSAIDs that are less likely to cause stomach irritation and bleeding. It is also less likely to cause kidney damage than traditional NSAIDs. It is commonly used for the treatment of arthritis and other painful conditions.

What are the side effects of Icel?

Common side effects of Icel include stomach upset, nausea, diarrhea, headache, and dizziness. Less common but more serious side effects include liver and kidney damage, increased risk of bleeding or stroke, and allergic reactions.

Is Icel safe to use long-term?

Icel is generally considered safe to use long-term, however it can increase risk of certain side effects such as stomach irritation and an increased risk of stroke or bleeding. Talk to your doctor to make sure Icel is right for you.

Can Icel be crushed or split in half?

No, Icel should not be crushed or split in half. Taking the whole capsule at once is the only safe way to take this medication.

What should be avoided while taking Icel?

Alcohol should be avoided while taking Icel, as it can increase the risk of stomach bleeding. You should also avoid using other medications including NSAIDs and steroids without talking to your doctor first, as they can increase the risk of side effects.

Is Icel safe to use during pregnancy and breastfeeding?

No, Icel should not be used during pregnancy or breastfeeding. If you are pregnant or think you might be pregnant, talk to your doctor before taking celecoxib.

Can Icel interact with other medications?

Yes, Icel can interact with other medications including NSAIDs, steroids, blood thinners, and some antibiotics. Talk to your doctor or pharmacist before starting or changing medications to make sure Icel is right for you.

How do you take Icel?

Icel should be taken exactly as your doctor or healthcare provider has prescribed. Do not take more or less than what is recommended. The usual recommended dose is 200 mg once or twice daily. It should be taken with food to reduce stomach irritation.

What should I do if I miss a dose of Icel?

If you miss a dose of Icel, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.

How long does it take for Icel to start working?

It can take up to a few weeks for Icel to start working. If your symptoms do not improve after 4-6 weeks, talk to your doctor, as the dose may need to be adjusted.

Is Icel habit forming?

No, Icel is not habit forming. However, it is important to take the medication as prescribed and not to stop taking it without talking to your doctor first.

Is Icel safe to use in children?

Icel is not approved for use in children. Talk to your doctor before giving your child Icel.

Can Icel cause weight gain?

No, Icel does not typically cause weight gain, however some patients taking this medication may experience appetite changes. Talk to your doctor if you experience significant weight gain while taking Icel.

Should I take Icel with food?

Yes, Icel should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Is Icel addictive?

No, Icel is not an addictive medication. However, it is important to take it as prescribed and not to stop taking it without talking to your doctor first.

Can Icel cause liver damage?

Yes, there is a risk of liver damage with long-term use of Icel. Your doctor may order regular blood tests to monitor your liver function if you take this medication for an extended period of time.

Can Icel be used for pain relief?

Yes, Icel is often used to treat pain and inflammation associated with arthritis and other conditions. Talk to your doctor to make sure Icel is right for you.

Should Icel be taken with other medications?

Icel can interact with many other medications. Talk to your doctor or pharmacist before starting or changing medications to make sure Icel is right for you.

Does Icel interact with birth control?

Yes, there is a potential for Icel to interact with birth control pills, leading to an increased risk of side effects. Talk to your doctor about safer alternatives for contraception if you take this medication.

Can Icel cause stomach pain?

Yes, some patients taking Icel may experience stomach pain. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Can Icel cause drowsiness?

Yes, drowsiness is a possible side effect of Icel. Talk to your doctor if you experience excessive drowsiness while taking this medication.

Can Icel cause erectile dysfunction?

Yes, erectile dysfunction is a possible side effect of Icel. Talk to your doctor immediately if you experience any changes in your sexual function while taking this medication.

Can I take Icel and ibuprofen together?

No, taking both Icel and ibuprofen at the same time can increase your risk of stomach irritation and bleeding. Make sure to tell your doctor if you are already taking any other medications.

Should I take Icel with food or on an empty stomach?

Icel should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Does Icel cause hair loss?

No, hair loss is not a common side effect of Icel. Talk to your doctor right away if you experience any changes in your hair while taking this medication.

Can Icel cause an allergic reaction?

Yes, allergic reactions to Icel are possible. Symptoms of an allergic reaction can include rash, itching, difficulty breathing, and swelling. Contact your doctor immediately if you experience any of these symptoms while taking this medication.

Can Icel cause constipation?

Yes, constipation is a possible side effect of Icel. If you experience constipation while taking this medication, talk to your doctor about ways to manage it.

Can Icel be used to treat fever?

No, Icel is not typically used to treat fever. Talk to your doctor about other options for treating fever.

Is Icel a blood thinner?

No, Icel is not a blood thinner. However, it can increase your risk of bleeding when taken with other blood thinning medications. Talk to your doctor before taking Icel with other medications.

Can Icel cause nausea?

Yes, nausea is a possible side effect of Icel. Talk to your doctor if you experience nausea while taking this medication.

Can Icel cause dehydration?

Yes, dehydration is a possible side effect of Icel. Make sure to drink plenty of fluids while taking this medication, especially if you are experiencing other symptoms such as nausea, vomiting, and diarrhea.

Can Icel cause stomach upset?

Yes, stomach upset is a possible side effect of Icel. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

What is the maximum daily dose of Icel?

The maximum recommended daily dose of Icel is 400 mg. Taking more than this can increase your risk of side effects. Talk to your doctor if you are prescribed a higher dose.

How long can I take Icel?

The maximum recommended duration of use of Icel is six months. Talk to your doctor if you need to take this medication for longer than this, as it can increase your risk of side effects.

Does Icel cause dizziness?

Yes, dizziness is a common side effect of Icel. If you experience dizziness while taking this medication, talk to your doctor about ways to manage it.

Should I take Icel with food or milk?

Icel should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Does Icel reduce inflammation?

Yes, Icel is an anti-inflammatory drug that helps reduce inflammation by inhibiting the production of prostaglandins. This can reduce pain and inflammation in patients with arthritis and other conditions.

Does Icel cause weight gain?

No, weight gain is not typically caused by Icel. However, some patients taking this medication may experience appetite changes. Talk to your doctor if you experience significant weight gain while taking Icel.

Can Icel cause fatigue?

Yes, fatigue is a possible side effect of Icel. Talk to your doctor if you experience fatigue while taking this medication.

Can Icel cause heartburn?

Yes, heartburn is a possible side effect of Icel. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Do I need to have regular blood tests while taking Icel?

Your doctor may order regular blood tests to monitor your liver function if you take this medication for an extended period of time. Talk to your doctor about any other tests you may need while using Icel.