Gynozol
Gynozol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Gynozol is a brand name. Its generic name is Butoconazole.
What is Gynozol?
Gynozol is an antifungal medication that is used to treat certain types of fungal and yeast infections. It is a topical medication meaning it is applied to the affected area of the skin. It is usually applied to the vagina and surrounding skin. The active ingredient of the brand Gynozol Nitrate is butoconazole. It belongs to the azole antifungal class of medications.
Uses for Gynozol
Gynozol is used to treat infections caused by certain types of fungi and yeast. It is frequently used to treat vaginal yeast infections, but can also be used to treat athlete’s foot, jock itch, and other fungal skin infections. It is only meant to be used to treat external fungal infections and should not be used to treat internal fungal infections.
Mechanism of Action
Gynozol works by stopping the fungi and yeast from growing and spreading. It does this by inhibiting the production of ergosterol, which is an essential component of the fungal cell membrane. Without the ergosterol, the fungal cell membrane breaks down which kills the fungi and yeast.
How Long Does it Take to Work?
Gynozol starts to work quickly to treat fungal infections. Most people experience relief from symptoms within 1 to 3 days after starting treatment. It is important to follow the directions and continue using the medication as prescribed even if symptoms improve.
Absorption
Gynozol is absorbed quickly and easily through the skin. The antifungal medication is found in the bloodstream and is distributed throughout the body within 24 hours of application.
Route of Elimination
Gynozol is eliminated from the body through the kidneys, with about 65% of it being eliminated through urine and 35% through feces. The elimination time of butoconazole varies but usually ranges from 16-24 hours.
Dosage and Administration
The usual recommended dosage of butoconazole is a single application of 2%. Gynozol is usually applied to the affected area twice a day (once in the morning and once at night) for 3 or 7 days, depending on the condition being treated. The cream should be applied to the affected external skin area and around it. Patients should not apply more than 8g of cream in a single application or more than 16g in a day.
Side Effects
The side effects most commonly associated with Gynozol are skin irritation, rash, and itching. Other less common side effects include burning, dryness, redness, pain, and swelling. In rare cases, people may also experience an allergic reaction, including hives and difficulty breathing.
Toxicity
The general toxicity of butoconazole is relatively low. It is important to note that if too much butoconazole is used or the medication is ingested, it may cause more serious symptoms such as dizziness, confusion and seizures.
Precaution
Gynozol should not be used for more than 7 days in a row, as it may cause skin irritation. Patients should also use appropriate protection (e.g. gloves or a mask) when applying butoconazole to reduce the risk of absorbing it through the skin.
Interaction
Gynozol can interact with other medications. It can also interact with certain foods and dietary supplements. Patients should always inform their doctor of all medications they are taking before starting treatment with butoconazole.
Disease Interaction
Gynozol should not be used for the treatment of skin irritation caused by certain diseases such as psoriasis or seborrheic dermatitis. It may also not be suitable for people with inflammatory skin conditions.
Drug Interaction
Gynozol may interact with certain other medications. The most common drugs that may interact with butoconazole are ketoconazole, clotrimazole, terconazole, miconazole, and fluticasone. Always consult with your doctor or pharmacist before taking any new medications.
Food Interactions
Gynozol does not interact with any foods or beverages. There is no need to restrict or change your diet in any way while taking butoconazole.
Pregnancy Use
The safety of butoconazole for use in pregnancy has not been established. The medication should only be used if the potential benefit to the mother outweighs the potential risk to the unborn baby.
Lactation Use
It is not known if butoconazole passes into the breast milk. It should be used with caution in breastfeeding women and only if the potential benefit outweighs the potential risks.
Acute Overdose
An overdose of butoconazole is very unlikely. However, if too much of the medication is applied or it is ingested, serious symptoms such as dizziness, confusion, and seizures may occur.
Contraindication
Gynozol should not be used by people with an allergy to any of the ingredients in the medication. It also should not be used to treat internal fungal infections.
Use Direction
Apply a thin layer of Gynozol 2% cream to the affected external skin area and surrounding it. Use the medication twice a day (morning and night) for 3 to 7 days, or as directed by your doctor. Applying the cream more often or using more than the prescribed amount may increase the risk of skin irritation.
Storage Conditions
Gynozol should be stored at room temperature, away from light and moisture. Do not freeze or refrigerate the cream.
Volume of Distribution
Gynozol has an apparent volume of distribution of 0.4 L/kg
Half-Life
The half-life of butoconazole is approximately 0.9 hours.
Clearance
The systemic clearance of butoconazole is approximately 0.2 L/h/kg.
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