Globcal C Max
Globcal C Max Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Globcal C Max is a brand name. Its generic name is Tedizolid Phosphate.
Introduction
Globcal C Max is a prescription antibiotic used to treat certain bacterial infections. It is the prodrug of tedizolid, meaning that it is converted into Tedizolid in the body for it to be effective. It is typically used to treat skin and respiratory infections.
Uses
Globcal C Max is used to treat a variety of bacterial skin infections, including: impetigo, folliculitis, cellulitis, and others. It can also be used to treat community-acquired bacterial pneumonia.
Mechanism of Action
Globcal C Max works by disrupting bacterial cells’ ability to synthesize protein, which stops them from multiplying and repairing. This leads to a decrease in the amount of bacteria in the body, which helps to treat the infection.
How Long Does It Take To Work?
Once Globcal C Max is taken, it is quickly converted in the body into its active form, Tedizolid. This active form of the medication then begins to act on the bacteria, and symptoms may begin to improve within the first few days of taking it. However, as with all antibiotics, Globcal C Max must be taken as prescribed for the full course of treatment in order to ensure that the infection is properly treated.
Absorption
Globcal C Max is rapidly absorbed into the bloodstream and converted to its active form, Tedizolid. Its time to peak concentration (Tmax) is approximately 3 to 4 hours after single and multiple doses.
Route of Elimination
Globcal C Max is rapidly eliminated from the body, mainly by the kidneys, and has a half-life of approximately 11 hours. It is eliminated largely unchanged in the urine.
Dosage & Administration
Globcal C Max is available in tablets (200 mg) and injections (2 mg/mL) for intravenous administration. The recommended dosage is 200 mg once daily for six days for treating bacterial skin infections. For treating community-acquired bacterial pneumonia, the recommended dosage is 600 mg once daily for five days.
Side Effects
Globcal C Max can cause mild to moderate side effects, including nausea, vomiting, diarrhea, headache, and rash. Severe side effects, such as anaphylaxis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, are rare. Patients should contact their doctor if they experience any of these side effects.
Toxicity
Globcal C Max is generally well tolerated. Its toxicity is low and it does not appear to accumulate in the body. However, it can accumulate in the kidneys if the patient has renal impairment and the dosage should be adjusted as necessary.
Precaution
Patients with known hypersensitivity to tedizolid or other oxazolidinones should not take Globcal C Max. Patients with renal impairment should take reduced doses as necessary.
Interaction
Globcal C Max should not be taken with other drugs that inhibit CYP3A4/5; these drugs may decrease the effectiveness of Globcal C Max. These drugs include erythromycin, ketoconazole, itraconazole, ritonavir, and others. Patients should inform their healthcare provider of all medications they are currently taking in order to prevent potential interactions.
Disease Interaction
There are no known disease interactions with Globcal C Max. Patients with hepatic impairment should take reduced doses as necessary.
Drug Interaction
Globcal C Max should not be taken with other medications that inhibit CYP3A4/5. These medications include erythromycin, ketoconazole, itraconazole, ritonavir and others. Patients should inform their healthcare provider of all medications they are currently taking in order to prevent potential interactions.
Food Interactions
Globcal C Max can be taken with or without food. However, patients with reduced stomach acidity should take it with food in order to optimize its absorption.
Pregnancy Use
Globcal C Max is in category C for pregnancy, meaning it may pose a risk to the fetus. Women should consult their doctor before taking this medication if they are pregnant or planning to become pregnant.
Lactation Use
There are no established studies on the use of Globcal C Max while nursing. It is recommended that women consult their healthcare provider before taking this medication while breastfeeding.
Acute Overdose
An acute overdose of Globcal C Max is unlikely to cause serious harm, as it rapidly eliminated from the body. The treatment of an overdose with Globcal C Max is primarily supportive, aimed at treating any symptoms that may arise as a result.
Contraindication
Globcal C Max should not be given to patients who are known to be allergic to tedizolid or any other oxazolidinone. Patients with hepatic or renal impairment should consult their doctor before taking this medication.
Use Direction
Globcal C Max should be taken as prescribed by the doctor. It should be taken with food if the patient has reduced stomach acidity, and should be taken consistently for the entire course of treatment. Patients should not skip or discontinue therapy without consulting their doctor.
Storage Condition
Globcal C Max should be stored at room temperature, away from heat, light, and moisture. It should be kept out of reach of children.
Volume of Distribution
Globcal C Max is widely distributed throughout the body, with a volume of distribution of approximately 1012 L.
Half Life
Globcal C Max has a half-life of approximately 11 hours, with the active metabolite, Tedizolid, having a half-life of approximately 13.5 hours.
Clearance
Globcal C Max is rapidly eliminated from the body, mostly by the kidneys, with a clearance rate of approximately 134 L/h.
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