Gadamide
Gadamide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Gadamide is a brand name. Its generic name is Gadoversetamide.
Gadamide
Gadamide, also known as gliatech, is a radiopaque contrast agent that is used in MRI and CT scans to enhance images of the brain and spinal cord. It is administered intravenously and works by delaying the passage of water molecules through the cell membrane, causing them to appear brighter on the scan images.
Uses
Gadamide is used to help radiologists visualize and interpret brain and spinal cord images. It is particularly helpful in detecting neurological diseases, tumors, infections, or areas of bleeding.
Mechanism of Action
Gadamide works by delaying the passage of water molecules through the cell membrane. This results in a brighter appearance on the scan images.
How Long Does it Take to Work?
Gadamide has an onset of action of about 30 - 90 seconds. The effects of the drug can last for several hours.
Absorption
Gadamide is rapidly absorbed from the gastrointestinal tract after oral administration.
Route of Elimination
Gadamide is eliminated primarily through the urine by glomerular filtration and tubular secretion.
Dosage
The dosage of Gadamide depends on the indication for use and the patient’s age, weight, allergies, medical history, and other medications being taken. The usual dose range for MRI imaging is 0.1 – 0.5 mmol/kg IV. Generally, the higher doses are used for MRI imaging and the lower doses for CT imaging.
Administration
Gadamide is administered intravenously, usually as a bolus injection.
Side Effect
The most common side effects of Gadamide are nausea, vomiting, headache, and dizziness. Other, more serious side effects include an increased risk of allergic reactions, increased risk of skin reactions or anaphylaxis, and the risk of nephrotoxicity.
Toxicity
Gadamide is generally well tolerated if used at the recommended dose range, but there is a risk of nephrotoxicity with excessive doses. In cases of overdose, supportive measures should be taken and hemodialysis may be necessary.
Precaution
It is important to tell your doctor about any allergies and medical conditions before taking Gadamide. Additionally, it is important to tell your doctor about any medications or supplements that you are taking, including over-the-counter medications.
Interaction
Gadamide may interact with other medications, including anticoagulants, diuretics, and other contrast agents. It is important to tell your doctor about all medications being taken before using Gadamide.
Disease Interaction
Gadamide should be used with caution in patients with renal impairment or kidney disease, as there is an increased risk of nephrotoxicity. It should also be used with caution in elderly patients, as there is an increased risk of adverse effects.
Drug Interaction
Gadamide may interact with other medications, including anticoagulants, diuretics, and other contrast agents. When taking medications concomitantly with Gadamide, it is important to tell your doctor about all medications being taken beforehand.
Food Interactions
Gadamide is not known to interact with food.
Pregnancy Use
Gadamide should be avoided in pregnant women unless the potential benefit outweighs the risk. Animal studies have not demonstrated any risk of fetal harm, but there are no adequate studies in pregnant women.
Lactation Use
Gadamide is not recommended for use in breastfeeding women. Animal studies have not demonstrated any risk of harms to the nursing infant, but there are no adequate studies in breastfeeding women.
Acute Overdose
The symptoms of Gadamide overdose can include nausea, vomiting, abdominal pain, hematemesis, low blood pressure, and renal failure. Treatment for an overdose typically involves supportive care and hemodialysis.
Contraindications
Gadamide should not be used in patients with known hypersensitivity to the drug, or in patients with renal failure or severe renal impairment.
Use Direction
Gadamide should be administered as an intravenous bolus injection as directed by the physician. Care should be taken to ensure that the dose and rate are correct.
Storage Condition
Gadamide should be stored at room temperature away from light and moisture. It should be disposed of according to manufacturer directions or local regulations.
Volume of Distribution
The volume of distribution of Gadamide is 0.64 L/kg.
Half Life
The half-life of Gadamide is 0.5 to 1.5 hours.
Clearance
The clearance of Gadamide is 0.11 L/h/kg.
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