Exjade
Exjade Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Exjade is a brand name. Its generic name is Deferasirox.
Exjade Introduction
Exjade (Exjade) is an oral iron chelator developed and marketed by Novartis. It is used to reduce the amount of iron in the body, specifically in those with chronic iron overload due to regular red blood cell transfusions. It acts by removing excess iron from the body, preventing further tissue damage caused by iron accumulation, which can lead to organ damage and death.Exjade Uses
Exjade is used to treat chronic iron overload in adults and children 6 years of age and older who have received frequent blood transfusions to treat certain types of anemia (low red blood cell count). It is also used to treat elevated levels of iron in the blood caused by blood transfusions or by taking medications that contain iron or vitamin A.Exjade Mechanism of Action
Exjade works by binding to iron and forming a compound that can be eliminated through the urine. The drug is rapidly absorbed from the GI tract and enters the circulatory system, where it is distributed to various organs. Once in the organs, the drug binds to iron and forms a complex that can be eliminated through the urine.How Long Does It Take to Work?
Exjade takes effect in 4 to 6 weeks after beginning the drug. It may take several months or longer before the full benefits of the drug are experienced.Exjade Absorption
Exjade is well absorbed from the GI tract after oral administration. It has a bioavailability of about 75%.Exjade Route of Elimination
The drug is excreted from the body primarily in the urine. Some of the drug is excreted in the feces as well.Exjade Dosage
The recommended starting dose of Exjade is 10 mg per kg of body weight once daily. The dose may be increased as needed based on the patient’s response and tolerability of the drug. The maximum recommended dose is 30 mg per kg of body weight per day.Exjade Administration
Exjade tablets should be taken whole and not crushed or chewed. The tablets should be taken with a full glass of water. tablets should be taken at the same time each day.Exjade Side Effects
Common side effects of Exjade include headache, dizziness, nausea, vomiting, diarrhea, rash, and itching.Exjade Toxicity
Exjade is generally well tolerated at the recommended doses. At higher doses, the drug may cause serious side effects, including liver and kidney damage, abnormal heart rhythms, and allergic reactions.Exjade Precaution
Patients taking Exjade should be closely monitored for signs of liver and kidney damage. Patients should also be monitored for signs of anemia. Patients should be advised to take the medication as prescribed and to not exceed the recommended dose.Exjade Interaction
Exjade may interact with other medications including anticoagulants, anithyroid medications, and medications used to treat cancer.Exjade Disease Interaction
Exjade should not be used in patients with certain conditions, such as anemia, hypoproteinemia, and low white blood cell counts. The drug can also lower the blood supply to the kidney or liver, which can increase the risk for developing life-threatening infections.Exjade Drug Interaction
Exjade may interact with other medications including anticoagulants, anithyroid medications, and medications used to treat cancer. Patients should tell their healthcare provider about all the medications and supplements they are taking.Exjade Food Interactions
Food does not appear to significantly affect the absorption or effectiveness of Exjade when taken with or without food.Exjade Pregnancy Use
Exjade should not be used during pregnancy unless the benefits outweigh the risks. It is not known if deferasirox passes into breast milk.Exjade Lactation Use
It is not known if deferasirox passes into breast milk. Exjade should not be used during lactation unless the benefits outweigh the risks.Exjade Acute Overdose
Symptoms of an acute overdose may include nausea, vomiting, dizziness, and abdominal pain. Treatment of an overdose may include supportive care, including observation, and symptomatic management.Exjade Contraindication
Exjade should not be used in patients with severe kidney or liver dysfunction or in those with an allergy or hypersensitivity to the drug or any of its components.Exjade Use Directions
Exjade should be taken as directed by the healthcare provider. The tablets should be taken whole and not crushed or chewed, and with a full glass of water. The tablets should be taken at the same time every day.Exjade Storage Condition
Exjade tablets should be stored at room temperature and away from moisture and light.Exjade Volume of Distribution
The volume of distribution for deferasirox is approximately 10 liters.Exjade Half Life
The half-life of deferasirox is approximately 17 hours.Exjade Clearance
The clearance of deferasirox is approximately 42 mL/min.Here you find in details version of Exjade
Some Frequently Asked Questions About Exjade
What is Exjade?
Exjade is a prescription drug used for the treatment of chronic iron overload resulting from regular transfusions in people with thalassemia. It works by binding to iron so that it can be removed from the body through the urine.
How should Exjade be taken?
Exjade should be taken exactly as prescribed by your doctor. It is typically taken in tablet form once or twice a day with food. Follow all instructions on your prescription label.
What are the possible side effects of Exjade?
Common side effects of Exjade include nausea, vomiting, diarrhea, headache, dizziness, stomach pain, and rash. In rare cases, more serious side effects may occur, such as liver damage, decreased white blood cell count, and kidney failure.
What should I do if I miss a dose of Exjade?
If you miss a dose of Exjade, take it as soon as you remember. Do not take two doses at the same time. Contact your doctor or pharmacist for advice.
Are there any drug interactions I should be aware of?
Exjade may interact with other medications, such as certain antibiotics, antacids, anticoagulants, and anticonvulsants. Be sure to tell your doctor about all medications you are taking before starting treatment with Exjade.
What should I do if I experience side effects from Exjade?
If you experience side effects from Exjade, contact your doctor or pharmacist right away. They may be able to change your dose or recommend a different medication.
Is there a generic version of Exjade available?
No, there is currently no generic version of Exjade available.
What is the usual dose of Exjade?
The usual dose of Exjade is 10-20 mg/kg body weight, taken once or twice a day with food. The exact dose depends on the individual and their condition, and should be determined by a doctor.
Do I need frequent blood tests when taking Exjade?
Yes, it is important to have periodic blood tests while taking Exjade, as it can cause changes in liver, kidney, and blood cell functions. These tests will help your doctor monitor your condition and make sure the drug is working properly.
Is there an age restriction for taking Exjade?
Yes, Exjade is not recommended for use in children under 6 years of age. Always follow your doctor's instructions and advice when it comes to taking medications.
What should I do if I get pregnant while taking Exjade?
If you become pregnant while taking Exjade, contact your doctor immediately. Exjade has not been studied in pregnant women, and there is not enough information to know if it could cause harm to a developing fetus.
What is the best way to store Exjade?
Exjade tablets should be stored at room temperature away from light, moisture, and heat. Tablets should also be kept out of reach of children and pets.
What should I do if I overdose on Exjade?
If you suspect an overdose, contact a poison control center right away. You can also call your local emergency services, if necessary. It is important to always keep Exjade tablets out of the reach of children and pets.
Does Exjade have any interactions with alcohol?
It is not known if Exjade interacts with alcohol, so it is best to avoid alcohol while taking it. Always talk to your doctor about any risks associated with drinking alcohol while taking medications.
What are the warnings and precautions with Exjade?
Common warnings and precautions with Exjade include close monitoring of liver and kidney function, avoiding activities that could increase the risk of injury or bleeding, and avoiding alcohol and other drugs that can interact with the medication. Contact your doctor for more information.
Is there a drug class for Exjade?
Yes, Exjade belongs to a drug class called iron chelators. Iron chelators work by binding to excess iron in the body, allowing it to be eliminated through the urine.
Are there any other drugs that work in a similar way to Exjade?
Yes, other drugs that work in a similar way to Exjade include Deferiprone and Exjade (deferasirox). These drugs are also iron chelators and are used to treat chronic iron overload.
What is the most important information I should know about Exjade?
The most important information to know about Exjade is that it may cause serious side effects, including liver and kidney damage, decreased white blood cell count, and an increased risk of infection. Contact your doctor right away if you experience any unusual symptoms while taking this medication.
What should I do if I have forgotten to take my Exjade dose?
If you have forgotten to take your Exjade dose, take it as soon as you remember. Do not take two doses at the same time. Contact your doctor or pharmacist for advice.
Are there any certain foods or drinks that should be avoided when taking Exjade?
Specific foods and drinks should be avoided when taking Exjade, including alcohol and grapefruit juice. Iron supplements and dairy products should also be avoided. Always talk to your doctor about specific dietary restrictions while taking Exjade.
What is the overall success rate of treatment with Exjade?
The overall success rate of treatment with Exjade is generally good, as it is effective at reducing and controlling iron overload. However, treatment success will depend on the individual and should always be discussed with a doctor.
Are there any patient assistance programs available for Exjade?
Yes, there are patient assistance programs available for Exjade. These programs provide financial assistance to those who cannot afford the cost of the prescription. Eligibility for the programs varies, so contact your doctor or pharmacist for more information.
Can Exjade be taken with other medications?
Exjade can interact with other medications. Be sure to tell your doctor about all medications you are taking before starting treatment with Exjade. Your doctor can determine the best course of treatment for you.
What kind of laboratory tests should be done while taking Exjade?
While taking Exjade, it is important to have periodic blood tests to monitor liver, kidney, and blood cell functions. Tests can also check for anemia, high levels of iron, and electrolyte balances. It is important to follow your doctor’s instructions for all laboratory tests.
Is it safe to take Exjade long-term?
Exjade is generally safe to take long-term, but it is important to follow your doctor’s instructions about taking the medication. Long-term use may increase your risk of developing serious side effects, so talk to your doctor regularly.
What happens if I stop taking Exjade suddenly?
It is not recommended to stop taking Exjade suddenly, as this may lead to an increase in iron levels. If you wish to stop taking the medication, talk to your doctor first. They will help you decrease your dosage slowly.
Does Exjade have any drug-drug or food-drug interactions?
Exjade may have drug-drug or food-drug interactions with other medications, such as certain antibiotics, antacids, anticoagulants, and anticonvulsants. Be sure to tell your doctor about all medications and supplements you are taking before starting treatment with Exjade.
Is it safe to use Exjade in combination with other medications?
Exjade can be used in combination with other medications, but it is important to tell your doctor about all medications and supplements you are taking before starting treatment. Your doctor can determine if it is safe and effective to take Exjade with other medications.
Should I be careful when taking Exjade with certain types of food?
Yes, certain types of food should be avoided while taking Exjade, including alcohol, dairy products, and iron supplements. Always talk to your doctor about specific dietary restrictions while taking Exjade.
What should I do if I develop a rash while taking Exjade?
If you develop a rash while taking Exjade, contact your doctor right away. They may recommend a different medication or recommend changing your dose. Be sure to talk to your doctor if you experience any side effects while taking Exjade.
What is the best time of day to take Exjade?
Exjade should be taken exactly as prescribed by your doctor. It is typically taken in tablet form once or twice a day with food. Follow all instructions on your prescription label and talk to your doctor if you have any questions.
Is there a difference between the liquid and tablet forms of Exjade?
Yes, there is a difference between the liquid and tablet forms of Exjade. The liquid form must be taken with food, while the tablet form can be taken with or without food. Talk to your doctor to determine which form is right for you.
Can Exjade be taken with food?
Yes, Exjade can be taken with food. It is typically taken in tablet form once or twice a day with food. The liquid form of Exjade must be taken with food. Follow all instructions on your prescription label.
Can the dose of Exjade be changed?
Yes, the dose of Exjade can be changed. The exact dose depends on the individual and their condition, and should be determined by a doctor. Do not change your dose without talking to your doctor first.
Are there any lifestyle changes I should make while taking Exjade?
Yes, it is important to make certain lifestyle changes while taking Exjade. These changes include avoiding activities that could increase the risk of injury or bleeding, avoiding alcohol and other drugs that can interact with the medication, and following a healthy diet and exercise plan. Talk to your doctor for more information.
What should I do if I experience nausea or vomiting when taking Exjade?
If you experience nausea or vomiting when taking Exjade, contact your doctor right away. They may recommend different medications or recommend changing your dose. Be sure to talk to your doctor if you experience any side effects while taking Exjade.
Does Exjade have any interactions with over-the-counter medications or supplements?
Exjade may interact with over-the-counter medications and supplements. Be sure to tell your doctor about any medications or supplements you are taking before starting treatment with Exjade. Your doctor can determine if it is safe and effective to take Exjade with other medications.
What should I do if I experience kidney or liver problems while taking Exjade?
If you experience kidney or liver problems while taking Exjade, contact your doctor right away. You may need to have your dose adjusted or stop taking the medication. Be sure to talk to your doctor if you experience any side effects while taking Exjade.