Entralin

Entralin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Entralin is a brand name. Its generic name is Meropenem.

Introduction

Entralin is an antibiotic prescribed to treat serious, usually bacterial, infections. It works by stopping the growth of harmful bacteria in the body. It belongs to a class of antibiotics called carbapenem antibiotics, and it is often used to treat infections in people with reduced immunity, such as those with cancer, HIV, or other immunosuppressive diseases.

Uses for

Entralin is used to treat many types of bacterial infections, including skin infections, urinary tract infections, and blood infections. It is also used to prevent infections related to surgery, and to treat certain serious illnesses caused by bacteria, such as bacterial meningitis. Entralin is used in both adults and children.

Mechanism of Action

Entralin works by interfering with the cell wall synthesis of the bacteria. It binds to certain penicillin-binding proteins in the bacteria, weakening the cell wall and leading to the death of the bacteria. Entralin is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacterial species.

How Long Does It Take to Work?

Entralin begins to work within two to four hours of taking the first dose. The full effect may not be seen for up to 24 hours, depending on the severity of the infection.

Absorption

Entralin is rapidly and completely absorbed after oral administration. The absorption is not affected by food.

Route of Elimination

Entralin is eliminated mainly by the kidney and is excreted unchanged in the urine. Small amounts of the drug may also be eliminated in the feces.

Dosage

The recommended dose of Entralin is 500 mg to 2 g given intravenously every eight hours for seven to 14 days, depending on the type and severity of the infection. The total daily dose should not exceed 8 g per day. The dose should be adjusted for people with reduced kidney function.

Administration

Entralin must be administered intravenously. It is available in powder form and must be reconstituted with sterile water before administration. The reconstituted solution must then be further diluted in 100 ml of compatible infusion fluid and administered over 15 to 30 minutes.

Side Effects

Common side effects associated with Entralin include nausea, vomiting, headache, diarrhoea, abdominal pain, and rash. Serious side effects, such as allergic reactions, kidney damage, or seizures, may occur in some cases.

Toxicity

Entralin has been associated with kidney damage at high doses. The risk of kidney damage increases with higher doses and longer treatment courses. People taking Entralin should be monitored for signs of kidney damage such as decreased urine output, worsening kidney function tests, or high levels of creatinine.

Precautions

Entralin should be used with caution in people with kidney disease or poor kidney function, as well as those with a history of allergies or seizures. People with a high risk of infection or taking other medications that may interact with Entralin should also be monitored closely.

Interaction

Entralin may interact with other medications, such as diuretics, anticoagulants, antibiotics, and HIV medications. Entralin should not be taken together with methotrexate or probenecid. It is important to speak to a healthcare provider before taking Entralin if taking any other medication.

Disease Interaction

Entralin should be used with caution in people with kidney disease, liver disease, a history of seizures, or any other serious medical condition. Patients with any of these conditions should be closely monitored while taking Entralin.

Drug Interaction

Entralin may interact with other medications, such as diuretics, anticoagulants, antibiotics, and HIV medications. Entralin should not be taken together with methotrexate or probenecid. It is important to speak to a healthcare provider before taking Entralin if taking any other medication.

Food Interactions

Entralin is not affected by food or milk. It can be taken with or without meals.

Pregnancy Use

Entralin is not recommended during pregnancy due to the potential risk of harm to the developing fetus. Women who are pregnant or planning to become pregnant should speak to their healthcare provider before taking the drug.

Lactation Use

Entralin is not recommended for use while breastfeeding due to the potential risk of harm to the infant.

Acute Overdose

An acute overdose of Entralin is not common and is unlikely to cause serious side effects. If an overdose is suspected, it is important to seek medical attention immediately.

Contraindication

Entralin is not recommended for use in people with a known allergy to carbapenems. It is also not recommended for people with severe liver disease.

Use Direction

Entralin should be taken exactly as prescribed by your healthcare professional. Do not take more or less than the prescribed dose or take it for longer or shorter than recommended.

Storage Condition

Entralin should be stored at room temperature away from moisture and heat. Keep it in a tightly sealed container. Do not store it in the bathroom.

Volume of Distribution

The volume of distribution of Entralin is about 0.9 L/kg.

Half Life

The half-life of Entralin is 1.6 to 2.3 hours.

Clearance

The clearance of Entralin is 0.7 to 1.2 L/h/kg.

Here you find in details version of Entralin

Some Frequently Asked Questions About Entralin

What is Entralin?

Entralin is an antibiotic medicine used to treat a variety of bacterial infections. It belongs to a class of drugs called carbapenems. Entralin works by interfering with the production of the bacteria’s cell wall, which results in the death of the bacteria.

What infections can Entralin treat?

Entralin is used to treat a range of infections including pneumonia, meningitis, skin infections and urinary tract infections.

Who can take Entralin?

Entralin is approved for use in adults, and in children 3 months and older.

How do I take Entralin?

Entralin is usually given as an injection into a vein or as an infusion over a period of time. It is important to follow your doctor’s instructions regarding the dosage, frequency, and route of administration.

Are there any side effects to taking Entralin?

Common side effects include diarrhea, nausea, vomiting, and rash. Those can be treated with medications, and symptoms usually go away on their own after treatment is stopped. Serious side effects such as severe allergic reaction or blood disorders are rare, but they can occur in some patients. Talk to your doctor about the risks of taking Entralin.

Does Entralin interact with other medications?

Yes, Entralin can interact with other medications, including over-the-counter drugs, vitamins, and herbal supplements. Be sure to tell your doctor about all the medications and supplements you are taking before starting Entralin.

What are the possible risks of taking Entralin?

Entralin can cause serious side effects, such as an increased risk of Clostridium difficile infection, decreased white blood cell counts, seizures, and allergic reactions. Talk to your doctor about the risks associated with taking Entralin.

How long should I take Entralin?

It is important to take Entralin for the entire duration of your treatment, even if you are feeling better. Do not stop taking it without talking to your doctor first.

Is Entralin safe for pregnant and breastfeeding women?

Entralin should not be used by pregnant or breastfeeding women unless the benefit outweighs the risks. Talk to your doctor about the risks associated with taking Entralin if you are pregnant or breastfeeding.

What should I do if I miss a dose of Entralin?

If you miss a dose of Entralin, contact your doctor or pharmacist right away for further instructions. Do not take a double dose to make up for a missed dose.

Can I drink alcohol while taking Entralin?

It is not recommended to drink alcohol while taking Entralin, as it can increase the risk of side effects from the medication.

Is Entralin available over-the-counter?

No, Entralin is a prescription medication and is not available over-the-counter.

Can I take Entralin with food?

Yes, you can take Entralin with food. It is recommended to take it with food or a snack.

Can Entralin be used to treat infections caused by viruses?

No, Entralin is not effective against viral infections. It is only used to treat bacterial infections.

Do I need to finish the entire course of Entralin to be cured?

Yes, it is important to finish the entire course of Entralin to ensure that the infection is cured. Do not stop taking Entralin without talking to your doctor first.

What should I do if I experience a severe side effect while taking Entralin?

If you experience a severe side effect such as rash, difficulty breathing, or hives while taking Entralin, seek medical attention right away.

What should I do if I experience a diarrhea while taking Entralin?

If you experience diarrhea while taking Entralin, contact your doctor right away. Do not take any over-the-counter medications to treat the diarrhea without your doctor’s approval.

Will Entralin affect my laboratory test results?

Entralin may interfere with laboratory tests, including complete blood cell count (CBC) tests and platelet count tests. Talk to your doctor or laboratory personnel about any possible interference.

Are there any alternatives to Entralin?

Yes, there are other antibiotics that can be used to treat bacterial infections. Talk to your doctor about the best treatment option for your specific condition.

Does Entralin have any drug interactions?

Yes, Entralin can interact with other medications, including over-the-counter drugs, vitamins, and herbal supplements. Be sure to tell your doctor about all the medications and supplements you are taking before starting a course of Entralin.

What should I do if I overdose on Entralin?

If you think you may have overdosed on Entralin, seek medical attention immediately. Signs of an overdose include a rapid and/or irregular heartbeat, hallucinations, decreased urination, and seizures.

Does Entralin have potential side effects in children?

Yes, Entralin can have side effects in children. Common side effects include diarrhea, nausea, vomiting, and rash. If your child experiences any of these side effects, contact your doctor right away.

Is Entralin a sulfa drug?

No, Entralin is not a sulfa drug. It is a carbapenem antibiotic.

Can I take Entralin with ibuprofen?

Yes, you can take Entralin with ibuprofen. However, it is important to talk to your doctor about the potential risks and side effects associated with taking both medications before starting a course of Entralin.

What is the difference between Entralin and other antibiotics?

Entralin is a carbapenem antibiotic. Many other antibiotics belong to different drug classes, such as penicillins, cephalosporins, or quinolones. These medications work differently and may not work as well or as quickly as Entralin for certain infections.

Can Entralin be used to treat a sinus infection?

Yes, Entralin can be used to treat a sinus infection, but it is best to talk to your doctor about the specific strain of bacteria causing the infection first.

Can I take antacids with Entralin?

It is generally safe to take antacids with Entralin, but it is best to consult your doctor first before taking any medications with Entralin.

Can I take Entralin if I have kidney problems?

Yes, but people with kidney problems need to talk to their doctor about the potential risks and side effects of taking Entralin. Your doctor may need to adjust the dosage and frequency of administration for best results.

Should I avoid certain foods while taking Entralin?

No, there are no foods that should be avoided while taking Entralin. However, it is best to talk to your doctor before eating any foods that may interact with Entralin.

What are the storage requirements for Entralin?

Entralin should be stored away from light and moisture. It should be stored at room temperature, and protect from freezing. Do not store Entralin in the refrigerator.

Is Entralin safe for use in pets?

Entralin is not approved for use in pets, and is not recommended for use in cats or dogs. Talk to your veterinarian about the best medication for your pet.

Can Entralin cause an upset stomach?

Yes, some people may experience an upset stomach while taking Entralin. Talk to your doctor if this occurs as this may be a sign of an underlying condition.

Should I take Entralin with food or without food?

It is recommended to take Entralin with food or a snack. Doing so may help to reduce the chance of an upset stomach and other side effects.

Does Entralin contain a sulfa drug?

No, Entralin does not contain a sulfa drug. It is a carbapenem antibiotic.

How quickly does Entralin work?

The effects of Entralin can vary from person to person. Some people may experience relief of symptoms within a few days, while others may need to continue taking Entralin for a few weeks or longer.

What should I do if I experience an allergic reaction to Entralin?

If you experience any symptoms of an allergic reaction, such as hives, difficulty breathing, or swelling, seek medical attention right away. Do not stop taking Entralin without first talking to your doctor.

Does Entralin have any interactions with other medications?

Yes, Entralin can interact with other medications. Be sure to tell your doctor about all the medications and supplements you are taking before starting a course of Entralin.

Can I take Entralin if I am allergic to penicillin?

Yes, Entralin is safe to take if you are allergic to penicillin. However, it is important to tell your doctor about your allergy before taking Entralin.

Can Entralin make birth control pills less effective?

Yes, Entralin can potentially make birth control pills less effective. Talk to your doctor about the risks associated with taking Entralin if you are taking birth control pills.

Should I take Entralin if I am sick with the flu?

No, Entralin is not effective against the flu, as it is only used to treat bacterial infections. Talk to your doctor about the best treatment for your condition.

Can Entralin cause stomach cramps?

Yes, some people may experience stomach cramps while taking Entralin. Talk to your doctor if this occurs, as this may be a sign of an underlying condition.

What is the recommended dosage for Entralin?

The recommended dosage for Entralin varies depending on the type and severity of the infection. It is important to follow your doctor’s instructions regarding the dosage, frequency, and route of administration.