Endotel
Endotel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Endotel is a brand name. Its generic name is Lynestrenol.
Introduction
Endotel (INN, USAN, BANM) (brand names Estranor, Lutenyl, Norpregnyl, Primogynon, Primogynyl, Primulut, Primuluton) is a progestin used as an oral contraceptive and in menopausal hormone therapy. It was introduced by Organon in 1965 and has been widely used since then.
Uses for
Endotel is used as a combined oral contraceptive and is also used for the treatment of menopausal symptoms and some forms of endometriosis.
Mechanism of Action
Endotel works by inhibiting the gonadotropic hormones released by the pituitary gland and blocking ovulation. It also thickens the cervical mucus, which prevents sperm from entering the uterus.
How Long Does It Take To Work?
The effects of Endotel are usually seen within the first month of taking the pill. It controls the menstrual cycle and prevents ovulation.
Absorption
Endotel is rapidly and completely absorbed from the gastrointestinal tract after oral administration.
Route of Elimination
Endotel is eliminated mainly via the biliary and urinary routes. A small amount is excreted via the feces.
Dosage and Administration
Endotel is available as a 0.3 mg oral tablet. It is typically taken once daily on the same day each day, with food or milk to reduce the risk of stomach upset. It should be taken at the same time each day to ensure effective contraception.
Side Effects
Common side effects of Endotel include nausea, breast tenderness, headaches, skin rash, alterations in the menstrual cycle, depression, and some weight gain.
Toxicity
Endotel has not been found to be toxic in animal studies at high doses.
Precautions
Endotel should not be used by women with a history of stroke or blood clots, liver disease, or any history of breast cancer. It also should not be used if you are pregnant or breastfeeding.
Interactions
Endotel interacts with some drugs, such as the anticonvulsants phenobarbital and phenytoin and may reduce the effectiveness of some oral contraceptives.
Disease Interaction
Endotel should be used with caution in patients with a history of stroke, hypertension, diabetes, heart disease, or liver disease.
Drug Interaction
Endotel may interact with some drugs, such as anticonvulsants, antibiotics, and antifungals. It may also interact with some herbal supplements and birth control pills.
Food Interactions
Endotel should be taken with food or milk to reduce the risk of stomach upset. Grapefruit juice should be avoided, as it may increase the levels of Endotel in the body.
Pregnancy Use
Endotel should not be used during pregnancy, as it can cause harm to a developing fetus.
Lactation Use
Endotel should not be used while breastfeeding, as it can pass into breast milk.
Acute Overdose
Symptoms of an acute overdose include nausea, vomiting, irregular menstruation, and breast tenderness.
Contraindication
Endotel should not be used in women who are pregnant, breastfeeding, have a history of stroke or blood clots, liver disease, or any history of breast cancer.
Use Direction
The recommended dose for Endotel is 0.3 mg once daily, with food or milk to reduce the risk of stomach upset. It should be taken at the same time each day, as directed by your doctor, to ensure effective contraception.
Storage Conditions
Endotel should be stored at room temperature, away from heat and moisture, and in a tightly closed container.
Volume of Distribution
The volume of distribution of Endotel is 0.89 L/kg.
Half Life
The half life of Endotel is 7-8 hours.
Clearance
The clearance of Endotel is 1.8 L/h/kg.
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