Nestril
Nestril Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nestril is a brand name. Its generic name is Lynestrenol.
Introduction
Nestril (INN, USAN, BANM) (brand names Estranor, Lutenyl, Norpregnyl, Primogynon, Primogynyl, Primulut, Primuluton) is a progestin used as an oral contraceptive and in menopausal hormone therapy. It was introduced by Organon in 1965 and has been widely used since then.
Uses for
Nestril is used as a combined oral contraceptive and is also used for the treatment of menopausal symptoms and some forms of endometriosis.
Mechanism of Action
Nestril works by inhibiting the gonadotropic hormones released by the pituitary gland and blocking ovulation. It also thickens the cervical mucus, which prevents sperm from entering the uterus.
How Long Does It Take To Work?
The effects of Nestril are usually seen within the first month of taking the pill. It controls the menstrual cycle and prevents ovulation.
Absorption
Nestril is rapidly and completely absorbed from the gastrointestinal tract after oral administration.
Route of Elimination
Nestril is eliminated mainly via the biliary and urinary routes. A small amount is excreted via the feces.
Dosage and Administration
Nestril is available as a 0.3 mg oral tablet. It is typically taken once daily on the same day each day, with food or milk to reduce the risk of stomach upset. It should be taken at the same time each day to ensure effective contraception.
Side Effects
Common side effects of Nestril include nausea, breast tenderness, headaches, skin rash, alterations in the menstrual cycle, depression, and some weight gain.
Toxicity
Nestril has not been found to be toxic in animal studies at high doses.
Precautions
Nestril should not be used by women with a history of stroke or blood clots, liver disease, or any history of breast cancer. It also should not be used if you are pregnant or breastfeeding.
Interactions
Nestril interacts with some drugs, such as the anticonvulsants phenobarbital and phenytoin and may reduce the effectiveness of some oral contraceptives.
Disease Interaction
Nestril should be used with caution in patients with a history of stroke, hypertension, diabetes, heart disease, or liver disease.
Drug Interaction
Nestril may interact with some drugs, such as anticonvulsants, antibiotics, and antifungals. It may also interact with some herbal supplements and birth control pills.
Food Interactions
Nestril should be taken with food or milk to reduce the risk of stomach upset. Grapefruit juice should be avoided, as it may increase the levels of Nestril in the body.
Pregnancy Use
Nestril should not be used during pregnancy, as it can cause harm to a developing fetus.
Lactation Use
Nestril should not be used while breastfeeding, as it can pass into breast milk.
Acute Overdose
Symptoms of an acute overdose include nausea, vomiting, irregular menstruation, and breast tenderness.
Contraindication
Nestril should not be used in women who are pregnant, breastfeeding, have a history of stroke or blood clots, liver disease, or any history of breast cancer.
Use Direction
The recommended dose for Nestril is 0.3 mg once daily, with food or milk to reduce the risk of stomach upset. It should be taken at the same time each day, as directed by your doctor, to ensure effective contraception.
Storage Conditions
Nestril should be stored at room temperature, away from heat and moisture, and in a tightly closed container.
Volume of Distribution
The volume of distribution of Nestril is 0.89 L/kg.
Half Life
The half life of Nestril is 7-8 hours.
Clearance
The clearance of Nestril is 1.8 L/h/kg.
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