Enap L Combi
Enap L Combi Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Enap L Combi is a brand name. Its generic name is Enalapril + Lercanidipin.
Enap L Combi: Introduction
Enap L Combi is a fixed-dose combination medication used to treat hypertension (high blood pressure). It is composed of enalapril (an angiotensin-converting enzyme, or ACE, inhibitor) and lercanidipine (a calcium channel blocker). It is a prescription medication, meaning that it can only be legally obtained with a doctor’s approval.Uses for Enap L Combi
Enap L Combi is typically prescribed for the treatment of hypertension (high blood pressure). Enalapril helps to relax the blood vessels, while lercanidipine works to block the flow of calcium into coronary arteries and causes the arteries to relax and widen, which further lowers blood pressure.Mechanism of Action
Enap L Combi works to lower blood pressure by relaxing the blood vessels and blocking the flow of calcium into the coronary arteries. Enalapril works to block the production of the hormone angiotensin II in the body. This hormone constricts blood vessels and temporarily raises blood pressure. Therefore, blocking its production results in relaxed blood vessels and lower blood pressure. Lercanidipine blocks the flow of calcium into coronary arteries and causes these vessels to relax. This further lowers blood pressure.How Long Does it Take to Work?
Enap L Combi can take anywhere from 24-72 hours to take effect and lower blood pressure. It is important to continue taking the medication regularly and as prescribed by your doctor in order to receive the full benefits of the medication.Absorption
Enap L Combie is rapidly absorbed after oral administration. Enalapril is rapidly and almost completely absorbed in the intestine, while lercanidipine is slowly and incompletely absorbed in the intestine.Route of Elimination
Enap L Combie is metabolized by the liver and eliminated from the body through the kidneys.Dosage
The dosage of Enap L Combie is dependent directly on the patient’s individual characteristics, including age, sex, weight, kidney and liver function, and other medical conditions. The usual starting dose for adults is 5 mg enalapril/20 mg lercanidipine once a day. The maximum daily dose should not exceed 10 mg of enalapril/20 mg of lercanidipine per day. Care should be taken when prescribing Enap L Combie to elderly patients or patients with a history of cardiac disease.Administration
Enap L Combie should be taken orally with a glass of water. It should be taken at the same time each day for best results. Patients should talk to their doctor before changing the dosage or stopping the medication.Side Effects
The most common side effects of taking Enap L Combie include dizziness, headache, fatigue, diarrhea, nausea, blurred vision, lightheadedness, and muscle cramps. If any of these symptoms worsen or persist, patients should contact their doctor. Rare side effects may include more serious effects such as chest pain, rash, or difficulty breathing.Toxicity
Enap L Combie is generally well tolerated, but overdose can lead to serious adverse reactions. Symptoms of an overdose may include hypotension, bradycardia, tachycardia, severe nausea, vomiting, and dehydration. If an overdose is suspected, contact a poison control center or seek medical attention immediately.Precautions
Enap L Combie may not be suitable for certain individuals. People with known hypersensitivity to either enalapril or lercanidipine should not take this medication. Women who are pregnant or breastfeeding should also not take this medication. Additionally, people with severe kidney or liver disease and/or certain hereditary forms of angioedema should use caution before taking Enap L Combie.Interactions
Enap L Combie may interact with certain drugs and herbal supplements. Before taking Enap L Combie, patients should inform their doctor about any other medications or supplements they are taking.Disease Interactions
Enap L Combie may interact with certain medical conditions. People who have a history of angioedema, aortic stenosis, or kidney and/or liver disease should talk to their doctor about taking this medication.Drug Interactions
Enap L Combie may interact with certain medications. People taking nonsteroidal anti-inflammatory drugs, potassium supplements, diuretics, or potassium-sparing diuretics should talk to their doctor before taking Enap L Combie.Food Interactions
Dietary changes can affect the effectiveness of Enap L Combie. Patients should eat a low-salt diet while taking this medication.Pregnancy Use
Enap L Combie is not recommended for use by pregnant women. The combination medication may cause harm to the unborn baby if taken during pregnancy.Lactation Use
Enap L Combie is not recommended for use by breastfeeding women. The combination medication may pass into breastmilk and may harm the baby if taken while breastfeeding.Acute Overdose
Overdose of Enap L Combie can be potentially dangerous. Symptoms of an overdose may include hypotension, bradycardia, tachycardia, severe nausea, vomiting, and dehydration. If an overdose is suspected, contact a poison control center or seek medical attention immediately.Contraindication
Enap L Combie is contraindicated in patients with known hypersensitivity to either enalapril or lercanidipine and patients with certain hereditary forms of angioedema.Use Direction
Enap L Combie should be taken orally with a glass of water. It should be taken at the same time each day for best results. Patients should talk to their doctor before changing the dosage or stopping the medication.Storage Condition
Enap L Combie should be stored at room temperature and away from light and moisture. It should not be stored in the bathroom.Volume of Distribution
Enap L Combie has a volume of distribution of approximately 55-78 L.Half Life
Enalapril has a half-life of 5-11 hours, while lercanidipine has a half-life of 17-32 hours.Clearance
Enap L Combie has an average clearance of 31-50 mL/min/1.73 m2.Here you find in details version of Enap L Combi