Eloxib

Eloxib Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Eloxib is a brand name. Its generic name is Celecoxib.

Introduction

Eloxib, also known as Celebrex, is an NSAID medication used to treat various conditions of inflammation and pain. Commonly used to treat arthritis, Eloxib works by inhibiting the enzyme COX-2, reducing inflammation and decreasing pain.

Uses

Eloxib is commonly used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, menstrual pain, and pain caused by inflammation (such as that associated with injuries). It is also used to reduce the number of colorectal polyps in people with familial adenomatous polyposis.

Mechanism of Action

Eloxib works by inhibiting the COX-2 enzyme, which is responsible for the production of several pro-inflammatory mediators in the body. By blocking the action of this enzyme, the amount of these mediators is reduced, leading to decreased inflammation and pain.

How Long Does It Take to Work?

The effects of Eloxib usually begin within 3-4 days of taking the medication. It may take up to two weeks to feel the full effects of the medication.

Absorption

Eloxib is rapidly and extensively absorbed from the gastrointestinal tract after oral administration.

Route of Elimination

Eloxib is eliminated in the feces and urine. About 80% of an administered dose is recovered in feces as unchanged drug, metabolites, and biliary excretion products. About 30% of the drug is eliminated unchanged in the urine.

Dosage

The recommended adult dose for Eloxib is 200-400 mg taken twice daily. The maximum daily dose is 800 mg. Dosage should be adjusted in patients with impaired kidney function.

Administration

Eloxib should be taken with a full glass of water and should be taken on an empty stomach.

Side Effects

Common side effects of Eloxib include nausea, stomach pain, diarrhea, dizziness, constipation, gas, heartburn, drowsiness, headache, and rash. Some serious side effects may include swelling of the face, hands, feet, ankles, stomach pains, chest pain, and difficulty breathing.

Toxicity

Eloxib is generally well tolerated. However, Eloxib can cause serious side effects if taken in high doses and when used for long periods of time. The risk of serious side effects increases with the duration of treatment.

Precautions

Patients taking Eloxib should be aware of the potential risk for stomach ulcers and bleeding. Patients should also be aware of the risk of hypersensitivity reactions and kidney impairment associated with this medication.

Interaction

Eloxib can interact with other medications, including inhibitors of cytochrome P-450 isoenzymes, antibiotics, antifungals, antihypertensives, anticonvulsants, and some corticosteroids. Before using Eloxib, consult your doctor or pharmacist.

Disease Interaction

Patients with heart failure, high blood pressure, blood clotting disorders, or an allergy to NSAIDs should not take Eloxib. Patients with a pre-existing bleeding disorder, bleeding ulcer, or liver disease should use Eloxib with caution.

Drug Interactions

Eloxib may interact with a number of drugs, including warfarin, lithium, methotrexate, ACE inhibitors, and corticosteroids. Consult your doctor or pharmacist for a complete list of drug interactions.

Food Interactions

Alcohol should be avoided while taking Eloxib. Other foods high in fat may increase the rate of absorption of the medication.

Pregnancy Use

Eloxib is contraindicated in pregnant women. Other NSAIDs should be considered in pregnant women to avoid risk.

Lactation Use

Eloxib is contraindicated in breastfeeding women. Other NSAIDs should be considered in breastfeeding women to avoid risk.

Acute Overdose

In case of acute overdose, seek medical attention immediately. Symptoms may include confusion, vomiting, rash, stomach pain, and breathing difficulty.

Contraindication

Eloxib is contraindicated in pregnant women and breastfeeding women. Eloxib is also contraindicated in patients with a history of hypersensitivity reaction to Eloxib or any other NSAID.

Use Direction

Eloxib should be taken as directed by your health care provider. It should be taken with a full glass of water, and should be taken on an empty stomach. Do not exceed the recommended dosage.

Storage Condition

Eloxib should be stored at room temperature away from direct sunlight and heat. Keep out of reach of children.

Volume of Distribution

The average volume of distribution for Eloxib is approximately 17 L/kg.

Half Life

The average half-life of Eloxib is approximately 11 hours.

Clearance

The clearance for Eloxib is approximately 0.4 L/hr/kg.

Here you find in details version of Eloxib

Some Frequently Asked Questions About Eloxib

What is Eloxib?

Eloxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and stiffness caused by arthritis and some other conditions. It is sold under the brand names Celebrex and Celebra.

How does Eloxib work?

Eloxib is an anti-inflammatory drug that works by inhibiting the production of prostaglandins, substances that cause inflammation. This reduction in prostaglandins helps reduce pain and inflammation in patients with arthritis and other conditions.

What is the difference between Eloxib and other NSAIDs?

Eloxib is a newer generation of NSAIDs that are less likely to cause stomach irritation and bleeding. It is also less likely to cause kidney damage than traditional NSAIDs. It is commonly used for the treatment of arthritis and other painful conditions.

What are the side effects of Eloxib?

Common side effects of Eloxib include stomach upset, nausea, diarrhea, headache, and dizziness. Less common but more serious side effects include liver and kidney damage, increased risk of bleeding or stroke, and allergic reactions.

Is Eloxib safe to use long-term?

Eloxib is generally considered safe to use long-term, however it can increase risk of certain side effects such as stomach irritation and an increased risk of stroke or bleeding. Talk to your doctor to make sure Eloxib is right for you.

Can Eloxib be crushed or split in half?

No, Eloxib should not be crushed or split in half. Taking the whole capsule at once is the only safe way to take this medication.

What should be avoided while taking Eloxib?

Alcohol should be avoided while taking Eloxib, as it can increase the risk of stomach bleeding. You should also avoid using other medications including NSAIDs and steroids without talking to your doctor first, as they can increase the risk of side effects.

Is Eloxib safe to use during pregnancy and breastfeeding?

No, Eloxib should not be used during pregnancy or breastfeeding. If you are pregnant or think you might be pregnant, talk to your doctor before taking celecoxib.

Can Eloxib interact with other medications?

Yes, Eloxib can interact with other medications including NSAIDs, steroids, blood thinners, and some antibiotics. Talk to your doctor or pharmacist before starting or changing medications to make sure Eloxib is right for you.

How do you take Eloxib?

Eloxib should be taken exactly as your doctor or healthcare provider has prescribed. Do not take more or less than what is recommended. The usual recommended dose is 200 mg once or twice daily. It should be taken with food to reduce stomach irritation.

What should I do if I miss a dose of Eloxib?

If you miss a dose of Eloxib, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.

How long does it take for Eloxib to start working?

It can take up to a few weeks for Eloxib to start working. If your symptoms do not improve after 4-6 weeks, talk to your doctor, as the dose may need to be adjusted.

Is Eloxib habit forming?

No, Eloxib is not habit forming. However, it is important to take the medication as prescribed and not to stop taking it without talking to your doctor first.

Is Eloxib safe to use in children?

Eloxib is not approved for use in children. Talk to your doctor before giving your child Eloxib.

Can Eloxib cause weight gain?

No, Eloxib does not typically cause weight gain, however some patients taking this medication may experience appetite changes. Talk to your doctor if you experience significant weight gain while taking Eloxib.

Should I take Eloxib with food?

Yes, Eloxib should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Is Eloxib addictive?

No, Eloxib is not an addictive medication. However, it is important to take it as prescribed and not to stop taking it without talking to your doctor first.

Can Eloxib cause liver damage?

Yes, there is a risk of liver damage with long-term use of Eloxib. Your doctor may order regular blood tests to monitor your liver function if you take this medication for an extended period of time.

Can Eloxib be used for pain relief?

Yes, Eloxib is often used to treat pain and inflammation associated with arthritis and other conditions. Talk to your doctor to make sure Eloxib is right for you.

Should Eloxib be taken with other medications?

Eloxib can interact with many other medications. Talk to your doctor or pharmacist before starting or changing medications to make sure Eloxib is right for you.

Does Eloxib interact with birth control?

Yes, there is a potential for Eloxib to interact with birth control pills, leading to an increased risk of side effects. Talk to your doctor about safer alternatives for contraception if you take this medication.

Can Eloxib cause stomach pain?

Yes, some patients taking Eloxib may experience stomach pain. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Can Eloxib cause drowsiness?

Yes, drowsiness is a possible side effect of Eloxib. Talk to your doctor if you experience excessive drowsiness while taking this medication.

Can Eloxib cause erectile dysfunction?

Yes, erectile dysfunction is a possible side effect of Eloxib. Talk to your doctor immediately if you experience any changes in your sexual function while taking this medication.

Can I take Eloxib and ibuprofen together?

No, taking both Eloxib and ibuprofen at the same time can increase your risk of stomach irritation and bleeding. Make sure to tell your doctor if you are already taking any other medications.

Should I take Eloxib with food or on an empty stomach?

Eloxib should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Does Eloxib cause hair loss?

No, hair loss is not a common side effect of Eloxib. Talk to your doctor right away if you experience any changes in your hair while taking this medication.

Can Eloxib cause an allergic reaction?

Yes, allergic reactions to Eloxib are possible. Symptoms of an allergic reaction can include rash, itching, difficulty breathing, and swelling. Contact your doctor immediately if you experience any of these symptoms while taking this medication.

Can Eloxib cause constipation?

Yes, constipation is a possible side effect of Eloxib. If you experience constipation while taking this medication, talk to your doctor about ways to manage it.

Can Eloxib be used to treat fever?

No, Eloxib is not typically used to treat fever. Talk to your doctor about other options for treating fever.

Is Eloxib a blood thinner?

No, Eloxib is not a blood thinner. However, it can increase your risk of bleeding when taken with other blood thinning medications. Talk to your doctor before taking Eloxib with other medications.

Can Eloxib cause nausea?

Yes, nausea is a possible side effect of Eloxib. Talk to your doctor if you experience nausea while taking this medication.

Can Eloxib cause dehydration?

Yes, dehydration is a possible side effect of Eloxib. Make sure to drink plenty of fluids while taking this medication, especially if you are experiencing other symptoms such as nausea, vomiting, and diarrhea.

Can Eloxib cause stomach upset?

Yes, stomach upset is a possible side effect of Eloxib. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

What is the maximum daily dose of Eloxib?

The maximum recommended daily dose of Eloxib is 400 mg. Taking more than this can increase your risk of side effects. Talk to your doctor if you are prescribed a higher dose.

How long can I take Eloxib?

The maximum recommended duration of use of Eloxib is six months. Talk to your doctor if you need to take this medication for longer than this, as it can increase your risk of side effects.

Does Eloxib cause dizziness?

Yes, dizziness is a common side effect of Eloxib. If you experience dizziness while taking this medication, talk to your doctor about ways to manage it.

Should I take Eloxib with food or milk?

Eloxib should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Does Eloxib reduce inflammation?

Yes, Eloxib is an anti-inflammatory drug that helps reduce inflammation by inhibiting the production of prostaglandins. This can reduce pain and inflammation in patients with arthritis and other conditions.

Does Eloxib cause weight gain?

No, weight gain is not typically caused by Eloxib. However, some patients taking this medication may experience appetite changes. Talk to your doctor if you experience significant weight gain while taking Eloxib.

Can Eloxib cause fatigue?

Yes, fatigue is a possible side effect of Eloxib. Talk to your doctor if you experience fatigue while taking this medication.

Can Eloxib cause heartburn?

Yes, heartburn is a possible side effect of Eloxib. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Do I need to have regular blood tests while taking Eloxib?

Your doctor may order regular blood tests to monitor your liver function if you take this medication for an extended period of time. Talk to your doctor about any other tests you may need while using Eloxib.