Efrome

Efrome Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Efrome is a brand name. Its generic name is Cefpirome.

Introduction

Efrome is an intravenous cephalosporin antibiotic used to treat infections caused by certain bacteria. It is commonly prescribed for the treatment of pneumonia, skin and urinary tract infections. Efrome is classified as a fourth-generation cephalosporin and has a broad spectrum of activity against both gram-positive and gram-negative bacteria.

Uses

Efrome is mainly used to treat infections of the lower respiratory tract, skin, and urinary tract caused by bacteria. These infections can include bacterial pneumonia, skin infections, urinary tract infections, and bronchitis. Efrome can also be used to treat certain skin infections caused by staphylococcus aureus and streptococcus pyogenes.

Mechanism of Action

Efrome works by preventing the bacteria from forming their cell wall, which allows for their destruction. By blocking the formation of the cell wall, cefpirome is able to kill the bacteria and stop the infection from spreading. Additionally, cefpirome also prevents the bacteria’s cell components from being released into the surrounding environment, which further helps to reduce the spread of the infection.

How Long Does It Take to Work?

The effects of cefpirome can usually be seen within 24 to 48 hours. However, it can take up to four to seven days for the infection to completely clear up.

Absorption

When administered intravenously, cefpirome is rapidly and almost completely absorbed into the bloodstream. It has a bioavailability of 80-85%.

Route of Elimination

After absorption, cefpirome is metabolized in the liver and excreted in the bile. It is then eliminated primarily through the kidneys in the urine.

Dosage

• For Adults: The recommended dose for cefpirome is 2 to 2.5 grams intravenously every 12 hours for 7–10 days.
• For Children: The recommended dose for cefpirome is 40–50 milligrams per kilogram of body weight, intravenously, every 8–12 hours.

Administration

Efrome should be administered intravenously by a healthcare provider. It can be given as a single injection or as an infusion over 60 minutes. It should not be given by any other route, including intramuscular, subcutaneous, or oral.

Side Effects

Common side effects of cefpirome include nausea, vomiting, diarrhea, abdominal pain, headache, and allergic reactions. Other more serious side effects may occur, including anaphylaxis, seizures, and increased risk of bleeding. If any of these side effects occur, contact your doctor immediately.

Toxicity

Efrome is generally well tolerated and has a low risk of toxicity. However, it can cause adverse reactions such as nausea, vomiting, diarrhea, abdominal pain, and headache.

Precautions

Patients should inform their doctor if they have any allergies or are taking any other medications. Pregnant or breastfeeding women should also inform their doctor before taking cefpirome. Additionally, cefpirome should be used with caution in patients with renal impairment and patients with a history of bleeding.

Interaction

Efrome may interact with certain drugs, including antacids, probenecid, iron supplements, and oral contraceptives. These interactions can alter the efficacy of cefpirome or increase the risk of side effects. To avoid any potential interactions, always let your doctor know what medications or supplements you are taking.

Disease Interaction

Efrome can interact with certain diseases, including diabetes, renal insufficiency, and a bleeding disorder. Patients with these conditions should inform their doctor before taking cefpirome, as it may increase their risk of adverse reactions.

Drug Interaction

Efrome may interact with certain medications, such as antacids, probenecid, iron supplements, and oral contraceptives. These interactions can change the efficacy of cefpirome or increase the risk of side effects. To avoid any potential interactions, always let your doctor know what medications or supplements you are taking.

Food Interactions

Efrome should be taken at least 1 hour before or 2 hours after meals. Taking cefpirome with food can make it less effective or increase the risk of side effects.

Pregnancy Use

The safety of cefpirome during pregnancy has not been established. Pregnant women should use cefpirome with caution, as it may cause harm to the fetus. Breastfeeding women should also use cefpirome with caution.

Lactation Use

Efrome is not recommended for use in lactating women due to the potential for adverse reactions in the infant. The safety of cefpirome during pregnancy has not been established.

Acute Overdose

Acute overdoses of cefpirome can cause nausea, vomiting, and diarrhea. Additionally, high doses of cefpirome may cause kidney damage, which can be reversed with appropriate treatment. If an overdose is suspected, contact your doctor or poison control center immediately.

Contraindication

Efrome is contraindicated in patients with a known hypersensitivity to it or any other cephalosporin, penicillin, or who have had an allergic reaction to another beta-lactam antibiotic.

Use Direction

Efrome should be taken as prescribed by your doctor. Patients should follow their doctor’s instructions carefully and take the medication on time each day. Also, patients should not increase or decrease their dose without consulting a healthcare provider.

Storage Conditions

Efrome should be stored at room temperature, away from direct sunlight and heat. Furthermore, it should be kept in an airtight container and away from moisture.

Volume of Distribution

The volume of distribution of cefpirome is 8-14 liters per kilogram of bodyweight.

Half-life

The elimination half-life of cefpirome is 3-5 hours.

Clearance

The clearance of cefpirome is 5-7 ml/min/kg.

Here you find in details version of Efrome

Some Frequently Asked Questions About Efrome

What is Efrome?

Efrome is a third-generation cephalosporin antibiotic used to treat a variety of bacterial infections. It is used to treat serious infections caused by Gram-positive and Gram-negative bacteria.

What are the uses of Efrome?

Efrome is used to treat a variety of infections caused by both Gram-positive and Gram-negative bacteria. These include infections of the urinary tract, skin and soft tissue, respiratory tract, and bone and joint. Efrome is also used for prophylaxis before caesarean section surgery and may help prevent postoperative infections.

How effective is Efrome?

Efrome is a highly effective antibiotic that is effective against both Gram-positive and Gram-negative bacteria. Studies have shown that Efrome exerts a bactericidal action against many bacterial species and thus works to kill bacteria rather than just inhibit their growth.

Is Efrome safe?

Efrome is generally considered to be a safe antibiotic. Most people who take Efrome do not have any side effects. However, some people may experience nausea, vomiting, or diarrhea. If any of these symptoms occur, contact your doctor immediately.

What is the dosage for Efrome?

The dosage of Efrome varies depending on the severity of infection and the patient’s response to the medication. The usual adult dosage of Efrome is 4g daily, given either as an intravenous or intramuscular injection. The pediatric dosage is 20-30mg/kg/day, given either as an intravenous or intramuscular injection.

What forms does Efrome come in?

Efrome comes in the form of a sterile powder for intramuscular or intravenous injection. It is available in vials containing 4g of Efrome.

Who should not take Efrome?

Efrome is not recommended for patients who are allergic to cephalosporins or are pregnant. Additionally, Efrome should not be used in patients with severe renal impairment.

What if I miss a dose of Efrome?

If you miss a dose of Efrome, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses at once as this could increase the risk of side effects.

What are the side effects of Efrome?

The most common side effects of Efrome include nausea, vomiting, diarrhea, and abdominal discomfort. Less common but more serious side effects may include an allergic reaction and joint pain. If any of these side effects occur, contact your doctor immediately.

Can Efrome cause interactions with other medications?

Yes, Efrome can interact with other medications. It is important to tell your doctor about all medications and supplements you are taking prior to taking Efrome. This will help to prevent a potential interaction and ensure the safety and efficacy of the medication.

Should I take Efrome with food?

No, Efrome should not be taken with food. Taking Efrome with food may reduce the absorption of the medication and may decrease its effectiveness.

How long does Efrome take to work?

The length of time it takes for Efrome to start working varies depending on the type of infection being treated. The medication usually takes 1-2 days to take effect and the full course of treatment is typically 7-14 days.

Can I take other medications while on Efrome?

It is generally recommended to not take additional medications while on Efrome, unless prescribed by your doctor. There is a risk of interactions with other medications while on Efrome, so it is important to check with your doctor first to ensure the safety and effectiveness of the medication.

How long will I need to take Efrome?

The duration of treatment with Efrome depends on the type of infection being treated. Generally, the duration of treatment is 7-14 days; however, it may be longer or shorter depending on the severity of the infection.

Can I drink alcohol while taking Efrome?

It is not recommended to drink alcohol while taking Efrome. Alcohol can increase the risk of side effects or reduce the effectiveness of the medication. It is best to avoid alcohol while taking any antibiotic.

Are there any foods or drinks that I should avoid while taking Efrome?

It is best to avoid anything that could interact with or reduce the effectiveness of Efrome, including dairy products and antacids. It is beneficial to talk to your doctor or pharmacist about potential food interactions prior to starting any antibiotic.

Are there any over the counter medications that I should avoid while taking Efrome?

Yes, there are certain over the counter medications that you should avoid while taking Efrome, such as ibuprofen and naproxen. Additionally, it is important to avoid taking any other antibiotics while on Efrome, as they may interact.

Should I avoid any activities while taking Efrome?

It is important to avoid any activities that could potentially put you at risk for infections while on Efrome, such as swimming or working in a garden. Additionally, avoid contact sports or any activities that could cause injury, as the risk of infection is higher when you are on antibiotics.

Can I still exercise while taking Efrome?

Yes, you can still exercise while taking Efrome. However, it is important to talk to your doctor regarding any strenuous activities prior to beginning any exercise regimen.

Can I still go outside while taking Efrome?

Yes, you can still go outside while taking Efrome as long as you follow the safety precautions to avoid potential infections, such as wearing long sleeves and pants and avoiding contact with people who have had recent infections.

What should I do if I experience an allergic reaction while taking Efrome?

If you experience an allergic reaction while taking Efrome, contact your doctor immediately. An allergic reaction can include hives, difficulty breathing, and swelling of the face. Seek emergency medical attention if the reaction is severe.

Can Efrome be taken with other antibiotics?

No, Efrome should not be taken with any other antibiotic as this could cause interactions. Additionally, Efrome should not be taken with any herbal supplements or over the counter medications as this could also cause potential interactions.

Should I stop taking Efrome if it seems to be making me sick?

If Efrome is making you sick, contact your doctor immediately. Do not stop taking Efrome without talking to your doctor first, as this could decrease the effectiveness of the medication and hinder your recovery.

Can I take Efrome if I have kidney problems?

If you have kidney problems, talk to your doctor before taking Efrome. Your doctor may decide to lower your dosage or choose a different antibiotic to avoid further complications.

Can I take Efrome while pregnant or breastfeeding?

No, Efrome should not be taken by pregnant or breastfeeding women as it is not recommended for use in these populations. If you are pregnant or breastfeeding, talk to your doctor about any medications you may need to take.

Can Efrome be taken with other drugs?

Yes, Efrome can be taken with other drugs, however, it is important to inform your doctor of all medications and supplements you are taking prior to starting Efrome as they may interact. Additionally, certain medications should not be taken with Efrome, such as over the counter medications and herbal supplements.

Can Efrome cause a yeast infection?

Yes, Efrome can potentially cause a yeast infection. It is important to monitor for any signs of a yeast infection while on Efrome, such as vaginal itching, burning, and discharge. If you experience any of these symptoms, contact your doctor immediately.

Should I finish my course of Efrome even if I feel better?

Yes, it is important to finish your full course of Efrome even if you feel better. This will help to ensure that all the bacteria responsible for the infection have been killed and reduce the risk of the infection coming back.

What should I do if I experience pain or redness at the injection site of Efrome?

If you experience pain or redness at the injection site of Efrome, contact your doctor immediately. This may be a sign of an allergic reaction or infection. Your doctor may decide to switch your medication to an oral form or may decide to change the site of injection.

Are there any long-term side effects of taking Efrome?

No, there are no known long-term side effects associated with taking Efrome. However, it is important to monitor for any potential side effects while taking Efrome, such as nausea, vomiting, or diarrhea. If any of these occur, contact your doctor immediately.

Can Efrome be taken with other medications that are prescribed for the same condition?

No, Efrome should not be taken with other medications that are prescribed for the same condition. Taking multiple antibiotics at once increases the risk of interactions and may decrease the effectiveness of both medications.

What are the storage requirements for Efrome?

Efrome should be stored at room temperature and away from moisture and direct sunlight. It should also be kept out of reach of children and pets.

What should I do if I forget to take my dose of Efrome?

If you forget to take a dose of Efrome, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double dose as this could increase the risk of side effects.

Can I stop taking Efrome if I start feeling better?

No, it is important to finish the full course of Efrome, even if you start to feel better. It is possible for the infection to come back if the full course is not taken. Talk to your doctor before stopping Efrome.

Can Efrome cause constipation?

Yes, Efrome can cause constipation as a side effect. If you experience constipation while on Efrome, talk to your doctor about ways to alleviate it, such as increasing your dietary fiber intake or taking a laxative.

Can I take antacids while taking Efrome?

No, antacids should be avoided while taking Efrome as they can reduce the absorption of the medication and decrease the effectiveness of the antibiotic.