Duphapro

Duphapro Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Duphapro is a brand name. Its generic name is Prucalopride.

Duphapro

Duphapro belongs to a group of medications known as selective serotonin receptor agonists. It is used for the treatment of constipation in adults. Duphapro works by increasing the movement of the colon and rectum, thereby making it easier for the patient to pass stools.

Uses for

Duphapro is used for the treatment of constipation, particularly when other constipation medications do not provide relief. It is also useful in patients who have not responded well to other treatments such as laxatives.

Mechanism of Action

Duphapro works by stimulating 5-hydroxytryptamine 4 (5-HT4) receptors in the intestine wall. 5-HT4 receptors are involved in regulating secretory and motor functions of the gut. Stimulation of 5-HT4 receptors leads to the secretion of water and electrolytes, as well as increasing the rate of muscle contractions in the intestine wall, leading to increased passage of stool.

How long does it take to work?

Duphapro usually takes 1-2 days for patients to experience relief from constipation. The effects are expected to be felt within 7-10 days of taking this medication. Higher doses are needed to achieve a greater effect.

Absorption

Duphapro is well absorbed (more than 90%) from the gut. The peak concentration of the medication is reached in 4 to 5 hours.

Route of Elimination

Duphapro is eliminated through the kidneys.

Dosage

For adults the recommended dosage of prucalopride is 1 mg once a day. Dosage can be increased up to 4 mg a day if needed, depending on individual response to the medication. The dosage for children is not yet established.

Administration

Duphapro is available as a tablet and should be taken orally with water. It should be taken with food or immediately after a meal to reduce the potential for GI side effects.

Side Effect

The most common side effects of prucalopride are gastrointestinal upset such as nausea, diarrhoea and abdominal discomfort. Other rarer side effects include headache, dizziness, stomach pain, bloating and flatulence. If any of these symptoms occur, please contact your doctor immediately.

Toxicity

No toxicity has been reported with prucalopride. However, overdose may lead to severe constipation, diarrhoea, dizziness, headache, nausea and vomiting.

Precaution

Duphapro should not be taken by patients who are hypersensitive to it. It is also not suitable for use in pregnant or breastfeeding women, or in young children. People with liver and kidney related diseases should not take this medication. People taking other medications must consult their doctor before taking prucalopride.

Interactions

Duphapro interacts with certain other medications, including antidepressant and opioid formulations, so they should not be taken together. Some vitamins and herbal supplements can also interact with this drug, so consult your doctor before starting them.

Disease Interaction

Duphapro is not suitable for patients with renal impairment or those with severe liver disease. It is also not suitable for those with GI obstruction or perforation.

Drug Interaction

Duphapro may interact with medications such as antidepressants, opioids and certain vitamins and herbal supplements. Patients on these medications must consult their doctor before taking prucalopride.

Food Interactions

Duphapro does not interact with food and can be taken with or without food.

Pregnancy use

Duphapro is not suitable for pregnant or breastfeeding women. Consult your doctor before taking it.

Lactationuse

Duphapro is not suitable for breastfeeding women. Consult your doctor before taking it.

Acute Overdose

An overdose of prucalopride can lead to severe constipation, diarrhoea, dizziness, headache, nausea and vomiting. Seek medical attention immediately if any of these symptoms occur.

Contraindication

Duphapro is not suitable for pregnant or breastfeeding women, people with hypersensitivity to the medication, liver or kidney related diseases, and those with GI obstruction or perforation.

Use Direction

Duphapro should be taken orally with water and with food or immediately after meal. The recommended dosage for adults is 1 mg once a day, which may be increased up to 4 mg a day depending on individual response to the medication.

Storage Condition

Duphapro should be stored at room temperature and protected from light and moisture.

Volume of Distribution

The volume of distribution of prucalopride is approximately 2.2 L/kg.

Half Life

The half life of prucalopride is 8 hours.

Clearance

The clearance of prucalopride is 66.6 mL/min/kg.

Here you find in details version of Duphapro

Some Frequently Asked Questions About Duphapro

What is Duphapro?

Duphapro is a medication used to treat chronic idiopathic constipation (CIC). It works by selectively stimulating certain receptors in the digestive tract, which increases the movement of the gut and speeds up digestion.

How does Duphapro work?

Duphapro selectively stimulates certain receptors in the digestive tract, which increases the movement of the gut and speeds up digestion. It also helps increase the absorption of water, which softens stool and makes it easier to pass.

How is Duphapro taken?

Duphapro is available in tablet and oral suspension forms. The recommended adult dosage is one 2 mg tablet each day taken on an empty stomach, one hour before or two hours after a meal.

What are the side effects of Duphapro?

The most common side effects of Duphapro include headache, nausea, abdominal pain, and diarrhea. Other side effects may include dizziness, sleeping difficulties, constipation, and flatulence.

What should I do if I experience side effects with Duphapro?

If you experience side effects with Duphapro, stop taking the medication and contact your doctor right away. It is important to tell your doctor about any side effects so that they can determine the best course of treatment.

Who should not take Duphapro?

Duphapro should not be taken by people who are allergic to it or any of its ingredients. It should also not be taken by pregnant or breastfeeding women, and it should be used with caution in people with kidney or liver diseases.

What should I tell my doctor before taking Duphapro?

Before taking Duphapro, it is important to tell your doctor about any other medications you may be taking, as well as any allergies you have. Your doctor will also need to know about any medical conditions you may have, such as kidney or liver disease.

Is Duphapro safe for long-term use?

Duphapro is generally considered safe for long-term use. However, it is important to speak to your doctor before continuing to use it for an extended period of time.

What should I do if I miss a dose of Duphapro?

If you miss a dose of Duphapro, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your normal dosing schedule.

Can I take Duphapro with other medications?

Duphapro can interact with some medications, so it is important to tell your doctor about any other medications you are taking. It is also important to speak to your doctor before taking any new medications while taking Duphapro.

What are the precautions associated with taking Duphapro?

Common precautions associated with taking Duphapro include avoiding alcohol and other drugs that cause drowsiness, talking to your doctor about any other medications you may be taking, monitoring your weight, and informing your doctor of any side effects you may be experiencing.

Is there a generic version of Duphapro?

No, there is currently no generic version of Duphapro available. Brand-name versions of the medication are available in most countries.

Can children take Duphapro?

No, Duphapro is not recommended for use in children under the age of 18.

What is the usual dose of Duphapro?

The recommended adult dosage is one 2 mg tablet each day taken on an empty stomach, one hour before or two hours after a meal.

Can I take Duphapro while pregnant?

No, Duphapro should not be taken by pregnant women.

Can I take Duphapro with other digestive medications?

It is important to talk to your doctor before taking Duphapro with other digestive medications. Certain drugs can interact with each other and cause dangerous side effects.

Can I take Duphapro while breastfeeding?

No, Duphapro should not be taken by breastfeeding women.

What foods should I avoid while taking Duphapro?

It is important to avoid foods that can cause constipation such as processed convenience foods, cheese, white flour products, and high-fat foods.

Are there any drug interactions with Duphapro?

Yes, certain drugs such as anticholinergics, opioid drugs, and certain antacids can interact with Duphapro. It is important to tell your doctor about any medications you may be taking before starting Duphapro.

Does Duphapro cause weight gain?

No, Duphapro does not typically cause weight gain.

Does Duphapro work immediately?

No, it may take several weeks for Duphapro to take effect. Some people may experience relief of symptoms within 1-2 weeks, while others may take longer.

What are the potential drug interactions with Duphapro?

Duphapro can interact with certain drugs such as anticholinergics, opioid drugs, and certain antacids. It is important to tell your doctor about any other medications you may be taking before starting Duphapro.

Can I take Duphapro while taking other medications?

Yes, you can take Duphapro with other medications, but it is important to talk to your doctor before taking Duphapro with other drugs. Certain drugs can interact with each other and cause dangerous side effects.

Should I stop taking Duphapro if my symptoms get worse?

Yes, if your symptoms get worse after starting Duphapro, stop taking the medication and contact your doctor right away.

What other medications should I avoid while taking Duphapro?

Certain drugs such as anticholinergics, opioid drugs, and certain antacids can interact with Duphapro. To avoid potential drug interactions, it is important to tell your doctor about any other medications you may be taking before starting Duphapro.

Can I drink alcohol while taking Duphapro?

No, it is recommended to avoid alcohol while taking Duphapro. Alcohol can interact with certain medications and can increase the risk of some side effects.

Can Duphapro be used to treat irritable bowel syndrome?

No, Duphapro is not indicated for the treatment of irritable bowel syndrome.

What other conditions is Duphapro used to treat?

Duphapro is indicated for the treatment of chronic idiopathic constipation (CIC).

How quickly will I see results with Duphapro?

Some people may experience relief of symptoms within 1-2 weeks, while others may take longer to see results. If you do not see improvement within 2-4 weeks, speak to your doctor.

Are there any potential risks associated with taking Duphapro?

The most common risks associated with taking Duphapro include headache, nausea, abdominal pain, and diarrhea. Less common side effects may include dizziness, sleeping difficulties, constipation, and flatulence. If you experience any of these side effects, stop taking the medication and contact your doctor right away.

Should elderly people use Duphapro?

Yes, although elderly people should take caution when using Duphapro. It is important to speak to your doctor before taking any medication while elderly.

What precautions should I take while taking Duphapro?

Common precautions associated with taking Duphapro include avoiding alcohol and other drugs that cause drowsiness, talking to your doctor about any other medications you may be taking, monitoring your weight, and informing your doctor of any side effects you may be experiencing.

Is Duphapro banned in any countries?

No, Duphapro is not banned in any countries. Brand-name versions of the medication are available in most countries.

How long does Duphapro stay in the body?

The half-life of Duphapro is approximately 16 hours, meaning it takes approximately 16 hours for half of the dose of the medication to be eliminated from the body.

What is the difference between Duphapro and other medications for constipation?

Duphapro works by selectively stimulating certain receptors in the digestive tract, which increases the movement of the gut and speeds up digestion. Other medications for constipation, such as laxatives, work by either increasing the movement of the gut or softening stool.

Is there a generic version of Duphapro available?

No, there is currently no generic version of Duphapro available. Brand-name versions of the medication are available in most countries.

Can Duphapro be used to treat conditions other than constipation?

No, Duphapro is not indicated for the treatment of any conditions other than chronic idiopathic constipation (CIC).

Can I become addicted to Duphapro?

No, it is very unlikely that one can become addicted to Duphapro. However, it is important to take the medication as directed by your doctor.

Are there any special instructions for storage of Duphapro?

Duphapro should be stored at room temperature, away from light and moisture. Keep the medication out of the reach of children and pets.