Dofexim

Dofexim Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dofexim is a brand name. Its generic name is Cefpodoxime.

Introduction

Dofexim (also referred to as cefpodoxime proxetil) is an antibiotic used to treat sinus infections, bronchitis, pneumonia, ENT infections, skin infections, and certain urinary tract infections. The drug belongs to a class of antibiotics called cephalosporins and is produced in oral, and intravenous formats.

Uses

Dofexim is used to treat a variety of bacterial infections such as sinusitis, bronchitis, pneumonia, otitis media, cellulitis, urinary tract infections, skin and skin structure infections, and pharyngitis/tonsillitis.

Mechanism of Action

Dofexim works by inhibiting bacterial cell wall synthesis. This leads to an influx of water and causes the cell wall to rupture, thus killing the bacteria. In addition, the drug has some activity against certain types of fungi, viruses and protozoa.

How Long Does It Take to Work

Dofexim usually begins to take effect within 1-2 days of administration. However, it may take up to 5-7 days to experience full relief of symptoms.

Absorption, Route of Elimination, Dosage and Administration

Dofexim is rapidly and almost completely absorbed from the gastrointestinal tract. The drug is eliminated primarily through the kidneys and the excretion rate is slow. The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours. Oral suspension formulations are available in 50 and 100 mg/5 mL strengths.

Side Effects

Common side effects of cefpodoxime include diarrhea, nausea, vomiting, abdominal pain, dizziness, headache, fatigue, rash, and skin sensitivity. Severe side effects include anaphylaxis, kidney damage, and fainting. Dofexim can also cause abnormal liver function test results and thrombocytopenia.

Toxicity

Dofexim is generally well-tolerated. Overdose symptoms include nausea, vomiting, diarrhea, dizziness, rapid heart rate, and rare seizures.

Precautions

Dofexim should be avoided in patients with history of allergy to cephalosporins. The drug should not be used in patients with impaired kidney or liver function. It should also be used with caution in pregnant and breastfeeding women.

Interaction

Dofexim may interact with other medications such as antacids, warfarin, digoxin, probenecid, and certain drugs for HIV/AIDS, etc. Drugs that interact with cefpodoxime include: paroxetine; phenytoin; ritonavir; certain fluoroquinolone antibiotics such as ciprofloxacin, norfloxacin, and ofloxacin; and certain anti-seizure drugs such as phenytoin, valproic acid, and carbamazepine.

Disease Interaction

Dofexim may interact with certain medical conditions such as kidney disease, history of allergic reactions to other cephalosporin antibiotics, and intestinal inflammation due to infection or the use of antibiotics. Dofexim should be used with caution in patients with kidney disease. It should not be used in patients if there is an existing intestine infection or if the patient has recently been taking antibiotics.

Drug Interaction

Drug interactions may occur when cefpodoxime is taken with other medications such as antacids, warfarin, probenecid, and certain HIV drugs. Dofexim should not be used together with drugs like paroxetine, phenytoin, ritonavir, certain fluoroquinolone antibiotics (ciprofloxacin, norfloxacin, ofloxacin), certain anti-seizure drugs (phenytoin, valproic acid, carbamazepine), etc. Patients should inform their physicians of any medications they are currently taking before taking cefpodoxime.

Food Interactions

Dofexim should be taken with a full glass of water. Food can decrease the absorption of cefpodoxime, so the drug should be taken at least 2 hours before or after a meal. Avoid consumption of dairy products, antacids, iron supplements, and vitamins within 2 hours of taking cefpodoxime.

Pregnancy Use

Dofexim is likely safe to use during pregnancy. However, it is best to consult a doctor before taking cefpodoxime during pregnancy.

Lactation Use

Dofexim is not known to be harmful when breastfeeding. However, it is best to consult a doctor before taking cefpodoxime while breastfeeding.

Acute Overdose

Acute overdose of cefpodoxime can result in nausea, dizziness, rapid heart rate, and seizures. Seek medical help if overdose is suspected.

Contraindication

Dofexim is contraindicated in patients with known allergy to cephalosporins.

Dosage Information

The usual adult dosage for oral administration ranges from 200 to 400 mg, taken every 12 hours.

Direction of Use

Dofexim should be taken orally with a full glass of water. It should be taken with or without food. It should not be taken with dairy products, antacids, iron supplements, or vitamins.

Storage Condition

Dofexim should be stored in a tight container, away from light and moisture, at room temperature (15-30°C).

Volume of Distribution

Dofexim has a volume of distribution of 0.3 - 0.5 L/kg.

Half-Life

The average half-life of cefpodoxime is about 2 - 4 hours.

Clearance

The average clearance of cefpodoxime is 50 - 70 mL/min.

Here you find in details version of Dofexim

Some Frequently Asked Questions About Dofexim

What is Dofexim?

Dofexim is an antibiotic used to treat certain types of bacterial infections. It belongs to a class of antibiotics called cephalosporins that work by stopping the growth of bacteria.

What infections does Dofexim treat?

Dofexim is used to treat infections caused by certain bacteria, such as lower respiratory tract infections, otitis media (middle ear infections), skin infections, and urinary tract infections.

How does Dofexim work?

Dofexim works by attacking the bacteria that cause the infection. It works by interfering with the bacteria’s ability to make cell walls, which results in the death of the bacteria.

Who should take Dofexim?

Dofexim should be taken by those who have been prescribed it by a doctor to treat a bacterial infection. It should not be taken by anyone who has an allergy to cephalosporin antibiotics.

How do I take Dofexim?

Dofexim should be taken as directed by your doctor. The dosage and length of treatment will depend on the infection being treated. The tablets should be taken with a full glass of water. If you forget to take a dose, take it as soon as you remember.

What are the possible side effects of taking Dofexim?

Some common side effects of taking Dofexim may include nausea, vomiting, diarrhea, or skin rash. Serious side effects include easy bleeding or bruising, yellowing skin or eyes, chest pain, or difficulty breathing. Tell your doctor if you experience any of these side effects.

What if I am allergic to Dofexim?

If you are allergic to Dofexim or other cephalosporin antibiotics, do not take this drug. Tell your doctor about any allergies that you have before beginning treatment.

Can I take Dofexim with other medications?

Before taking Dofexim, tell your doctor if you are taking any other medications, especially probenecid, sulfamethoxazole, or valproic acid. Some medications may interact with Dofexim, so it is important to discuss them with your doctor before beginning treatment.

Can Dofexim be used to treat a viral infection?

No, Dofexim is not effective for treating viral infections since it only attacks bacterial infections.

What is the recommended dosage for Dofexim?

The recommended dosage of Dofexim depends on the infection being treated and on the patient's age and weight. It is important to follow your doctor's instructions when taking Dofexim.

Can Dofexim be used during pregnancy?

Dofexim is generally considered safe to use during pregnancy, but it is always best to consult your doctor before taking any medication during pregnancy.

Can I miss a dose of Dofexim?

If you miss a dose of Dofexim, take it as soon as possible. However, if it is close to the time for your next dose, skip the missed dose and continue with your normal schedule.

Is Dofexim safe for children?

Yes, Dofexim is safe to use in children. However, it is important to follow your doctor's instructions for dosage and duration of treatment.

Does Dofexim have any interactions with food?

No, Dofexim does not have any known food interactions.

Can I drink alcohol while taking Dofexim?

It is not recommended to drink alcohol while taking Dofexim, as it may increase the chance of side effects.

Does Dofexim cause headaches?

Dofexim can cause headaches as a side effect in some people. If you experience headaches while taking Dofexim, contact your doctor.

How long should I take Dofexim?

Your doctor will determine how long you should take Dofexim. It is important to follow your doctor’s instructions for the duration of treatment.

Can Dofexim affect the liver?

Dofexim can potentially cause liver damage in rare cases. If you notice any symptoms of liver damage, such as yellowing of the skin or eyes, contact your doctor.

What should I do if I develop an allergic reaction to Dofexim?

If you develop an allergic reaction while taking Dofexim, stop taking the medication and contact your doctor immediately.

Is Dofexim available as a generic drug?

Yes, Dofexim is available as a generic drug.

Does Dofexim cause drowsiness?

Dofexim can cause drowsiness as a side effect in some people. If you experience drowsiness while taking Dofexim, contact your doctor.

Can I take Dofexim with other antibiotics?

No, Dofexim should not be taken with other antibiotics since it can lead to increased side effects and altered effectiveness.

Can Dofexim treat sore throats?

No, Dofexim is not effective for treating sore throat caused by viral infections.

Can Dofexim be used to treat bacterial meningitis?

Yes, Dofexim can be used to treat bacterial meningitis.

Can Dofexim be used to treat strep throat?

Yes, Dofexim can be used to treat strep throat.

Is Dofexim available in other forms such as an oral suspension?

Yes, Dofexim is also available as an oral suspension.

Can I take Dofexim for a long period of time?

It is not recommended to take Dofexim for a long period of time, as it can lead to overgrowth of certain bacteria and lead to antibiotic resistance.

Can I take Dofexim with ibuprofen?

Yes, Dofexim can be taken with ibuprofen.

Is it safe to take Dofexim while breastfeeding?

It is not recommended to take Dofexim while breastfeeding because it can pass into breast milk and affect the infant. Contact your doctor before taking Dofexim while breastfeeding.

Can Dofexim be used to treat ear infections?

Yes, Dofexim can be used to treat ear infections.

Can Dofexim treat urinary tract infections?

Yes, Dofexim can be used to treat urinary tract infections.

Is Dofexim safe for people with kidney or liver disease?

People with kidney or liver disease should use Dofexim with caution, as it is broken down by the kidneys and liver. Talk to your doctor before taking Dofexim if you have kidney or liver disease.

Can Dofexim make you tired?

Yes, Dofexim can cause fatigue as a side effect in some people. Talk to your doctor if you experience fatigue while taking Dofexim.

How often do I need to take Dofexim?

You should take Dofexim as directed by your doctor. The frequency of doses will depend on the infection as well as the patient’s age and weight.

What laboratory tests should be done while taking Dofexim?

Your doctor may recommend certain laboratory tests such as a complete blood count, liver function tests, or kidney function tests while taking Dofexim.

Can Dofexim be used in animals such as cats or dogs?

Yes, Dofexim can be used in cats and dogs, but only under the direction of a veterinarian.

What should I do if I miss a dose of Dofexim?

If you miss a dose of Dofexim, take it as soon as possible. If it is close to the time for your next dose, skip the missed dose and continue on your regular schedule.

What can happen if I take an overdose of Dofexim?

If you take an overdose of Dofexim, contact your doctor or local poison control center immediately. Symptoms of an overdose may include nausea, dizziness, or difficulty breathing.

Should I avoid activities that require mental alertness while taking Dofexim?

Yes, it is best to avoid activities that require mental alertness while taking Dofexim because it can cause drowsiness and dizziness as side effects.

Can Dofexim cause nausea and vomiting?

Yes, Dofexim can cause nausea and vomiting as side effects. Talk to your doctor if you experience nausea and vomiting while taking Dofexim.