Diloxide
Diloxide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Diloxide is a brand name. Its generic name is Diloxanide Furoate.
Introduction
Diloxide is an antimicrobials drug used to treat certain parasitic infections. It belongs to the group of medication called anti-gastrointestinal amoebicides which works by killing the microorganisms causing the infection. It is commonly used to treat intestinal infection caused by E. histolytica.Uses for
Diloxide is used to treat intestinal infections caused by Entamoeba histolytica. It can be used in older children and adults, and is most commonly used to treat diarrhea caused by the parasites.Mechanism of action
Diloxide works by killing the microorganisms that cause the infection by blocking the ability of the parasites to make DNA. This prevents them from multiplying and eventually kills them.How long does it take to work?
It typically takes a few days for the medication to be effective. Most people experience complete relief after taking Diloxide for 1-2 weeks.Absorption
Diloxide is absorbed relatively well in the intestine, resulting in a peak plasma concentration after about 4 hours.Route of Elimination
Diloxide is eliminated in urine as furoate or glucuronide metabolites. It undergoes both enterohepatic and renal recirculation and can reach detectable levels in the feces after 1-2 days.Dosage
The usual dose of Diloxide for adults is 500 mg (2 tablets) orally every eight hours for 10 to 14 days. Children aged 12 and above should take 250 mg (one tablet) orally every eight hours for 10 to 14 days.Administration
Diloxide should be taken orally, with or without food.Side Effect
Common side effects of Diloxide include nausea, vomiting, abdominal cramps, diarrhea, rash, and headache. If any of these effects worsen or persist, contact your doctor.Toxicity
Diloxide is generally well tolerated. In rare cases, severe allergic reactions to the medication can occur. In these cases, contact your doctor immediately.Precautions
Before taking Diloxide, inform your doctor if you have any allergies, kidney disease, or any other medical condition. This medication can cause dizziness and drowsiness, so use caution when driving or operating heavy machinery. Avoid drinking alcoholic beverages while taking this medication.Drug Interactions
Diloxide can interact with other medications, specifically antacids, other amoebicides, and certain antibiotics. Avoid taking these medications within 2 hours of taking Diloxide. If you are taking any of these medications, inform your doctor.Food Interactions
Food can affect the absorption of Diloxide; therefore, take the medication with or without food. Avoid taking this medication with high fat meals, which can reduce its effectiveness.Pregnancy Use
Pregnant women should avoid taking Diloxide as it can cause harm to the unborn baby.Lactation Use
This medication is not recommended for use while breastfeeding as it can be excreted in breast milk and may cause harm to the baby.Acute Overdose
Symptoms of an overdose include nausea, vomiting, excessive urination, dizziness, and confusion. If you or someone you know has taken an overdose, seek medical advice immediately.Contraindication
This medication should not be used in patients with an allergy or sensitivity to Diloxide.Use Direction
For best results, it is important to take Diloxide exactly as directed. Take the entire course of medication, even if symptoms improve after a few days. Do not stop taking the medication without consulting your doctor.Storage Condition
It is important to store Diloxide at room temperature, in a cool, dry place. Keep out of reach of children and pets.Volume of Distribution
The volume of distribution of Diloxide is approximately 0.7 L/kg.Half Life
The half-life of Diloxide is approximately 1.9 +/- 0.8 hours.Clearance
Diloxide has a renal clearance rate of approximately 0.9 +/- 0.3 L/hour/kg.Here you find in details version of Diloxide
Some Frequently Asked Questions About Diloxide
https://www.medicinesfaq.com/brand/diloxide,
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http://www.hmdb.ca/metabolites/HMDB0015684,
http://www.genome.jp/dbget-bin/www_bget?drug:D02480,
http://www.genome.jp/dbget-bin/www_bget?cpd:C07637,
https://www.chemspider.com/Chemical-Structure.18400.html,
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=70295,
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=4601,
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1334860,
https://zinc.docking.org/substances/ZINC000000001300,
https://en.wikipedia.org/wiki/Diloxanide,