Dihidroergotamina

Dihidroergotamina Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dihidroergotamina is a brand name. Its generic name is Dihydroergotamine.

Introduction

Dihidroergotamina (DHE) is an ergot alkaloid derivative used in the treatment of acute migraine headache.

Uses

Dihidroergotamina is used to treat acute migraine headaches, and to reduce their frequency and severity.

Mechanism of Action

Dihidroergotamina works by stimulating serotonin and opioid receptors in the brain, thus decreasing the neurotransmitter, serotonin, which reduces the sensation of headaches.

How Long Does it Take to Work?

Dihidroergotamina usually works within 15-45 minutes of administration.

Absorption

Dihidroergotamina is rapidly and well absorbed from the gastrointestinal tract.

Route of Elimination

Dihidroergotamina is eliminated primarily via the urine.

Dosage

The usual recommended dose for treating acute migraine headaches in adults is 1-2 milligrams (mg) per day, taken intramuscularly or via subcutaneous injection. Intravenous doses may range from 0.5-2 mgs per day and intranasal doses may range from 0.5-2 mgs per day.

Administration

Dihidroergotamina can be administered orally or via intramuscular, subcutaneous, intravenous, or intranasal injection.

Side Effects

Common side effects of DHE include nausea and vomiting, dizziness, weakness, drowsiness, muscle cramps, headache, tingling or numbness in the extremities, diarrhea, constipation, abdominal pain, facial flushing, and chest discomfort.

Toxicity

DHE is generally well tolerated, but may cause severe adverse effects in high doses. Signs of an overdose are muscle weakness, numbness, shyness, hallucinations, difficulty breathing, fainting, convulsions, and coma.

Precautions

Dihidroergotamina should not be used by pregnant or nursing women, or by people who have previously had an allergic reaction to it.

Interactions

DHE can interact with other medications, including anti-depressants, blood thinners, muscle relaxants, or drugs that affect the central nervous system. Careful monitoring is recommended if taken concurrently with these drugs.

Disease Interactions

DHE is contraindicated in people with heart disease, high blood pressure, a history of stroke, liver or kidney problems, Raynaud's phenomenon, or with an allergy or sensitivity to ergot-type medications.

Drug Interactions

DHE can interact with certain medications such as lithium, anti-depressants, and drugs used to treat seizures. Careful monitoring is advised if taken concurrently with these drugs.

Food Interactions

DHE may interact with certain foods or dietary supplements, such as vitamin B-12 and folic acid. Careful monitoring is advised if taken concurrently with these foods or supplements.

Pregnancy and Lactation Use

DHE is not recommended for use during pregnancy or lactation.

Acute Overdose

An acute overdose can be fatal, and should be treated immediately. Symptoms of an overdose may include extreme confusion, difficulty breathing, slow heartbeat, loss of consciousness, and seizures.

Contraindication

DHE is contraindicated in people with an allergy or sensitivity to ergot-type medications, an increased risk of cardiovascular disease, Raynaud’s phenomenon, a history of stroke, cancer of the pituitary gland, high blood pressure, kidney or liver diseases, and those taking certain medications such as lithium, anti-depressants, or drugs used to treat seizures.

Use Directions

Follow your doctor’s instructions and directions on the medication packaging when using DHE. Do not exceed the recommended dose without doctor’s approval.

Storage Conditions

Store at room temperature away from light and moisture. Do not store in the bathroom.

Volume of Distribution

The volume of distribution for DHE is 5.5 L/kg.

Half Life

The elimination half-life of DHE is 4.5-5.0 hours.

Clearance

The clearance rate of DHE is 0.82 ml/min/kg.

Here you find in details version of Dihidroergotamina

Some Frequently Asked Questions About Dihidroergotamina

What is dihydroergotamine?

Dihidroergotamina (DHE) is a synthetic ergot alkaloid used to treat migraine headaches. It is an ergot alkaloid that works by constricting blood vessels and blocking the release of certain neurotransmitters that can trigger migraines.

Does dihydroergotamine work?

Yes. Dihidroergotamina has been used to treat migraine headaches for over 50 years. Studies have shown that it is effective in treating the symptoms of migraine, including nausea, vomiting, and sensitivity to light and sound.

What is the difference between dihydroergotamine and ergotamine?

The difference between dihydroergotamine and ergotamine is that dihydroergotamine is a synthetic version of ergotamine, while ergotamine is a naturally occurring alkaloid found in some species of fungi. Dihidroergotamina is generally more effective at treating migraine headaches than ergotamine.

How does dihydroergotamine work?

Dihidroergotamina works by constricting certain blood vessels in the brain that are associated with migraine headaches. It also helps block the release of certain neurotransmitters that can trigger migraines. This helps reduce headache pain, nausea, sensitivity to light and sound, and other symptoms.

How is dihydroergotamine taken?

Dihidroergotamina is usually taken as an intramuscular injection or as a nasal spray. It can also be taken in pill form, but it is not as effective as the injection or nasal spray forms.

When should dihydroergotamine be taken?

Dihidroergotamina should be taken at the first sign of a migraine headache, or when symptoms begin to worsen. It should not be taken more than 2 days per week to avoid the risk of rebound migraines.

What are the side effects of dihydroergotamine?

Common side effects of dihydroergotamine include nausea, vomiting, dizziness, light sensitivity, and nasal irritation. Less common but more serious side effects include chest pain, irregular heartbeat, and stroke.

Is dihydroergotamine safe?

When taken as directed, dihydroergotamine is generally safe. As with any medication, it is important to talk to your doctor about the potential risks and benefits before taking it.

How quickly does dihydroergotamine work?

Dihidroergotamina usually begins working within 30-45 minutes of taking it. However, it may take longer if it is taken in pill form, as it first needs to be digested before it can take effect.

Can dihydroergotamine be taken with other medications?

It is usually safe to take dihydroergotamine with other medications, but it is important to talk to your doctor about the potential risks and benefits before taking it. Certain medications, such as anti-depressants, birth control pills, and certain antibiotics, may interact with dihydroergotamine.

Can dihydroergotamine be taken while pregnant?

No. It is not recommended to take dihydroergotamine while pregnant or breastfeeding. Some studies have shown that it may be associated with an increased risk of birth defects. It is important to talk to your doctor before taking any medication during pregnancy.

Is dihydroergotamine habit-forming?

No. Dihidroergotamina is not known to be habit-forming. However, it is important to take it as prescribed and not to exceed the recommended dosage.

What is the recommended dosage of dihydroergotamine?

The recommended dosage of dihydroergotamine is 2-3 mg, taken as an intramuscular injection, a nasal spray, or in pill form. It is important to follow the directions on the package and to talk to your doctor about the best way to take this medication.

Can dihydroergotamine be taken long-term?

No. Dihidroergotamina should not be taken long-term, as it can cause rebound headaches and is not recommended for more than two days per week. Talk to a doctor about the best long-term treatment for your migraine headaches.

Is dihydroergotamine covered by health insurance?

It depends on the health insurance plan. Some health insurance plans may cover dihydroergotamine, while others may not. It is best to check with the health insurance provider before using this medication.

Is there an over-the-counter version of dihydroergotamine?

No. Dihidroergotamina is only available with a prescription from a doctor, and is not available over the counter.

How long should dihydroergotamine be used for?

Dihidroergotamina should be used only for as long as it is needed to treat the symptoms of migraine. It should not be used for more than two days in a week, as it can cause rebound headaches. It is important to talk to a doctor about the best long-term treatment for your migraine headaches.

Can dihydroergotamine be used for other conditions?

No. Dihidroergotamina is only approved for the treatment of migraine headaches. It should not be used to treat any other medical conditions.

Does dihydroergotamine interact with birth control?

Yes. Dihidroergotamina may interact with certain birth control medications, so it is important to talk to a doctor about the potential risks and benefits before taking it. Birth control pills may also make this medication less effective.

Can dihydroergotamine be used in combination with other medications?

It is usually safe to take dihydroergotamine with other medications, but it is important to talk to your doctor about the potential risks and benefits before taking it. Certain medications, such as anti-depressants, birth control pills, and certain antibiotics, may interact with dihydroergotamine.

What should I do if I miss a dose of dihydroergotamine?

If you miss a dose of dihydroergotamine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

What happens if I take too much dihydroergotamine?

If you take too much dihydroergotamine, it can lead to serious side effects, including chest pain, irregular heartbeat, and stroke. It is important to take this medication as prescribed by your doctor and not to exceed the recommended dosage.

Is dihydroergotamine available in generic form?

Yes. Dihidroergotamina is available in both brand name and generic form. The generic version is usually less expensive than the brand name version.

What is the cost of dihydroergotamine?

The cost of dihydroergotamine varies depending on factors such as your insurance coverage and the form of the medication you are taking. The cost can range from a few dollars to hundreds of dollars for a month’s supply.

Is dihydroergotamine safe for children?

No. Dihidroergotamina is not approved for use in children and there is not enough information to know if it is safe and effective for children. It is important to talk to a doctor before giving any medication to a child.

Can dihydroergotamine be taken with food?

Yes. Dihidroergotamina can be taken with food. However, fatty foods may interfere with the absorption of this medication, so it is best to avoid fatty foods when taking dihydroergotamine.

What other migraine treatments can be used with dihydroergotamine?

Other migraine medications, such as triptans, can be used in combination with dihydroergotamine. It is important to talk to a doctor about the potential risks and benefits of taking multiple migraine medications.

Can dihydroergotamine be used to prevent migraines?

No. Dihidroergotamina is not approved for use in migraine prevention. It is only approved to be used to treat the symptoms of migraine headaches.

Can dihydroergotamine be taken with ibuprofen?

Yes. Dihidroergotamina can be taken with ibuprofen, but it is important to talk to your doctor about the potential risks and benefits before taking any medication.

Is dihydroergotamine injection painful?

No. The dihydroergotamine injection should not be painful. Some people experience a mild stinging sensation at the injection site that should not last more than a few seconds.

Do I need to take another dose of dihydroergotamine if my migraine returns?

No. You should not take a second dose of dihydroergotamine for the same migraine. Taking a second dose can increase the risk of side effects and could cause rebound headaches. Talk to a doctor if your migraine symptoms persist.

What should I do if I experience side effects from dihydroergotamine?

It is important to tell your doctor if you experience any side effects from dihydroergotamine. Your doctor may be able to adjust your dosage or prescribe a different medication that may better suit your needs.

Will dihydroergotamine help with other types of headaches?

No. Dihidroergotamina is only approved to be used for the treatment of migraine headaches. It should not be used to treat any other type of headache.

What is the best way to store dihydroergotamine?

Dihidroergotamina should be stored at room temperature in a cool, dry place. It should be kept away from direct heat and sunlight. The medication should not be frozen or refrigerated.

Can dihydroergotamine be addictive?

No. Dihidroergotamina is not known to be addictive. However, it is important to take this medication as prescribed by your doctor and not to exceed the recommended dosage.

Can I take dihydroergotamine if I have high blood pressure?

It is generally safe to take dihydroergotamine if you have high blood pressure, but it is important to talk to your doctor about the potential risks and benefits before taking it. Certain medications, such as stimulants, can interact with dihydroergotamine and may raise your blood pressure.

Is there a generic form of dihydroergotamine?

Yes. Dihidroergotamina is available in both brand name and generic form. The generic version is usually less expensive than the brand name version.

Can dihydroergotamine be taken with other migraine medications?

It is usually safe to take dihydroergotamine with other migraine medications, but it is important to talk to your doctor about the potential risks and benefits before taking it. Certain medications, such as stimulants, can interact with dihydroergotamine and may increase the risk of side effects.

What should I do if I think my medication is not working?

If you think your medication is not working, it is important to talk to your doctor. Your doctor may be able to adjust your dosage or prescribe a different medication that may better suit your needs.

Can dihydroergotamine be taken with caffeine?

It is generally safe to take dihydroergotamine with caffeine, but it is important to talk to your doctor about the potential risks and benefits before taking it. Caffeine can interact