Clobazamum

Clobazamum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Clobazamum is a brand name. Its generic name is Clobazam.

Clobazamum

Clobazamum is an anticonvulsant and anxiolytic medicine in the benzodiazepine family of drugs used to treat anxiety disorders, epileptic seizures, and behavioral problems in children. It is also used to relieve muscle pain and discomfort due to various conditions.

Uses

Clobazamum is used to treat a number of conditions including anxiety disorders, epilepsy, and behavioral problems in children. It is also used to treat certain types of seizures, as an adjunct to other anti-epileptic medications.

Mechanism Of Action

Clobazamum works by suppressing the abnormal electrical activity in the brain that causes seizures and other neurological disorders. It does so by binding to the benzodiazepine receptor in the brain and activating the neurotransmitter GABA. This leads to increased levels of GABA, which in turn decreases the excitability of neurons. The binding of Clobazamum also enhances the inhibitory effects of the neurotransmitter dopamine.

How Long Does It Take To Work?

Clobazamum usually takes effect within about an hour of ingestion. The peak effect usually occurs 2-4 hours after consumption.

Absorption

Clobazamum is rapidly and completely absorbed in the gastrointestinal tract and is widely distributed in the body. The mean bioavailability of Clobazamum is 70%.

Route Of Elimination

Clobazamum is metabolized in the liver and excreted through the kidneys. It is primarily eliminated as its glucuronide conjugate, which is excreted in the urine.

Dosage

The dosage of clobazam depends on the indication and patient’s age and medical condition. The dose may be increased as tolerated, typically starting with 0.5-1 mg daily in adults and 0.25 mg per day in children. The maximum dose for adults is 20 mg per day while the maximum dose in children is 10 mg per day.

Administration

Clobazamum can be administered orally, rectally or intramuscularly. The oral form of clobazam must be taken with or after food. It should be taken with a full glass of water.

Side Effect

Some of the common side effects of clobazam include drowsiness, dizziness, headache, nausea, difficulty focusing, vision changes, and changes in weight or appetite. More serious side effects include confusion, seizures, difficulty breathing, unusual behavior, and severe allergic reactions.

Toxicity

Overdosing on clobazam can be serious and even life-threatening. Symptoms of overdose include excessive drowsiness, disorientation, confusion, depression, changes in muscle tone, respiratory depression, and coma.

Precautions

Before taking clobazam, it is important to inform your healthcare provider about any other medications that you are taking, any allergies you may have, and any medical conditions such as liver or kidney disease. Clobazamum may impair your thinking or reactions and make you drowsy. Do not drive or do anything that requires alertness until you know how this medication affects you. Clobazamum should not be used in children younger than 6 years old.

Interactions

Clobazamum can interact with other medications. Some medications that may interact with clobazam include MAO inhibitors, benzodiazepines, alcohol, opioids, barbiturates, narcotics, muscle relaxants, and anti-seizure medications. Make sure to inform your healthcare provider about any medications that you are taking.

Disease Interaction

Clobazamum can interact with certain conditions or diseases, including liver or kidney disease, glaucoma, depression, psychosis, and suicidal thoughts or behavior. Your healthcare provider may need to adjust or reduce your dosage of clobazam if you have any of these conditions.

Drug Interaction

Drug interactions can occur if clobazam is taken with other medications, such as MAO inhibitors, alcohol, muscle relaxants, narcotics, barbiturates, or other anticonvulsant drugs. Make sure to tell your healthcare provider about any other medications that you are taking.

Food Interactions

Food can interact with clobazam, particularly grapefruit juice and other citrus fruits. These can decrease the effectiveness of clobazam. It is best to avoid these foods while taking clobazam.

Pregnancy Use

Clobazamum is not recommended for use during pregnancy due to potential risks to the unborn baby. Talk to your healthcare provider about other medications that can be taken during pregnancy.

Lactation Use

Clobazamum is not recommended for use in breastfeeding women due to the potential for harm to the infant. Talk to your healthcare provider about other medications that can be taken while breastfeeding.

Acute Overdose

In case of acute overdose, seek immediate medical attention. Symptoms of overdose include excessive drowsiness, disorientation, confusion, depression, changes in muscle tone, respiratory depression, and coma.

Contraindications

Clobazamum should not be used in people with known hypersensitivity to benzodiazepines, as well as in those who are pregnant, breastfeeding, or have a history of drug or alcohol abuse. It should also be used with caution in those with hepatic or renal impairment.

Use Direction

Clobazamum should be taken as directed by your healthcare provider. For oral administration, the tablet should be taken with food. It should not be taken more than the prescribed amount. The dose may need to be adjusted depending on your response to the medication.

Storage Condition

Clobazamum should be stored at room temperature in a tightly closed container. Keep this medicine away from light, moisture, and heat. Do not store in the bathroom or near a sink. Keep away from children and pets.

Volume Of Distribution

Clobazamum has a mean volume of distribution of 0.8 L/kg.

Half Life

The half-life of clobazam is 27-47 hours.

Clearance

The mean clearance of clobazam is 17 L/hr.

Here you find in details version of Clobazamum

Some Frequently Asked Questions About Clobazamum

What is Clobazamum?

Clobazamum is a benzodiazepine medication used to treat anxiety and seizures. It can also be prescribed to help control agitation related to schizophrenia or to treat insomnia.

Why is Clobazamum prescribed?

Clobazamum is used to reduce the intensity of seizures caused by certain forms of epilepsy, as well as to help manage anxiety and agitation related to schizophrenia.

How does Clobazamum work?

Clobazamum works by binding to receptors in the brain to reduce the number of nerve impulses reaching the brain, which can reduce the frequency and intensity of seizures or reduce anxiety and agitation.

What are the possible side effects of Clobazamum?

Common side effects of Clobazamum include drowsiness, fatigue, dizziness, blurred vision, dry mouth, and nausea. Less common side effects may include breathing issues, confusion, muscle weakness, headache, depression, and changes in behavior.

Is Clobazamum habit-forming?

Yes, Clobazamum can be habit-forming and should be taken exactly as prescribed by a doctor. It’s important to follow all instructions and your doctor’s recommendations carefully.

What is the recommended dosage of Clobazamum?

The recommended starting dose of Clobazamum is 10 mg per day (or 2.5 mg twice per day for children). Your doctor may adjust your dose depending on your condition and response to treatment.

How long does it take Clobazamum to work?

Clobazamum usually takes effect within 1 to 2 hours after taking it. The effects of Clobazamum can last for up to 8 hours.

What should I avoid while taking Clobazamum?

People taking Clobazamum should avoid operating machinery, driving, and other activities that require alertness, coordination, or physical dexterity. Alcohol should also be avoided while taking Clobazamum as it may increase the risk of side effects.

Does Clobazamum interact with any other drugs?

Yes, Clobazamum can interact with other medications, including some antidepressants, antibiotics, narcotics, anticonvulsants, anti-anxiety drugs, and antihistamines. Talk to your doctor about any potential drug interactions before taking Clobazamum.

What is an overdose of Clobazamum?

An overdose of Clobazamum can cause symptoms such as confusion, sedation, coma, loss of muscular coordination, or breathing problems. If you think you or someone else may have overdosed on Clobazamum, call 911 immediately.

What should I do if I miss a dose of Clobazamum?

If you miss a dose of Clobazamum, take it as soon as you remember, unless it’s close to the time for your next dose. In that case, just skip the missed dose and take your next dose as scheduled. Do not double your dose to make up for a missed dose.

What should I do if I think I am having an allergic reaction to Clobazamum?

If you think you are having an allergic reaction to Clobazamum, contact your doctor right away. Symptoms of an allergic reaction include hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Can I take Clobazamum if I am pregnant or breastfeeding?

Clobazamum should not be used by pregnant or breastfeeding women unless the benefits outweigh the risks. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding so they can adjust your dose if necessary.

Can I take Clobazamum with other medications?

Clobazamum can interact with other medications, so tell your doctor about any drugs, vitamins, or supplements you are taking. Your doctor can then adjust your dose if necessary to avoid interactions.

Can children take Clobazamum?

Yes, Clobazamum is approved for use in children ages 2 and older. However, the dosage and side effects may be different for children than for adults.

Can I drink alcohol while taking Clobazamum?

No, it is not advised to drink alcohol while taking Clobazamum as it may increase the risk of side effects. Talk to your doctor if you have any questions about drinking alcohol while taking Clobazamum.

Does Clobazamum cause weight gain?

Some people may experience weight gain while taking Clobazamum, although weight gain is not listed as a common side effect. If you are concerned about weight gain, talk to your doctor.

Does Clobazamum cause drowsiness?

Yes, drowsiness is a common side effect of Clobazamum and can last up to 8 hours. Do not operate heavy machinery or drive while taking Clobazamum if you experience drowsiness.

How long should I take Clobazamum?

Clobazamum should be taken as long as your doctor prescribes it. It is important to follow your doctor's instructions for taking Clobazamum and not to stop taking it without consulting your doctor first.

What are the long-term effects of taking Clobazamum?

The long-term effects of taking Clobazamum have not been fully established. It is important to take Clobazamum exactly as prescribed by your doctor and to not exceed the recommended dosage.

Can Clobazamum be used to treat anxiety?

Yes, Clobazamum can be used to treat anxiety. It is a benzodiazepine medication that works by binding to receptors in the brain to reduce the number of nerve impulses reaching the brain, which can reduce anxiety.

When should I take Clobazamum?

Your doctor will advise you when to take Clobazamum. It is typically taken one or two times per day, depending on your doctor’s instructions. It is important to take Clobazamum at the same time each day to maintain a consistent level of the medication in your system.

What should I do if I experience serious side effects from taking Clobazamum?

If you experience serious side effects from taking Clobazamum, such as difficulty breathing or changes in behavior, contact your doctor or go to the emergency room right away.

Should I take Clobazamum with food?

Clobazamum can be taken with or without food. Your doctor will advise you on the best way to take it, but typically it is best to take it with food to reduce the risk of side effects.

How can I reduce my risk of experiencing side effects from Clobazamum?

To reduce your risk of experiencing side effects from Clobazamum, take it exactly as prescribed by your doctor. Avoid drinking alcohol and do not operate machinery while taking Clobazamum. Talk to your doctor if you have any questions about taking Clobazamum.

Are there any alternatives to Clobazamum?

Yes, there are several alternatives to Clobazamum, including other benzodiazepines and some anticonvulsants. Talk to your doctor about the best treatment for your condition.

Are there any drug interactions I should be aware of with Clobazamum?

Yes, Clobazamum can interact with other medications, including some antidepressants, antibiotics, narcotics, anticonvulsants, anti-anxiety drugs, and antihistamines. Talk to your doctor about potential drug interactions before taking Clobazamum.

Are there any foods or drinks I should avoid while taking Clobazamum?

It is important to avoid drinking alcohol while taking Clobazamum as it may increase the risk of side effects. Talk to your doctor to find out if there are any other foods or drinks that you should avoid while taking Clobazamum.

How should I store Clobazamum?

Clobazamum should be stored at room temperature, away from direct sunlight and moisture. Keep Clobazamum out of reach of children and pets, and dispose of any unused medication properly.

Should I take other drugs while taking Clobazamum?

Talk to your doctor before taking any other medications while taking Clobazamum as some drugs can interact with each other and increase the risk of side effects. It is best to tell your doctor about any other drugs, vitamins, or supplements you are taking.

Can I take Clobazamum if I have a history of depression?

Yes, Clobazamum can be taken if you have a history of depression. However, it is important to tell your doctor about any mental health issues you may have as Clobazamum can cause changes in mood or behavior.

Can I take herbal supplements while taking Clobazamum?

It is best to check with your doctor before taking any herbal supplements while taking Clobazamum, as some herbs can interact with Clobazamum and increase the risk of side effects. Your doctor can advise you on the best course of action.

Does Clobazamum work for everyone?

No, Clobazamum may not work for everyone. Some people may experience no benefit from taking Clobazamum, while others may experience both positive and negative effects. Talk to your doctor to discuss any concerns you may have about taking Clobazamum.

Can Clobazamum be used to treat insomnia?

Yes, Clobazamum can be used to treat insomnia. It is a benzodiazepine medication that works by binding to receptors in the brain to reduce the number of nerve impulses reaching the brain, which can reduce anxiety and reduce the frequency of awakenings.

What are the signs of a Clobazamum overdose?

Signs of a Clobazamum overdose can include confusion, sedation, coma, loss of muscular coordination, or breathing problems. If you think you or someone else may have overdosed on Clobazamum, call 911 immediately.

What are the withdrawal symptoms of Clobazamum?

Withdrawal symptoms that can occur after stopping Clobazamum may include headache, insomnia, nausea, vomiting, irritability, anxiety, dizziness, tremors, sweating, or seizures. It is important to talk to your doctor before stopping Clobazamum to avoid serious withdrawal symptoms.

What should I do if my symptoms are not improving while taking Clobazamum?

If your symptoms are not improving while taking Clobazamum, contact your doctor right away. Your doctor may need to adjust your dose or change the medication you are taking.

Can I take Clobazamum if I have a kidney or liver disease?

Yes, Clobazamum can be taken if you have a kidney or liver disease. However, it is important to talk to your doctor as your dose may need to be adjusted. Your doctor can also advise you on any other precautions you may need to take while taking Clobazamum.

Is Clobazamum safe for long-term use?

The long-term safety of Clobazamum has not been fully established. It is important to take Clobazamum exactly as prescribed by your doctor, and not to exceed the recommended dosage. Talk to your doctor if you have any concerns about the long-term safety of Clobazamum.