Cipremi
Cipremi Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cipremi is a brand name. Its generic name is Remdesivir.
Introduction
Cipremi is a broad-spectrum antiviral medicine developed and approved for the treatment of severe coronavirus disease 2019 (COVID-19). It was initially developed for the treatment of the hepatitis virus.
Uses
Cipremi is used to treat severe coronavirus disease 2019 (COVID-19) in adult and pediatric patients who have been hospitalized and have evidence of moderate to severe disease. It is also being evaluated for potential use in the treatment of other viruses.
Mechanism of Action
Cipremi works by blocking the virus’s ability to replicate. It does this by inhibiting a viral enzyme known as RNA-dependent-RNA polymerase, which is responsible for producing new virus particles from viral genetic material. This stops the virus from spreading and reproducing, limiting its growth in the body.
How Long Does it Take to Work?
The effects of remdesivir can vary significantly depending on the patient and their particular infection. Generally, it is expected to take anywhere from a few days to two weeks for the drug to take effect and begin to reduce symptoms.
Absorption
Cipremi is rapidly and widely distributed throughout the body after being orally administered. It is extensively absorbed via the intestine and has a bioavailability of around 64%.
Route of Elimination
Cipremi is primarily eliminated through the kidneys, with around 95% of the drug being eliminated within three days.
Dosage
The recommended daily dose of remdesivir is 200mg administered intravenously over one hour, followed by 100mg administered every 24hours for five days. In adults and pediatric patients, this dose should be administered as an intravenous infusion over one hour.
Administration
Cipremi is administered intravenously via a drip. It is important to ensure that the infusion is at a slow and steady rate, with no interruption of the infusion.
Side Effects
The most common side effects of remdesivir include nausea, vomiting, headache, weakness, dizziness, diarrhea, difficulty sleeping, and abdominal pain. Other more serious side effects can occur, although these are much rarer.
Toxicity
Cipremi is generally well-tolerated and has a low risk of toxicity. However, seizure has been reported in rare cases where the drug was overdosed or used in patients with reduced renal or hepatic function.
Precautions
Cipremi should be used with caution in patients with impaired liver or kidney function, as well as in pregnant or lactating women. It should also be used with caution in patients with preexisting cardiovascular conditions or who are taking any other medications that may interact with remdesivir.
Interactions
Cipremi may interact with other medications, including antibiotics, anticonvulsants, immunosuppressants, and antiretroviral drugs. It is important to tell your doctor about all other medications you are taking before starting treatment with remdesivir.
Disease Interaction
Cipremi should not be used in patients with severe hepatic impairment or in patients with HIV infection. Its efficacy in the treatment of other diseases is not yet known.
Drug Interaction
Cipremi may interact with various other medications, including antibiotics, anticonvulsants, immunosuppressants, and antiretroviral drugs. Before starting treatment with remdesivir, it is important to tell your doctor about all other medications you are taking.
Food Interactions
It is not known if food or other substances will affect the absorption of remdesivir. Therefore, it is recommended that you take remdesivir on an empty stomach.
Pregnancy Use
Cipremi should be used with caution in pregnant females as the safety and effectiveness of the drug have not been established in this population.
Lactation Use
Cipremi should be used with caution in nursing mothers as the safety and effectiveness of the drug have not been established in this population.
Acute Overdose
Cipremi should not be used in larger doses than recommended, as this may lead to an acute overdose. Symptoms of an overdose can include seizures, confusion, disorientation, agitation, tremors, and coma. If you suspect an overdose, seek medical help immediately.
Contraindication
Cipremi should not be used in patients with moderate to severe hepatic impairment or in patients with HIV infection.
Use Direction
Cipremi should be administered intravenously over one hour, followed by a second dose one hour later and a third dose twenty-four hours later. Patients should be monitored for at least sixty minutes after the administration of each dose.
Storage Condition
Cipremi should be stored at room temperature, between 20 and 25oC. It should not be frozen or refrigerated.
Volume of Distribution
The volume of distribution of remdesivir is approximately 18 L.
Half Life
The half-life of remdesivir is approximately 4.8 hours.
Clearance
The clearance of remdesivir is approximately 5.4 L/hr.
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