Cilny O
Cilny O Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cilny O is a brand name. Its generic name is Cilnidipine + Olmesartan.
Cilny O Introduction
Cilny O is a combination of two medicines – Cilnidipine and Olmesartan which help treat hypertension (high blood pressure). Cilnidipine is a calcium channel blocker, which helps to prevent calcium from entering the cells of the heart and blood vessels. Olmesartan is an angiotensin II receptor antagonist, which helps to block the action of certain natural substances that tightens the blood vessels, resulting in a lowering of blood pressure.Uses For Cilny O
Cilny O is used for the treatment of hypertension (high blood pressure). It helps to prevent and reduce the risk of heart attacks, strokes, and kidney disease. It may also be used to treat other conditions as determined by your doctor.Mechanism of Action
Cilnidipine is a calcium channel blocker that works by keeping calcium from entering the cells of the heart and blood vessels. This helps widen (dilate) blood vessels and helps reduce the risk of stroke, heart attack, and kidney disease. Olmesartan is an angiotensin II receptor blocker that works by blocking the action of angiotensin, a substance that narrows the blood vessels, increasing blood pressure. By blocking the action of angiotensin, blood vessels remain open and blood pressure is lowered.How Long Does it Take to Work?
Cilny O should begin to work within several hours. It may take weeks or even months for the full benefits of Cilny O treatment to be seen. If you do not notice any improvement after several weeks of treatment, consult your doctor.Absorption
Cilnidipine is rapidly and almost completely absorbed in the gastrointestinal tract after oral administration. Olmesartan is rapidly and completely absorbed in the small intestine with peak plasma concentrations reached in approximately 1 to 4 hours.Route of Elimination
Cilnidipine is eliminated mainly by the kidneys; approximately 5% of the dose is eliminated unchanged in the urine. Olmesartan is excreted mainly by the kidneys, with only 2-3% of the dose excreted unchanged in the urine.Dosage
The usual starting dose for Cilny O is 10 mg/20 mg of Cilnidipine and Olmesartan once daily. Your doctor may increase the dose after 3–4 weeks if needed. Maximum recommended dose is 40 mg/20 mg of Cilnidipine and Olmesartan once daily.Administration
Cilny O should be taken orally with or without food. It should be taken at the same time each day, at least 8 hours apart.Side Effects
The most common side effects of Cilny O include headache, dizziness, fatigue, and diarrhea. Other side effects include low blood pressure, chest pain, nausea, and vomiting.Toxicity
High doses of Cilny O may cause severe hypotension, cardiotoxicity, and renal failure.Precautions
Before taking Cilny O, you should inform your doctor if you have a history of heart disease, kidney disease, or liver disease. You should also tell your doctor about any other medications that you are taking, as some may interact with the effects of Cilny O.Interaction
Cilny O may interact with other medications such as warfarin, diuretics, non-steroidal anti-inflammatory drugs (NSAIDs), and angiotensin-converting enzyme inhibitors (ACEIs).Disease Interaction
Cilny O may interact with certain diseases. Cilny O may cause an increased risk of hypotension (low blood pressure) in patients with renal disease, heart failure, or diabetes.Drug Interactions
Cilny O may interact with certain drugs such as alcohol, lithium, diuretics, non-steroidal anti-inflammatory drugs (NSAIDs), and angiotensin-converting enzyme inhibitors (ACEIs).Food Interactions
It is not known if Cilny O interacts with food.Pregnancy Use
Cilny O is not recommended for use during pregnancy.Lactation Use
It is not known if Cilny O is safe for use in women who are breastfeeding.Acute Overdose
Symptoms of an acute Cilny O overdose may include hypotension (low blood pressure), dizziness, weakness, and confusion. Treatment of an overdose of Cilny O should include supportive care and administration of activated charcoal to reduce absorption.Contraindication
Cilny O is contraindicated in patients with a known hypersensitivity to any of the components of Cilny O.Use Direction
Take Cilny O exactly as directed by your doctor. The usual daily dose is 10 mg/20 mg of Cilnidipine and Olmesartan once daily. Do not increase or decrease the dose of Cilny O without consulting your doctor.Storage Condition
Store Cilny O at room temperature between 15°C and 30°C (59°F and 86°F). Keep away from moisture and light.Volume of Distribution
The volume of distribution of Cilnidipine is approximately 21 L/kg. The volume of distribution of Olmesartan is approximately 8.37 L/kg.Half Life
The half life of Cilnidipine is approximately 8-12 hours. The half life of Olmesartan is approximately 10-14 hours.Clearance
The clearance of Cilnidipine is approximately 132 mL/min. The clearance of Olmesartan is approximately 0.70 L/hr.Here you find in details version of Cilny O