Etova Mr Forte
Etova Mr Forte Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Etova Mr Forte is a brand name. Its generic name is Etodolac + Thiocolchicoside.
Introduction
Etodolac and Thiocolchicoside are both non-steroidal anti-inflammatory drugs (NSAIDs) that are commonly used to treat a wide range of inflammatory and musculoskeletal conditions, such as rheumatoid arthritis, osteoarthritis, and gout. Etodolac is a long-acting non-selective COX inhibitor while Thiocolchicoside is a muscle relaxant with a spasmolytic action.
Uses and Mechanism of Action
Etodolac is used for the relief of pain and inflammation in acute mild to moderate pain from traumatic musculoskeletal injuries, acute bursitis, and acute gout. It works by inhibiting the production of inflammatory mediators known as prostanoids. Thiocolchicoside is used to treat muscle spasms and is used to treat conditions such as abnormalities in the vertebral column, sciatica, peripheral neuralgias, and spasms associated with muscular dystrophy. It acts by inhibiting the release of neurotransmitters known as gamma-aminobutyric acids (GABA), which cause muscle relaxation.
How Long Does It Take To Work?
The onset of action of Etodolac typically occurs within 2 to 4 hours after administration. Thiocolchicoside tends to take effect within one hour.
Absorption
Etodolac is readily absorbed after oral administration. The peak plasma concentration is reached in 1 to 3 hours and is maximal at 12 hours post dose. Thiocolchicoside is also rapidly absorbed after administration.
Route of Elimination
Etodolac and Thiocolchicoside are both predominantly eliminated through the kidneys.
Dosage and Administration
Etodolac is available as an oral tablet, capsule, or suspension and should be taken with food. The recommended dosage for adults is 200 to 400 mg every 8 to 12 hours, with a maximum dosage of 1,200 mg per day. Thiocolchicoside is available as an oral tablet and usually taken 4 times a day; the recommended dosage is 8 to 16 mg per day.
Side Effects
The most common side effects associated with Etodolac and Thiocolchicoside are nausea, vomiting, constipation, stomach pain, abdominal discomfort, blurred vision, dizziness, headache, drowsiness, and rash. Less common and more serious side effects include liver injury, kidney damage, and gastrointestinal bleeding.
Toxicity
It is possible to overdose on Etodolac or Thiocolchicoside, but overdoses are generally not fatal. In the event of an overdose, it is recommended to seek medical attention. Symptoms of an overdose may include nausea, vomiting, headache, dizziness, and abdominal discomfort.
Precaution
Patients should speak to their medical provider before taking Etodolac or Thiocolchicoside to ensure they are safe to take the medications. Patients should not take these medications if they have a history of allergies to NSAIDs, gastrointestinal problems, or kidney disease. Women who are pregnant or breastfeeding should speak to a healthcare provider before using these medications.
Interactions
Etodolac and Thiocolchicoside can interact with other medications such as aspirin, blood thinners, non-steroidal anti-inflammatory drugs (NSAIDs), anticoagulants, diuretics, and lithium. It is important to inform your healthcare provider about all medications you are taking before starting treatment with these medications.
Disease Interactions
Etodolac and Thiocolchicoside may not be appropriate for certain health conditions such as asthma, heart disease, glaucoma, or liver or kidney problems. Patients with any of these conditions should speak to their doctor before taking these medications.
Drug Interactions
Etodolac and Thiocolchicoside may interact with other medications such as aspirin, blood thinners, non-steroidal anti-inflammatory drugs (NSAIDs), anticoagulants, diuretics, and lithium. It is important to inform your healthcare provider about all medications you are taking before starting treatment with these medications.
Food Interactions
Etodolac and Thiocolchicoside should be taken with food to increase the absorption of the medication. It is important to refrain from consuming grapefruit or grapefruit juice while taking these medications, as it can increase the levels of these medications in the bloodstream and lead to an increased risk of side effects.
Pregnancy and Lactation Use
Etodolac and Thiocolchicoside should be used with caution during pregnancy as they may be associated with an increased risk of certain birth defects. If there is potential for fetal exposure, use should be avoided. The safety of these medications during breastfeeding is not known; therefore, it is best to avoid using these medications while breastfeeding.
Acute Overdose
In the event of an overdose, it is recommended to seek medical attention. Symptoms of an overdose may include nausea, vomiting, headache, dizziness, and abdominal discomfort.
Contraindication
Etodolac and Thiocolchicoside are contraindicated in patients with a history of aspirin-sensitive asthma, gastrointestinal bleeding or perforation, intestinal obstruction or ileus, or apraglottic stenosis. Patients should not take multiple NSAIDs at the same time.
Use Direction
Etodolac and Thiocolchicoside should be taken by mouth at the prescribed dosage and should be taken with food to increase absorption. The medication should be taken at evenly spaced intervals throughout the day. It is important to take the medication as prescribed and to not take more than the recommended dosage.
Storage Condition
Etodolac and Thiocolchicoside should be stored at room temperature, away from light and moisture. These medications should be kept where children and pets cannot reach them.
Volume of Distribution
The volume of distribution of Etodolac and Thiocolchicoside is approximately 0.15 L/kg. This means that these medications are distributed to the body tissues relatively quickly.
Half-Life
The half-life of Etodolac is 8 - 10 hours and for Thiocolchicoside is 6-7 hours, which means that it takes approximately 8-10 hours for the body to metabolize and eliminate half of the medication.
Clearance
Etodolac is cleared from the body mainly via urinary excretion as metabolites. The clearance of Thiocolchicoside is approximately 1.6L/hr/kg and is also eliminated primarily via urinary excretion as metabolites.
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