Cellulose Hydroxypropyl Methyl Ether

Cellulose Hydroxypropyl Methyl Ether Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cellulose Hydroxypropyl Methyl Ether is a brand name. Its generic name is Hypromellose.

Introduction

Cellulose Hydroxypropyl Methyl Ether also known as hydroxypropyl methylcellulose (HPMC) is a polysaccharide often used as an aqueous dispersion of methylcellulose polymers. It is a semi-synthetic, non-ionic cellulose ether used as an excipient or pharmaceutical base in pharmaceuticals, foods, cosmetics, and industrial products. Cellulose Hydroxypropyl Methyl Ether is white to cream colored, odorless, and tasteless powder that is highly viscous, soluble in water, and forms stable gel.

Uses

Cellulose Hydroxypropyl Methyl Ether is used in the production of emulsions, tablets and capsules and other pharmaceutical forms due to its superior qualities such as water solubility, ease in dispersing, good resistance to salting out effects, and low irritation to the gastro-intestinal tract. It is also used to thicken and stabilize lotions, creams and other cosmetic and personal care products. Additionally, Cellulose Hydroxypropyl Methyl Ether is also used as an eye drop since it helps keep the tear film moisten and comfortable.

Mechanism of action

Cellulose Hydroxypropyl Methyl Ether is a non-ionic cellulose ether which forms a gel when it comes into contact with water. When it is used in Pharmaceuticals, it helps stabilize and thicken the mixture. This helps to keep the device from separating and ensures its effective performance. In cosmetics, it helps retain moisture in the skin, which prevents irritation and keeps the skin hydrated. As an eye drop, it helps keep the tear film moist.

How long does it take to work?

The exact time it takes for Cellulose Hydroxypropyl Methyl Ether to work varies depending on the application. For eye drops, it takes about 5-10 minutes for the effects to be noticeable. For use on pharmaceuticals and cosmetics, it depends on the formulation and how it is processed.

Absorption

Cellulose Hydroxypropyl Methyl Ether is poorly absorbed by the body and only a small amount is absorbed in the gastro-intestinal tract. Most of it is eliminated from the body unchanged in the feces.

Route of Elimination

Cellulose Hydroxypropyl Methyl Ether is eliminated from the body unchanged in the feces.

Dosage

The dosage of Cellulose Hydroxypropyl Methyl Ether is dependent on the application. The recommended dosage for its eye drop application is up to 4 times a day, but this should be determined by an ophthalmologist. For pharmaceutical and cosmetics applications, the dosage varies depending on the formulation and the desired effect. Generally, it is used in the range of 0.5 - 3.0 % w/w.

Administration

Cellulose Hydroxypropyl Methyl Ether can be administered orally, topically, or as an eye drop according to the indication. For eye drops, the drop should be instilled into the lower conjunctival sac of the affected eye(s). For external use, the product should be applied with a sterile cotton wool swab or other suitable application.

Side Effects

The most common side effects of Cellulose Hydroxypropyl Methyl Ether are stinging, redness, and irritation of the affected area. Other common side effects include dryness, itching, and peeling of the skin.

Toxicity

Cellulose Hydroxypropyl Methyl Ether is generally considered non-toxic when taken orally in the recommended dosage. It is safe to use topically at the recommended dosages.

Precautions

Cellulose Hydroxypropyl Methyl Ether should not be used by people who are allergic to cellulose or other cellulose derivatives. It should also be used with caution in people with sensitive skin or eyes.

Interactions

Cellulose Hydroxypropyl Methyl Ether may interact with other medications so it is important to consult with a doctor before taking. It may also interact with certain foods such as dairy and eggs, so it is important to discuss potential interactions with a healthcare professional.

Disease Interactions

Cellulose Hydroxypropyl Methyl Ether may interact with certain medical conditions such as ulcerative colitis, Crohn’s disease, and irritable bowel syndrome. Therefore, it is important to talk to a doctor before taking the medication.

Drug Interactions

Cellulose Hydroxypropyl Methyl Ether may interact with other medications, such as antacids or antidiarrheal agents. It is important to talk to a healthcare professional about potential drug interactions.

Food Interactions

Cellulose Hydroxypropyl Methyl Ether may interact with certain food components such as dairy and eggs. Therefore, it is important to talk to a healthcare professional before taking Cellulose Hydroxypropyl Methyl Ether if you have any food allergies.

Pregnancy Use

Cellulose Hydroxypropyl Methyl Ether is generally considered safe to use during pregnancy and lactation. However, it is important to discuss the potential risks with a healthcare professional before taking the medication.

Lactation Use

Cellulose Hydroxypropyl Methyl Ether is generally considered safe to use during nursing. However, it is important to discuss the potential risks with a healthcare professional before taking the medication.

Acute Overdose

Signs of acute overdose may include nausea, vomiting, and abdominal pain. If an overdose is suspected, it is important to seek medical attention immediately.

Contraindication

Cellulose Hydroxypropyl Methyl Ether should not be used by people who are allergic to cellulose or other cellulose derivatives.

Use Directions

The exact directions of use for Cellulose Hydroxypropyl Methyl Ether depends on the application. Generally, it is applied topically or instilled via eye drops.

Storage Condition

Cellulose Hydroxypropyl Methyl Ether should be stored in a cool, dry, and dark place away from direct light, moisture, and heat. It should be kept out of reach of children and pets.

Volume of Distribution

Cellulose Hydroxypropyl Methyl Ether is poorly absorbed by the body and most of it is eliminated in the feces.

Half Life

The half-life of Cellulose Hydroxypropyl Methyl Ether is not clearly known.

Clearance

Cellulose Hydroxypropyl Methyl Ether is eliminated from the body unchanged in the feces.

Here you find in details version of Cellulose Hydroxypropyl Methyl Ether

Some Frequently Asked Questions About Cellulose Hydroxypropyl Methyl Ether

What is Cellulose Hydroxypropyl Methyl Ether?

Cellulose Hydroxypropyl Methyl Ether, also known as hydroxypropyl methylcellulose or HPMC, is a gelling and thickening agent derived from cellulose. It is used in a variety of industries, including medical, pharmaceutical, and food.

What is Cellulose Hydroxypropyl Methyl Ether used for?

Cellulose Hydroxypropyl Methyl Ether is used to thicken, stabilize, and bind drugs and food products. It is often used as an excipient in tablets and capsules and is frequently used in pharmaceutical ophthalmic solutions, suspensions, and ointments.

How does Cellulose Hydroxypropyl Methyl Ether work?

Cellulose Hydroxypropyl Methyl Ether works by absorbing and dissolving in water as it forms a gel-like consistency similar to that of agar. This thick gel matrix then prevents the active ingredients in the drug from settling or separating out. Additionally, the gel helps to stabilize and bind the drug molecules, thus improving drug efficacy and shelf life.

What is Cellulose Hydroxypropyl Methyl Ether made of?

Cellulose Hydroxypropyl Methyl Ether is derived from cellulose, which is a polymer of glucose units linked together. It is produced by a chemical process that involves hydroxypropylation, which replaces some of the hydrogens on the cellulose molecule with hydroxypropyl groups.

What is the difference between Cellulose Hydroxypropyl Methyl Ether and cellulose?

The main difference between Cellulose Hydroxypropyl Methyl Ether and cellulose is that Cellulose Hydroxypropyl Methyl Ether is a modified form of cellulose, with some of the hydrogens on the cellulose molecule replaced with hydroxypropyl groups. This modified cellulose has the ability to absorb, dissolve, and form a gel, making it an excellent thickening and gelling agent.

What are the benefits of Cellulose Hydroxypropyl Methyl Ether?

The benefits of Cellulose Hydroxypropyl Methyl Ether include its ability to thicken, stabilize, and bind drugs and food products, which improves drug efficacy and shelf life. It is also non-toxic, non-allergenic, and has been approved by the FDA for use in pharmaceutical and food products.

What products contain Cellulose Hydroxypropyl Methyl Ether?

Cellulose Hydroxypropyl Methyl Ether is used to thicken, stabilize, and bind a variety of products, from pharmaceutical tablets and capsules to food products such as jams and jellies. It is also found in ophthalmic solutions, suspensions, and ointments.

Is Cellulose Hydroxypropyl Methyl Ether safe?

Yes, Cellulose Hydroxypropyl Methyl Ether is generally regarded as safe and has been approved by the FDA for use in food and pharmaceutical products. It is non-toxic, non-allergenic, and does not have any serious side effects.

What are the side effects of Cellulose Hydroxypropyl Methyl Ether?

The most common side effect of Cellulose Hydroxypropyl Methyl Ether is digestive upset, including nausea, abdominal pain, and diarrhea. It can also cause allergic reactions in some people.

Can Cellulose Hydroxypropyl Methyl Ether be used in food?

Yes, Cellulose Hydroxypropyl Methyl Ether is approved by the FDA for use in food products as an emulsifying, stabilizing, or suspending agent, so it can be used to thicken jams and jellies, improve the texture of baked goods, and increase the shelf life of other food items.

What is the difference between Cellulose Hydroxypropyl Methyl Ether and Methylcellulose?

Methylcellulose is a modified form of cellulose with some of the hydrogens replaced with methyl groups, whereas Cellulose Hydroxypropyl Methyl Ether is a modified form of cellulose with some of the hydrogens replaced with hydroxypropyl groups. While both are used as thickening and gelling agents, Methylcellulose is generally used in food products and Cellulose Hydroxypropyl Methyl Ether is usually used in pharmaceutical products.

What is the shelf life of Cellulose Hydroxypropyl Methyl Ether?

The shelf life of Cellulose Hydroxypropyl Methyl Ether will vary depending on the specific product, but in general, products made with Cellulose Hydroxypropyl Methyl Ether can be stored for up to two years. It is important to store such products in a cool, dry place away from direct light and heat.

How do you dissolve Cellulose Hydroxypropyl Methyl Ether?

Cellulose Hydroxypropyl Methyl Ether can be dissolved in hot or cold water. It should be added to the water slowly and stirred continuously until it is completely dissolved. For best results, it can be dissolved in a blender or homogenizer.

Is Cellulose Hydroxypropyl Methyl Ether vegan?

Yes, Cellulose Hydroxypropyl Methyl Ether is vegan-friendly as it is derived from plant-based cellulose. Cellulose Hydroxypropyl Methyl Ether does not contain any animal-derived ingredients.

Is Cellulose Hydroxypropyl Methyl Ether gluten free?

Yes, Cellulose Hydroxypropyl Methyl Ether is gluten free. It is derived from plant-based cellulose and does not contain any wheat, barley, or rye, which are the sources of gluten.

Is Cellulose Hydroxypropyl Methyl Ether harmful to humans?

No, Cellulose Hydroxypropyl Methyl Ether is generally regarded as safe and does not have any serious side effects. It is non-toxic and non-allergenic, and has been approved by the FDA for use in food and pharmaceutical products.

How do you use Cellulose Hydroxypropyl Methyl Ether?

Cellulose Hydroxypropyl Methyl Ether can be used as a thickening, stabilizing, and binding agent in a variety of pharmaceutical, food, and cosmetic products. It is often used in ophthalmic solutions, suspensions, and ointments, as well as in jams and jellies to improve texture, shelf life, and the overall quality of the product.

Does Cellulose Hydroxypropyl Methyl Ether contain preservatives?

No, Cellulose Hydroxypropyl Methyl Ether does not contain any preservatives. It is a pure gelling and thickening agent derived from cellulose.

Is Cellulose Hydroxypropyl Methyl Ether non-GMO?

Yes, Cellulose Hydroxypropyl Methyl Ether is non-GMO as it is derived from plant-based cellulose.

What is the molecular weight of Cellulose Hydroxypropyl Methyl Ether?

The molecular weight of Cellulose Hydroxypropyl Methyl Ether varies depending on the specific product, but in general, it typically ranges from 10,000 to 600,000 daltons.

Is Cellulose Hydroxypropyl Methyl Ether Kosher?

Yes, Cellulose Hydroxypropyl Methyl Ether is Kosher as it is a plant-based product.

Is Cellulose Hydroxypropyl Methyl Ether non-allergenic?

Yes, Cellulose Hydroxypropyl Methyl Ether is non-allergenic and does not usually cause any allergic reactions.

Is Cellulose Hydroxypropyl Methyl Ether halal?

Yes, Cellulose Hydroxypropyl Methyl Ether is halal as it is a plant-based product.

What is the pH of Cellulose Hydroxypropyl Methyl Ether?

The pH of Cellulose Hydroxypropyl Methyl Ether varies depending on the specific product, but it typically ranges from 5.5 to 8.

Does Cellulose Hydroxypropyl Methyl Ether contain artificial colors or flavors?

No, Cellulose Hydroxypropyl Methyl Ether is a pure gelling and thickening agent and does not contain any artificial colors or flavors.

Is Cellulose Hydroxypropyl Methyl Ether soluble in oil?

No, Cellulose Hydroxypropyl Methyl Ether is not soluble in oil and will not dissolve in oil or any other non-polar solvents.

Can Cellulose Hydroxypropyl Methyl Ether be used in cosmetics?

Yes, Cellulose Hydroxypropyl Methyl Ether is often used as an emulsifying, stabilizing, or suspending agent in a variety of cosmetics, including creams, lotions, and shampoos.

Does Cellulose Hydroxypropyl Methyl Ether contain hormones?

No, Cellulose Hydroxypropyl Methyl Ether does not contain any hormones or other active ingredients.

What is the trade name of Cellulose Hydroxypropyl Methyl Ether?

The trade name of Cellulose Hydroxypropyl Methyl Ether is HPMC, which stands for hydroxypropyl methylcellulose.

What is the melting point of Cellulose Hydroxypropyl Methyl Ether?

The melting point of Cellulose Hydroxypropyl Methyl Ether varies depending on the specific product, but it typically ranges from 240°F to 250°F (116°C to 121°C).

Can Cellulose Hydroxypropyl Methyl Ether be used to sweeten food?

No, Cellulose Hydroxypropyl Methyl Ether is not sweet and is not suitable for use as a sweetener.

How long does Cellulose Hydroxypropyl Methyl Ether take to dissolve?

The amount of time it takes for Cellulose Hydroxypropyl Methyl Ether to dissolve will depend on the specific product, but in general, it can take anywhere from 10 minutes to several hours for it to dissolve completely.

What is the melting behaviour of Cellulose Hydroxypropyl Methyl Ether?

The melting behaviour of Cellulose Hydroxypropyl Methyl Ether is largely dependent on the specific product, but in general, it will form a thick, jelly-like consistency when heated. It will not liquefy when heated, and will become solid when cooled.

Is Cellulose Hydroxypropyl Methyl Ether flammable?

No, Cellulose Hydroxypropyl Methyl Ether is not flammable. It is a non-flammable, plant-based gelling and thickening agent.

Is Cellulose Hydroxypropyl Methyl Ether a natural product?

Yes, Cellulose Hydroxypropyl Methyl Ether is a natural product derived from plant-based cellulose.

Is Cellulose Hydroxypropyl Methyl Ether toxic?

No, Cellulose Hydroxypropyl Methyl Ether is non-toxic and does not present any serious health risks.

Is Cellulose Hydroxypropyl Methyl Ether biodegradable?

Yes, Cellulose Hydroxypropyl Methyl Ether is biodegradable. It will break down over time when exposed to microbes and other organic matter in the environment.

What is the solubility of Cellulose Hydroxypropyl Methyl Ether?

The solubility of Cellulose Hydroxypropyl Methyl Ether varies depending on the specific product, but in general, it is soluble in cold and hot water but not in oil or any other non-polar solvents.

Can Cellulose Hydroxypropyl Methyl Ether be used as a thickening agent?

Yes, Cellulose Hydroxypropyl Methyl Ether is often used as a thickening agent in food, pharmaceutical, and cosmetic products. It can be used to thicken jams and jellies, improve the texture of baked goods, and increase the shelf life of other products.

Does Cellulose Hydroxypropyl Methyl Ether contain any allergens?

No, Cellulose Hydroxypropyl Methyl Ether does not contain any known allergens and does not usually cause any allergic reactions.

Can Cellulose Hydroxypropyl Methyl Ether be used as a binding agent?

Yes, Cellulose Hydroxypropyl Methyl Ether is often used as a binding agent to stabilize, emulsify, and suspend active ingredients in a variety of products, from pharmaceutical tablets and capsules to food items.

Can Cellulose Hydroxypropyl Methyl Ether be used in capsules and tablets?

Yes, Cellulose Hydroxypropyl Methyl Ether is often used as an excipient in capsules and tablets. It helps to stabilize and bind the active ingredients, thus improving drug efficacy and shelf life.

What is the viscosity of Cellulose Hydroxypropyl Methyl Ether?

The viscosity of Cellulose Hydroxypropyl Methyl Ether varies depending on the specific product, but in general, it can range from 1000 to 100,000 centipoise.