Hypromelloses

Hypromelloses Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Hypromelloses is a brand name. Its generic name is Hypromellose.

Introduction

Hypromelloses also known as hydroxypropyl methylcellulose (HPMC) is a polysaccharide often used as an aqueous dispersion of methylcellulose polymers. It is a semi-synthetic, non-ionic cellulose ether used as an excipient or pharmaceutical base in pharmaceuticals, foods, cosmetics, and industrial products. Hypromelloses is white to cream colored, odorless, and tasteless powder that is highly viscous, soluble in water, and forms stable gel.

Uses

Hypromelloses is used in the production of emulsions, tablets and capsules and other pharmaceutical forms due to its superior qualities such as water solubility, ease in dispersing, good resistance to salting out effects, and low irritation to the gastro-intestinal tract. It is also used to thicken and stabilize lotions, creams and other cosmetic and personal care products. Additionally, Hypromelloses is also used as an eye drop since it helps keep the tear film moisten and comfortable.

Mechanism of action

Hypromelloses is a non-ionic cellulose ether which forms a gel when it comes into contact with water. When it is used in Pharmaceuticals, it helps stabilize and thicken the mixture. This helps to keep the device from separating and ensures its effective performance. In cosmetics, it helps retain moisture in the skin, which prevents irritation and keeps the skin hydrated. As an eye drop, it helps keep the tear film moist.

How long does it take to work?

The exact time it takes for Hypromelloses to work varies depending on the application. For eye drops, it takes about 5-10 minutes for the effects to be noticeable. For use on pharmaceuticals and cosmetics, it depends on the formulation and how it is processed.

Absorption

Hypromelloses is poorly absorbed by the body and only a small amount is absorbed in the gastro-intestinal tract. Most of it is eliminated from the body unchanged in the feces.

Route of Elimination

Hypromelloses is eliminated from the body unchanged in the feces.

Dosage

The dosage of Hypromelloses is dependent on the application. The recommended dosage for its eye drop application is up to 4 times a day, but this should be determined by an ophthalmologist. For pharmaceutical and cosmetics applications, the dosage varies depending on the formulation and the desired effect. Generally, it is used in the range of 0.5 - 3.0 % w/w.

Administration

Hypromelloses can be administered orally, topically, or as an eye drop according to the indication. For eye drops, the drop should be instilled into the lower conjunctival sac of the affected eye(s). For external use, the product should be applied with a sterile cotton wool swab or other suitable application.

Side Effects

The most common side effects of Hypromelloses are stinging, redness, and irritation of the affected area. Other common side effects include dryness, itching, and peeling of the skin.

Toxicity

Hypromelloses is generally considered non-toxic when taken orally in the recommended dosage. It is safe to use topically at the recommended dosages.

Precautions

Hypromelloses should not be used by people who are allergic to cellulose or other cellulose derivatives. It should also be used with caution in people with sensitive skin or eyes.

Interactions

Hypromelloses may interact with other medications so it is important to consult with a doctor before taking. It may also interact with certain foods such as dairy and eggs, so it is important to discuss potential interactions with a healthcare professional.

Disease Interactions

Hypromelloses may interact with certain medical conditions such as ulcerative colitis, Crohn’s disease, and irritable bowel syndrome. Therefore, it is important to talk to a doctor before taking the medication.

Drug Interactions

Hypromelloses may interact with other medications, such as antacids or antidiarrheal agents. It is important to talk to a healthcare professional about potential drug interactions.

Food Interactions

Hypromelloses may interact with certain food components such as dairy and eggs. Therefore, it is important to talk to a healthcare professional before taking Hypromelloses if you have any food allergies.

Pregnancy Use

Hypromelloses is generally considered safe to use during pregnancy and lactation. However, it is important to discuss the potential risks with a healthcare professional before taking the medication.

Lactation Use

Hypromelloses is generally considered safe to use during nursing. However, it is important to discuss the potential risks with a healthcare professional before taking the medication.

Acute Overdose

Signs of acute overdose may include nausea, vomiting, and abdominal pain. If an overdose is suspected, it is important to seek medical attention immediately.

Contraindication

Hypromelloses should not be used by people who are allergic to cellulose or other cellulose derivatives.

Use Directions

The exact directions of use for Hypromelloses depends on the application. Generally, it is applied topically or instilled via eye drops.

Storage Condition

Hypromelloses should be stored in a cool, dry, and dark place away from direct light, moisture, and heat. It should be kept out of reach of children and pets.

Volume of Distribution

Hypromelloses is poorly absorbed by the body and most of it is eliminated in the feces.

Half Life

The half-life of Hypromelloses is not clearly known.

Clearance

Hypromelloses is eliminated from the body unchanged in the feces.

Here you find in details version of Hypromelloses

Some Frequently Asked Questions About Hypromelloses

What is Hypromelloses?

Hypromelloses, also known as hydroxypropyl methylcellulose or HPMC, is a gelling and thickening agent derived from cellulose. It is used in a variety of industries, including medical, pharmaceutical, and food.

What is Hypromelloses used for?

Hypromelloses is used to thicken, stabilize, and bind drugs and food products. It is often used as an excipient in tablets and capsules and is frequently used in pharmaceutical ophthalmic solutions, suspensions, and ointments.

How does Hypromelloses work?

Hypromelloses works by absorbing and dissolving in water as it forms a gel-like consistency similar to that of agar. This thick gel matrix then prevents the active ingredients in the drug from settling or separating out. Additionally, the gel helps to stabilize and bind the drug molecules, thus improving drug efficacy and shelf life.

What is Hypromelloses made of?

Hypromelloses is derived from cellulose, which is a polymer of glucose units linked together. It is produced by a chemical process that involves hydroxypropylation, which replaces some of the hydrogens on the cellulose molecule with hydroxypropyl groups.

What is the difference between Hypromelloses and cellulose?

The main difference between Hypromelloses and cellulose is that Hypromelloses is a modified form of cellulose, with some of the hydrogens on the cellulose molecule replaced with hydroxypropyl groups. This modified cellulose has the ability to absorb, dissolve, and form a gel, making it an excellent thickening and gelling agent.

What are the benefits of Hypromelloses?

The benefits of Hypromelloses include its ability to thicken, stabilize, and bind drugs and food products, which improves drug efficacy and shelf life. It is also non-toxic, non-allergenic, and has been approved by the FDA for use in pharmaceutical and food products.

What products contain Hypromelloses?

Hypromelloses is used to thicken, stabilize, and bind a variety of products, from pharmaceutical tablets and capsules to food products such as jams and jellies. It is also found in ophthalmic solutions, suspensions, and ointments.

Is Hypromelloses safe?

Yes, Hypromelloses is generally regarded as safe and has been approved by the FDA for use in food and pharmaceutical products. It is non-toxic, non-allergenic, and does not have any serious side effects.

What are the side effects of Hypromelloses?

The most common side effect of Hypromelloses is digestive upset, including nausea, abdominal pain, and diarrhea. It can also cause allergic reactions in some people.

Can Hypromelloses be used in food?

Yes, Hypromelloses is approved by the FDA for use in food products as an emulsifying, stabilizing, or suspending agent, so it can be used to thicken jams and jellies, improve the texture of baked goods, and increase the shelf life of other food items.

What is the difference between Hypromelloses and Methylcellulose?

Methylcellulose is a modified form of cellulose with some of the hydrogens replaced with methyl groups, whereas Hypromelloses is a modified form of cellulose with some of the hydrogens replaced with hydroxypropyl groups. While both are used as thickening and gelling agents, Methylcellulose is generally used in food products and Hypromelloses is usually used in pharmaceutical products.

What is the shelf life of Hypromelloses?

The shelf life of Hypromelloses will vary depending on the specific product, but in general, products made with Hypromelloses can be stored for up to two years. It is important to store such products in a cool, dry place away from direct light and heat.

How do you dissolve Hypromelloses?

Hypromelloses can be dissolved in hot or cold water. It should be added to the water slowly and stirred continuously until it is completely dissolved. For best results, it can be dissolved in a blender or homogenizer.

Is Hypromelloses vegan?

Yes, Hypromelloses is vegan-friendly as it is derived from plant-based cellulose. Hypromelloses does not contain any animal-derived ingredients.

Is Hypromelloses gluten free?

Yes, Hypromelloses is gluten free. It is derived from plant-based cellulose and does not contain any wheat, barley, or rye, which are the sources of gluten.

Is Hypromelloses harmful to humans?

No, Hypromelloses is generally regarded as safe and does not have any serious side effects. It is non-toxic and non-allergenic, and has been approved by the FDA for use in food and pharmaceutical products.

How do you use Hypromelloses?

Hypromelloses can be used as a thickening, stabilizing, and binding agent in a variety of pharmaceutical, food, and cosmetic products. It is often used in ophthalmic solutions, suspensions, and ointments, as well as in jams and jellies to improve texture, shelf life, and the overall quality of the product.

Does Hypromelloses contain preservatives?

No, Hypromelloses does not contain any preservatives. It is a pure gelling and thickening agent derived from cellulose.

Is Hypromelloses non-GMO?

Yes, Hypromelloses is non-GMO as it is derived from plant-based cellulose.

What is the molecular weight of Hypromelloses?

The molecular weight of Hypromelloses varies depending on the specific product, but in general, it typically ranges from 10,000 to 600,000 daltons.

Is Hypromelloses Kosher?

Yes, Hypromelloses is Kosher as it is a plant-based product.

Is Hypromelloses non-allergenic?

Yes, Hypromelloses is non-allergenic and does not usually cause any allergic reactions.

Is Hypromelloses halal?

Yes, Hypromelloses is halal as it is a plant-based product.

What is the pH of Hypromelloses?

The pH of Hypromelloses varies depending on the specific product, but it typically ranges from 5.5 to 8.

Does Hypromelloses contain artificial colors or flavors?

No, Hypromelloses is a pure gelling and thickening agent and does not contain any artificial colors or flavors.

Is Hypromelloses soluble in oil?

No, Hypromelloses is not soluble in oil and will not dissolve in oil or any other non-polar solvents.

Can Hypromelloses be used in cosmetics?

Yes, Hypromelloses is often used as an emulsifying, stabilizing, or suspending agent in a variety of cosmetics, including creams, lotions, and shampoos.

Does Hypromelloses contain hormones?

No, Hypromelloses does not contain any hormones or other active ingredients.

What is the trade name of Hypromelloses?

The trade name of Hypromelloses is HPMC, which stands for hydroxypropyl methylcellulose.

What is the melting point of Hypromelloses?

The melting point of Hypromelloses varies depending on the specific product, but it typically ranges from 240°F to 250°F (116°C to 121°C).

Can Hypromelloses be used to sweeten food?

No, Hypromelloses is not sweet and is not suitable for use as a sweetener.

How long does Hypromelloses take to dissolve?

The amount of time it takes for Hypromelloses to dissolve will depend on the specific product, but in general, it can take anywhere from 10 minutes to several hours for it to dissolve completely.

What is the melting behaviour of Hypromelloses?

The melting behaviour of Hypromelloses is largely dependent on the specific product, but in general, it will form a thick, jelly-like consistency when heated. It will not liquefy when heated, and will become solid when cooled.

Is Hypromelloses flammable?

No, Hypromelloses is not flammable. It is a non-flammable, plant-based gelling and thickening agent.

Is Hypromelloses a natural product?

Yes, Hypromelloses is a natural product derived from plant-based cellulose.

Is Hypromelloses toxic?

No, Hypromelloses is non-toxic and does not present any serious health risks.

Is Hypromelloses biodegradable?

Yes, Hypromelloses is biodegradable. It will break down over time when exposed to microbes and other organic matter in the environment.

What is the solubility of Hypromelloses?

The solubility of Hypromelloses varies depending on the specific product, but in general, it is soluble in cold and hot water but not in oil or any other non-polar solvents.

Can Hypromelloses be used as a thickening agent?

Yes, Hypromelloses is often used as a thickening agent in food, pharmaceutical, and cosmetic products. It can be used to thicken jams and jellies, improve the texture of baked goods, and increase the shelf life of other products.

Does Hypromelloses contain any allergens?

No, Hypromelloses does not contain any known allergens and does not usually cause any allergic reactions.

Can Hypromelloses be used as a binding agent?

Yes, Hypromelloses is often used as a binding agent to stabilize, emulsify, and suspend active ingredients in a variety of products, from pharmaceutical tablets and capsules to food items.

Can Hypromelloses be used in capsules and tablets?

Yes, Hypromelloses is often used as an excipient in capsules and tablets. It helps to stabilize and bind the active ingredients, thus improving drug efficacy and shelf life.

What is the viscosity of Hypromelloses?

The viscosity of Hypromelloses varies depending on the specific product, but in general, it can range from 1000 to 100,000 centipoise.