Cefotetanum
Cefotetanum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cefotetanum is a brand name. Its generic name is Cefotetan.
Introduction
Cefotetanum (brand name: Cefotan) is a broad-spectrum, beta-lactam antibiotic used to help treat a wide variety of bacterial infections. It belongs to the cephalosporin class of antibiotics. Cefotetanum is used to help treat ear infections, skin infections, urinary tract infections, and certain types of stomach and intestinal infections. It may also be used to help treat some sexually transmitted diseases.
Uses For
Cefotetanum is used to help treat the following conditions:
- Ear infections
- Skin infections
- Urinary tract infections
- Certain types of stomach and intestinal infections
- Some sexually transmitted diseases
Mechanism of Action
Cefotetanum belongs to the class of antibiotics known as cephalosporins. It works by inhibiting the growth of bacteria. It binds to penicillin-binding proteins, which are enzymes responsible for the formation of the bacterial cell wall. This prevents the bacteria from making their cell wall, resulting in their death.
How Long Does it Take to Work?
Cefotetanum begins to work within a few hours of administration, but it may take up to two weeks for the medication to be fully effective. It is important to complete the entire course of medication even if you start to feel better after a few days so that the bacteria does not become resistant to the medication.
Absorption
Cefotetanum is rapidly and completely absorbed after oral administration. The peak concentrations in the serum occur two to three hours after administration.
Route of Elimination
Cefotetanum is eliminated primarily through bile. Approximately 60-70% of the dose is excreted unchanged in the bile.
Dosage
Cefotetanum is available in tablet and injection form. The typical adult dosage is 1-2 grams administered every 12 hours, depending on the severity of the infection. For infections caused by specific bacteria, the dosage may need to be adjusted. It is important to follow the directions of your healthcare provider when taking Cefotetanum.
Administration
Cefotetanum can be taken orally or injected intravenously. Oral tablets should be swallowed with a full glass of water. Intravenous injections should be given slowly over a 2-3 minute period.
Side Effects
Common side effects of Cefotetanum include:
- Nausea
- Vomiting
- Diarrhea
- Headaches
- Abdominal cramps
Toxicity
Cefotetanum has a low potential for toxicity. The most common adverse side effects are gastrointestinal in nature. Rare but serious toxicity including anaphylaxis, renal and hepatic failure, and hemolytic anemia have been reported.
Precautions
Cefotetanum should be used with caution in patients who are pregnant, breastfeeding, or have a history of allergies or kidney disease. It should not be used in patients with severe liver diseases or with a known sensitivity to cephalosporins. It should also not be used in patients who are receiving probenecid or another beta-lactamase inhibitor.
Interaction
Cefotetanum can interact with several medications. Patients taking cefotetan should inform their doctor if they are taking any other medications including prescription, over-the-counter, herbal, and vitamin supplements.
Disease Interaction
Cefotetanum can interact with some diseases. Patients should inform their doctor if they have any other chronic conditions before taking cefotetan. Patients with kidney disease, liver disease, allergies, or a history of bacterial resistance should use the medication with caution.
Drug Interaction
Cefotetanum may interact with other drugs used to treat infections. Tell your doctor if you are taking any of the following medications:
- Aminoglycosides
- Vancomycin
- Cephalosporin antibiotics
- Penicillins
- Tetracycline antibiotics
- Macrolide antibiotics
Food Interactions
Cefotetanum may interact with certain foods. Patients should avoid taking the medication with dairy products and fatty or high-fiber foods, and should eat food with the medication to prevent nausea. Grapefruit juice should also be avoided.
Pregnancy Use
Cefotetanum should be used during pregnancy only if it is clearly needed and the benefits outweigh the risks. It should be used with caution in women who are breastfeeding.
Lactation Use
Cefotetanum should be used with caution in breastfeeding mothers, as it may be excreted in breast milk and may cause side effects in breastfed infants. Patients should consult their doctor before taking the medication while breastfeeding.
Acute Overdose
Acute overdosage of cefotetan is rare. The most common symptoms of overdose are nausea, vomiting, and diarrhea. More serious side effects include seizures, renal impairment, and thrombocytopenia.
Contraindication
Cefotetanum should not be used in patients with a known allergies or sensitivities to cephalosporins, as it may cause serious allergic reactions. It should also not be used in patients with severe liver diseases or in those receiving probenecid or other beta-lactamase inhibitors.
Use Direction
Cefotetanum should be taken exactly as directed by your doctor. The dosage and frequency of the medication will vary depending on the severity of the infection being treated. It is important to follow your doctor’s instructions and complete the entire course of medication even if you start to feel better after a few days.
Storage Condition
Cefotetanum should be stored at room temperature, away from direct light and moisture. Keep the medication in its unopened original container. Do not allow the medication to freeze.
Volume of Distribution
Cefotetanum has a large volume of distribution. It is distributed to many tissues including the brain, lungs, liver, kidneys and spleen.
Half Life
The half-life of cefotetan is 2-3 hours. This means that half of the medication will be eliminated from the body within 2-3 hours of administration.
Clearance
Cefotetanum is cleared by the kidneys. Renal clearance is reduced in patients with impaired kidney function, so the dosage should be adjusted accordingly.
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