Cefantral

Cefantral Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cefantral is a brand name. Its generic name is Cefotaxime.

Cefantral Introduction

Cefantral is a cephalosporin-type antibiotic used to treat a variety of bacterial infections, including pneumonia, sepsis, meningitis, endocarditis, and urinary tract infections. It belongs to the third-generation cephalosporin class of antibiotics and should only be used after other antibiotics have been considered.

Uses For

Cefantral is used to treat a number of bacterial infections, including pneumonia, sepsis, meningitis, endocarditis, and urinary tract infections. It is effective against both aerobic and anaerobic bacteria, and is particularly effective against gram-negative bacteria such as Escherichia coli and Klebsiella pneumonia.

Mechanism of Action

Cefantral works by interrupting cell wall synthesis of bacteria. The antibiotic prevents bacteria from forming the cross-links between peptidoglycan chains that are necessary for the stability and integrity of bacterial cell walls. This results in a weakened cell wall, which causes cell lysis and death.

How Long Does it Take to Work?

Cefantral typically begins to work within 2-3 hours of administration. However, the time it takes for the antibiotic to fully eliminate the infection can vary depending on the severity of the infection and the individual's response to the medication.

Absorption

Cefantral is well absorbed when taken orally and is also well absorbed following intramuscular administration. As a cephalosporin antibiotic, it is designed to be administered parenterally.

Route of Elimination

Cefantral is mainly eliminated through the kidneys, and some is eliminated through the bile as well. Approximately 40% of a dose of the drug is eliminated through the kidneys, while the remaining is eliminated through biliary excretion.

Dosage

The dosage and administration of cefotaxime vary depending on the severity and type of infection being treated. Generally, the drug is administered as an intravenous infusion over 30-60 minutes. The typical recommended dose for adults is 500-1000mg every 8-12 hours for mild to moderate infections, and 2g every 8 hours for severe infections. For children, the dosage is 30-50mg/kg per day in divided doses every 6-8 hours.

Administration

Cefantral is usually administered intravenously as an infusion over a period of 30-60 minutes or as an intramuscular injection. Intramuscular injections should be administered slowly and deeply into the gluteal muscle.

Side Effects

Common side effects of cefotaxime include mild nausea, vomiting, diarrhea, rash, and benign skin reactions. Less common but more serious side effects include allergic reactions, fever, chills, sore throat, abdominal pain, and joint pain. Rarely, cefotaxime can cause seizures, coma, confusion, and kidney problems.

Toxicity

Cefantral is generally well tolerated in most people, but it is not recommended for use in individuals with a penicillin allergic reaction. Overdosing also can lead to severe side effects, including convulsions, watery or bloody diarrhea, fever, and confusion.

Precautions

Cefantral should be used with caution in people with kidney or liver impairments. People with a history of allergies to other antibiotics and those with heart or blood diseases should discuss with their doctor before taking the drug. In addition, cefotaxime should not be taken if there is an active infection with a virus, fungus, or parasite.

Interactions

Cefantral has been known to interact with a number of other drugs, including other antibiotics, anticoagulants, and anticonvulsants. Patients should be instructed to let their healthcare provider know of any drug or herbal supplements they are taking before starting cefotaxime treatment.

Disease Interactions

Cefantral can interact with some diseases and conditions, such as kidney/liver diseases, active infection with a virus, fungus, or parasite, or a history of allergy to penicillins. Patients with any of these diseases or conditions should talk to their doctor before taking cefotaxime.

Drug Interactions

Cefantral can interact with some drugs that may effect the way they work, or can make the side effects worse. These include anticoagulants, anticonvulsants, birth control pills, and diuretics. Patients should tell their doctor about all medications they are taking before starting cefotaxime to prevent possible interactions.

Food Interactions

Cefantral may interact with food. Foods that contain calcium, magnesium, aluminum, and zinc can decrease the absorption of cefotaxime. Patients should ask their doctor or pharmacist about their food interactions before taking cefotaxime.

Pregnancy Use

Cefantral is generally not recommended for use in pregnant women. Studies in animals have demonstrated fetal harm, and it is unknown if it can cause similar effects in humans. Pregnant women should consult their doctor before taking cefotaxime.

Lactation Use

Cefantral is excreted in human milk and may lead to milk-borne infections in infants. Therefore, women who are breastfeeding should discuss with their doctor before taking cefotaxime.

Acute Overdose

An acute overdose of cefotaxime can lead to severe side effects including nausea, vomiting, diarrhea, seizures, and coma. Immediate medical attention should be sought if an overdose is suspected.

Contraindication

Cefantral is contraindicated in patients with a known hypersensitivity to cephalosporin antibiotics, such as cefotaxime, or any of its ingredients. Patients with a history of allergy to penicillins should also avoid taking cefotaxime.

Use Direction

The recommended dosage and duration of treatment with cefotaxime can vary depending on the type and severity of the infection being treated. Always follow your doctor's instructions and the directions on the prescription label. Do not take more or less than the recommended dose or duration of treatment.

Storage Conditions

Cefantral should be stored at room temperature away from direct light and moisture. Keep the medication in the original container and tightly closed when not in use. Do not freeze the medication or leave it out of reach of children and pets.

Volume of Distribution

The estimated volume of distribution (Vd) of cefotaxime is 0.4L/kg. This volume of distribution is a measure of the amount of drug that is present in the body and indicates how well it is distributed in the body.

Half Life

The half-life of cefotaxime is between 0.68-1.8 hours in adults, and 1.5-4.2 hours in newborns. This is the time it takes for the body to reduce the concentration of a drug by half.

Clearance

The clearance rate of cefotaxime is 0.24L/h/kg. This is a measure of how quickly the body eliminates the drug. The higher the clearance rate, the faster the drug is eliminated from the body.

Here you find in details version of Cefantral

Some Frequently Asked Questions About Cefantral

What is Cefantral?

Cefantral is a third-generation cephalosporin antibiotic used to treat a variety of infections caused by susceptible organisms, including gram-negative and gram-positive bacteria, as well as some anaerobic bacteria.

What types of infections is Cefantral used to treat?

Cefantral is used to treat a variety of infections caused by susceptible organisms, including gram-negative and gram-positive bacteria, as well as some anaerobic bacteria, e.g. sepsis, meningitis, bronchitis, pneumonia, urinary tract infections, and ear/stomach/intestine/skin/bone and joint infections.

What are the side effects of Cefantral?

The most common side effects observed with Cefantral include nausea, diarrhoea, rash, headache and yeast infection. Less common side effects include abdominal pain, indigestion, dizziness, vomiting, constipation and itching.

What is the standard dosage for Cefantral?

The standard dosage for Cefantral is 1 to 2 grams every 8 to 12 hours, depending on the severity of the infection, as prescribed by the doctor.

Does Cefantral have any interactions with other medications?

Yes. Cefantral may interact with other medications, such as probenecid, methotrexate, and warfarin. Always consult your doctor before taking any medication, including Cefantral, to check for possible interactions.

What are the warnings for taking Cefantral?

Cefantral may cause an overgrowth of Candida, a fungus which can cause vaginal and other types of yeast infections. Patients with kidney or liver disease, diabetes or HIV/AIDS may be at an increased risk of side effects, and may need to have their dose adjusted. Always consult your doctor before taking Cefantral.

Is Cefantral safe for children?

Yes, Cefantral is considered safe for use in children. However, dosage may be adjusted based on individual child's weight and age, as instructed by the doctor.

Can Cefantral be used for treating gonorrhea?

Yes, Cefantral can be used to treat gonorrhea, although it is not the first-line treatment. It is usually prescribed as part of a combination therapy.

Are there any long-term side effects of taking Cefantral?

Long-term use of Cefantral may cause overgrowth of Candida, a yeast infection which can affect the vagina, mouth and other parts of the body. Long-term use may also cause other side effects, such as diarrhea, rash and headache.

What should I do if I miss a dose of Cefantral?

If you miss a dose of Cefantral, take it as soon as you can. If it is close to your next dose, skip the missed dose and take your next dose at the regular time. Do not double your dose to make up for the missed one.

Can I take antacids with Cefantral?

Yes, you can take antacids with Cefantral, but make sure to leave a gap of at least two hours between the antacid and Cefantral. This is because antacids can change the way Cefantral is absorbed into the bloodstream.

What is the storage condition of Cefantral?

Cefantral should be stored at room temperature, away from direct sunlight and moisture. Keep it in the original packaging until you are ready to take it. Do not refrigerate Cefantral, as this may affect its potency.

Is Cefantral safe during pregnancy?

Yes, Cefantral is generally considered safe to use during pregnancy, but the doctor will need to decide if it is appropriate for you. If you are pregnant, you should inform your doctor before taking Cefantral.

Can Cefantral be used for long-term treatment?

Yes, Cefantral can be used for long-term treatment, although your doctor may need to adjust the dosage or duration of treatment based on individual cases. It is important to take Cefantral exactly as prescribed by your doctor.

What are the most common adverse effects of Cefantral?

The most common adverse effects observed with Cefantral include nausea, diarrhoea, rash, headache and yeast infection. Less common adverse effects include abdominal pain, indigestion, dizziness, vomiting, constipation and itching.

What should I avoid while taking Cefantral?

Avoid grapefruit juice, as it may interact with Cefantral and cause side effects. Avoid taking alcohol while taking Cefantral as it may increase the risk of certain side effects. Also, if you are allergic to penicillin or cephalosporin antibiotics, you should avoid taking Cefantral.

Does Cefantral affect the liver?

Yes, Cefantral can affect the liver, although it is usually seen in rare cases. Patients with Hepatic Impairment (liver disease) may need to have their dose adjusted, as instructed by the doctor.

Can Cefantral be used to treat a urinary tract infection (UTI)?

Yes, Cefantral can be used to treat a urinary tract infection (UTI), although it is not the first-line treatment. Your doctor may prescribe it if more commonly-used antibiotics fail to treat your infection.

Can I take Cefantral if I am allergic to Penicillin?

Yes, you can take Cefantral if you are allergic to Penicillin, as Cefantral is a cephalosporin antibiotic. However, before taking Cefantral, tell your doctor if you are allergic to Penicillin, as well as any other medications or food products.

Can I take Cefantral if I am taking Warfarin?

Yes, you can take Cefantral if you are taking Warfarin, although it is important to inform your doctor as both medications can interact with each other. Your doctor may adjust the dose of either or both medications to avoid possible interaction between them.

Is Cefantral safe during breastfeeding?

Yes, Cefantral can be taken during breastfeeding, although the doctor may need to adjust the dosage accordingly. Always inform your doctor if you are breastfeeding before taking Cefantral.

What are the signs or symptoms that Cefantral is not working?

If your symptoms have not improved after taking Cefantral for two to three days, or have worsened, it may be sign that Cefantral is not working for you. Contact your doctor immediately for further check-up and advice.

What is the usual duration of treatment with Cefantral?

The usual duration of treatment with Cefantral is 7-14 days, depending on the severity of the infection. Your doctor may also adjust the dosage or duration of treatment based on individual case.

What type of bacteria does Cefantral treat?

Cefantral is used to treat a variety of infections caused by susceptible organisms, including gram-negative and gram-positive bacteria, as well as some anaerobic bacteria.

What does Cefantral interact with?

Cefantral may interact with other medications, such as probenecid, methotrexate, and warfarin. Always consult your doctor before taking any medication, including Cefantral, to check for possible interactions.

Can I take Cefantral with food?

Yes, you can take Cefantral with food, although it is advised to take it at least 1 hour before or 1 hour after meals. This is to ensure that the Cefantral is absorbed properly into the bloodstream.

Is Cefantral effective against staphylococcal infections?

Yes, Cefantral is effective against staphylococcal infections, as it belongs to a class of antibiotics known as cephalosporins, which work by killing or inhibiting the growth of certain bacteria.

Are there any what is the difference between Cefantral and Ceftazidime?

Yes, Cefantral and Ceftazidime are two different antibiotics. Cefantral is a third-generation cephalosporin used to treat a variety of infections, while Ceftazidime is a fourth-generation cephalosporin used to treat serious infections.

Is Cefantral safe to use for a long period of time?

Yes, Cefantral can be used for a long period of time, although your doctor may need to adjust the dosage or duration of treatment based on individual cases. It is important to take Cefantral exactly as prescribed by your doctor.

Does Cefantral cause any allergic reactions?

Yes, Cefantral may cause allergic reactions in some people, such as skin rash, itching or swelling of the face, lips or tongue, difficulty breathing or dizziness. If you experience any of these symptoms, stop taking Cefantral and inform your doctor immediately.

Can I take Cefantral with other antibiotics?

Yes, you can take Cefantral with other antibiotics, although it is important to inform your doctor as some antibiotics may interact with Cefantral. Your doctor may adjust the dose or duration of treatment to avoid possible interactions.

Is Cefantral safe to take with other medications?

Yes, you can take Cefantral with other medications, but it is important to inform your doctor as certain medications may interact with Cefantral. Always check with your doctor if it is safe to take Cefantral with any other medications.

Can Cefantral cause dizziness or drowsiness?

Yes, Cefantral may cause dizziness or drowsiness in some patients. It is important to take this medication with caution, especially when driving or operating machinery. If you experience any dizziness or drowsiness, stop taking Cefantral and inform your doctor immediately.

Can Cefantral be used to treat bacterial meningitis?

Yes, Cefantral can be used to treat bacterial meningitis, although it is usually used in combination with another antibiotic. It is important to take Cefantral exactly as prescribed by your doctor.

What are the precautions to be taken while taking Cefantral?

Cefantral should be taken exactly as prescribed by your doctor. Inform your doctor if you are pregnant, breastfeeding or have any allergies or kidney or liver disease. Avoid grapefruit juice or alcohol while taking Cefantral.

Can Cefantral be used for bacterial vaginosis?

Yes, Cefantral can be used for bacterial vaginosis, although it is usually used in combination with another antibiotic. It is important to take Cefantral as prescribed by your doctor.

Are there any over-the-counter alternatives to Cefantral?

No, there are no over-the-counter alternatives to Cefantral. Cefantral is a prescription medication, and must be taken under the supervision of a doctor.

Can Cefantral be taken with probenecid?

Yes,