Avolide

Avolide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Avolide is a brand name. Its generic name is Nimesulide.

Avolide

Avolide is a nonsteroidal anti-inflammatory drug (NSAID) indicated for pain relief, fever and inflammation associated with several inflammatory diseases. It was first introduced in clinical use in early 1990s. It is available in the form of tablets, orally disintegrating tablets, suspensions or syrups.

Uses For

Avolide is generally used for the relief of acute and chronic pain relief associated with various infections such as dental pain, dysmenorrhea (painful menstrual cramps),musculoskeletal conditions like arthritis, tendinitis, bursitis and acute gouty arthritis. It is also used for symptomatic relief of fever like spongy fever and recurrent fever.

Mechanism of Action

Avolide works by inhibiting the inflammatory enzyme, cyclooxygenase (COX). This enzyme is responsible for the production of prostaglandins which are necessary for the inflammatory process. By inhibiting this enzyme, COX-2 mediates the anti-inflammatory effects of Avolide.

How Long Does It Take to Work?

Avolide typically takes about 30 minutes to an hour to become effective. The onset of action varies among individuals depending on the type and intensity of the pain.

Absorption

Avolide is quickly and completely absorbed after oral administration. It reaches the peak serum level within 1-2 hours. The plasma half-life of Avolide is approximately 1 hour.

Route of Elimination

Avolide is mainly eliminated through the faecal route, with only a small fraction being eliminated through the urine.

Dosage

The recommended dose of Avolide is 10-25mg twice a day, with an increase of up to 50mg per dose after 3-5 days if required. The maximum daily dose should not exceed 100mg. It should be taken with food to reduce gastric irritation.

Administration

Avolide can be taken orally or rectally, depending on the form. It is available in the form of tablets, orally disintegrating tablets, suspensions or syrups for oral administration. It can also be administered intramuscularly, subcutaneously or intravenously.

Side Effect

Common side effects associated with Avolide use include nausea, vomiting, abdominal pain, headache, dizziness, rash, itching, dry mouth and increased risk of gastrointestinal bleeding and ulceration. Other rare but serious side effects include, insomnia, depression, anxiety, blurred vision, confusion, hallucination, anaphylaxis and liver injury.

Toxicity

The most severe toxic effect due to Avolide overdose is liver injury with prolonged use of high doses. Other toxicities that may occur due to overdose include gastrointestinal bleeding, convulsions, hypotension, shock, nephrotoxicity and respiratory depression.

Precaution

Avolide should be taken with caution in patients with pre-existing gastrointestinal bleeding, liver and kidney ailments. It should be used with caution in elderly and in children, as it has a higher risk of gastrointestinal bleeding in these patients. It should not be used in pregnant and breastfeeding women as it can affect the foetus or baby.

Interaction

Avolide can interact with other drugs like antiplatelet agents, high blood pressure medications, and cyclosporine. So, it should be taken with caution when taken with other medications. Also, it should be taken with caution in patients with allergy to other non steroidal anti-inflammatory drugs,and should not be taken if you are taking aspirin.

Disease Interaction

Avolide should be used with caution in patients with bleeding disorders, heart or kidney diseases, as it can cause a further increase in the risk of serious side effects. Also, it should not be used if you have a history of asthma, as it can trigger an asthma attack.

Drug Interaction

Avolide may interact with other medications like anticoagulants, aspirin, corticosteroids, antimalarials, lithium, aspirin, phenytoin, phenobarbital and warfarin. So, if you are taking any of these drugs, you should inform your doctor.

Food Interactions

Avolide should be taken with food to reduce stomach irritation. Alcohol should be avoided while using Avolide; as it can increase the risk of stomach bleeding.

Pregnancy Use

Avolide should not be used during pregnancy as it can affect the health of the baby or the mother. The risks associated with taking Avolide are more than the benefits during pregnancy. So, it is recommended to avoid taking Avolide during pregnancy.

Lactation Use

Avolide should not be used during lactation as it can get into the breast milk, which may affect the baby. Also, the risks associated with taking Avolide are more than the benefits during lactation.

Acute Overdose

Acute overdose of Avolide may lead to symptoms like nausea, vomiting, drowsiness, abdominal pain, dizziness, sweating, and confusion. Liver and kidney toxicity can also occur due to prolonged use or overdose. In case of acute overdose, immediate medical attention should be sought.

Contraindication

Avolide should not be used in patients with hypersensitivity to this drug, those with pre-existing liver, kidney, and heart diseases, and those with gastrointestinal bleeding or ulcers. It should also not be used in pregnant and breastfeeding women, and in patients taking aspirin.

Use Directions

Avolide should be administered as per the doctor’s advice. It should not be taken in excess of the recommended dose, and should be taken with food to reduce the risk of gastrointestinal side effects. It should also be stored at room temperature and should be kept away from direct sunlight.

Storage Condition

Avolide should be stored at room temperature away from direct sunlight and moisture. It should be kept out of reach of children and pets.

Volume of Distribution

The volume of distribution of Avolide is 0.3 L per kg.

Half Life

The half life of Avolide is 1 hour.

Clearance

The clearance of Avolide is 1.2 mL per minute per kg.

Here you find in details version of Avolide

Some Frequently Asked Questions About Avolide

What is Avolide?

Avolide is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation.

Who manufactures Avolide?

Avolide is manufactured and marketed by various pharmaceutical companies.

What are the uses of Avolide?

Avolide is used to treat symptoms of arthritis, menstrual cramps, and other types of pain. It is also used to reduce fever.

What are the side effects of Avolide?

Common side effects of Avolide include nausea, vomiting, diarrhea, stomach pain, indigestion, headache, dizziness, and rash. Serious side effects may include heart attacks, strokes, and kidney damage.

Is Avolide safe to use?

Avolide should only be used under the supervision of a medical doctor. It is important to follow all the instruction provided by your doctor.

How long should I take Avolide?

The duration of treatment with Avolide must be determined by your doctor. It should not be used longer than the recommended period.

Does Avolide interact with any other drugs?

Avolide may interact with other drugs, including certain antibiotics, blood thinners, diuretics, and medications for high blood pressure. It is important to tell your doctor about any medications you are taking before taking Avolide.

What are the warnings associated with Avolide?

Avolide should not be used in people with conditions such as asthma, bleeding or blood clotting problems, or heart problems. It is also not recommended for people who are pregnant or breastfeeding. It should be avoided in people with liver or kidney disease.

What is the dosage of Avolide?

The dosage of Avolide will depend on the condition being treated, your age, and other factors. It is important to follow your doctor’s instructions carefully when taking this medication.

What should I do if I miss a dose of Avolide?

If you miss a dose of Avolide, take it as soon as possible. Do not take two doses at the same time. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule.

What should I do if I overdose on Avolide?

If you or someone else has overdosed on Avolide, seek immediate medical attention. Symptoms of an overdose may include nausea, vomiting, dizziness, and abdominal pain.

Can Avolide be used in children?

Avolide is not recommended for use in children under 12 years of age. If your child needs a pain reliever, speak to your doctor about alternative medications.

Is Avolide available over-the-counter?

No, Avolide is not available over-the-counter. It requires a prescription from your doctor.

Can I take Avolide with food?

Yes, it is recommended to take Avolide with food or a glass of milk. This will help reduce the risk of stomach upset.

Does Avolide cause drowsiness?

Yes, Avolide may cause drowsiness or dizziness. It is important to avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you.

Can Avolide be taken with alcohol?

No, it is not recommended to mix Avolide with alcohol. Alcohol can increase the risk of side effects from this medication.

What should I avoid while taking Avolide?

You should avoid activities that require mental alertness, such as driving or operating machinery, until you know how Avolide affects you. It is also important to avoid taking other medications that could interact with Avolide, unless instructed by your doctor.

Can Avolide cause weight gain?

There is no evidence that Avolide causes weight gain. However, it is possible to gain weight while taking Avolide if you are not careful with your diet.

What should I do if I experience an allergic reaction to Avolide?

If you experience any signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, stop taking the medication and contact your doctor immediately.

What should I tell my doctor before taking Avolide?

Before starting treatment with Avolide, it is important to tell your doctor about any other medications you are taking, your medical history, and any allergies you may have.

What form of Avolide is available?

Avolide is available in tablet, capsule, and oral suspension form.

What is the generic name of Avolide?

The generic name of Avolide is Avolide.

Does Avolide cause constipation?

Yes, Avolide may cause constipation. If you experience constipation while taking Avolide, speak to your doctor about other medications that may reduce this side effect.

Should Avolide be taken with food?

It is recommended to take Avolide with food or a glass of milk to reduce the risk of stomach upset.

What if I forget to take my dose of Avolide?

If you forget to take a dose of Avolide, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule.

Is it safe to take Avolide while pregnant?

No, it is not recommended for pregnant women to take Avolide. Speak to your doctor about alternative medications.

Does Avolide cause dehydration?

Dehydration may be a side effect of Avolide use. It is important to drink plenty of fluids while taking this medication.

Can Avolide lower blood pressure?

Yes, Avolide may lower blood pressure. If you are taking medications to lower your blood pressure, speak to your doctor before taking Avolide.

Can I take Avolide with other NSAIDs?

No, it is not recommended to take Avolide with other NSAIDs. Taking multiple NSAIDs could increase your risk of side effects.

Should I take Avolide with food or on an empty stomach?

It is recommended to take Avolide with food or a glass of milk to reduce the risk of stomach upset.

Can Avolide be crushed or split?

You may be able to crush or split Avolide tablets. However, it is important to check with your doctor before doing so.

What are the possible drug interactions with Avolide?

Avolide may interact with certain antibiotics, blood thinners, diuretics, and medications for high blood pressure. It is important to tell your doctor about any medications you are taking before taking Avolide.

Is it safe to use Avolide long-term?

No, it is not recommended to use Avolide long-term. Long-term use of Avolide may increase the risk of side effects.

Can Avolide be used to treat stomach ulcers?

No, Avolide is not recommended for treating stomach ulcers. Speak to your doctor about other medications that may be more effective.

Can I take ibuprofen and Avolide together?

No, it is not recommended to take ibuprofen and Avolide together. Taking multiple NSAIDs could increase your risk of side effects.

Can I take Avolide while breastfeeding?

No, it is not recommended for breastfeeding women to take Avolide. Speak to your doctor about alternative medications.

Does Avolide cause kidney damage?

Yes, long-term use of Avolide may increase the risk of kidney damage. It is important to use this medication only under the guidance of your doctor.

Can Avolide be used to treat fever?

Yes, Avolide is used to treat fever by reducing inflammation and reducing body temperature.

Can Avolide cause skin rash?

Yes, Avolide may cause a skin rash. If you experience any skin rash while taking Avolide, contact your doctor immediately.

Can Avolide be taken with antibiotics?

Yes, Avolide can be taken with certain antibiotics. However, it is important to tell your doctor about any medications you are taking before taking Avolide.

Does Avolide elevate liver enzymes?

Yes, long-term use of Avolide may cause elevated liver enzymes. It is important to speak to your doctor if you experience any signs of liver problems while taking this medication.

Can I buy Avolide online?

No, Avolide is not available to buy online. It requires a prescription from your doctor.