Active P

Active P Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Active P is a brand name. Its generic name is Triprolidine.

Active P Introduction

Active P is an anticholinergic antihistamine used to treat a wide range of allergic and non-allergic symptoms such as sneezing, runny nose, itchy eyes, watery eyes, and hay fever. It works by blocking the effects of histamine, a chemical released by the body during an allergic reaction. It is also used to treat motion sickness, nausea, vomiting, and dizziness caused by motion sickness.

Uses for Active P

Active P is used to relieve the symptoms from allergies, hay fever, and the common cold. It is also used to treat motion sickness, nausea, vomiting, dizziness, and other associated symptoms caused by motion. It can be used as a preventative treatment to reduce the risk of motion sickness or as a treatment for motion sickness symptoms already occurring.

Mechanism of Action

Active P works by blocking the effects of histamine, a chemical the body releases during allergic reactions. It also blocks the reuptake of dopamine and serotonin, which are naturally produced neurotransmitters in the brain and can impact the body’s sleep-wake cycle.

How Long Does it Take to Work?

The effects of Active P typically occur within 30 minutes after taking the medication, however, the exact time frame may vary from person to person.

Absorption

Active P is well-absorbed in the gastrointestinal tract.

Route of Elimination

Active P is eliminated from the body primarily through metabolism, hydroxylation, and renal excretion.

Dosage

The dosage of Active P depends on the individual and the condition being treated. The usual adult dose for allergic symptoms is 5mg given three times a day (every 8 hours). For motion sickness, the adult dosage is 2.5-5mg given twice per day (every 12 hours). The recommended pediatric dosage for allergic symptoms is 2.5mg given three times a day (every 8 hours). For motion sickness, the recommended pediatric dosage is 1.25-2.5mg given twice a day (every 12 hours).

Administration

Active P can be taken orally or can be injected intramuscularly.

Side Effect

Common side effects of Active P include drowsiness, dry mouth, dizziness, headache, stomach upset, constipation, and blurred vision.

Toxicity

The acute toxicity of Active P is low and the risk of overdose is low even at higher doses.

Precaution

Active P should be used with caution in people with glaucoma, cardiovascular diseases, respiratory diseases, and diabetes.

Interaction

Active P may interact with several other medications such as antihistamines, sedatives, antidepressants, and anticonvulsants. It should not be used with alcohol or other sedatives.

Disease Interaction

Active P may interact with certain diseases, including asthma and kidney or liver dysfunction.

Drug Interaction

Active P may interact with certain drugs, including barbiturates, benzodiazepines, narcotics, and non-steroidal anti-inflammatory drugs.

Food Interaction

Active P may interact with some foods, including alcohol, chocolate, and spicy foods.

Pregnancy Use

Active P should be used with caution during pregnancy.

Lactation Use

Active P should not be used while breastfeeding.

Acute Overdose

If an overdose occurs, seeking immediate medical attention is advised. Symptoms of an overdose may include lethargy, drowsiness, agitation, confusion, dilated pupils, rapid heartbeat, and seizures.

Contraindication

Active P should not be used in patients with a known hypersensitivity to the drug or other anticholinergic drugs.

Use Direction

It is important to take Active P exactly as prescribed by your doctor. Do not take more or less of the medication than prescribed. The medicine should be taken at the same time every day.

Storage Condition

Store Active P in a cool, dark place away from heat and moisture. Keep the medication away from children and pets.

Volume of Distribution

Active P has a volume of distribution = 15-77 L/Kg.

Half Life

Active P has a half life of 1-6 hours.

Clearance

Active P has an oral clearance rate of 3-10 L/hr/kg.

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