Brain-Ox
Brain-Ox Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Brain-Ox is a brand name. Its generic name is Vincamine.
Introduction
Brain-Ox is a naturally-occurring alkaloid, isolated from the Vinca minor plant, traditionally used for circulation problems and migraine. It is now commonly used as pharmaceutical supplement prescribed for cognitive impairments, stroke, and aging-related cognitive decline.Uses
Brain-Ox is used for promoting cerebral metabolic activity, increasing intracranial circulation, and supporting neurological rehabilitation. It is also used to improve cognitive impairment, mental alertness, and memory functions among elderly people and people suffering from stroke, cortical dementia, and Parkinson's disease.Mechanism of Action
Brain-Ox works primarily by improving cerebral perfusion, i.e. increasing blood flow to the brain's blood vessels and tissue. It is thought to act by inhibiting the breakdown of the important neurotransmitter acetylcholine via catechol-O-methyl-transferase (COMT). Additionally, Brain-Ox is thought to act as a vasodilator, improving blood flow to the brain and other tissues.How Long Does it Take to Work?
Brain-Ox begins to work after about 30 minutes. Its effects can last for up to 8-12 hours.Absorption
Brain-Ox is easily absorbed in the gastrointestinal tract and can be detected in systemic circulation 30 minutes after ingestion.Route of Elimination
Brain-Ox is mainly eliminated through the kidneys and fecal excretion.Dosage
The recommended dose of Brain-Ox is 50 mg to 200 mg twice a day, or as prescribed by a doctor. The dosage may be adjusted according to the individual needs and clinical response of the patient.Administration
Brain-Ox should be taken orally, preferably after meals. It is available in tablet or capsule form.Side Effects
Common side effects associated with Brain-Ox use include headache, nausea, and dizziness.Toxicity
The recommended doses of Brain-Ox are considered safe but long-term use, or use of high doses, may lead to increased cardiac side effects and toxicity.Precautions
Brain-Ox should be avoided in patients with cardiac arrhythmias, coronary artery disease, hypertension, or hypotension. It should also be used cautiously in patients with liver or kidney disease, or those taking drugs known to increase the risk of bleeding, as Brain-Ox may increase the risk of bleeding.Interactions
Brain-Ox may interact with certain drugs, including anticoagulants, anti-platelet drugs, and blood pressure lowering medications. It may also interact with certain herbs and supplements, such as saw palmetto.Disease Interactions
Brain-Ox may interact with certain diseases and conditions, such as coronary artery disease, hypertension, or hypotension.Drug Interactions
Brain-Ox may interact with certain drugs, such as anticoagulants, anticonvulsants, antibiotics, beta blockers, ACE inhibitors, calcium channel blockers, HMG-CoA reductase inhibitors, and NSAIDs.Food Interactions
Brain-Ox may interact with certain foods and food components, such as alcohol and caffeine.Pregnancy Use
Brain-Ox should not be used during pregnancy and lactation due to the potential risks to the fetus and newborn; pregnant and nursing women should choose another therapy.Lactation Use
Brain-Ox should be avoided during lactation due to the risk of toxicity to the infant.Acute Overdose
An acute overdose of Brain-Ox may lead to severe side effects, including arrhythmia, hypotension, and cardiac failure. Emergency medical care should be sought in case of acute overdose.Contraindications
Brain-Ox should not be used in patients with known hypersensitivity or allergy to the drug, or in patients with hepatic and renal impairment.Use Direction
Brain-Ox should be taken orally, with or without food, twice a day at regular intervals. It is important to follow the exact amount prescribed by the healthcare provider, and not to exceed the prescribed dosage.Storage Condition
Brain-Ox should be stored at room temperature, away from direct light, moisture and heat.Volume of Distribution
The volume of distribution of Brain-Ox is 0.9 to 3.1 L/kg.Half Life
The elimination half-life of Brain-Ox is 1-3 hours.Clearance
The clearance of Brain-Ox is 0.13-0.26 L/hour/kg.Here you find in details version of Brain-Ox
Some Frequently Asked Questions About Brain-Ox
https://www.medicinesfaq.com/brand/Brain-Ox,
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https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15376,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=347829295,
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https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=11201,
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=9985,
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1165342,
https://zinc.docking.org/substances/ZINC000001069082,
https://en.wikipedia.org/wiki/Vincamine,