Acnetrox
Acnetrox Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Acnetrox is a brand name. Its generic name is Nadifloxacin.
Acnetrox
Acnetrox is a fluoroquinolone antibacterial used to treat a variety of skin infections, such as acne vulgaris and cutaneous infections among other conditions. It works by inhibiting the activity of bacterial type II topoisomerase or DNA gyrase, which is essential for bacterial replication.
Uses for
Acnetrox is used to treat bacterial skin infections including acne vulgaris and cutaneous infections. It may also be used to treat other infections caused by susceptible bacteria.
Mechanism of Action
Acnetrox works by inhibiting the activity of bacterial type II topoisomerase or DNA gyrase, which is essential for bacterial replication. By preventing bacterial DNA replication, it kills the bacteria and eliminates the infection.
How Long Does it Take to Work?
Acnetrox usually begins working within 24-48 hours. The amount of time for improvement to be seen can vary from patient to patient depending on the severity of the infection.
Absorption
Acnetrox is absorbed rapidly from the gastrointestinal tract and is rapidly distributed to most body tissues.
Route of Elimination
Acnetrox is excreted primarily by the kidneys and secondarily in bile.
Dosage
The recommended dosage of nadifloxacin for the treatment of acne vulgaris:
- Adult and adolescent patients 12 years and older: Apply the cream or solution to the affected area once daily.
- Children younger than 12 years: Use and dosage must be determined by your doctor.
Administration
Acnetrox topical cream or solution should be applied to the affected areas once daily, ideally in the evening. It should be applied to the entire affected area and not just parts of it.
Side Effects
The most common side effects of nadifloxacin include skin irritation, dry skin, redness, itching, and burning. Less common side effects may include hives, rash, or allergic reactions.
Toxicity
Acnetrox has a low risk of toxicity in humans. However, prolonged use can lead to the development of bacterial resistance, which can make the drug ineffective.
Precautions
Before using nadifloxacin, inform your doctor or pharmacist of all the medications you are currently taking including prescription and nonprescription drugs, as well as any other health and dietary supplements. Do not apply nadifloxacin to eyes, mouth, or mucous membranes. Do not use this medication more often or for longer than prescribed.
Interactions
Acnetrox topical may interact with topical corticosteroids or other topical products applied to the skin. Tell your doctor or pharmacist of all the medications and products you are taking to prevent possible interactions.
Disease Interaction
Acnetrox should not be used by patients with known hypersensitivity to fluoroquinolones or any other ingredient in the medication. People with myasthenia gravis should not take nadifloxacin.
Drug Interaction
Acnetrox can interact with other drugs, such as antacids, iron supplements, or drugs that contain magnesium, calcium, or aluminum. Check with your doctor before taking any of these drugs while taking nadifloxacin.
Food Interactions
Acnetrox should not be taken with milk, yogurt, or any other dairy products. It is also best to limit intake of alcohol or other beverages containing alcohol while taking nadifloxacin.
Pregnancy Use
Acnetrox is classified as a pregnancy category C. This means that it may not be safe for use during pregnancy. Ask your doctor before taking this medication if you are pregnant or plan to become pregnant.
Lactation Use
Acnetrox is not recommended for use during lactation due to potential adverse effects on the infant. Use of this medication during lactation should be discussed with your doctor.
Acute Overdose
Symptoms of an acute overdose of nadifloxacin may include nausea, vomiting, diarrhea, abdominal pain, dizziness, agitation, confusion, and seizures. Seek medical attention right away if you experience any of these symptoms.
Contraindication
Acnetrox is contraindicated in patients with known hypersensitivity to fluoroquinolones or any other ingredient in the medication. It is also contraindicated in patients with myasthenia gravis.
Dose Directions
Acnetrox should be applied to the affected area once daily, ideally in the evening. Thoroughly cleanse the affected area before applying the medication. Do not use Acnetrox more often or for longer than prescribed.
Storage Conditions
Acnetrox should be stored at room temperature between 15°C to 30°C. Keep it away from light and moisture.
Volume of Distribution
The volume of distribution of nadifloxacin is approximately 91 liters.
Half Life
The half-life of nadifloxacin is approximately 10 hours.
Clearance
Acnetrox is eliminated via renal clearance and has an estimated clearance of 27 liters/hour.
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